Aggregator

Brain aging can cause cognitive and motor disabilities which often correlate with changes in dendritic branch, axon collateral, and synapse numbers. However, from invertebrates to mammals, age-related decline is typically restricted to specific neuron types or brain parts, indicating differential vulnerability. The rules to pinpoint the susceptibility of distinct brain elements to aging remain largely unknown. Here, we combine longitudinal studies with neuroanatomical, electrophysiological, and...

Ziziphus jujuba Mill. (ZJ) is a traditional medicinal plant known for its antioxidant, anti-inflammatory, and neuroprotective properties, yet its role in learning and cognitive regulation remains insufficiently explored. Huang Jing (Polygonatum sibiricum), a Qi- and Yin-tonifying herb in Traditional Chinese Medicine, has historically been used to combat fatigue, support brain function, delay aging, and regulate metabolic balance. In this study, we evaluated the neuroprotective and antioxidant...

CONCLUSION: Cardiometabolic risk factors play a significant role in late-life cognitive decline and death among older Indians. These longitudinal relationships from LASI-DAD highlight potentially modifiable risk factors and inform potential prevention policies.

CONCLUSIONS: Higher prevalence of clinically relevant depression in certain groups and increased risk possibly reflect unfavorable socioeconomic changes that occurred for the elderly population in Poland in the analyzed period.

Artificial Intelligence (AI) is transforming geriatric healthcare by improving early disease detection, optimizing patient management, and enhancing clinical decision-making. AI-driven tools, including machine learning (ML) algorithms, predictive analytics, and assistive robotics, are increasingly utilized to address challenges associated with aging, such as frailty, multimorbidity, polypharmacy, and fall prevention. These technologies can facilitate personalized medicine, improve diagnostic...

This scoping review provides key trends in the use of the Delphi method applied to geriatrics and gerontology research, and documents key information that can be used in the planning of future Delphi studies, like recruitment rates, number of Delphi rounds and panelists, attrition, consensus definitions, and stakeholders engaged.

Astronauts could theoretically harness frozen water on the Red Planet to construct habitats and research stations, new analysis suggests

Parkinson's Disease (PD) is characterized by motor symptoms, loss of dopaminergic neurons, and oxidative stress in the Substantia Nigra pars compacta (SNpc) and striatum of patients, as well as in models of parkinsonism. Recent studies show that the endocannabinoid system present in the basal ganglia has a strong influence on the progression of PD, with the inhibition of the enzyme Monoacylglycerol Lipase (MAGL) being a promising therapeutic strategy. Therefore, the aim of this study was to...

Worldwide, the population is aging. Most older adults would prefer not to move from their current residence; however, there are human resource challenges in home care service provision. Smart home technology has evolved over the past decades and could provide an adjunct to home care and potentially delay moving to a higher level of care. This paper provides an overview of supportive smart home technology, which expands smart home technology to enable feedback and action based on daily...

CONCLUSION: Twelve weeks of ST, but not PT, significantly increased circulating sαKL levels in pre-frail older adults. Given the beneficial health effects of increased sαKL, these findings suggest that ST may offer additional biological advantages relevant to healthy aging. sαKL may serve as a promising biomarker for training-induced adaptions, but prospective trials are needed to confirm long-term effects and further clarify underlying mechanisms.

Multimorbidity elevates late-life mortality, yet existing tools remain complex. Using two nationally representative Chinese cohorts-the Chinese Longitudinal Healthy Longevity and Happiness Family Study (CLHLS-HF; n = 8675) and the China Health and Retirement Longitudinal Study (CHARLS, n = 4171)-we developed and externally validated a simplified, time-dependent, interpretable survival model. A four-stage feature-selection pipeline (univariate Cox, L1-penalized Cox, multi-model importance with...

Senescent cells secrete proinflammatory factors known as the senescence-associated secretory phenotype (SASP), contributing to tissue dysfunction and aging. Mitochondrial dysfunction is a key feature of senescence, influencing SASP via mitochondrial DNA (mtDNA) release and cGAS/STING pathway activation. Here, we demonstrate that mitochondrial RNA (mtRNA) also accumulates in the cytosol of senescent cells, activating RNA sensors RIG-I and MDA5, leading to MAVS aggregation and SASP induction....

Despite systemic viral suppression, people living with HIV (PLHIV) on antiretroviral therapy (ART) remain highly susceptible to pneumococcal colonisation and disease. Here, we show that long-term ART does not restore nasal mucosal immunity. Using flow cytometry, single-cell transcriptomics, and neutrophil functional assays, we identify a persistent mucosal immune signature in PLHIV-ART > 1 yr marked by epithelial-driven neutrophilic inflammation, T cell exhaustion, and cellular senescence....

CONCLUSIONS: Older adult's functional limitations and negative generalization of ageing may have prevented them from actively seeking health information and health-promoting behaviors. To enhance the intervention's effectiveness, the health education contents should be customized based on their health needs, functional capabilities, and readiness to change health behaviors.

We aimed to develop and validate a urinary miRNA aging clock, positioning urine as a scalable, non-invasive aging-biomarker source. Using machine learning on 6331 adults, our clock achieved MAE ≈ 4.4 years (R² ≈ 0.79) in independent validation. The clock's key biomarkers included well-established geromiRs miR-34a-5p, miR-31-5p, miR-146a-5p, and miR-155-5p. While slightly less accurate than DNA-methylation clocks, our model outperformed blood-based miRNA and mRNA clocks, underscoring urinary...