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The brain may have a built-in way to quickly settle disagreements between regions processing the same scene. Researchers found that matching signals between two visual areas lasted longer, while conflicting signals rapidly faded away. This “consensus building” mechanism could help explain how the brain turns many specialized inputs into one unified view of the world.

A 70-year-old leukemia drug is still revealing new secrets. Researchers found that removing a protein called NUDT5 protected cells from the drug, even though simply blocking the protein had little effect. The unexpected result points to a hidden cellular role that could help explain why people respond differently to certain leukemia treatments.

A newly identified breakdown in communication between nerves and muscles could help explain why people lose strength as they age. Researchers were able to improve muscle strength in an animal model by targeting a key protein, raising hopes that some age-related weakness could eventually be treated.

CONCLUSION: Midlife MetS was associated with modest reductions in within-network DMN connectivity, with abdominal obesity and low HDL cholesterol as the primary contributing MetS components. Reduced DMN connectivity was associated with poorer verbal fluency performance. These findings suggest that subtle differences in higher-order functional brain network organization associated with metabolic syndrome can be detected during midlife and are related to cognitive functioning, highlighting the...

β-Nicotinamide mononucleotide (NMN), as the precursor of nicotinamide adenine dinucleotide (NAD^(+)), has remarkable therapeutic potential in aging-associated diseases. Skeletal muscle exhibits not only reduced mass but also impaired strength and function during aging. However, the protective effects of NMN against skeletal muscle cell senescence remain to be fully elucidated. In this study, we used D-galactose (D-gal) to establish a senescence model in C2C12 cells. Our results demonstrate that...

Extracellular vesicles (EVs) are membrane-enclosed nanoparticles that mediate intercellular communication by transferring proteins, nucleic acids, and lipids. Within the hematopoietic system, EVs orchestrate critical signaling between bone marrow (BM) niche cells and hematopoietic stem and progenitor cells (HSPCs) to regulate quiescence, proliferation, and lineage commitment. During aging, senescence and telomere attrition drive a profound remodeling of EV biogenesis and cargo. Aged EVs,...

CONCLUSIONS: Although AgeTech standardization is advancing, critical gaps remain. Limited attention to safety, security, privacy, and digital economy and community inclusion raises concerns for trust, equity, and sustainable adoption. Addressing these gaps through targeted and coordinated standardization efforts is essential to support inclusive, trustworthy, and scalable AgeTech solutions in the context of rapid global population aging.

Science, Ahead of Print.

Science, Ahead of Print.

Science, Ahead of Print.

Science, Ahead of Print.