Aggregator
Pan-Epigenetic Age Prediction in Mammals
Epigenetic remodeling is a hallmark of aging, yet which epigenetic layers are most affected during aging-and the extent to which they are interrelated-is not well understood. Here, we perform a comprehensive analysis of epigenetic aging encompassing 6 histone marks and DNA methylation measured across 12 tissues from > 1000 humans and mice. We identify a synchronized pattern of age-related changes across these epigenetic layers, with all changes converging upon a common set of genes. Notably, an...
Friction-controlled reentrant aging and fluidization in granular materials
Granular materials densify under repeated mechanical perturbations, nonequilibrium dynamics that underlies many natural and industrial processes. Because granular relaxation is governed by frictional contacts and energy dissipation, this aging behavior fundamentally differs from that of thermal glasses despite their apparent similarities. Here, we uncover how friction controls the compaction dynamics of granular packings subjected to quasistatic cyclic shear. Using discrete element simulations,...
In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation
Partial reprogramming has emerged as a promising strategy to reset the epigenetic landscape of aged cells towards more youthful profiles. Recent advancements have included the development of chemical reprogramming cocktails that can lower the epigenetic and transcriptomic age of cells and upregulate mitochondrial biogenesis and oxidative phosphorylation. However, the ability of these cocktails to affect biological age in a mammalian aging model has yet to be tested. Here, we have characterized...
Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
The geroscience hypothesis suggests that understanding mechanisms underlying aging will enable us to delay and lessen age-related disability and diseases. The role of mechanical factors has been increasingly appreciated in many aspects of the aging process. Here, we use mouse models to investigate changes in the biomechanics of the proximal pulmonary artery, lung function, and right ventricle function in aging. We found an age-related decreased capacity to store energy and increased...
Still working at 107: supercentenarian study probes genetics of extreme longevity
Sensors are transforming the world — work together to maximize their benefits
Author Correction: Nutrient-sensing nuclear receptors coordinate autophagy
Author Correction: Relatively warm deep-water formation persisted in the Last Glacial Maximum
Should professors be forced to retire?
How to eat well and within Earth’s limits
What were the first animals? The fierce sponge–jelly battle that just won’t end
African science needs to cut reliance on foreign donors
Spotting viral invaders in koala family trees
Street-dog policy in India is barking up the wrong tree
Social-media bans: why corporate fines could backfire
Volcanic personality: the man who recognized volcanoes as a planet-shaping force of nature
Fluttering ‘tails’ on bird nests confuse would-be predators
Blue manakins in Brazil use “disruptive camouflage” to protect their eggs, new study finds
Splat! Could roadkill replace some studies of live animals?
Science chats with an ecologist about the advantages of using discarded carcasses for research
Congress set to cut defense science funding
But lawmakers reject Trump’s call for deeper downsizing and boost medical research
Daily briefing: Why cancer might protect against Alzheimer's disease
No abstract