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A newly identified protein may be one of the biggest obstacles holding CAR T-cell therapy back. Researchers found that NFIL3 causes these engineered immune cells to become exhausted and lose their cancer-fighting power over time. When NFIL3 was disabled, the cells remained stronger for longer and controlled tumors more effectively in animal models.

A major study suggests that some of the groundwork for brain development may be shaped before birth through a surprising partnership between a baby’s genes and gut microbes. Researchers found that epigenetic changes present at birth can influence how the gut microbiome develops during the first year of life, and certain combinations were linked to early signs of autism and ADHD by age three.

Glucagon-like peptide-1 receptor agonists, including long-acting semaglutide, are transformative anti-obesity therapies. However, emerging evidence indicates that weight loss may come at the expense of skeletal muscle mass, a tissue essential for mobility, metabolic regulation, and overall health. Here, we show that inhibition of the gerozyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a prostaglandin-degrading enzyme that increases with injury and aging, improves muscle repair and strength...

Trade-offs between lifespan and reproduction are a central theme in evolution and ecology, often attributed to physiological constraints on the allocation of limiting resources. However, recent work suggests such trade-offs may depend on macro- and micronutritional context. We examined how macronutrient balance and cholesterol availability shape lifespan and reproductive performance in male Drosophila melanogaster, explicitly testing both unmated males and those permitted to mate freely...

Ovarian cancer is characterized by a high recurrence rate, and platinum resistance often contributes to poor patient outcomes. Cellular senescence can influence the tumor microenvironment, metabolic status, and immune regulation. However, the role of senescence-associated genes (SAGs) in the heterogeneity, prognosis, and treatment-related features of ovarian cancer remains to be further clarified. This study integrated data from TCGA, GEO, and single-cell RNA sequencing to systematically analyze...

Systemic microbial infection leading to septic shock with multiple organ dysfunction syndrome (MODS) is a major cause of mortality and represents a substantial unmet medical need. We recently observed that, compared with uninfected controls, patients with septic shock exhibit significantly elevated circulating concentrations of the tissue hormone acyl-CoA binding protein (ACBP), encoded by the diazepam binding inhibitor (DBI) gene, a potent inhibitor of autophagy. Increased plasma DBI/ACBP...

Gases released from satellites could slash the threat of severe space weather

Researchers found that social behavior begins in the brain before it becomes visible as movement. In zebrafish, a coordinated pattern of activity spread across the brain several seconds before the animals approached another fish. A higher brain region called the pallium played a key role, and fish with stronger neural signals were generally more social.

New policy hands universities the reins in probing allegations against faculty