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Scientists have captured virus-like particles assembling themselves step by step, revealing how a surprisingly simple process of trial and error produces complex structures with remarkable precision. The discovery uncovers a crucial molecular turning point that speeds up assembly and could lead to new ways to disrupt viruses and develop vaccines.

Researchers have developed a revolutionary microscope that uses an incredibly powerful laser to make previously invisible cellular structures easier to see. The technology dramatically improves image clarity, allowing scientists to examine small proteins that conventional electron microscopes struggle to capture. It could eventually reveal how tiny molecular machines interact inside cells, providing an unprecedented look at the hidden workings of life.

Your morning coffee may be packing more calories than you realize, and sugar isn't the biggest reason. A study of 30,000 Americans found that non-dairy creamer has overtaken sugar and milk as the leading source of added coffee calories, helping drive a nearly 40% increase between 2003 and 2018.

Scientists have discovered why common marmosets have unusually small, smooth brains despite starting development much like other primates. The secret lies in subtle changes to brain-building cells that slow neuron production, revealing new clues about how the large, folded human brain evolved.

X-ray experiments reveal cubic crystals that could complicate the picture of the inner core

A natural compound extracted from a medicinal plant has shown surprising promise against rheumatoid arthritis. In rats, it reduced joint swelling, protected cartilage, and calmed the immune responses responsible for chronic inflammation. Scientists discovered that the compound works by targeting a specific protein and restoring balance to fatty acid metabolism, revealing a previously underexplored way to fight the disease.

A simple, steroid-free procedure could offer lasting relief for people struggling with carpal tunnel syndrome, potentially helping them avoid surgery. In a clinical trial involving 63 patients, researchers found that ultrasound-guided hydrodissection, which uses fluid to free a compressed nerve in the wrist, provided longer-lasting improvements in pain, numbness, and hand function than traditional steroid injections.

Researchers analyzing nearly 150,000 Reddit posts uncovered unexpected symptom reports linked by users to unapproved versions of retatrutide, including increased appetite, sleep disturbances, and elevated heart rates. The findings differ from clinical trial results and highlight how AI could help identify potential drug safety signals that warrant further investigation.

A massive study of more than 460,000 Americans found that ultra-processed foods were not associated with increased colorectal cancer risk overall, challenging a widely held assumption. While processed meat was linked to higher cancer incidence, ultra-processed whole grains and dairy products were associated with lower incidence.

Scientists have uncovered an unexpected danger lurking inside cells: too much RNA can damage the structures responsible for producing energy. A new study found that excess RNA, including the normally essential messenger RNA (mRNA), can directly disrupt mitochondria without relying on the immune system. The discovery could help explain how viral infections and certain aging-related diseases damage cells.

A new study tracking 13 astronauts suggests that the human heart may be surprisingly well equipped for a journey to Mars, especially with regular exercise during spaceflight. Researchers found that astronauts' hearts adapted to months of weightlessness and handled simulated Martian gravity without major problems, offering new hope for future missions to the Red Planet.

Scientists have turned blood cells from an 80-year-old into neural stem cells with a molecular age of less than 20, effectively reversing more than 60 years of cellular aging in the laboratory. The discovery offers a new way to investigate how cells become younger and could help researchers better understand age-related diseases such as Alzheimer's.

Brian Stone and Rebecca Keiser are leaving as unofficial head and chief of staff

CONCLUSIONS: This study underscores the public health need for addressing caregiver burden and mental health among understudied older caregivers. Although financial assistance, psychosocial services, and respite care have reduced caregiver burden in other settings, context-specific services and policies in Lebanon warrant evaluation. Future research should account for care recipients' characteristics and the multidimensional nature of social and financial resources.

CONCLUSIONS: Frailty assessed using the mFI-11 was not independently associated with IOH occurrence in older adults undergoing hip fracture surgery. However, frail patients tended to experience a longer cumulative duration of IOH once it developed, suggesting a possible link between frailty and the persistence rather than the occurrence of intraoperative hemodynamic instability. These findings highlight the importance of vigilant intraoperative hemodynamic monitoring and individualized...

CONCLUSIONS: Culturally specific early-life adversity patterns, particularly household dysfunction and pervasive adversity, predict adverse successful aging trajectories. These childhood patterns are associated with a more rigid late-life mind-body network characterized by tight pathological coupling between cognition and physical illness. Importantly, broader structural inequalities across the life course, particularly low educational attainment and rural residence, operate alongside early-life...

CONCLUSIONS: Interventions with similar short-term clinical outcomes may differ substantially in their economic and population health value. Within the short-term trial horizon, lifestyle-based strategies were associated with more favorable cost-utility profiles. These findings should be interpreted as exploratory and should not be extrapolated to long-term comparative effectiveness, particularly given the established long-term cardiovascular and renal benefits of SGLT2 inhibitors that could not...