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A blood biomarker reveals the mechanistic shift from amyloid to tau pathology.

P. F. Giannopoulos, J. Chiu, and D. Praticò, "Antileukotriene Therapy by Reducing Tau Phosphorylation Improves Synaptic Integrity and Cognition of P301S Transgenic Mice," Aging Cell 17, no. 3 (2018): e12759, https://doi.org/10.1111/acel.12759. The above article, published online on 01 April 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Monty Montano; The Anatomical Society; and John Wiley & Sons Ltd. The retraction has...

Myocardial infarction (MI) is the leading cause of cardiovascular-related deaths worldwide, with risk increasing sharply with age. Fibrosis and inflammation occur soon after a pathological event and reflect perturbation of tissue repair that accompanies aging in general. Yet not old, but young animals are typically used for studying MI, emphasizing the unmet need for more relevant preclinical models. We previously determined that plasma dilution, also termed neutral blood exchange (NBE)...

Environmental antibiotic pollution is an underexplored contributor to gut aging and chronic intestinal diseases. We provide evidence that chronic exposure to enrofloxacin (ENR), a commonly detected veterinary antibiotic, accelerates gut aging and disease progression through a mitochondria-centered mechanism. In a population-based cross-sectional analysis, recent antibiotic use was associated with increased biological age and a higher risk of diarrhea in middle-aged and older adults, supporting a...

All organisms employ strategies to cope with changing environmental conditions. In budding yeast, nutrient deprivation induces a reversible non-proliferative state known as quiescence, characterized by extensive remodeling of gene expression, metabolism, and cellular biophysical properties. Yeast cells survive prolonged periods of starvation-induced quiescence, provided they can respire in the early stages of glucose withdrawal, and blocking respiration causes premature aging and markedly...

CONCLUSION: This study demonstrates that specific gut microbial profiles are significantly associated with sarcopenia. Akkermansia and Lactobacillus were associated with sarcopenia, although greater Roseburia levels were beneficial. These microbial signatures are associated with sarcopenia and warrant further longitudinal investigation.

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CONCLUSIONS: What mattered most to the patients was closely related to the World Health Organization's recommendations for ethical and good quality health care. Generally, the patients agreed on what mattered most. Further studies are needed to enrich the understanding of what is important to older patients.

CONCLUSIONS: This study demonstrates that feeling younger than one's age is associated with better overall intrinsic capacities at baseline and lesser decline over the monitoring period. Routine assessment of subjective age could help to identify individuals who may benefit from prevention strategies and could promote patient-centered care by providing deeper insights into individuals' perceptions of aging.

Changes to government’s vaccine purchase system after 2024 revolution led to nationwide shortages, gaps in immunity

Science, Volume 392, Issue 6797, April 2026.

Science, Volume 392, Issue 6797, April 2026.

Science, Volume 392, Issue 6797, April 2026.