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N-type semiconducting hydrogel

1 day ago
Science, Volume 384, Issue 6695, Page 557-563, May 2024.
Peiyun Li, Wenxi Sun, Jiulong Li, Ju-Peng Chen, Xinyue Wang, Zi Mei, Guanyu Jin, Yuqiu Lei, Ruiyun Xin, Mo Yang, Jingcao Xu, Xiran Pan, Cheng Song, Xin-Yu Deng, Xun Lei, Kai Liu, Xiu Wang, Yuting Zheng, Jia Zhu, Shixian Lv, Zhi Zhang, Xiaochuan Dai, Ting…

Actin-nucleation promoting factor N-WASP influences alpha-synuclein condensates and pathology

1 day 20 hours ago
Abnormal intraneuronal accumulation of soluble and insoluble α-synuclein (α-Syn) is one of the main pathological hallmarks of synucleinopathies, such as Parkinson's disease (PD). It has been well documented that the reversible liquid-liquid phase separation of α-Syn can modulate synaptic vesicle condensates at the presynaptic terminals. However, α-Syn can also form liquid-like droplets that may convert into amyloid-enriched hydrogels or fibrillar polymorphs under stressful conditions. To advance...
Joshua Jackson

Cerebrospinal fluid reference proteins increase accuracy and interpretability of biomarkers for brain diseases

1 day 20 hours ago
Cerebrospinal fluid (CSF) biomarkers reflect brain pathophysiology and are used extensively in translational research as well as in clinical practice for diagnosis of neurological diseases, e.g., Alzheimer's disease (AD). However, CSF biomarker concentrations may be influenced by non-disease related inter-individual variability. Here we use a data-driven approach to demonstrate the existence of inter-individual variability in mean standardized CSF protein levels. We show that these non-disease...
Linda Karlsson

A systems biology-based identification and in vivo functional screening of Alzheimer's disease risk genes reveal modulators of memory function

1 day 20 hours ago
Genome-wide association studies (GWASs) have uncovered over 75 genomic loci associated with risk for late-onset Alzheimer's disease (LOAD), but identification of the underlying causal genes remains challenging. Studies of induced pluripotent stem cell (iPSC)-derived neurons from LOAD patients have demonstrated the existence of neuronal cell-intrinsic functional defects. Here, we searched for genetic contributions to neuronal dysfunction in LOAD using an integrative systems approach that...
Adam D Hudgins

D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer's disease

1 day 20 hours ago
Amyloid fibrils of tau are increasingly accepted as a cause of neuronal death and brain atrophy in Alzheimer's disease (AD). Diminishing tau aggregation is a promising strategy in the search for efficacious AD therapeutics. Previously, our laboratory designed a six-residue, nonnatural amino acid inhibitor D-TLKIVW peptide (6-DP), which can prevent tau aggregation in vitro. However, it cannot block cell-to-cell transmission of tau aggregation. Here, we find D-TLKIVWC (7-DP), a d-cysteine...
Ke Hou

Vaccination for healthy aging

1 day 20 hours ago
As the world's population grows older, vaccination is becoming a key strategy for promoting healthy aging. Despite scientific progress in adult vaccine development, obstacles such as immunosenescence and vaccine hesitancy remain. To unlock the potential of adult vaccines fully, we must enhance immunization programs, dispel misinformation, and invest in research that deepens our understanding of aging and immunity.
David E Bloom

Cellular senescence is a double-edged sword in regulating aged immune responses to influenza

1 day 20 hours ago
Clearance of senescent cells has demonstrated therapeutic potential in the context of chronic age-related diseases. Little is known, however, how clearing senescent cells affects the ability to respond to an acute infection and form quality immunological memory. We aimed to probe the effects of clearing senescent cells in aged mice on the immune response to influenza (flu) infection. We utilized a p16 trimodality reporter mouse model (p16-3MR) to allow for identification and selective clearance...
Blake L Torrance