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Gait characteristics in older adults using the ProtoKinetics Zeno walkway: the atherosclerosis risk in communities (ARIC) study

12 hours 38 minutes ago
CONCLUSION: Gait mat and stopwatch measurements showed acceptable agreement, supporting clinical use. However, greater disagreement at faster speeds suggests gait mats may be more appropriate for faster walking speeds. These findings support future investigations of ST and DT gait performance within ARIC and other aging cohorts, including relationships with cognitive decline, mobility limitations, and adverse health outcomes.
Katherine J Hunzinger

A Crosswalk of the IQCODE and AD8 Proxy Dementia Screening Tools

12 hours 38 minutes ago
INTRODUCTION: Since many hospitalized older adults have delirium, assessment of baseline cognitive function often requires proxy-based measures. While the 16-item Informant Questionnaire on Cognitive Decline in Elderly (IQCODE) specifies cutoff scores for mild cognitive impairment (MCI) and dementia, the 8-item Informant Interview to Differentiate Aging and Dementia (AD8) provides only a single cutoff for "cognitive impairment," limiting its usefulness and precision. Our aim was to develop a...
Priyanka Shrestha

Scientists gave worms magnetic bacteria. They lived 43% longer

18 hours 46 minutes ago
A magnet-producing bacterium extended the average lifespan of C. elegans worms by more than 43% while helping protect their neurological and intestinal health. Researchers traced much of the effect to suppression of ferroptosis, a damaging form of cell death linked to iron buildup and oxidative stress.

When what you see doesn’t make sense, your brain does something remarkable

1 day 9 hours ago
The brain may have a built-in way to quickly settle disagreements between regions processing the same scene. Researchers found that matching signals between two visual areas lasted longer, while conflicting signals rapidly faded away. This “consensus building” mechanism could help explain how the brain turns many specialized inputs into one unified view of the world.

Scientists thought they knew how this 70-year-old leukemia drug worked

1 day 9 hours ago
A 70-year-old leukemia drug is still revealing new secrets. Researchers found that removing a protein called NUDT5 protected cells from the drug, even though simply blocking the protein had little effect. The unexpected result points to a hidden cellular role that could help explain why people respond differently to certain leukemia treatments.

Spatiotemporal characterization of Alzheimer disease pathology in living human brain tissue

1 day 12 hours ago
Alzheimer disease begins in the brain many years before symptoms, but early changes are usually studied after death or indirectly through fluid and imaging biomarkers. Here we show that small brain biopsies collected during ventriculoperitoneal shunt surgery can be used to study Alzheimer disease pathology and protein turnover during life. We analysed biopsies from 18 individuals with suspected normal pressure hydrocephalus, alongside matched ventricular and lumbar cerebrospinal fluid and...
Aram Aslanyan

Deep learning aging marker from retinal images unveils sex-specific clinical and genetic signatures

1 day 12 hours ago
Retinal fundus images offer a non-invasive window into systemic aging. Here, we fine-tune a foundation model (RETFound) to predict chronological age from color fundus images in 71,343 participants from the UK Biobank, achieving a mean absolute error of 2.85 years. The resulting retinal age gap, i.e. the difference between predicted and chronological age, is associated with cardiometabolic traits, inflammation, cognitive performance, all-cause mortality, dementia, cancer, and incident...
Olga Trofimova