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A new needle-thin brain implant can record neural activity, deliver drugs, and stimulate multiple brain regions using a single flexible fiber. Successful tests in mice suggest it could give scientists a more precise, less invasive way to study the brain and may eventually help treat neurological disorders such as epilepsy.

Chronic inflammation tied to stress, lifestyle, mental health, and socioeconomic conditions may silently change the heart for years before any symptoms appear. People with the highest inflammation levels faced a 43% greater risk of heart attack and stroke, raising hopes that earlier testing and anti-inflammatory treatments could help prevent serious heart disease.

The behavior, known as kleptoparasitism, marks one of the few well-documented examples of a cetacean stealing food

Scientists have found that the human brain develops from two distinct cellular systems, suggesting that evolution fused together two ancient nervous systems with very different jobs. The discovery also allowed researchers to grow human hindbrain neurons in the lab, opening new possibilities for studying ALS, spinal muscular atrophy, and other brainstem diseases.

Bilingualism has been proposed to confer advantages in cognitive aging, yet the neural mechanisms underlying any such advantages remain debated. In a pre-registered analysis of cross-sectional and longitudinal data from elders in the HABS-HD cohort, we asked whether bilingualism is associated with three measures of brain structure (total brain volume, hippocampal volume and white-matter lesions) and/or moderates the relationship between brain structure and two measures of cognition (executive...

Neurodegenerative diseases (NDs) are chronic neurological diseases characterized by progressive neuronal loss and pathological protein deposition in specific brain regions. With the deepening of population aging, these diseases have become one of the most serious public health challenges. Due to the high heterogeneity of these disorders and the complex pathogenesis, it brings great challenges to clinical precision diagnosis and treatment. In this context, nuclear medicine molecular imaging...

Handgrip strength asymmetry (HGSA) and low handgrip strength (LHGS) reflect distinct aspects of muscle health, but their changes over time have been less studied. We examined whether two-wave status patterns of HGSA and LHGS were associated with all-cause mortality in middle-aged and older Chinese adults. We analyzed 8924 participants aged ≥ 45 years from the China Health and Retirement Longitudinal Study. HGSA and LHGS were assessed in 2011 and 2013 and classified as normal at both waves, newly...

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CONCLUSIONS: In this population-based cohort study, participation in a low-intensity preventive health program delivered in routine care was associated with a lower incidence of diabetes among older adults. However, the observational study design limits evidence on the intervention's role in the observed association, and more robust evidence is needed. Nevertheless, these findings suggest that scalable, population-wide prevention strategies may complement intensive high-risk approaches in...

ObjectivesThis study examines how early-life hardship, wartime exposure, military service, and adult socioeconomic position are associated with grip strength-based possible sarcopenia among older adults in postwar Vietnam.MethodsWe analyzed data from the Wave 1 Vietnam Health and Aging Study among 2,166 adults aged 59 and older. Possible sarcopenia was defined using Asian Working Group for Sarcopenia 2019 grip-strength thresholds; survey-adjusted logistic regression models were...

CONCLUSIONS: Elevated and persistent BNP abnormalities are consistently associated with IC decline, supporting BNP as a practical biomarker for early identification of older adults at risk of functional deterioration.