Aggregator

Eating too much junk food early in life may rewire the brain in ways that last into adulthood, even after switching to a healthier diet. Scientists found that high-fat, high-sugar diets changed feeding behavior and disrupted appetite-control regions in the brain. Excitingly, certain gut-friendly bacteria and prebiotic fibers appeared to help undo some of the damage.

A huge international review found that GLP-1 weight-loss drugs significantly reduce the risk of heart attacks, strokes, heart failure, and premature death over the long term. Researchers say these medications could become a major weapon against cardiovascular disease — not just obesity and diabetes.

Scientists have uncovered alarming new evidence that a common insecticide may leave lasting marks on the developing brain before a child is even born. Researchers studying New York City children found that prenatal exposure to chlorpyrifos — a pesticide once widely used indoors and still used in agriculture — was linked to widespread brain abnormalities and weaker motor skills years later.

Scientists have unveiled a powerful new tool called PerturbFate that could change how researchers tackle diseases driven by huge numbers of genetic mutations, including cancer and Alzheimer’s. Instead of trying to target every faulty gene individually, the system tracks how different mutations reshape cells over time and identifies the hidden “control hubs” where those pathways converge.

Puzzling JWST observation could instead be one of the universe's first galaxies—or something more mundane

T cells are central to adaptive immunity, and continuously sense, generate, and respond to mechanical forces. Advances in mechanoimmunology show that T-cell behavior is tightly shaped by the physical properties of their environment, including stiffness, viscoelasticity, ligand arrangement, and tissue topography. T-cell activation depends not only on biochemical signals but also on forces transmitted through the T-cell receptor, coreceptors, and mechanosensitive ion channels, which converge on...

CONCLUSIONS: Living arrangement, social activity and residence were the most significant factors associated with the types of LTC utilization by older adults in China. Overall, enabling and predisposing factors had a greater influence than the need factors. These findings not only demonstrate the potential value of ML for LTC policy development, but also provide empirical support for the Chinese government to adopt targeted interventions that enhance LTC service accessibility and affordability.

Transcription factor (TF) modules interact to regulate key biological processes and cell-state transitions in normal physiology and disease. Understanding these modules and how they evolve over time can be accomplished by constructing gene regulatory networks (GRNs). To identify context-specific TF subnetworks, we developed ChEA-KG, which generates enriched TF regulatory subnetworks for input gene sets. ChEA-KG is based on a GRN connecting 1559 human TFs via 131 181 signed and directed edges...

Science, Ahead of Print.

Science, Ahead of Print.

Science, Ahead of Print.

Researchers discovered that leucine, a nutrient found in protein-rich foods, can supercharge mitochondria by protecting crucial energy-producing proteins inside cells. The breakthrough uncovers a powerful new link between diet and cellular energy — with possible implications for cancer and metabolic disease treatments.

MIT scientists have identified cysteine — an amino acid found in foods like meat, dairy, beans, and nuts — as a potent trigger for intestinal repair. In mice, a cysteine-rich diet activated immune cells that released healing signals, helping stem cells rebuild damaged intestinal tissue after radiation exposure. Researchers say the discovery could eventually lead to new dietary therapies for cancer patients suffering from treatment-related gut damage.