Aggregator
Scientists say a daily multivitamin may help slow aging
A daily multivitamin may help slow biological aging, according to researchers studying older adults in a large clinical trial. After two years, participants taking multivitamins showed slower aging in several DNA-based “epigenetic clocks,” with the effect equal to about four months less biological aging. People who started out biologically older than their actual age appeared to benefit the most. The findings hint that a simple supplement could play a role in healthier aging.
Molecules emerge as a new kind of building block for quantum computers
Storing quantum information in designer molecules could hold advantages over atoms, ions, and other kinds of qubits
Brain senescence drives sarcopenia-like transcriptomic remodeling in skeletal muscle
Aging is accompanied by a progressive decline in skeletal muscle mass and function, culminating in sarcopenia, a major contributor to frailty, disability, and mortality in older adults. While skeletal muscle aging has traditionally been attributed to cell-autonomous and local tissue mechanisms, increasing evidence suggests that systemic, cell non-autonomous processes play a central role in coordinating aging across organs. The brain, particularly the hypothalamus, has emerged as a key regulator...
A Person-Centered Exploration of Mental and Cognitive Health Risk Profiles in Community-Dwelling Older Adults
IntroductionThis study extends prior work by identifying multidimensional profiles of co-occurring mental health and cognitive symptoms that better reflect the complexity of aging and identify high-risk subgroups with more severe symptom profiles.MethodsThis secondary analysis used Wave II data from the National Social Life, Health, and Aging Project (NSHAP). Latent profile analysis was conducted to identify distinct symptom profiles and examine associated sociodemographic, clinical, and...
Beyond survival: Redefining successful aging in the era of medical complexity
A common misconception is that increasing longevity reflects slower aging. Instead, most longevity gain comes from medical advances that allow survival with disease, rather than changes to the biology of aging itself, challenging how we study aging and health.
Skin Aging and Mitochondrial Dysfunction: Structural Changes, Mechanistic Insights, and Therapeutic Perspectives
This narrative review discusses the relationship between structural changes in the skin and mitochondrial function during aging and evaluates emerging therapeutic interventions targeting mitochondrial dysfunction. An analysis of 49 scientific articles published between 2015 and 2025 was conducted using descriptors including "skin aging," "mitochondrial dysfunction," "oxidative stress," and "cutaneous senescence," and articles were retrieved from PubMed, Scopus, and ScienceDirect. Additional...
Mapping the network structure of dementia and its associated factors among older adults in Singapore: evidence from two national cross-sectional studies
CONCLUSIONS: This study highlights the complex web of interrelations linking dementia with social, behavioural, and health-related factors in later life. Rather than implying causal direction, these findings illustrate how multiple factors cluster and coexist within older adults' lives. These interconnections may inform the design of holistic strategies that integrate employment opportunities, physical activity promotion, social participation, sleep health, and cerebrovascular prevention into...
Cognitive decline and risk of all-cause mortality in older women: a cohort study
CONCLUSION: Cognitive decline over four years was associated with an increased risk of mortality among older women. Further studies should explore whether declines earlier in life or among men are also associated with an increased risk of mortality.
Glutamine-driven reductive TCA cycle metabolism supports aged muscle stem cell function via de novo lipogenesis
Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer’s disease pathology
NIH staffing shortage could slash number of new grants issued this year
Procrastination, productivity and inspiration: how research is like designing video games
Mental-health research is too often invisible — it is time to change that
Immune cells in the blood drive cognitive ageing — blocking them improves memory
Hallucinated citations highest in social sciences preprints site
Are we really headed for a ‘super’ El Niño? What the science says
Author Correction: The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis
Author Correction: Postprandial lipid metabolism durably enhances T cell immunity
Who are the Japanese? Huge DNA discovery rewrites history
Scientists analyzing the genomes of thousands of people across Japan discovered evidence for a previously overlooked third ancestral group, challenging the long-accepted “dual origins” theory. The newly identified ancestry appears linked to the ancient Emishi people of northeastern Japan. Researchers also uncovered inherited Neanderthal and Denisovan DNA connected to conditions like diabetes, heart disease, and cancer.
In unreleased document, fired U.S. science board issues stark warning about keeping pace with China
The National Science Board urges robust response to China’s rise in cover letter to its biennial report on the global research enterprise