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Non-invasive ovulation tracking enables genetic engineering in wild rodents

10 hours 18 minutes ago
Many non-model rodent species are inaccessible to genetic engineering due to our limited understanding of their reproductive biology. Here, we present a low-cost, camera-based estrous-tracking technology that enables transgenesis in the white-footed mouse Peromyscus leucopus, a key reservoir for Lyme disease. We demonstrate the efficient generation of pregnant and pseudopregnant mice via timed ovulation, provide protocols for embryo generation, cultivation, microinjection, and transplantation as...
Joanna Buchthal

Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice

10 hours 18 minutes ago
Endothelial cells (ECs) are key metabolic gatekeepers, yet their role in metabolic health remains unclear. Given their central involvement in energy metabolism, mitochondria are ideally positioned to enable ECs to adapt to ever-changing metabolic requirements. Here, we explore the hypothesis that mitochondrial dynamics proteins in ECs influence whole-body metabolic status. Genetic deficiency of Mfn2 in ECs (Mfn2^(iΔEC)), but not of Mfn1^(iΔEC), induces a mitohormetic response in the adipose...
Iñigo Chivite

Which aspects of the everyday behavior of older dogs correlate with performance on a visuo-spatial memory test and the canine cognitive dysfunction rating scale (CCDR)?

10 hours 18 minutes ago
The behavioral aspects of aging in the domestic dog have primarily been investigated through owner-reported scales that measure specific behavioral signs of aging, and laboratory-based memory and cognitive tests. We need to know more about how aging affects everyday behavior and functionality in owned dogs. This study tested a methodology for identifying patterns in everyday physical and behavioral function associated with behavioral tests and scales. Fifty-seven family dogs aged 8+ years were...
E García

Carbonated ultramafic igneous rocks in Jezero crater, Mars

13 hours 18 minutes ago
Science, Volume 391, Issue 6787, February 2026.
Kenneth H. Williford, Kenneth A. Farley, Briony H. N. Horgan, Brad Garczynski, Allan H. Treiman, Sanjeev Gupta, Alexander J. Jones, Sandra Siljeström, Elise Clavé, Lisa Mayhew, Jeffrey T. Osterhout, Eleni Ravanis, Kathryn M. Stack, Sarah Fagents, Candice…

In Science Journals

14 hours 18 minutes ago
Science, Volume 391, Issue 6787, Page 777-779, February 2026.
Michael Funk, and Yevgeniya Nusinovich, Keith T. Smith, Yury V. Suleymanov, Di Jiang, Dorothy Hallberg, Stella M. Hurtley, Sacha Vignieri, Peter Stern, Mattia Maroso, Angela Hessler, Ekeoma Uzogara, Christiana N. Fogg, and Wei Wong

The science and practice of proportionality in AI risk evaluations

14 hours 18 minutes ago
Science, Volume 391, Issue 6787, Page 769-771, February 2026.
Carlos Mougan, Lauritz Morlock, Jair Aguirre, James R. M. Black, Jan Brauner, Simeon Campos, Sunishchal Dev, David Fernández Llorca, Alberto Franzin, Mario Fritz, Emilia Gómez, Friederike Grosse-Holz, Eloise Hamilton, Max Hasin, Jose Hernandez-Orallo,…