Aging & Longevity

Accumulating evidence suggests that mitogenic signaling during cell cycle arrest can lead to severe cytotoxic outcomes, such as senescence, though the underlying mechanisms remain poorly understood. Here, we explored the link between cell cycle dynamics and the formation of PML-nuclear bodies (PML-NBs), intranuclear structures known to mediate cellular stress responses. Our findings demonstrate that PML-NBs increase their number during interphase arrest. Moreover, the activation of mitogenic ERK...

Cognitive aging is associated with increased prefrontal cortex (PFC) activity, often interpreted as either a compensatory mechanism or a sign of neural inefficiency. In the context of speech-in-noise perception, it remains unclear whether this increase supports or impairs performance, as findings across studies are mixed. This study investigated age-related differences in PFC activity during sentence comprehension in noise using functional near-infrared spectroscopy. Fifty-seven participants (22...

Combating aging has become a central challenge in the life sciences, and myocardial aging, as a fundamental pathological process underlying the development and progression of various cardiovascular diseases, has become a key area in anti-aging research. In recent years, lactylation and methylation, two metabolism-dependent epigenetic modifications, have garnered increasing attention in the context of myocardial aging. Lactylation, mediated by lactate accumulation due to metabolic dysregulation,...

CONCLUSION: All visceral fat accumulation indicators were positively associated with sarcopenia risk and WWI identified as the most important predictor. The ML model achieved high predictive accuracy, highlighting the role of visceral fat accumulation in sarcopenia risk and healthy aging promotion.

Epigenetic drift refers to the gradual and stochastic accumulation of epigenetic changes, such as DNA methylation variability, with advancing age. Although increasingly recognized for its potential role in aging biology, its extent, biological significance, and population specificity remain insufficiently characterized. Here, we present the first comprehensive epigenome-wide drift study (EWDS) in a large Chinese cohort (n = 3,538), with replication in two independent Chinese (total n = 1,467)...

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Engram cells storing episodic memories are allocated to separate neuronal ensembles. However, how these ensembles maintain their stability to drive precise memory expression, and whether their destabilization contributes to aging-related memory deficits, remain elusive. Here, we show that during contextual fear memory consolidation, neuronal pentraxin 1 (NPTX1) in Fos transcription-dependent ensemble (F-RAM) of the dentate gyrus (DG) promotes memory expression in the fear context. NPTX1...

This study investigates the association between park proximity and self-reported health among older adults in China, with particular attention to the moderating effects of housing characteristics. Drawing on large-scale individual survey data and 2015 park point-of-interest (POI) data, the analysis shows that closer proximity to formally designated public parks is significantly associated with better self-reported health among older adults. The study further explores whether housing features...

CONCLUSIONS: LA and LA types are independently associated with IC in community-dwelling older adults. Therefore, participation in diverse leisure activities is necessary for maintaining and improving IC in the older adults.

CONCLUSIONS: These findings enrich our understanding of CCRC decision-making in China by highlighting the ongoing influence of sociocultural values and personal autonomy throughout the process. Importantly, the need for personalized care persists throughout all stages, with particular emphasis on psychological support and cultural sensitivity in service delivery. Policy recommendations include improving affordability, accessibility, and community integration to better support older adults and...

Aging poses significant challenges to cardiovascular health necessitating novel therapeutic approaches. This study investigates the potential of the brown adipose tissue (BAT) derived lipokine 12,13-diHOME to mitigate age-induced impairments in cardiovascular function. Analysis of human and rodent plasma signaling lipids reveals a decline in 12,13-diHOME levels with age. Transplantation of BAT or sustained upregulation of 12,13-diHOME effectively preserved cardiac function in aged male and...

Healthy aging relies on a symbiotic host-microbiota relationship. The age-associated decline of the immune system can pose a threat to this delicate equilibrium. In this work, we investigated how the functional deterioration of T cells can affect host-microbiota symbiosis and gut barrier integrity and the implications of this deterioration for inflammaging, senescence, and health decline. Using the Tfam^(fl/fl)Cd4^(Cre) mouse model, we found that T cell failure compromised gut immunity leading...

ObjectivesSensory loss is associated with increased dementia risk, yet the underlying mechanisms remain unclear. This longitudinal study examined the association between self-reported sensory difficulty (vision, hearing, dual), social and physical activity, and dementia risk among older U.S. adults.MethodsData were drawn from the 2015-2020 National Health and Aging Trends Study (N = 6,295). Discrete-time survival mediation models with a structural equation modeling-based approach were estimated...

The disposable soma theory (DST) posits that organisms prioritize reproductive success over long-term somatic maintenance, resulting in an inevitable decline after reproduction. However, such a basis does not fully explain the human brain's capacity to preserve metabolically costly, plastic, and cognitively essential functions well beyond the reproductive peak. This Perspective challenges the universality of DST by proposing that brain aging follows a selectively resilient trajectory, shaped by...

Torpor is a naturally occurring state of metabolic suppression that enables animals to adapt and survive extreme environmental conditions. Inspired by this adaptation, researchers have pursued synthetic torpor-an artificially induced, reversible hypometabolic state with transformative medical potential. Achieving synthetic torpor has been pursued for over a hundred years, with earlier work focused on identifying drugs for systemically suppressing metabolism. Breakthroughs in 2020 identified key...

Introduction Cardiac autonomic dysfunction reduces the cardiac system's ability to respond to stressors and is prevalent in aging and diseases, especially cardiovascular diseases like aortic stenosis (AS). Heart rate variability (HRV) is a common measure for evaluating parasympathetic activity and cardiac autonomic function; similarly, heart rate (HR) changes during exercise are utilized in determining cardiac health. However, directly measuring HR parameters from an electrocardiogram (ECG) is...

The global demographic shift towards an ageing population has rendered cardiovascular ageing and its associated pathologies a growing challenge for health. Emerging evidence highlights the critical role of exercise in mitigating age-associated cardiovascular alterations in structure and function and preventing ageing-associated cardiovascular diseases. However, the precise molecular mechanisms mediating these exercise-induced benefits in promoting healthy cardiovascular ageing remains...

The endocycle is a specialized cell cycle during which cells undergo repeated G/S phases to replicate DNA without division, leading to large polyploid cells. The transition from a mitotic cycle to an endocycle can be triggered by various stresses, which results in unscheduled, or induced endocycling cells (iECs). While iECs can be beneficial for wound healing, they can also be detrimental by impairing tissue growth or promoting cancer. However, the regulation of endocycling and its role in...

Reproductive longevity is essential for female fertility and healthy aging; however, the role of stress response, especially stress granule accumulation, in ovarian aging remains elusive and interventions are lacking. Here, we identified deleterious mutations and decreased expression of NCOA7, a stress-response protein related to granulosa cell senescence in women with physiological and pathological ovarian aging. NCOA7 deletion accelerates oxidative stress-related cellular senescence, ovarian...

This randomized cross-over study examined the acute effects of single-task or dual-task walking physical activity (PA) breaks of prolonged sitting among healthy older adults on cognitive performance and cerebral blood flow velocity (CBFv). Twenty-seven healthy older adults (69.4 ± 5.6 years, 25 female) were randomly assigned to engage in three experimental conditions (i.e., control, single-task, and dual-task walking), each one on a different day. All conditions included 3 h of sitting time,...