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Bats carry dangerous viruses without getting sick. This may be why
Scientists discovered that more than 500 species of vesper bats possess two separate sets of antibody genes, an immune arrangement never before found in mammals. The surprising system could help explain how bats tolerate so many viruses without becoming seriously ill.
One immune switch may help drive aging across the body
Aging may be partly fueled by immune cells losing their ability to clear away damaged, inflammation-promoting cells. Blocking a single receptor restored that cleanup process in mice, reducing inflammation and helping their organs, muscles, and memory remain remarkably youthful.
Somatic mutations reveal the ontogeny of microglia in human ageing
Microglia are the resident macrophages of the central nervous system¹. In mice, microglia seed the brain during embryogenesis and can be maintained throughout life with minimal input from adult haematopoiesis^(2-4). The origins of human microglia are less clear, but recent evidence suggests that bone-marrow-derived cells contribute to the human microglial pool in certain individuals^(5-9). Here, to investigate the ontogeny of human microglia, we develop an approach that uses the collection of...
Weight-loss drug slows ageing in female mice
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Blood cells replace the immune cells of the ageing human brain
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Can GLP-1 drugs slow ageing? Mouse study shows promise
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Audio long read: Could mending damaged DNA prolong life?
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Somatic mutations reveal the ontogeny of microglia in human ageing
Microglia are the resident macrophages of the central nervous system¹. In mice, microglia seed the brain during embryogenesis and can be maintained throughout life with minimal input from adult haematopoiesis^(2-4). The origins of human microglia are less clear, but recent evidence suggests that bone-marrow-derived cells contribute to the human microglial pool in certain individuals^(5-9). Here, to investigate the ontogeny of human microglia, we develop an approach that uses the collection of...
Thermally evaporated perovskite/silicon tandems via formamidinium eutectic
Solution processing remains the dominant route to high-performance perovskite/silicon tandems, but it remains challenging to simultaneously achieve industrial scalability and long-term reliability^(1-3). Thermal evaporation is more industrially viable, yet it has not been successfully demonstrated for large-area perovskite/silicon tandems, largely due to the thermal degradation of formamidinium iodide (FAI) during high-temperature evaporation. Here we synthesize a formamidinium-based eutectic...
Late-life semaglutide treatment slows ageing and extends lifespan in female mice
Pharmacological glucagon-like peptide-1 receptor (GLP-1R) activation reduces food intake and is an effective therapy for type 2 diabetes and obesity¹. The use of GLP-1 medicines has revealed pleiotropic beneficial effects beyond glucose and weight control^(2-5), but little is known about the underlying basis of the pleiotropic effects. Here, treatment of 20-month-old female C57BL/6 mice with the GLP-1R agonist semaglutide for 3 months improved physiological function, attenuated hallmarks of...
Targeting cellular senescence mitigates chemotherapy-induced bone loss in young and aged mice
Chemotherapy-induced bone loss represents a major clinical challenge, particularly in aging populations, yet the contribution of cellular senescence to this process and its therapeutic potential remain incompletely understood. Here, we investigated the role of chemotherapy-induced cellular senescence in mediating skeletal deterioration following chemotherapy and evaluated the therapeutic potential of senolytic treatment. Young (3-month-old) and aged (20-month-old) male and female mice were...
PCSK9 inhibition attenuates alcohol-induced cardiovascular dysfunction and links hepatic lipid accumulation to impaired myocardial contractile reserve
Excessive alcohol consumption accelerates cardiovascular aging by promoting oxidative stress, inflammation, lipid dysregulation, fibrotic remodeling, and loss of ventricular-vascular reserve. PCSK9, a key regulator of cholesterol metabolism, has emerged as a mediator of age-related cardiovascular dysfunction and alcohol-associated liver and neurovascular injury. We investigated whether PCSK9 inhibition protects against alcohol-induced cardiovascular dysfunction and associated cardiac-hepatic...
Reframing the epidemiological transition as increasing returns to tackling aging-related diseases
Global life expectancy has risen since 1973 from 58 to over 73 years, while the share of people aged 65 years and older has doubled to 10% and is projected to reach 21% by 2073. This shift is linked to an epidemiological transition from infectious to chronic disease. Here, using Global Burden of Disease data, we reframe this transition by statistically grouping diseases on the basis of their impact over the life cycle, yielding four clusters: infant, early-adult, later-adult and aging-related....
Sex-specific control of locomotor behavior by neuronal Arhgef10 in aged Drosophila
Mutations and polymorphisms in the Rho guanine nucleotide exchange factor 10 (ARHGEF10) locus are associated with behavioral and locomotor dysfunctions in humans, including psychiatric disorders and polyneuropathies that show age- and sex-specific prevalence. ARHGEF10 encodes a conserved guanine exchange factor that activates Rho GTPases and has proposed roles in cell migration and adhesion, but the relevant cell types and mechanisms underlying its age- and sex-dependent effects remain unclear....
A consensus roadmap from the SENESCENCE2030 network towards precision senescence medicine
GLP-1 receptor agonism extends median lifespan in mice
Immune therapy engineered inside the body eases multiple sclerosis
ADHD may have a surprising creative advantage
Some of the attention patterns that make ADHD challenging may also help spark creativity by allowing the brain to explore more ideas and unexpected connections. Researchers think creative activities could potentially channel this “defocused attention” while helping strengthen the brain systems involved in focus and self-control.
Each extra hour of prolonged sitting linked to 9% higher cancer death risk
Sitting for long, uninterrupted stretches may carry greater health risks than sitting the same amount of time in shorter bouts. Researchers found that each extra hour of prolonged sedentary behavior was associated with a 9% higher risk of cancer death. Breaking up sitting with movement showed the opposite pattern, while replacing an hour of prolonged sitting with light activity was linked to a 12% lower risk.
“Broken heart syndrome” can look just like a heart attack. This test can tell them apart
“Broken heart syndrome” can mimic a heart attack so closely that patients often need invasive testing to tell the difference. Researchers have now developed the BioTAK score, which combines biological sex with blood biomarkers to identify the condition before cardiac catheterization. In a validation study of nearly 1,800 patients, it correctly classified almost 90% of participants.