Aging & Longevity

Artificial light at night accelerates aging processes in pre-pubertal female rats

1 month 3 weeks ago
Urbanization has introduced multiple factors that promote circadian clock dependent or independent disruption of physiology. Conditions such as late-night light (ALAN) exposure, shift working, cross-continental traveling may lead to circadian dysregulation leading to obesity, metabolic disorders and physiological alterations. As ALAN affects the circadian clock with concomitant effects on stress and free radical physiology, we hypothesised that night exposure to artificial light may affect the...
Garima Yadav

Precision nutrition in epigenetic aging: SHAP-optimized machine learning identifies omega-3 constituent-specific associations with aging biomarkers

1 month 3 weeks ago
This cross-sectional investigation seeks to examine the association between dietary omega-3 fatty acids (including α-linolenic acid [ALA], eicosapentaenoic acid [EPA], and docosahexaenoic acid [DHA]) and biomarkers of cellular aging, specifically DNA methylation age (Horvathage) and telomere length (Horvathtelo), in older adults. Our analysis leveraged nationally representative data from 2,136 participants aged ≥ 50 years in the 1999-2002 NHANES cycles. Multivariable linear regression models...
Zhaoqi Yan

Genetic "expiry-date" circuits control lifespan of synthetic scavenger bacteria for safe bioremediation

1 month 3 weeks ago
Synthetic biology enabled the systematic engineering of bacteria for diverse applications, but their deployment in open environments raises concerns about their persistence and unintended ecological impacts. To address these challenges, genetic "expiry-date" circuits were designed to impose a tunable lifespan on bacteria. These circuits, structured as a feedforward activation network, regulate the timing of cell death by controlling the expression of Lysis E, enabling a programmed lifespan...
Kha Mong Tran

Soil nitrogen drives inverse acclimation of xylem growth cessation to rising temperature in Northern Hemisphere conifers

1 month 3 weeks ago
Controlled experiments suggest that the seasonal build-up of nitrogen (N) limitation constrains the responses of forest autumn phenology to elevated temperatures. Therefore, rising soil N is expected to increase the delaying effects of elevated temperature on the end of the season, i.e., leaf senescence. However, the interactive effects of temperature, soil N, and aridity on xylem autumn phenology remain unknown. We conducted a wide spatial analysis from 75 conifer sites in the Northern...
Yaling Zhang

Pre-Vaccination Immunotypes and Immune Entropy Are Indicators of Multiple Vaccine Responsiveness

1 month 3 weeks ago
Immune aging is associated with decreased vaccine responses, but biomarkers for vaccine responsiveness remain unidentified. We analyzed immunotypes describing pre-vaccination immune cell profiles and their associations with triple vaccine responsiveness to influenza, pneumococcal, and SARS-CoV-2 vaccines in adults aged 25-78 years. Additionally, we developed an innovative measure, immune entropy, to quantify cumulative perturbations in the immune cell subset network. Specific immunotypes were...
Alper Cevirgel

Rapamycin Does Not Compromise Exercise-Induced Muscular Adaptations in Female Mice

1 month 3 weeks ago
An increasing number of physically active adults are taking the mTOR inhibitor rapamycin off label with the goal of extending healthspan. However, frequent rapamycin dosing disrupts metabolic health during sedentary conditions and abates the anabolic response to exercise. Intermittent once-weekly rapamycin dosing minimizes many negative metabolic side effects of frequent rapamycin in sedentary mice. However, it remains unknown how different rapamycin dosing schedules impact metabolic, physical,...
Christian J Elliehausen

Micro/nanoplastic-driven cardiovascular senescence and multi-target intervention by traditional Chinese medicine

1 month 3 weeks ago
Micro/nanoplastics (MNPs), pervasive environmental pollutants, accumulate in cardiovascular tissues and drive premature aging through multiscale pathophysiological cascades. This review synthesizes evidence establishing environmental phenotypic aging as a novel mechanistic link between MNP exposure and cardiovascular senescence. MNPs induce mitochondrial damage involving cristae disruption and mtDNA leakage activating cGAS-STING, epigenetic reprogramming encompassing METTL3-mediated m6A...
Yuan Liu

Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activity

1 month 3 weeks ago
Our brain is bathed in cerebrospinal fluid (CSF) that is produced by the choroid plexus. CSF serves as a dispersion route for hormones and nutrients, and a conduit for waste clearance. Age-dependent reduction in the CSF secretion rate could influence cerebral waste clearance and thereby promote cognitive deficits in the elderly. Here, we resolve age-dependent modulation of CSF dynamics and choroid plexus function by complementary in vivo determinations of intracranial pressure (ICP) and CSF...
Sara D Lolansen

