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A massive national study found that nearly half of Americans with kidney failure who are referred for a transplant never even begin the evaluation process, and only 19% make it onto the transplant waitlist. Researchers discovered that factors such as where a person lives, whether they are married, their income level, language, age, and even which transplant center they use can dramatically affect their chances of moving forward.

A surprising discovery is overturning a long-held assumption about how the brain’s movement center works. Researchers found that two key cerebellar cell types—thought to be tightly linked—often don’t behave in predictable ways, even though one directly influences the other. The finding suggests scientists may have been relying on the wrong signals when studying disorders such as dystonia, ataxia, and tremor.

A synthetic cell can now grow and divide—but it’s still far from alive

Telomeres progressively shorten and accumulate damage with aging, and this contributes to cellular senescence and hematopoietic dysfunction. We previously showed that telomere dysfunction induces synthesis of telomeric noncoding RNAs required for activation of the telomeric DNA damage response (tDDR), a driver of senescence and inflammation. However, whether the tDDR causally impairs hematopoiesis remained unclear. Here we show in telomerase-deficient Terc^(-/-) mice, which recapitulate...

CONCLUSIONS: These findings provide novel evidence for the interactive effects of objective and subjective age, psychosocial resources, and cultural context on cognitive aging, highlighting the potential importance of age perceptions and social participation in cognitive aging.

CONCLUSIONS: The findings of this study demonstrate that adequate sleep duration and PA are crucial independent and synergistic protective factors against rapid frailty progression. These findings highlight that concurrently targeting both behaviors is a vital clinical strategy to mitigate severe frailty and promote healthy aging.

CONCLUSIONS: This study highlights the importance of multidimensional health profiles in understanding cognitive vulnerability among older adults. The identified patterns of co-occurring physical and psychosocial symptoms highlight the importance of adopting holistic, tailored strategies to support cognitive health. Developing profile-specific interventions addressing physical function, symptom management, and psychosocial well-being is essential for preventing cognitive decline in this...

CONCLUSION: Home rehabilitation comprises three main intervention approaches. The Activity-based and Exercise-based yield small improvements in BADL and physical performance. Evidence for other ADL outcomes and the Reablement-based remains limited.

INTRODUCTION: Aging is associated with reduced accuracy in recognizing others' emotions, an ability that is important for maintaining social connectedness in later life. Laughter is a social signal with multiple functions, as it can facilitate social bonding but also convey negative social meanings, for example when directed at someone. In previous research we have shown that younger adults are able to classify spontaneously emitted joyful, schadenfreude, and tickling laughter above chance...

CONCLUSION: Conclusion: Fallers presented more depressive symptoms, morbidities, polypharmacy, and worse subjective health status. Depressive symptoms do not act directly over the number of falls; nonetheless, those with depressive symptoms presented a higher chance of falling, which may be associated to slower reaction time. Psychological symptoms play an important role in falls, and should, therefore, be considered in identifying older people at risk and in developing prevention programs.

Orbiting data centers and sunlight reflectors would scupper astronomy by leaving streaks on telescope images and brightening skies, study finds

What if Sigmund Freud was onto something that modern neuroscience is only now beginning to explain? A new paper argues that today's leading theory of the brain—as a prediction machine constantly anticipating the world—closely mirrors ideas psychoanalysis has explored for more than a century.