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Scientists are calling for a major rethink of how we manage high blood pressure, suggesting that eating more potassium could be just as important as cutting back on salt. A new report finds that combining increased potassium intake with reduced sodium consumption may offer greater benefits for blood pressure control than sodium reduction alone.

Researchers have developed a remarkable new electronic implant that could transform type 2 diabetes treatment by lowering blood sugar without insulin or traditional drugs. The device uses a special electrically powered catalyst to convert excess glucose into a substance that the body eliminates through urine, potentially preventing unwanted energy from being stored as fat. In diabetic mice, the implant precisely controlled blood sugar and promoted weight loss.

In a surprising discovery, scientists found that certain diets associated with obesity can make cancer immunotherapy more effective in mice, challenging traditional assumptions about diet and cancer treatment. The findings suggest that the secret may lie in how food interacts with gut bacteria to strengthen the immune system's response to cancer.

There is an urgent global need for affordable, large-scale health screening to enhance preventive care in the ageing population. Using low-cost, non-invasive retinal photographs and leveraging large foundation models, we developed a deep learning-based biomarker, Retinal Mortality Equivalent (RetiME), that directly mapped retinal features to individual mortality risk. Trained on a European cohort and externally validated across three independent external cohorts spanning Southeast Asia, Eurasia...

Assessing and validating circulating biomarkers is essential for developing preclinical measures of biological aging in mice. However, comprehensive serum proteomics are limited by technical challenges and low sample volumes. Here we present a quantitative nanoparticle-based enrichment workflow coupled with data-independent acquisition mass spectrometry for deep proteomic profiling of low-volume mouse serum. This approach increased proteomic coverage by 3-6-fold with median coefficient of...

Iron accumulation is a conserved hallmark of cellular as well as organismal aging, yet its mechanistic role in senescence remains largely elusive. Here we show that the accumulation of ferrous iron (Fe^(2+)) in lysosomes, a unique feature of senescent cells, is crucial for the induction of multiple senescence-associated phenotypes. Intriguingly, we found that this lysosomal Fe^(2+) sequestration is rendered "safe" by a dual metabolic adaptation that confers robust resistance to ferroptosis....

Reproductive aging impairs female fertility, and oocyte aging is considered a major driver of this phenotype, which manifests with increased aneuploidy and miscarriage risk, while no effective treatments have been widely implemented to date. Here, we report comprehensive protein expression profiling of oocytes during human aging, comparing fully grown germinal vesicle oocytes (FGO) and metaphase II (MII) oocytes; we describe the effect of aging on the maturation profiles across multiple age...

CONCLUSION: The Korean short-form AARC is better interpreted as a subscale-based measure than as a single total score. Further validation and refinement are needed, particularly regarding selected item wording, item coverage, response category functioning, and subgroup comparability, before the scale is used for precise individual-level assessment.

When subject to damage or stress, cells develop responses in order to maintain tissue homeostasis. Two such responses are ferroptosis and cellular senescence, but how cells decide between these outcomes remains unclear. Here, we show that senescent cells increase import and membrane levels of multiple polyunsaturated fatty acids (PUFAs), but a specific intermediate PUFA, dihomo-gamma-linolenic acid (DGLA, 20:3ω-6), is reduced. Exogenous repletion of DGLA instead results in cell death by...

The major characteristics of cellular senescence are stable cell-cycle arrest, accumulation of DNA damage responses, mitochondrial dysfunction, metabolic remodeling, and the release of pro-inflammatory senescence-associated secretory phenotype (SASP) factors. Redox imbalance plays a significant role in the initiation and maintenance of senescence, and the mammalian thioredoxin system-comprising cytosolic Trx-1, mitochondrial Trx-2, thioredoxin reductases (TrxR1, TrxR2), and the inhibitor...

Chromatin stability and nuclear architectural integrity constitute the primary defense against cellular senescence. Their collapse precipitates genomic disarray, epigenetic misregulation, and functional decline in stem cells. Although TOP2A is conventionally known for resolving DNA topological stress, its role in aging remains largely unexplored. Here, we found that TOP2A expression progressively decreased in senescent mesenchymal stem cells (MSCs), and its depletion initiated a catastrophic...

Epigallocatechin gallate (EGCG), a major tea polyphenol, has been proposed to promote healthy aging, but population-level evidence and underlying mechanisms remain unclear. We analyzed 10,977 participants from the National Health and Nutrition Examination Survey (NHANES) and conducted mechanistic studies in Caenorhabditis elegans and AML12 hepatocytes. Compared with non-consumers, both lower and higher EGCG intake categories were associated with lower PhenoAge acceleration, lower all-cause...

As our young planet spun down, its bulging shape gave way to a sphere, driving the formation of continental crust

Scientists say work could help identify “castration mimetics” that boost longevity