Nipah virus vaccines evaluated in pigs as a 'One Health' approach to protect public health

1 month 3 weeks ago
Nipah virus (NiV) causes a severe neurological disease in humans. The first NiV outbreak, in Malaysia, involved pig-to-human transmission, that resulted in significant economic losses to the local pig industry. Despite the risk NiV poses to pig-dense regions, no licensed vaccines exist. This study therefore assessed three NiV vaccine candidates in pigs: (1) adjuvanted soluble NiV (s)G protein, (2) adjuvanted pre-fusion stabilised NiV (mcs)F protein, and (3) adenoviral vectored NiV G (ChAdOx1 NiV...
Rebecca K McLean

Identification of gut microbiota causally associated with aging and longevity and mediation roles of the cerebrospinal fluid proteins: proteomic genetic evidence from Mendelian randomization

1 month 3 weeks ago
Gut microbiota (GM) is implicated in aging biology, yet its dual regulatory role in the distinct yet interconnected processes of lifespan extension and aging remains poorly understood. This study employed genetic approaches to identify GM taxa exerting causal effects on longevity and aging and assess the mediation role of cerebrospinal fluid (CSF) proteins. We leveraged summary statistics of the GM taxa (207 taxa, 7738 participants from the Dutch Microbiome Project), the CSF proteins (7008...
Ruonan Liu

Large language model-based biological age prediction in large-scale populations

1 month 3 weeks ago
Accurate and convenient assessment of individual aging is crucial for identifying health risks and preventing aging-related diseases. Nonetheless, current aging proxies often face challenges such as methodological limitations, weak associations with adverse outcomes and limited generalizability. Here we propose a framework that leverages large language models (LLMs) to estimate individual overall and organ-specific aging using only health examination reports. We validated this approach across...
Yanjun Li

Advancing multiple sclerosis management in older adults

1 month 3 weeks ago
Multiple sclerosis (MS) typically presents in early to middle adulthood, but owing to advancements in health care, many individuals with MS now live a normal lifespan, and approximately half of the people currently living with MS are ≥50 years of age. As people living with MS age, their diagnosis, treatment and disease management become more complex owing to the effects of ageing, immunosenescence and comorbidities. Furthermore, diagnosis of late-onset MS (onset above 50 years of age) often...
Anneke van der Walt

Altered automatic gaze processing in older adults

1 month 3 weeks ago
From understanding others' mental states to interpreting social cues, aging impairs social abilities. These impairments might not seem surprising given they rely on other cognitive functions such as memory, attention and decision-making, which are known to decline with age. It is, however, unclear to what degree impairments of more basic perceptual abilities, such as eye-gaze detection, contribute to or even precede the decline in social skills. Previous studies have obtained mixed results when...
Roger Koenig-Robert

Efficiency of structural brain networks mediates age-associated differences in executive functioning in older adults

1 month 3 weeks ago
INTRODUCTION: Older age is associated with alterations in executive functioning (EF). Age-related alterations in the integrity of structural brain networks may contribute to EF decline, with potential consequences for independent living. Graph theory provides powerful metrics to examine the brain's structural connectome, but few studies have investigated the relationship of EF and structural brain networks, as described by graph-theoretical measures, in older adults. We aimed to investigate the...
Geraldine Rodríguez-Nieto

Associations of accelerated epigenetic aging with cancer and mortality risk in the USA

1 month 3 weeks ago
DNA methylation (DNAm) algorithms have been developed to assess biological aging and its association with cancer. Despite their potential, direct comparisons to identify the most accurate algorithm for predicting cancer risk and mortality remain limited. The study population (n = 2532) consisted of adults aged 50 years and older from the National Health and Nutrition Examination Survey, with 17-year follow-up mortality data. Twelve DNAm algorithms were evaluated using Illumina EPIC BeadChip...
Tongyan An

A novel synthetic 3,4,5-tri-feruloylquinic acid enhances learning and memory via neurotrophin signaling in an aging model senescence-accelerated prone 8 mice

1 month 3 weeks ago
This study is the first to investigate the anti-aging effects of the newly synthesized compound, 3,4,5-tri-feruloylquinic acid (TFQA), in vivo using the senescence-accelerated mouse prone 8 (SAMP8) model, through integrated whole-transcriptomic and biochemical analyses. Oral administration of TFQA (1 mg/kg body weight) for 37 days led to significant cognitive improvements, as demonstrated by enhanced performance in the Morris water maze (MWM) test, including reduced escape latency and increased...
Hongyu Lin
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