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Students seeking graduate research scholarships speculate that biology is being disfavored

Mitochondria regulate ATP production, calcium buffering, and apoptotic signaling, and clearing dysfunctional mitochondria by mitophagy is essential for cellular homeostasis. While PINK1-dependent mitophagy is well-characterized in neurons, its function in glial cells such as astrocytes is less understood. Our study demonstrates that PINK1-mitophagy in astrocytes occurs faster and with less spatial restriction compared to neurons. This pathway was specifically regulated in astrocytes by the...

Alterations in biological rhythms are a common feature of aging, and disruption of circadian rhythms can exacerbate age-associated pathologies. The retina is critical for detecting light for both vision and for transmitting time-of-day information to the brain, synchronizing rhythms throughout the body. Disruption of circadian rhythms by manipulating the molecular clock leads to premature retinal degeneration in flies and mice, and gene expression rhythms are altered in models of age-associated...

Frailty emerges as the intermediate stage preceding disability, but there is a gap in molecular signatures for early detection of subclinical cellular changes, which could help predict frailty onset or the effectiveness of interventions. In this randomized, controlled study, we assessed phenotypical and functional changes in frail individuals before and after a 6-month multidomain lifestyle intervention (nutritional supplement and supervised exercise) vs habitual care. We also analyzed...

Heat hormesis describes a biphasic, dose-dependent response in which low levels of heat stress induce beneficial effects, such as enhanced lifespan and stress resilience. This phenomenon is commonly studied in Caenorhabditis elegans using regimens that involve mild heat stress priming, followed by a recovery period and subsequent stress challenge or lifespan measurement. The concept is conserved across species and has gained renewed interest due to its potential relevance to therapeutic...

Frailty is a significant health issue among older adults. Oxidative stress (OS), indicated by elevated malondialdehyde (MDA) levels and reduced superoxide dismutase (SOD) activity, is implicated in age-related diseases. This study aims to explore the relationship between OS biomarkers, MDA and SOD, and frailty among older adults. This study investigated the association between MDA, SOD, and frailty in 3181 older adults from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Frailty was...

Mitochondrial quality control is tightly associated with aging-related neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). Previous studies reported that ALS/FTD-associated protein p62 drives "mitochondrial clustering" (perinuclear clustering of fragmented and swollen mitochondria) during PINK1/Parkin-mediated mitophagy, but the underlying molecular mechanism, especially the precise role of p62 in...

CONCLUSIONS: Moderate and high-intensity PA were associated with lower odds of falls, with important effect modification by cognitive status and health symptoms. These findings suggest that fall prevention strategies should account for cognitive function and symptom burden when promoting physical activity in older adults.

CONCLUSIONS: Bridging the willingness-utilization gap requires systemic reform across policy, organizational, service, and individual levels. Priorities include expanding LTCI eligibility, formalizing volunteer roles within interdisciplinary teams, establishing navigation mechanisms for unmet "grey-zone" needs, and enhancing digital literacy through hybrid information systems. By extending Haggerty's continuity framework beyond clinical care, this study illustrates how volunteers can be...

CONCLUSIONS: An in-home mobile integrated health (MIH) transitional care program for frail older adults after hospital discharge was associated with lower 30-day readmission rates. These findings highlight MIH as a promising model to support aging in place and suggest its potential value for adoption within age-friendly health systems.

Mitochondrial quality control is tightly associated with aging-related neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). Previous studies reported that ALS/FTD-associated protein p62 drives "mitochondrial clustering" (perinuclear clustering of fragmented and swollen mitochondria) during PINK1/Parkin-mediated mitophagy, but the underlying molecular mechanism, especially the precise role of p62 in...

Aging is the primary risk factor for many neuromuscular (NM) diseases that impair motor and cognitive function. Transplantation of young muscle-derived stem/progenitor cells (MDSPCs) has shown remarkable therapeutic potential across a range of age-related diseases, primarily through paracrine mechanisms. In this study, secretome profiling of young MDSPCs revealed a unique enrichment of pro-angiogenic and immunomodulatory proteins compared to their aged counterparts. Our systemic transplantation...

New approaches could put talented canines into the hands of more people with disabilities

As preparations for the fifth International Polar Year kick off, organizers grapple with U.S. climate skepticism and Russia’s invasion of Ukraine

Dredging and mining sediments increases flood risks and threatens infrastructure, researchers say