Aggregator

CONCLUSIONS: This study challenges the prevailing assumption that the "digital divide inevitably isolates the older adults from participating in a digitized society." By integrating digital technologies into older adults care services, we demonstrate that smart elderly care is positively associated with bridging technological barriers and addressing the unmet needs of aging populations. These findings further propose a synergistic mechanism-policy innovation, technological adaptation, and...

CONCLUSIONS: Multidomain predictors spanning objective movement behaviours, body-composition indicators, and built-environment measures showed value for identifying education-stratified MoCA-defined MCI in community-dwelling older adults. LightGBM achieved the best overall performance among the candidate models. These findings support the potential utility of integrating behavioural, biological, and environmental information for community-based cognitive-risk stratification, although external...

A new nature-inspired membrane uses perfectly uniform one-nanometer pores to filter molecules with remarkable precision. The technology could transform industries such as pharmaceuticals and textiles by reducing energy consumption, improving water reuse, and delivering separation performance far beyond current filters.

A low-calorie fasting-style diet significantly reduced inflammation linked to gum disease in a small clinical study. The findings suggest that what people eat may influence gum health almost as much as what they do with a toothbrush.

Researchers discovered that mutations linked to blood cancers may help trigger Alzheimer’s disease by creating overly inflammatory immune cells in the brain. The unexpected finding could lead to new blood-based screening methods and potential treatments borrowed from cancer medicine.

A new treatment that blocks an aging-related protein restored lost cartilage in old mice and helped prevent arthritis after knee injuries. Human cartilage samples showed similar signs of regeneration, raising hopes for a future drug that could repair joints instead of replacing them.

Neurodegenerative diseases share common pathophysiological mechanisms, including chronic neuroinflammation, glutamatergic excitotoxicity, oxidative stress, mitochondrial dysfunction, and disruptions in synaptic and lipid homeostasis. In this context, the endocannabinoid system has emerged as a key modulator of neuroimmune communication and neuronal survival. Within this system, Monoacylglycerol Lipase (MAGL) plays a central role by regulating the levels of the endocannabinoid...

No abstract

CONCLUSION: Operational definitions of multimorbidity substantially influence prevalence estimates, while associations with mortality appear more robust across count-based approaches. Clustering analyses provide complementary insights into heterogeneity within multimorbid populations. Future translational studies are warranted to determine how multimorbidity definitions can be optimized to ultimately improve clinical management and health outcomes in practice.

Metaplasticity is homeostatic regulation of brain excitability through which neurons change their threshold for response based on synaptic history. Transcranial direct current stimulation (tDCS) induced metaplastic shifts in cortical excitability have been shown to improve motor learning in older adults. However, this has not been explored in the context of a fatiguing contraction. We aimed to explore modulation of fatiguing exercise performance, corticospinal excitability and gamma-aminobutyric...

As a cutaneous appendage, the hair follicle is tightly associated with the skin during growth, pigmentation, and aging. These two interconnected tissues share evolutionarily conserved regulatory mechanisms-including stem cell niche signaling, inflammatory cascades, and oxidative stress-and collectively function as hallmarks of systemic organismal aging. Hair abnormalities are well-established concomitant manifestations of aged skin. The crosstalk between skin aging and hair aging is particularly...

Declining tissue function and regenerative capacity underlie many chronic diseases. Experimentally establishing the mechanistic basis for such tissue aging presents substantial challenges, given decades-long timescales and multifactorial origins. Epigenetic alterations have been proposed to have a key etiological role, but whether they are correlative or causal remains a key unanswered question, as does their contribution to specific age-related pathologies. Here we describe an epigenetically...

No abstract

WNT proteins have been recognized as key regulators of skeletal health. However, developing WNT-associated bone anabolic agents is clinically challenging and expensive. Here we identify the reconstructed thumb and index domains of WNT7B (WNT7B^(RTID)) as a WNT-derived bone anabolic peptide via Alphafold-empowered sequence prediction and in silico docking screening. In aged mice and pigs models of osteoporosis, WNT7B^(RTID) peptides demonstrate therapeutic potential by improving the osteogenic...

Adipose tissue has emerged as a dynamic endocrine organ that coordinates systemic energy balance and cardiometabolic health. This Review highlights the dual humoral and neuronal pathways through which adipose tissue regulates systemic metabolism. Humoral signals include peptide hormones, lipid mediators, metabolites, chemokines and exosomal microRNAs secreted by adipose depots. Neuronal circuits control adipose function rapidly and precisely: sympathetic efferents trigger lipolysis in white...

No abstract

White matter hyperintensities are ubiquitous in magnetic resonance imaging scans of older adults and reflect multiple pathological causes, particularly cardiovascular and metabolic disease risk factors. Elevated white matter hyperintensity burden is a predictor of dementia, but the relationship between white matter hyperintensity progression and cognitive change in typical aging remains unclear, arguably due to the scarcity of longitudinal evidence. Here, we estimated white matter hyperintensity...

Advanced age is a major determinant of adverse outcomes during acute infections, yet the immunological mechanisms by which aging alters immune regulation and shapes disease trajectories remain poorly understood. Using SARS-CoV-2 infection as a model of acute viral challenge, we investigated how aging alters myeloid responses in the lungs. Across infected mouse models and human cohorts, disease severity was associated with a pronounced shift in myeloid balance, characterized by an increased...

Frailty is a dynamic and potentially reversible condition, yet limited evidence has examined whether oral functional limitation is associated not only with frailty onset but also with long-term frailty transitions. We analyzed 6-year prospective data (2016-2023) from 2731 community-dwelling adults aged 70-84 years in the Korean Frailty and Aging Cohort Study. Oral functional limitation was defined as self-reported difficulty in chewing or pronunciation. Frailty was assessed using Fried's...

CONCLUSIONS: Abnormal health indicators among rural older adults exhibit a metabolism-centered and systemically interconnected co-occurrence pattern. Fatty liver, diabetes, and hypertension are structurally central nodes in the network, highlighting their prominence rather than implying causality. Females show stronger indicator interconnections, and advanced age is associated with more complex co-occurrence patterns. These findings provide network-based, hypothesis-generating evidence to...