Aggregator

Cinematic geologists are usually good guys—sometimes gals—but they have a one in three fatality rate, a film analysis show

Hidden chambers may provide Mediterranean monk seals refuge from tourists

Cannabis use among older adults is rising fast, but today’s marijuana is far more potent than many people realize — and experts warn the risks may be underestimated. Stanford Medicine specialists say modern cannabis can increase the chances of heart problems, falls, memory issues, dangerous drug interactions, and even addiction, especially for people over 65.

Scientists have uncovered a surprising dark side to vitamin B2: it may help cancer cells stay alive. The vitamin supports a cellular shield that protects tumors from ferroptosis, a form of programmed cell death linked to cancer suppression. In lab tests, researchers used a vitamin B2-like compound called roseoflavin to break down that protection and trigger cancer cell death.

Scientists have uncovered evidence that serotonin — the same brain chemical boosted by many antidepressants — may actually worsen tinnitus. Using advanced light-based brain stimulation in mice, researchers identified a serotonin-driven circuit linked directly to tinnitus-like behavior. The findings may explain why some people experience louder ringing in their ears while taking SSRIs.

Relocating plants’ light-capturing structures to the eye may fight damage from dry eye

Researchers analyzing over 20,000 patients found that very high levels of the inherited cholesterol particle Lp(a) dramatically raise the risk of stroke, cardiovascular death, and major heart complications. Because most people with elevated Lp(a) have no symptoms, experts say a simple blood test could uncover a dangerous hidden risk factor.

SMILE orbiter will use x-rays to map how the solar wind batters the magnetosphere

Apolipoprotein E4 (APOE4) is the leading genetic risk factor and an increasingly recognized causal contributor to Alzheimer's disease (AD). AD progresses along a temporal, pathological, and clinical continuum spanning preclinical, prodromal, and dementia stages. Across this continuum, APOE4 exerts detrimental effects at distinct times and in different cell types, underscoring the need for a model defining not only how but also when and in which cells these effects occur. In this review, we...

No abstract

Extracellular Vesicles (EVs), the nano-sized extracellular membrane-bound vesicles, facilitate cell-to-cell communication by transporting bioactive molecules like proteins, lipids, and nucleic acids. Their unique cargo, determined by the cell of origin, makes them valuable tools for studying disease pathogenesis and potential drug delivery systems. Research suggests that EVs play a role in the pathogenesis of various diseases, including neurodegenerative and neurodevelopmental disorders. They...

Single-cell multi-omics technologies profile multiple molecular layers in individual cells, but existing methods often struggle to integrate transcriptomic, proteomic, and epigenomic measurements into an interpretable representation while preserving relationships among cells. Here, we present the single-cell multi-omics adversarial graph convolutional autoencoder (scMAGCA), which constructs cell graphs and uses adversarial alignment to learn interpretable shared embeddings that capture cellular...

The APOE locus is the strongest genetic factor for Alzheimer's disease, with ε4 increasing and ε2 decreasing risk, yet the basis of these opposing effects remains unclear. Here we performed a multicohort proteomic analysis across plasma and cerebrospinal fluid in GNPC, BioFINDER-2, ADNI, UK BioBank, and PPMI. APOE-associated protein alterations are detectable before amyloid pathology and remain stable across age and disease progression. APOE2-associated proteins were enriched in pathways related...

Blood inflammatory marker studies in aging and Alzheimer's disease (AD) research have faced numerous interpretative and methodological challenges that have hindered the field's understanding of the relationship between immune network regulation/dysregulation and aging health factors. We examined how blood inflammation markers directly relate to each other in typical aging, cognitively unimpaired adults using a conditional network analytic modeling approach. We further evaluated how blood...

Changes in peripheral CD8^(+) T cells are a hallmark of immune aging. However, the role of aged non-infiltrating CD8^(+) T cells in brain aging remains to be fully defined. Here, we showed that aged circulating CD8^(+) T cells and their secreted factors drove hippocampal-dependent cognitive decline. Using heterochronic parabiosis and transcriptomics analysis, we observed that peripheral CD8^(+) T cells maintained properties intrinsic to their age. Systemic exposure of young mice to aged CD8^(+)...

A critical challenge in sepsis treatment lies in its complex immune microenvironment, characterized by concurrent hyperinflammation and immunosuppression. This imbalance is jointly driven by dysregulated neutrophil programmed death and abnormal activation of the PD-1/PD-L1 immune checkpoint. Therefore, precisely modulating neutrophil fate and blocking this immune checkpoint are highly promising therapeutic strategies. We engineered an artificial exosome nano-decoy (AT@NV-PD1) that homes to...

Ageing is an inevitable, yet highly heterogeneous process shaped by genetic, epigenetic, and environmental influences. While most individuals experience progressive functional decline, a minority exhibits accelerated degeneration due to rare pathogenic mutations, whereas others achieve exceptional healthy longevity. This continuum-from progeroid syndromes to centenarians-provides a unique framework to examine how deleterious and protective genetic variants differentially modulate conserved...

The Hallmarks of Aging framework has become a widely accepted schema within geroscience, organizing diverse mechanisms of cellular and molecular decline. This article examines whether the Hallmarks function as a scientific paradigm and, beyond that, whether they have enabled genuine scientific progress-an angle largely absents from current literature. Drawing on models from the philosophy of science, the article evaluates the framework's status and impact from multiple perspectives. From Kuhn,...

CONCLUSIONS AND IMPLICATIONS: Participation in community gatherings is associated with reduced LTC costs among older adults with mild disabilities under the LTCI system. These programs may promote more efficient use of care resources and support municipal strategies to contain LTC costs.

CONCLUSIONS AND IMPLICATIONS: Home care and dementia were the primary drivers of nursing home entry in Sweden between 2020 and 2022, while social factors played a smaller role. Further investigations should ensure that those with dementia who are living alone or have multimorbidity are receiving adequate care. With continued population aging, it is essential that we monitor and adapt our policies and systems to ensure needs dictate access to care.