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A protein once thought to mainly protect chromosome ends may also be essential for keeping muscle stem cells ready to repair injuries. Researchers found that TRF2 helps these cells maintain their identity and coordinate the cycle of rest, repair, and renewal.

The first transgenic mouse models of Alzheimer's disease (AD) developed in the 1990 s were hailed as a major breakthrough. As newer generations of models have emerged over the decades after, they still face growing criticism for translating poorly into clinical outcomes, even if the effects of newer therapeutic compounds, including monoclonal antibodies, align well with those seen in mice. Like any disease model, AD mice have substantial limitations. The real issue is that they are often treated...

Brain aging represents a critical risk factor for neurodegenerative diseases and cognitive decline, yet the measurement of biological brain age remains challenging. Brain aging clocks, which quantify the discrepancy between predicted brain age and chronological age, have emerged as powerful tools for assessing brain health and predicting disease outcomes. Recent advances have transformed these clocks from simple global metrics to sophisticated, multi-modal approaches that capture regional...

Global population aging challenges acute, disease-centric healthcare models and highlights the need for functional markers of aging. The World Health Organization's intrinsic capacity (IC) framework, encompassing cognition, vitality, locomotion, psychological well-being, and sensory function, provides a multidimensional measure of functional reserve. However, most longitudinal studies have collapsed IC into a single score, limiting insight into domain-specific trajectories and...

Skeletal muscle aging is associated with increased lipid accumulation, or myosteatosis, leading to lipotoxicity and loss of muscle function. Here, we report that loss of the lactate receptor GPR81 in cellular and progeroid models of muscle aging is associated with impaired lipid oxidation and enhanced lipid accumulation. Knockdown of GPR81 in young healthy myoblasts led to an increase in senescence hallmarks such as DNA damage, accumulation of reactive oxygen species (ROS), impaired...

A surprisingly small dose of exercise may deliver major health benefits for adults carrying excess fat around the waist. In a four-month trial involving 315 adults with central obesity, researchers found that completing 75 minutes of brisk interval walking in a single weekly session reduced body fat, trimmed waistlines, and improved cardiovascular fitness about as effectively as splitting the same exercise across three days.

A sweeping review of more than 350 studies suggests that the protein boom may be overselling what many people actually need. Eating less protein appears to improve metabolism, reduce inflammation and cellular damage, and activate pathways linked to healthier aging and longer life.

Cancer cells rely on powerful genetic switches to keep growth genes running at full speed, but that intense activity can damage their own DNA. The resulting breaks are repeatedly repaired, sometimes with small mistakes that allow new mutations to accumulate. Researchers believe this self-inflicted damage may help tumors evolve while also creating a potential target for new treatments.

A daily avocado may help lower heart disease risk in adults with obesity by reducing the number of LDL particles circulating in the blood. After six months, participants who ate an avocado each day experienced a decline associated with an estimated 4% reduction in cardiovascular risk.

Scientists have identified an immune response that may explain why statins cause muscle pain, weakness, and exercise intolerance in some people. The finding could eventually lead to treatments that protect muscles while preserving the drugs’ lifesaving cardiovascular benefits.

INTRODUCTION: Atrial fibrillation (AF) is associated with cognitive decline and dementia even in the absence of clinical stroke, potentially through mechanisms such as silent infarction, small-vessel disease, hypoperfusion, and systemic inflammation. However, most previous studies have focused on global brain measures, and little is known about region-specific structural alterations, particularly within deep gray-matter structures and hippocampal subfields. Evidence regarding atrial flutter...

INTRODUCTION: Mild cognitive impairment (MCI) is frequently accompanied by impairments in postural control and trunk muscle function. Although gamma-theta rhythmic stimulation has been reported to modulate neural oscillatory activity, its influence on brain-muscle interactions in individuals with MCI remains poorly understood. This exploratory pilot study investigated whether changes in EEG connectivity following gamma-theta stimulation were associated with alterations in trunk muscle...

INTRODUCTION: Age-related motor decline is particularly evident during complex movements that require sequencing and bimanual coordination. The one-target advantage (OTA), in which single-target movements are typically initiated faster than the first segment of a two-target sequence, provides a useful framework for assessing planning demands in older adults.

Aging-related neurological disorders, including stroke, Alzheimer's disease (AD), Parkinson's disease (PD), epilepsy, and various neuroinflammatory conditions, affect over three billion individuals worldwide and constitute leading causes of morbidity, disability, and socioeconomic burdens. Aging contributes not only to the increased incidence of these disorders but also to their progression through interconnected mechanisms, including endothelial dysfunction, oxidative stress, chronic...