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Some of the attention patterns that make ADHD challenging may also help spark creativity by allowing the brain to explore more ideas and unexpected connections. Researchers think creative activities could potentially channel this “defocused attention” while helping strengthen the brain systems involved in focus and self-control.

Sitting for long, uninterrupted stretches may carry greater health risks than sitting the same amount of time in shorter bouts. Researchers found that each extra hour of prolonged sedentary behavior was associated with a 9% higher risk of cancer death. Breaking up sitting with movement showed the opposite pattern, while replacing an hour of prolonged sitting with light activity was linked to a 12% lower risk.

“Broken heart syndrome” can mimic a heart attack so closely that patients often need invasive testing to tell the difference. Researchers have now developed the BioTAK score, which combines biological sex with blood biomarkers to identify the condition before cardiac catheterization. In a validation study of nearly 1,800 patients, it correctly classified almost 90% of participants.

Persistent financial hardship in early and middle adulthood was linked to poorer thinking skills by the 50s and more signs of brain aging later in life. Researchers say years of chronic stress and financial worry may gradually take a toll on the brain.

Brain changes associated with Alzheimer’s may begin at least seven years before amyloid plaques become detectable with current PET scans. Researchers uncovered the signal by tracking healthy older adults with repeated brain imaging over nearly 20 years. The discovery could help scientists identify Alzheimer’s earlier and suggests that important disease processes may start before visible plaque buildup.

Parkinson's disease (PD) is a neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TEs) have been linked to inflammation, but their potential role in PD remains unexplored. Using bulk- and single-nuclei RNA-seq of postmortem brain tissue from four brain regions, we studied TE transcription and its correlation with PD neuroinflammation. Over a thousand TEs, including LINE-1 s and ERVs, were expressed in a cell type- and...

Tau pathology closely tracks neuronal loss in Alzheimer's disease, but how phosphorylated tau becomes lethal has remained unclear. Chen et al. identify a dual-hit mechanism: glucose hypometabolism removes a protective A20-mediated brake on necroptosis while phosphorylated tau scaffolds RIPK1 activation, driving tau-associated neuronal death.¹.

Actin is a highly conserved cytoskeletal protein that regulates numerous cellular processes essential for tissue homeostasis and healthy aging. Although genetic studies have established important roles for actin and actin-binding proteins in longevity, pharmacological approaches offer complementary advantages for manipulating conserved cytoskeletal pathways across model systems. Here, we systematically evaluated the effects of small-molecule modulators targeting distinct actin regulatory...

Dietary isoleucine restriction improves metabolic health and lifespan in animal models. It is hypothesized that shifts in branched-chain amino acid catabolism drive longevity. We investigated dietary isoleucine restriction on organismal branched-chain amino acid catabolism and its association with longevity and reproduction. In two main experiments, adult female Lubber grasshoppers were assigned to a high-quality diet (Bal ile) or diets with two levels of isoleucine content (moderate isoleucine...

Aging is a multifaceted process where physiological metrics, such as brain age and muscle age (MA), provide deeper insights than chronological age alone. These nonlinear trajectories are heavily influenced by exogenous factors like lifestyle and nutrition. In older populations, muscle age acceleration (MAA) critically impacts functional autonomy and cognitive health, necessitating research into its link with brain network organization to refine assessments and, based on these, integrated motor...

A key question in human neuroscience is to understand how individual differences in brain function relate to cognitive differences. However, the optimal condition of brain function to study between-person differences in cognition remains unclear. While many studies have developed objective biomarkers to accurately predict intelligence and general cognition, consensus on domain-specific markers has not yet emerged. Brain age has been proposed as a potential candidate, but recent research suggests...

Age-related macular degeneration (AMD) is a leading cause of irreversible visual impairment in the aging population globally. Although genome-wide association studies (GWAS) have identified many AMD susceptibility loci, the genes and mechanisms underlying many of these associations remain unresolved. Here, we integrated expression quantitative trait locus (eQTL) data with AMD GWAS to prioritize nine putative genes. Through in vivo screening in zebrafish, we demonstrated that the downregulation...

The Tabula Sapiens is a reference human cell atlas containing single-cell transcriptomic data from more than two dozen organs and tissues. Here, we report Tabula Sapiens 2.0, which includes data from nine new donors, doubles the number of cells, and adds four new tissues. These new data include four donors with multiple organs contributed, thus providing a unique dataset in which genetic background, age, and epigenetic effects are controlled for. We illustrate applications of the Tabula Sapiens...

Life satisfaction is a key component of successful aging. This study investigated the correlates of life satisfaction in a sample of 127 older adults (M(age) = 73.1 years, SD = 5.4) from Sardinia, an Italian island known for successful aging. Participants were assessed for global cognitive efficiency, perceived health, lifestyle habits, life satisfaction, and specific cognitive functions using the digital screening tool DIGICOG-MS. After controlling for age, education, and global cognitive...

CONCLUSION: These findings indicate that aging induces changes in coordination modes during stair ascent in middle-aged and older adults, and that the effects of aging on dynamic stability, coordination variability, and muscle function are more pronounced in older adults. This study was limited by its age range and cross-sectional design; therefore, the generalizability of the results to older adults of advanced age and their relationship with fall risk require further verification.

Declining aerodigestive neuromotor function is a major aspect of human aging, with impaired airway defense and swallow manoeuvres implicated in pneumonia and dysphagia. Hypoglossal motor neurons (MNs) innervate tongue muscles, essential for these behaviours. Their degeneration contributes to age-related aerodigestive dysfunctions. In neurodegenerative diseases, the ubiquitin-proteasome system (UPS) is altered, disturbing mitochondrial proteostasis. We have previously shown reduced mitochondrial...

Age-related decline in muscle health is commonly defined using cut-offs for strength, muscle quantity or quality, and physical performance. These measures are essential for diagnosis, but prevention and recovery require an understanding of how muscle responds to stress over time. A central question is when recovery remains possible and why older adults with similar clinical measurements follow different trajectories. Clinical cohorts, animal studies and static cell models each address part of...

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CONCLUSION: Iron deposition in the PUT exhibits the most significant age dependence; the correlation of iron deposition among nuclei may indicate that specific nuclei share the same iron deposition patterns or are involved in the same pathological mechanisms.

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