Skip to main content

Aggregator

Mindfulness may lower blood pressure in just 8 weeks

20 hours 40 minutes ago
Mindfulness, gratitude, and optimism training may improve blood pressure, inflammation, and other heart-health measures within just eight to 12 weeks. The strongest programs paired daily practice with regular reinforcement, suggesting that improving psychological well-being could become another tool for protecting cardiovascular health.

Reaching 90 without dementia doesn’t mean you’re in the clear

21 hours 29 minutes ago
A study of people over 90 found that dementia risk remains strongly shaped by sex, race and genetics, with women and black participants facing notably higher risks. Intriguingly, some people stayed cognitively healthy despite carrying major risk factors, potentially offering clues to how the brain can resist dementia deep into old age.

The Gut Microbiota and Gut-Brain Axis in Alzheimer's Disease: From Pathogenesis to Treatment

23 hours 39 minutes ago
Alzheimer's disease (AD) is a progressive neurodegenerative disorder whose pathological course involves amyloid-β (Aβ) deposition, tau abnormalities, neuroinflammation, and neurovascular dysfunction. Interest in the microbiota-gut-brain axis does not arise because gut dysbiosis has been established as an independent initiating cause of sporadic AD, but because this axis connects modifiable peripheral factors-including diet, medication, ageing, and intestinal physiology-with barrier homeostasis,...
Jingyi Wang

Physical function moderates the relationship between white matter characteristics and gait variability during uneven terrain walking in aging

23 hours 39 minutes ago
Navigating uneven terrain poses a significant challenge for older adults, often resulting in falls. Identifying the neural correlates of walking on uneven terrain might help understand the mechanisms of age-related mobility decline. We examined age and physical function group differences in white matter microstructure and tested whether associations between white matter measures and uneven-terrain walking behavior differed between these groups. Twenty-two young adults (22.45 ± 2.58 years) and 86...
Seda Tasci

The Gut Microbiota and Gut-Brain Axis in Alzheimer's Disease: From Pathogenesis to Treatment

23 hours 39 minutes ago
Alzheimer's disease (AD) is a progressive neurodegenerative disorder whose pathological course involves amyloid-β (Aβ) deposition, tau abnormalities, neuroinflammation, and neurovascular dysfunction. Interest in the microbiota-gut-brain axis does not arise because gut dysbiosis has been established as an independent initiating cause of sporadic AD, but because this axis connects modifiable peripheral factors-including diet, medication, ageing, and intestinal physiology-with barrier homeostasis,...
Jingyi Wang

Targeting Senescence-Associated Biomarkers: Emerging Strategies for Anti-Ageing Therapy

23 hours 39 minutes ago
Ageing research has undergone a paradigm shift from descriptive theories to a mechanistic understanding grounded in the interconnected biological processes. This work synthesizes the current landscape of ageing research, emphasizing the critical role of biomarkers in translating mechanistic insights into clinical application. Biomarkers, ranging from molecular and cellular markers to functional and imaging parameters, serve as essential tools for quantifying biological age, assessing the...
Zhe Qin

The force-producing fraction: muscle quality as a therapeutic target in sarcopenia and a design framework for trials that can test it

23 hours 39 minutes ago
Sarcopenia has consensus criteria on three continents and an all-cause mortality hazard ratio near 1.6, yet no drug is approved for the primary age-related condition and agents that reliably enlarge muscle have not improved the strength and gait-speed endpoints that define it. We approach this translational failure from the biology rather than the pipeline. Ageing degrades four properties of skeletal muscle that jointly determine force production and are each druggable in principle: innervation,...
Ju Hun Oh

Reactive agility and motor-cognitive assessments for distinguishing community-dwelling older adults with and without a history of falls: a dual-centre cross-sectional study

23 hours 39 minutes ago
Although motor and cognitive functions are closely interconnected in daily life, they are typically assessed separately in fall assessments. This dual-center cross-sectional, observational study examined the discriminative performance of agility and motor-cognitive assessments to distinguish between community-dwelling older adults with and without a history of falls, compared with established motor and cognitive tests. A total of 231 participants (103 with a history of falls; age 71.9 ± 7.5...
Florian Giesche

MGRN1 preserves transiently damaged mitochondria for antioxidant-mediated repair

23 hours 39 minutes ago
Mitochondria are continuously exposed to damage that contributes to aging and disease. While prolongedly damaged mitochondria are eliminated by mitophagy, how cells respond to transient damage remains unclear. Here, we establish a cell-based system to induce transient mitochondrial stress and resolve its recovery dynamics. We identify the E3 ubiquitin ligase mahogunin ring finger 1 (MGRN1) as a damage-threshold sensor that discriminates between transient and prolonged mitochondrial insults....
Nuo Chen