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First complete genome loaded onto a quantum computer
Researchers encode the tiny hepatitis D virus in an early step toward “quantum genomics”
Ten thousand years ago, human evolution went into overdrive
Ancient DNA reveals “massive” genetic shifts tied to rise of farming, wheels, and metal tools
Astronomers complete largest 3D map of the universe ever made
Five-year quest to chart 47 million galaxies yields insights into mysterious “dark energy”
Non-telomeric TRF2 regulates differentiation-associated genes to maintain neural stem cell identity
Depletion of TRF2 from chromosome ends causes telomeric fusions and genome instability in mammals, but in mouse neural stem cells (mNSCs), Trf2's role is non-telomeric. Although essential for mNSC proliferation and survival, Trf2 does not protect telomeres, aligning with findings that Trf2 is dispensable for telomere protection in pluripotent stem cells. In Trf2-deficient adult mNSCs (Trf2fl/fl; Nestin-Cre), proliferation decreased and neuronal differentiation was impaired, yet no telomere...
Sempreverdita (evergreen vitality): a resilience-based, trajectory-oriented extension of healthy ageing
No abstract
Wobble-board dynamics as a scalable assay of long-latency reflex function in aging
Understanding how aging reshapes balance is essential for targeted assessment and rehabilitation. Because wobble boards impose continuous instability, their kinematics may provide a noninvasive readout of long-latency (transcortical) reflex function in ecologically valid conditions. We analyzed wobble-board dynamics in healthy younger adults ( 19 -- 35 y, n = 29 ) and community-dwelling older adults ( 56 -- 70 y, n = 29 ) performing with and without a concurrent cognitive load (Trail...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegeneration
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T(1)-weighted (T(1)w) MRI. By identifying MRI features unapparent to humans, DNNs can find aging-related structural alterations above and beyond cortical...
Sensory Impairment and Risk of Elder Mistreatment in Community-Dwelling Older Adults
CONCLUSION: Integrating assessments for multisensory impairment, vision, and hearing loss may add to elder mistreatment prevention and detection efforts.
The Role of the Glymphatic System in Alzheimer's Disease: Mechanisms, Evidence, and Therapeutic Implications
Alzheimer's disease (AD) is an aging-associated neurodegenerative disorder characterized by amyloid-β (Aβ) and tau accumulation and progressive cognitive decline. Increasing evidence implicates the glymphatic system, a brain-wide perivascular pathway involved in cerebrospinal fluid-interstitial fluid exchange and metabolic waste clearance, in the removal of Aβ, tau, and other solutes relevant to AD pathogenesis. Aging-related alterations in aquaporin-4 polarization, arterial pulsatility, sleep...
Analysis of Quantitative Susceptibility Mapping Data for Multi-Site and Multi-Modal Brain Imaging Studies: For Measuring Brain Iron and Its Changes with Age
CONCLUSION: The selection of QSM reconstruction pipelines impacts results obtained from multi-site studies, indicating the importance of harmonizing QSM pipelines when interpreting susceptibility measures across studies.
‘Invisible’ birds spotted with thermal imaging
Approach could help reveal which migrating species are most vulnerable to wind turbines and light pollution
Ozymandias undead
Why more fossil fuels won’t fix the Iran energy crisis
Can China’s Great Green Wall shape efforts to keep the world’s deserts at bay?
I was set to lead an undergraduate research trip abroad. Then my visa was denied
What China’s Great Green Wall can teach the world
Dozens of AI disease-prediction models were trained on dubious data
Imaging interface-controlled bulk oxygen spillover
Plasma phosphorylated tau 217 and longitudinal trajectories of Aβ, tau, and cognition in cognitively unimpaired older adults
Plasma phosphorylated tau 217 (pTau217) is an excellent biomarker of Alzheimer's disease (AD) pathology, but it remains uncertain whether pTau217 can predict amyloid-β (Aβ) and tau accumulation prior to Aβ positron emission tomography (PET) positivity. Here, we leverage data from a well-characterized prospective cohort of cognitively unimpaired older adults to examine mass spectrometry-based plasma %pTau217 (pTau217/non-phosphorylated-Tau217×100) relative to changes in Aβ/tau PET and cognition....
Signaling cascades shape functional subpopulations of cortical astrocytes in male wild-type mice and APP/PS1dE9 Alzheimer's disease model
Astrocytes are key partners for neurons and can impact diseases such as Alzheimer's disease (AD), as they exhibit multiple reactive changes. Recent single cell/nucleus genomics analyses evidence astrocyte subpopulations coexisting in normal and AD brains. However, the signaling cascades controlling them, their functional characteristics and roles in AD are still unknown. Here, thanks to astrocyte-specific reporters for STAT3 and NF-kB signaling pathways, two regulators of astrocyte reactivity,...