Aggregator

For years, “yo-yo dieting” has been blamed for wrecking metabolism and causing lasting damage, but a major new review says the fear may be wildly overblown. After analyzing decades of studies in humans and animals, researchers found little convincing evidence that losing weight and regaining it actually causes long-term harm. While regaining weight can erase some health improvements, it doesn’t appear to make people worse off than before.

Scientists have uncovered a surprising new trick used by one of cancer’s most notorious proteins. MYC, already infamous for fueling runaway tumor growth, also appears to help cancer cells survive by repairing their damaged DNA — including damage caused by chemotherapy and radiation. Researchers found that MYC can rush directly to broken DNA and recruit repair machinery, effectively helping tumors recover from treatments meant to destroy them.

Exercise may be training your brain just as much as your body. Researchers discovered that certain brain cells stay highly active even after a workout ends, and those lingering signals appear to help the body build endurance over time. In experiments with mice, blocking these brain cells prevented improvements in stamina, even when the animals still exercised normally.

Researchers have shown for the first time that malfunctioning mitochondria — the cell’s energy generators — may directly cause cognitive decline in neurodegenerative diseases. By creating a new tool that temporarily boosts mitochondrial activity in the brain, scientists restored memory performance in mouse models of dementia. The discovery hints that energy failure inside neurons could happen before brain cells die, potentially offering a new target for future Alzheimer’s treatments.

A major analysis of brain scans found that people with anxiety disorders have noticeably lower levels of choline, a nutrient crucial for healthy brain function. The strongest evidence appeared in the prefrontal cortex, the region tied to emotional control and decision-making. Researchers say the discovery is the first clear chemical brain pattern linked to anxiety and could eventually lead to new nutrition-based treatments.

No vaccines exist for Ebola Bundibugyo, which has caused 80 suspected deaths in the Democratic Republic of the Congo and one in Uganda

A new study suggests microscopic particles from the gut may actively drive inflammation and chronic diseases associated with aging. Remarkably, gut particles from young animals appeared to counter some aging-related damage in older animals, hinting at new possibilities for future treatments.

Scientists are uncovering a surprising link between hidden tooth infections and blood sugar problems. Deep infections around tooth roots can create chronic inflammation that spreads through the body and may interfere with insulin function. Studies found that people who underwent root canal treatment often experienced better blood sugar control and reduced inflammation afterward. The research suggests that treating an infected tooth could have benefits far beyond the mouth.

You may not need hours at the gym to boost your health after all. Researchers say just 30 minutes of high-intensity exercise per week — broken into tiny bursts of effort that leave you out of breath — can dramatically improve cardiovascular fitness, lower the risk of dozens of diseases, and even help protect the brain as we age. The key isn’t how long you exercise, but how hard you push yourself.

Cinematic geologists are usually good guys—sometimes gals—but they have a one in three fatality rate, a film analysis show

Hidden chambers may provide Mediterranean monk seals refuge from tourists

Cannabis use among older adults is rising fast, but today’s marijuana is far more potent than many people realize — and experts warn the risks may be underestimated. Stanford Medicine specialists say modern cannabis can increase the chances of heart problems, falls, memory issues, dangerous drug interactions, and even addiction, especially for people over 65.

Scientists have uncovered a surprising dark side to vitamin B2: it may help cancer cells stay alive. The vitamin supports a cellular shield that protects tumors from ferroptosis, a form of programmed cell death linked to cancer suppression. In lab tests, researchers used a vitamin B2-like compound called roseoflavin to break down that protection and trigger cancer cell death.

Scientists have uncovered evidence that serotonin — the same brain chemical boosted by many antidepressants — may actually worsen tinnitus. Using advanced light-based brain stimulation in mice, researchers identified a serotonin-driven circuit linked directly to tinnitus-like behavior. The findings may explain why some people experience louder ringing in their ears while taking SSRIs.

Relocating plants’ light-capturing structures to the eye may fight damage from dry eye

Researchers analyzing over 20,000 patients found that very high levels of the inherited cholesterol particle Lp(a) dramatically raise the risk of stroke, cardiovascular death, and major heart complications. Because most people with elevated Lp(a) have no symptoms, experts say a simple blood test could uncover a dangerous hidden risk factor.

SMILE orbiter will use x-rays to map how the solar wind batters the magnetosphere

Apolipoprotein E4 (APOE4) is the leading genetic risk factor and an increasingly recognized causal contributor to Alzheimer's disease (AD). AD progresses along a temporal, pathological, and clinical continuum spanning preclinical, prodromal, and dementia stages. Across this continuum, APOE4 exerts detrimental effects at distinct times and in different cell types, underscoring the need for a model defining not only how but also when and in which cells these effects occur. In this review, we...

No abstract

Extracellular Vesicles (EVs), the nano-sized extracellular membrane-bound vesicles, facilitate cell-to-cell communication by transporting bioactive molecules like proteins, lipids, and nucleic acids. Their unique cargo, determined by the cell of origin, makes them valuable tools for studying disease pathogenesis and potential drug delivery systems. Research suggests that EVs play a role in the pathogenesis of various diseases, including neurodegenerative and neurodevelopmental disorders. They...