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Sex and gender discussions don't need to be toxic
Dad’s microbiome can affect offspring’s health — in mice
Magnetic field effects on behaviour in <i>Drosophila</i>
A body–brain circuit that regulates body inflammatory responses
Support communities that will lose out in the energy transition
A snapshot of Lithuania’s life-sciences landscape
How bioinformatics led one scientist home to Lithuania
How to meet Africa’s grand challenges with African know-how
I fell out of love with the lab, and in love with business
Scientists tried to give people COVID — and failed
How I’m supporting other researchers who have moved to Lithuania
Chinese virologist who was first to share COVID-19 genome sleeps on street after lab shuts
U.S. moves to reclassify cannabis as a lower risk drug
Historic policy shift will make it easier for scientists to investigate potential medical uses
Scientists call new measures to control bird flu in cows ‘a drop in the bucket’
As restrictions take effect, new data show virus is pervasive in herds
Steel industry emissions are a big contributor to climate change. Can it go green?
Department of Energy funds research to take carbon out of iron and steel production
Nobel-winning neuroscientist faces scrutiny for data discrepancies in more than a dozen papers
Thomas Südhof says mistakes in co-authored publications are honest errors that don’t affect studies' conclusions
Protein mimetic 2D FAST rescues alpha synuclein aggregation mediated early and post disease Parkinson's phenotypes
Abberent protein-protein interactions potentiate many diseases and one example is the toxic, self-assembly of α-Synuclein in the dopaminergic neurons of patients with Parkinson's disease; therefore, a potential therapeutic strategy is the small molecule modulation of α-Synuclein aggregation. In this work, we develop an Oligopyridylamide based 2-dimensional Fragment-Assisted Structure-based Technique to identify antagonists of α-Synuclein aggregation. The technique utilizes a fragment-based...
Cost-effectiveness and cost-utility of a digital technology-driven hierarchical healthcare screening pattern in China
Utilization of digital technologies for cataract screening in primary care is a potential solution for addressing the dilemma between the growing aging population and unequally distributed resources. Here, we propose a digital technology-driven hierarchical screening (DH screening) pattern implemented in China to promote the equity and accessibility of healthcare. It consists of home-based mobile artificial intelligence (AI) screening, community-based AI diagnosis, and referral to hospitals. We...
Correlates of protection against symptomatic SARS-CoV-2 in vaccinated children
The paucity of information on longevity of vaccine-induced immune responses and uncertainty of the correlates of protection hinder the development of evidence-based COVID-19 vaccination policies for new birth cohorts. Here, to address these knowledge gaps, we conducted a cohort study of healthy 5-12-year-olds vaccinated with BNT162b2. We serially measured binding and neutralizing antibody titers (nAbs), spike-specific memory B cell (MBC) and spike-reactive T cell responses over 1 year. We found...
Fundamentals of redox regulation in biology
Oxidation-reduction (redox) reactions are central to the existence of life. Reactive species of oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular processes. Yet, excessive levels of oxidants are associated with ageing and many diseases, including cardiological and neurodegenerative diseases, and cancer. Hence, maintaining the fine-tuned steady-state balance of reactive species production and removal is essential. Here, we discuss new insights into the...