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Ice baths, massages, compression garments, and recovery supplements promise faster muscle recovery, but research suggests their benefits are often overstated, and some techniques may even undermine long-term gains. Scientists say the most effective recovery methods are far simpler and cheaper: getting enough sleep, eating well, and giving muscles time to rebuild.

Algal transfusion allows damaged coral to repopulate in as little as 4 weeks

Two unusually long-legged cats have helped scientists uncover the first genetically confirmed cases of Marfan syndrome in domestic felines. Researchers at Cornell University discovered that the brothers carried two altered copies of a gene linked to the rare connective tissue disorder, which can affect the eyes, heart, and blood vessels. Surprisingly, the cats survived into adulthood because their genetic mutation still allowed some normal function.

Exercise during childhood could have a surprising lifelong benefit, potentially making physical activity less exhausting in adulthood. In a study involving guinea fowl, researchers discovered that birds accustomed to carrying weights while growing up could carry those weights as adults without using extra energy, while untrained birds burned 23% more.

For decades, scientists have focused on amyloid beta as a major culprit behind Alzheimer’s disease, spending billions of dollars developing treatments that have often delivered disappointing results. Now, researchers at UC Santa Cruz are drawing attention to a largely overlooked peptide called P3 that could also play a role in the disease. Previously believed to be harmless, P3 can form harmful-looking protein clumps even faster than amyloid beta and may also damage brain cells.

Amid a U.S. push for “deprescribing,” researchers are finding new ways to match patients to their optimal treatment

Scientists have discovered a protein that may help harmful aging cells hide from the immune system, allowing them to accumulate and fuel age-related health problems. Blocking the protein in mice reduced these cells and inflammation while improving blood sugar regulation and strength, offering a promising new direction for anti-aging research.

Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no effective cure, characterized by the cerebral parenchymal and vascular accumulation of aggregated amyloid-β (Aβ) and hyperphosphorylated tau. Cerebrovascular and mitochondria dysfunction are early causal events in the progression of AD. Previous studies support that inhibiting carbonic anhydrases (CAs) may prevent mitochondrial and cerebrovascular dysfunction in AD models. Here, we selectively target the mitochondrial...

Microglial dysfunction is increasingly implicated in Alzheimer's disease (AD) pathogenesis, with loss-of-function variants in the microglial receptor TREM2 as major risk factors for late-onset AD. We report VG-3927, an oral, CNS-penetrant small-molecule TREM2 agonist that engages the transmembrane domains of TREM2 and its adaptor DAP12 to promote higher-order receptor complex formation and downstream signaling. VG-3927 and tool compound VG-3909 exhibited (sub)nanomolar potency, cooperated with...

As life expectancy increases globally, ageing has emerged as the main risk factor driving the increasing burden of neurological disorders. Although advances have been made in understanding their pathogenesis, current therapies remain largely symptomatic and do not prevent disease progression. There is a growing body of evidence that these disorders share common molecular mechanisms, including oxidative stress, mitochondrial dysfunction, neuroinflammation, impaired autophagy, ferroptosis, and...

Physical performance declines with age, but its association with circulating neurodegeneration biomarkers remains unclear. Blood biomarkers including NT1, NfL, oAβ, and pTau217 may reflect early neurodegenerative changes linked to physical performance decline. Evidence linking these biomarkers to physical performance is limited. We analyzed older adults in the COSMOS Clinic substudy with baseline and two-year follow-up assessments of plasma NT1, NfL, and oAβ and a single assessment of pTau217....

The slow kinetics of sulfur cathodes caused by the high energy barriers of Li^(+) desolvation stem primarily from the structure of the inner Helmholtz plane (IHP). Herein, a synergistic strategy combining electrochemical tandem catalysis with spatial nanoconfinement is proposed to regulate the Li(solvent)(x)^(+) dynamics. As a proof-of-concept, the porous covalent organic framework (denoted as TPBD) decorated MXene is in situ constructed, acting as a tandem kinetic promoter. The theoretical...

Ozone has been viewed as the principal oxidant of skin oils and other unsaturated surface films, but their fate under realistic indoor conditions remains poorly constrained. Here, we use squalene (SQ), a major component of skin lipids, to investigate the dominant oxidation pathways in occupied indoor environments and laboratory flow reactors. With exposure to indoor air, SQ decay and reactive oxygen species (ROS) formation accelerated over time, consistent with autoxidation. Laboratory...

Aging is characterized by progressive functional decline, yet metabolomic signatures across the human life span remain incompletely defined. Here, we profiled plasma metabolomes from 18,476 participants aged 1 to 96 years across six centers in China using nano-assisted laser desorption/ionization mass spectrometry (LDI-MS) and identified 56 representative age-associated metabolites. In a healthy cohort, we developed a stacking ensemble model to estimate metabolomic age and quantified metabolomic...

CONCLUSION: The temporal scalp θ/α ratio and right precuneus gray matter volume are promising candidate non-invasive auxiliary biomarkers for Aβ pathological stratification in aMCI, rather than validated clinical diagnostic biomarkers. The multimodal model provides supplementary subtyping value within this single-center cohort, while external multicenter validation is mandatory before clinical application. This cross-sectional dataset cannot support prediction of longitudinal progression to AD...

Autistic adults experience lifelong motor differences and may have increased vulnerability to parkinsonism, yet behavioral and neuroanatomical correlates of motor challenges across adulthood remain poorly understood. We examined cross-sectional behavioral and motor-related brain region morphology in autistic (n = 123) and non-autistic (n = 102) adults aged 18-71 years using the Parkinsonism Screening Questionnaire (PSQ), Adult Repetitive Behavior Questionnaire-2 (RBQ-2A), finger tapping, and...

The human ovary is among the first organs to show age-related functional decline, resulting in menopause. Beyond this transition, the postmenopausal ovary is often regarded as quiescent and remains poorly characterized. We analyzed the proteomes of healthy, non-pathological ovaries using mass spectrometry (data-independent acquisition) from 28 postmenopausal women (50-75 years old), stratified into three age groups (50-59, 60-69, ≥ 70). We quantified 5812 protein groups and observed progressive...