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Researchers discovered that declining levels of phosphatidylcholine may be a major cause of age-related mitochondrial dysfunction and loss of cellular energy. Remarkably, boosting this nutrient restored more youthful mitochondrial performance in aging organisms, suggesting some aspects of aging can be slowed or reversed.

Cancer cells often survive treatment by fixing the DNA damage that therapy is meant to cause. Researchers found that UNI418 can disrupt this repair ability, leaving cancer cells more exposed. When combined with a PARP inhibitor, it helped resistant cancer cells respond to treatment again. The findings point to a new strategy for overcoming cancer drug resistance.

NIH programs and leadership are hit especially hard, while other science agencies are barely mentioned

Stretching 1200 kilometers, the unusual collection of carcasses includes fossils older than 5 million years

Researchers gave top AI models a classic attention test used in psychology and found a major flaw. While the models could correctly name colors in short lists, their performance deteriorated sharply as the task became longer and more complex. Some leading systems fell from over 90% accuracy to nearly complete failure.

A groundbreaking new connectome maps every neural connection in an adult fruit fly’s central nervous system, creating an unprecedented view of how the brain and body work together. The findings suggest that complex behaviors emerge from distributed local circuits rather than a single central controller, offering new clues about intelligence, movement, and brain function.

Alzheimer's disease (AD), characterized by progressive cognitive decline, represents a major public health challenge in aging societies. Since the proposal of the amyloid cascade hypothesis, Aβ-targeted therapeutic strategies have dominated this field for over three decades. Although recent anti-Aβ antibodies have shown modest promise, their limited clinical benefits coupled with safety concerns underscore the necessity of re-evaluating the pathological mechanisms underlying AD. Cerebral...

The cerebellum contains most of the brain's neurons and supports many functions, yet how it changes with age remains unclear. Here we used three brain imaging studies spanning 47,000 adults and examined how different parts of the cerebellum age and their relation to cognition. We characterized cerebellar aging using volumetry and the T1-weighted/T2-weighted ratio, and corroborated these findings with quantitative magnetic resonance imaging in an independent sample. We show a spatially...

Restoring striatal dopamine synthesis is a promising gene therapy strategy for Parkinson's disease. Previous adeno-associated virus-mediated aromatic L-amino acid decarboxylase (AADC) monotherapies remain dependent on exogenous levodopa, whereas multigene delivery is constrained by strict adeno-associated virus packaging limits. A 'dual approach' targeting the two rate-limiting enzymes, tyrosine hydroxylase (TH) and AADC, offers the potential for autonomous dopamine synthesis. We report the...

A decline in nuclear factor erythroid 2-related factor 2 (NFE2L2)-orchestrated adaptive homeostasis and oxidative distress are thought to be key features of aging. In contracting skeletal muscle, the reactive oxygen species-producing enzyme NADPH oxidase 4 (NOX4) is a potent inducer of NFE2L2 adaptive homeostasis. Here, we report that skeletal muscle NOX4 levels decline in aged mice and humans, resulting in abrogated NFE2L2 adaptive homeostasis, increased protein oxidative damage, and decreased...

Growing energy demands and renewable integration are stressing the aging power grid infrastructure. Lignocellulosic oil-impregnated paper is widely used in power transformers but suffers from critical limitations, such as low dielectric strength, mechanical strength, and thermal conductivity, causing premature transformer failures. Here, we demonstrate a superior electrically insulating oil-impregnated paper design using the naturally anisotropic structure of densified wood veneer to achieve...

CONCLUSION: While rural Veterans were less likely to use HCBS overall, there was substantial variability across facilities. These findings demonstrate that some VAMCs counteract the overall trend by ensuring rural Veterans receive HCBS at rates comparable to urban Veterans.

Establishment of the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) barrier requires precise coordination between diverse cell types to protect and nourish the brain. Here, we identify developmentally programmed p21^(+) senescent cells that exhibit divergent senescence-associated features across these two brain interfaces in mice. In the choroid plexus (ChP), epithelial cells adopt a lifelong, non-inflammatory senescent state associated with CSF production and blood-CSF barrier...

Aging emerges from nonlinear interactions among primary, antagonistic, and integrative hallmarks that progressively erode tissue resilience. As global demographics shift and chronic disease burden intensifies, extending healthspan with mechanistic precision has become imperative, accelerating the incorporation of artificial intelligence into geroscience. AI leverages multi-omics, spatial biology, imaging, and clinical data to reveal nonlinear structures linking hallmark interactions to tissue...

Alzheimer's disease (AD), characterized by progressive cognitive decline, represents a major public health challenge in aging societies. Since the proposal of the amyloid cascade hypothesis, Aβ-targeted therapeutic strategies have dominated this field for over three decades. Although recent anti-Aβ antibodies have shown modest promise, their limited clinical benefits coupled with safety concerns underscore the necessity of re-evaluating the pathological mechanisms underlying AD. Cerebral...

Muscle regenerative capacity declines with aging and disease, which leads to muscle loss and reduced lifespan. Muscle regenerative failure is related to a disrupted network orchestrated by multiple muscle-harbored cell types; whether and how the interplay between macrophages and myofibers contributes to this process is largely unknown. Herein, we report upregulation of histone methyltransferase G9a in both aged human muscle and mouse muscle after injury. Deletion of G9a in either myeloid cells...

Cancer-related lymphedema (CRL) is an incurable disease characterized by progressive swelling of extremities. One of the risk factors in developing CRL is cancer treatments, including surgery and radiation. This leads to damage to the lymphatic system, causing accumulation of interstitial fluid, infiltration of inflammatory cells and cytokine release, tissue remodeling, accumulation of subcutaneous fat, and fibrosis. Radiation therapy (RT) inhibits lymphatic proliferation and survival by...

Identifying biomarkers that identify vulnerability to age-related cognitive decline is a major priority in aging research. Adropin, a circulating peptide that regulates metabolic and vascular homeostasis, has been associated with cognitive performance in humans, but its relevance across species has remained unclear. Here we report low plasma adropin concentrations associate with poor decision-making in aged rhesus macaques subject to an increasing food choice test paradigm. Animals with higher...