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Popular sweeteners may leave effects that last for generations

9 hours 51 minutes ago
Two widely used zero-calorie sweeteners, sucralose and stevia, may have effects that linger far longer than the sweet taste itself. In mice, researchers found that both sweeteners altered the gut microbiome, reduced beneficial compounds produced by gut bacteria, and changed the activity of genes involved in metabolism and inflammation. Some of those changes were also detected in later generations that had never consumed the sweeteners themselves.

One injection could keep osteoarthritis drugs working for weeks

10 hours 2 minutes ago
Scientists have created an injectable gel that can remain inside arthritic joints for weeks, slowly releasing medication while also improving lubrication. The approach could make it easier to deliver disease-modifying drugs directly where they are needed while limiting exposure elsewhere in the body.

Your waist size may reveal health risks BMI misses

10 hours 11 minutes ago
A simple waist measurement may be nearly as effective as more complicated methods for detecting unhealthy levels of body fat. Researchers also found that BMI alone missed many people with obesity, suggesting waist size could provide an important warning sign.

Scientists challenge a 70-year-old “lizard brain” myth

11 hours 1 minute ago
A long-standing picture of brain evolution as newer, rational layers stacked on top of an ancient “lizard brain” may be deeply misleading. Researchers found that evolution instead appears to balance two competing styles of brain wiring, expanding one while shrinking the other depending on what an animal needs to survive.

Common supplements rival antibiotics for severe gum disease

1 day 9 hours ago
Omega-3 and low-dose aspirin matched the effectiveness of antibiotics in a year-long study of patients with severe gum disease, with both approaches helping about 58% reach the treatment goal. The unexpected result could point to a new way to treat some patients while reducing reliance on antibiotics and the growing problem of antibiotic resistance.

Higher Frontal Cortex Angiotensin Type 2 Receptor-Interacting Protein (ATIP) Levels Are Associated With a Lower Amyloid-Beta Burden in Postmortem Brains of Older Adults With Alzheimer's Disease

1 day 13 hours ago
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by amyloid-β (Aβ) and tau accumulation. Dysregulation of the brain renin-angiotensin system, particularly hyperactivation of the angiotensin II type-1 receptor, contributes to AD pathogenesis. In contrast, activation of the angiotensin II type-2 receptor (AT(2)R) has been linked to neuroprotection and reduced Aβ accumulation. However, the underlying mechanisms of AT(2)R-related Aβ reduction and the role of...
Caglar Cosarderelioglu

SIRT1 Silences L1 Retrotransposons by Stabilizing Heterochromatin-Modifying Complexes

1 day 13 hours ago
SIRT1, a sirtuin family member, has been extensively documented to be closely linked to aging and aging-related disease. Cellular senescence is a state of irreversible cell cycle arrest that functions as a key driver of aging. During cellular senescence, LINE-1 (L1) retrotransposable elements become transcriptionally activated and stimulate a type-I interferon (IFN-I) response. L1 activity has been strongly linked to aging and a variety of age-related disorders. However, whether SIRT1 influences...
Xiaona Wang

Researchers unveil sustainable spirulina solution to vitamin B12 deficiency

1 day 18 hours ago
Researchers have produced a form of Spirulina containing biologically active vitamin B12 at levels comparable to beef. By carefully controlling the light used to grow the algae, they overcame a major problem with conventional Spirulina, which mainly contains a form of B12 the human body cannot use. The carbon-neutral system could provide a more sustainable source of the essential vitamin.