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Parkinson's disease-associated PINK1 loss disrupts ensheathing glia and causes dopaminergic neuron synapse loss
Parkinson's disease (PD) is commonly associated with the loss of dopaminergic neurons in the substantia nigra, but many other cell types are affected even before neuron loss occurs. Recent studies have linked oligodendrocytes to early stages of PD, though their precise role is still unclear. PINK1 is mutated in familial PD, and through unbiased single-cell sequencing of the entire brain of Drosophila Pink1 models, we observed significant gene deregulation in ensheathing glia (EG), cells that...
Nonlinear association between age and verbal fluency and moderation by adiposity: cross-sectional evidence from the Look Up 8+ study
CONCLUSION: Age and VF are nonlinearly associated across adulthood, with educational attainment being a major determinant. Higher central adiposity is associated with lower VF and moderates the associated with age. Lower-limb functional performance was independently associated with VF, potentially reflecting a functional pathway linking adiposity, mobility, and cognitive aging.
Ovarian Extracellular Matrix Mechanics Regulate Oocyte-Follicle Interactions During Female Reproductive Aging
Female reproductive aging is associated with ovarian functional decline, leading to infertility. During aging, biochemical and biophysical changes in the ovarian extracellular matrix (ECM) occur, yet how these properties affect follicle growth and oocyte quality remains poorly understood. Here we describe spatiotemporal changes in the ovarian ECM with age using mass spectrometry, immunohistochemistry, and nanoindentation. While follicle stiffness remains unchanged, stromal matrix remodeling is...
Luteolin and glycitein from Codonopsis pilosula ameliorate age-related locomotor decline in C. elegans via DAF-16-dependent but autophagy-divergent pathways
As global population aging accelerates, maintaining locomotor function in later life has become a critical biomedical challenge. This study investigates the effects of three bioactive compounds-Luteolin (Lut), Glycitein (Gly), and α-Spinasterol (α-Spin)-isolated from the traditional Chinese medicinal herb Codonopsis pilosula (Dangshen), on age-related locomotor decline using the Caenorhabditis elegans (C.elegans) model. We demonstrate that Lut and Gly significantly ameliorate the deterioration...
Distinct Transposable Element Transcript Patterns in Microglia Across Aging and Alzheimer's Disease
Microglia, the brain's resident immune cells, are transcriptionally diverse and highly dynamic, but during aging and disease they lose their transcriptomic flexibility and adopt a chronically activated state that is associated with neuroinflammation and pathology. An emerging transcriptomic process that is also increasingly implicated in brain aging, neuroinflammation, and disease is the dysregulation of transposable elements (TEs), repetitive genomic sequences with the potential to cause...
Protective role of hemokinin-1 against age-dependent spatial memory and attention decline in mice
Age-related cognitive decline is a major social and medical challenge, but its mechanisms remain poorly understood; prevention and therapy are unsatisfactory. The tachykinin hemokinin-1 (HK-1), encoded by the Tac4 gene, is expressed in brain regions involved in learning and memory and has been implicated in neuroimmune regulation, but its contribution to age-dependent cognitive impairment remains unclear. Here, we investigated whether endogenous HK-1 modulates cognitive performance during aging....
Sex-specific circadian and behavioral phenotypes in aged growth hormone receptor knockout mice
Growth hormone (GH) exerts complex effects on metabolism, cognition, and overall physiological well-being, and its secretion is highly regulated by the circadian clock. The Growth Hormone Receptor Knockout (GHR-KO) mouse, a model of GH insensitivity, characterized by chronically elevated circulating GH, provides a unique opportunity to examine the consequences of disrupted GH signaling during aging. Given the close relationship between circadian rhythmicity and GH secretion, we investigated sex-...
Barriers to Research Participation Among Older Rural Veterans: Early Insights to Strengthen Frameworks for Age-Inclusive Research
CONCLUSIONS: Research investigators, staff, Veterans, and caregivers identified several cross-cutting challenges that are important in the recruitment and retention of older rural Veterans in research. The adaptations proposed here demonstrate that the 5Ts Framework can extend to intersectional aging populations, providing a model for broader representation in research.
Distinct Transposable Element Transcript Patterns in Microglia Across Aging and Alzheimer's Disease
Microglia, the brain's resident immune cells, are transcriptionally diverse and highly dynamic, but during aging and disease they lose their transcriptomic flexibility and adopt a chronically activated state that is associated with neuroinflammation and pathology. An emerging transcriptomic process that is also increasingly implicated in brain aging, neuroinflammation, and disease is the dysregulation of transposable elements (TEs), repetitive genomic sequences with the potential to cause...
A National Institute on Aging workshop on sex differences in health across the lifespan
Will the mRNA flu shot work better than a regular seasonal one? What the science says
Author Correction: Structural mechanism of cGAS inhibition by the nucleosome
Why China should reassess how it rewards young scientists
AI isn’t ready to research itself
Can Anthropic’s invisible watermarks curb ‘AI slop’? Researchers remain sceptical
How to make your science business succeed when you’re a female founder
Author Correction: Cretaceous bird from Brazil informs the evolution of the avian skull and brain
Una investigación de <em>Science</em> arroja dudas sobre genes prometedores para prevenir la enfermedad de Alzheimer
Mutaciones encontradas en familias colombianas dieron esperanza para el desarrollo de tratamientos. Datos alterados e imágenes sospechosas ponen en cuestión los beneficios
A new explanation of why the universe’s supply of nuclear matter is fixed?
Experiments point to an alternative origin of a particle accounting tool called the baryon number
<em>Science</em> investigation casts doubt on genes hailed for warding off Alzheimer’s disease
Mutations found in Colombian families raised hopes for treatments. Altered patient data and suspect images call their benefits into question