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Two widely used zero-calorie sweeteners, sucralose and stevia, may have effects that linger far longer than the sweet taste itself. In mice, researchers found that both sweeteners altered the gut microbiome, reduced beneficial compounds produced by gut bacteria, and changed the activity of genes involved in metabolism and inflammation. Some of those changes were also detected in later generations that had never consumed the sweeteners themselves.

Scientists have created an injectable gel that can remain inside arthritic joints for weeks, slowly releasing medication while also improving lubrication. The approach could make it easier to deliver disease-modifying drugs directly where they are needed while limiting exposure elsewhere in the body.

A simple waist measurement may be nearly as effective as more complicated methods for detecting unhealthy levels of body fat. Researchers also found that BMI alone missed many people with obesity, suggesting waist size could provide an important warning sign.

A long-standing picture of brain evolution as newer, rational layers stacked on top of an ancient “lizard brain” may be deeply misleading. Researchers found that evolution instead appears to balance two competing styles of brain wiring, expanding one while shrinking the other depending on what an animal needs to survive.

A new foundation could help scientists assess the effects of fresh safety measures—if the company agrees to share its data

Alcohol-related liver disease may trap damaged liver cells in a regenerative limbo, preventing the organ from rebuilding itself even after drinking stops. Researchers linked the problem to inflammation-driven RNA errors and identified a pathway that could potentially be targeted to restore liver repair.

Levodopa is the gold-standard treatment for Parkinson's disease, but chronic use results in levodopa-induced dyskinesia (LID) in approximately 80% of patients. Previous research has identified critical network changes in the cortico-basal ganglia pathway associated with LID; however, no study has extensively recorded motor thalamus single-cell activity in a LID model. The motor thalamus is a key node in the movement pathway, receiving basal ganglia and cerebellar inputs and projecting an...

No abstract

Ageing is an independent, non-modifiable risk factor for myocardial infarction (MI). It is also characterized by chronic, low-grade inflammation (inflammaging) and progressive cardiovascular senescence. These ageing-associated processes alter cytokine networks and innate and adaptive immune-cell function, promote endothelial dysfunction, and compromise post-infarction repair, thereby increasing myocardial susceptibility to ischaemia and adverse cardiac remodelling in the elderly. Lifestyle...

Mesenchymal stem cells (MSCs) maintain bone homeostasis through osteogenic differentiation. During aging, MSCs undergo a fate shift toward adipogenesis rather than osteogenesis, but the post-transcriptional mechanisms remain unclear. Here, we identify ovarian tumor domain-containing protein 1 (OTUD1) as an RNA-binding protein that controls MSC fate by stabilizing osteogenic transcripts. OTUD1 directly binds and stabilizes BMP2 mRNA, thereby supporting osteogenic differentiation. In vivo, OTUD1...

We develop an integrated, high-throughput platform to evaluate pharmacological lifespan-extending interventions across five model organisms spanning unicellular to mammalian biology including yeast, nematodes, fruit flies, killifish, and mice. By combining automated imaging, miniaturized assays, and deep-learning-based death detection, we evaluate over 400 compounds across thousands of conditions. In S. cerevisiae, a miniaturized PI/flow cytometry CLS assay enables scalable screening and...

Mismatch between growth of body and digestive system bends the body, study suggests

The new plan, marked by a turbulent rollout and vote, urges more research on poorly understood “regression” to autism