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Correction: From sick care to healthspan: educating the longevity physician for health maintenance and health promotion
No abstract
The naked mole-rat microbiome is associated with healthy aging and social structure
The naked mole-rat (NMR), Heterocephalus glaber, is an unusual mammal that lives underground in eusocial colonies. NMRs show remarkable longevity and are resistant to cancer, neurodegeneration, and cardiovascular disease. The gut microbiome is known to modulate human health and disease; here, we investigate the microbiome of NMRs, comparing fecal samples from individuals over different social ranks and over a span of more than three decades. In contrast to a cohort of C57BL6/J mice, which showed...
Could the monocyte-to-high-density lipoprotein cholesterol ratio serve as a reliable marker for orthostatic hypotension in older adults? A cross-sectional study
No abstract
Spatiotemporal Transcriptomics Characterizes Immune Microenvironment During Mouse Liver Aging
The liver is a major metabolic organ, responsible for synthesizing and breaking down diverse metabolites. Recently, the liver's immunological functions have gradually been unveiled: combating pathogens and maintaining tissue homeostasis. Age-related functional alterations in these immune cells emerge as potential drivers of hepatic dysfunction and age-associated pathologies. However, systematic investigations into spatiotemporal immune cell dynamics during liver aging remain limited. To address...
Telomere Dysfunction and Proteostasis Decline Define Distinct Pathways of Cellular Senescence in the Human Respiratory Tract
As the global population ages, cellular senescence contributes increasingly to the burden of age-related diseases. Hallmarks of this process include telomere shortening and loss of proteostasis, frequently linked to DNA damage-associated transcriptional stress. Although telomere dysfunction-induced foci (TIF) have been well documented in lungs from patients with idiopathic pulmonary fibrosis (IPF), their occurrence and role during physiological lung aging remain unclear. Analysis of senescence...
UNC45B Reduction With Aging: A Myofiber-Intrinsic Promoting Factor for Sarcopenia
Skeletal muscle mass and force decline with age, and the loss of muscle force precedes muscle atrophy. However, the underlying mechanisms remain unclear. Here, we investigated the role of the myosin co-chaperone, uncoordinated mutant number-45 myosin chaperone B (UNC45B), in regulating muscle mass and force. UNC45B expression decreased in mouse gastrocnemius muscle with age, particularly at 24 months old, and adeno-associated virus vector-mediated knockdown of Unc45b in 3-month-old mouse triceps...
How big is Big <i>G</i>? Mystery deepens after ten-year effort to measure gravity’s strength
Vaccines mean malaria deaths should be falling — not rising
Triple-decker solar cells reach efficiency milestone
Forty years after Chornobyl, more nuclear disasters are inevitable — plan for them
Personalized CRISPR therapies could soon reach thousands — here’s how
AI doom warnings are getting louder. Are they realistic?
Yellow glass shows insect wings at their best
This simple house may help prevent multiple fatal diseases in African children
Randomized, controlled trial shows the $8800 design can reduce cases of malaria, diarrhea, and respiratory infection
Whistleblower alleges Finnish startup’s vaunted solid-state battery isn’t what it claims
Donut Lab’s assertions of lightning-fast charging and high energy storage have led to a criminal complaint
Watch a spider’s heart race when traffic gets too loud
Study captures a hidden stress response in roadside orb weavers
Cocaine pollution gives salmon wanderlust
First study of how drugs affect behavior of fish in the wild adds to concerns about chemical exposure
This disabled parrot has become king by learning to ‘joust’
Despite missing his entire upper beak, Bruce the kea is winning at life
The temperature dependence of amyloid <em>β</em> solubility reveals the hydrophobic effect as the main driving force for fibril formation
The aggregation of amyloid proteins into fibrillar and oligomeric aggregates is linked to a number of neurodegenerative diseases. While the disease onset remains elusive in many cases, an understanding of the driving forces for the aggregation may help finding possible causes. While effects on amyloid formation kinetics are more commonly studied, gaining insights into these driving forces require a thermodynamic approach with equilibrium measurements. Here we investigate the temperature...
Dopaminergic modulation of the sense of agency influences moral behavior in Parkinson's disease
Embodied accounts of morality propose that corporeal self-awareness helps restrain immoral actions. The Sense of Agency (SoA)-the feeling of controlling one's actions and their consequences-drops when individuals harm others. However, whether modulating SoA shifts moral behavior remains unclear. Parkinson's Disease (PD) offers a unique model to address this question, because dopaminergic dysfunction affects both SoA and moral decision-making. We tested 23 individuals with PD in ON and OFF...