Aggregator

Taking a daily multivitamin may help older adults preserve the strength and stamina needed for everyday activities. After three years, users reported better functional health than those taking a placebo, although the preliminary findings still require peer review.

A liquid brushed onto cavities in seconds may spare many young children from pain, infection, and surgery. A major U.S. trial found that silver diamine fluoride stopped decay in more than half of treated baby teeth. The treatment requires no drilling, shots, or sedation, although it does permanently darken the decayed area.

Signals traveling from the gut to the brain may help turn meals into lasting memories. Rats showed stronger memory activity after consuming nutritious foods, but not after drinking sweet liquids with little or no nutritional value. Blocking the vagus nerve erased this effect and made it harder for the animals to remember where food had been located. Over time, diets high in fat and sugar also weakened this memory system.

Newly found earthworks suggest about 3 million people might have lived in just about 3% of the forest’s entire area

A new cooking method could make French fries crispier in less time while significantly limiting how much oil they absorb. Researchers propose combining microwave heating, which keeps oil out, with conventional frying, which provides the crunch consumers expect.

Animals can initiate movements either in response to external cues or from internal drive, yet how the brain flexibly supports both remains unclear. Disorders such as Parkinson's disease disrupt these modes differently, suggesting distinct underlying mechanisms. These differences could arise from specialized circuits or from shared neuronal populations that shift their dynamics across contexts. To distinguish between these possibilities, we performed two-photon calcium imaging in the...

CONCLUSION: Systemic inflammation and metabolic dysregulation were associated with poorer cognitive performance, particularly executive dysfunction, in this rural aging cohort. These findings, while modest in effect size, support the importance of cardiometabolic health in cognitive aging, motivating future longitudinal and mechanistic studies.

CONCLUSION: The Adgrl2-Camk2d-TRPV1 signaling axis is a core driver pathway of perimenopausal cognitive impairment, exacerbating neuronal damage by mediating calcium overload, neuroinflammation, and metabolic disorders. This discovery provides a novel pathological mechanism for perimenopausal cognitive impairment, identifies Adgrl2 and TRPV1 as potential therapeutic targets, and designates Ca^(2+) as an ideal diagnostic biomarker, offering significant support for clinical diagnosis, treatment,...

In Hutchinson-Gilford progeria syndrome (HGPS), dysfunctional autophagy results in the accumulation of progerin, a lamin A mutant variant that alters a plethora of processes, inducing senescence and driving premature aging. Therefore, the elimination of progerin through autophagy restoration emerges as a therapeutic intervention against HGPS. However, a comprehensive study of autophagy flux in HGPS remains to be addressed. In this study, the dynamics of autophagy in HGPS fibroblasts were...

Sensory impairment (SI) and accelerated epigenetic aging are both linked to later-life vulnerability, yet their joint value for risk stratification remains poorly understood. We investigated whether the co-occurrence of sensory deficits and accelerated epigenetic aging identifies older adults at heightened risk of functional decline and mortality. We analyzed data from 2,395 participants in the 2016 wave of the Health and Retirement Study with valid DNA methylation (DNAm) and sensory data....

Fractures of long bones such as the femur are a common and serious health concern in the elderly, triggering immune responses essential for healing but also affecting remote organs like the liver. With age, the risk of fractures and immune imbalance increases, raising the likelihood of organ damage, infections, and mortality. To better understand age-dependent hepatic responses to bone injury, this study investigates early immune responses in the liver following femoral osteotomy, used here as a...

Epigenetic clocks are widely used to estimate biological age and predict health outcomes, but their translational value depends not only on accuracy but also on reliability. Using the TranslAGE platform, we evaluated both technical and biological reliability across 18 DNA methylation-based aging biomarkers, including chronological, mortality, and pace-of-aging clocks. Most clocks demonstrated excellent technical reproducibility across replicate assays on EPIC and 450 K arrays. However, several...

Mitochondrial dysfunction drives T cell aging in mice. Yet, due to fundamental differences in T cell aging mechanisms between species, whether human T cells exhibit similar mitochondrial alterations remains unclear, with existing evidence often conflicting. Using cryoelectron tomography, we resolved the structure and spatial organization of mitochondrial ribosomes in primary human CD8^(+) T cells under physiological conditions. Comparative analysis with human aging models revealed an age-related...

Membrane separation technology represents a promising and effective alternative to traditional energy-intensive gas separation technologies. However, most commercial membranes have low permeability and moderate selectivity, which limits their ability to meet the stringent gas purity requirements for hydrogen purification and natural gas upgrading. In this study, Matrimid, a widely used commercial polymer, was selected as the matrix material. Cucurbituril (CB) with selective cavity was...

The buried interface between the self-assembled monolayers (SAMs) and the perovskite plays a critical role in device performance and stability in inverted perovskite solar cells (PSCs). However, severe desorption and agglomeration of self-assembled molecules lead to interfacial losses and shorten device longevity. Herein, we design a molecule, 5,5',5″-(nitrilotri-4,1-phenylene)tris[2-thiophenecarboxylic acid] (TTA) with a noncoplanar molecular configuration and multiple functional groups. The...

The aging brain exhibits a decline in the regenerative populations of neural stem cells (NSCs). While mechanisms that restore old NSC function have started to be identified, the role of lipids-especially complex lipids-in NSC aging remains largely unclear. Using lipidomic profiling by mass spectrometry, we identify age-related changes in complex lipids in quiescent NSCs in vitro and in vivo. Moreover, several polyunsaturated fatty acids increase across lipid classes in quiescent NSCs during...