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Oxidative stress contributes to age-related musculoskeletal decline, partly through disruption of glutathione-dependent redox homeostasis. Although creatine and β-hydroxy-β-methylbutyrate (HMB) have been individually linked to antioxidant and cytoprotective effects, their combined influence on systemic redox balance in older adults remains insufficiently characterized.To examine the effects of creatine plus HMB supplementation on oxidative stress biomarkers and composite redox indices, and to...

Blood levels of neurofilament light chain (NfL) increase with age in healthy humans and have been shown to predict all-cause human mortality. To determine whether this relationship is conserved across species, we analyzed NfL in the blood of various animals. We observed age-related increases in NfL levels comparable to those seen in humans in mice, cats, dogs and horses. Longitudinal analysis of NfL trajectories in aged mice demonstrated that a faster rate of NfL increase predicts mortality....

New analysis sheds light on space junk’s small, growing effects on upper atmosphere

No abstract

Many non-model rodent species are inaccessible to genetic engineering due to our limited understanding of their reproductive biology. Here, we present a low-cost, camera-based estrous-tracking technology that enables transgenesis in the white-footed mouse Peromyscus leucopus, a key reservoir for Lyme disease. We demonstrate the efficient generation of pregnant and pseudopregnant mice via timed ovulation, provide protocols for embryo generation, cultivation, microinjection, and transplantation as...

Endothelial cells (ECs) are key metabolic gatekeepers, yet their role in metabolic health remains unclear. Given their central involvement in energy metabolism, mitochondria are ideally positioned to enable ECs to adapt to ever-changing metabolic requirements. Here, we explore the hypothesis that mitochondrial dynamics proteins in ECs influence whole-body metabolic status. Genetic deficiency of Mfn2 in ECs (Mfn2^(iΔEC)), but not of Mfn1^(iΔEC), induces a mitohormetic response in the adipose...

The behavioral aspects of aging in the domestic dog have primarily been investigated through owner-reported scales that measure specific behavioral signs of aging, and laboratory-based memory and cognitive tests. We need to know more about how aging affects everyday behavior and functionality in owned dogs. This study tested a methodology for identifying patterns in everyday physical and behavioral function associated with behavioral tests and scales. Fifty-seven family dogs aged 8+ years were...

White House push to boost nuclear power could lead to more cancer cases, some researchers say

Science, Volume 391, Issue 6787, February 2026.

Science, Volume 391, Issue 6787, February 2026.

Science, Volume 391, Issue 6787, February 2026.

Science, Volume 391, Issue 6787, February 2026.

Science, Volume 391, Issue 6787, February 2026.

Science, Volume 391, Issue 6787, February 2026.

Science, Volume 391, Issue 6787, February 2026.