Aggregator
The role of comorbidities in the associations between air pollution and Alzheimer's disease: A national cohort study in the American Medicare population
CONCLUSIONS: Our findings suggest that PM2.5 exposure was associated with increased AD risk, primarily through direct rather than comorbidity-mediated pathways. Stroke may modestly increase susceptibility. These findings highlight the need for air quality interventions as part of dementia prevention strategies in aging populations, especially those facing overlapping environmental and clinical vulnerabilities.
RNA-binding activity of PHGDH drives amyloid-beta production in a human brain organoid model of sporadic Alzheimer's disease
Pathological progression in sporadic Alzheimer's disease (sAD) initiates with an early rise in soluble amyloid-β (Aβ), preceding plaque formation and neurodegeneration. However, the molecular event triggering this initial accumulation remains unknown. We report that phosphoglycerate dehydrogenase (PHGDH), a consistent biomarker of prodromal sAD, drives Aβ production through a previously unrecognized RNA-binding function. Specifically, PHGDH binds the 3'UTR of EIF2AK1 mRNA, enabling the physical...
Peucedanum japonicum Thunb. ameliorates age-related muscle loss by improving mitochondrial function in aged mice
Peucedanum japonicum Thunb. (PJ), also known as costal hog fennel, is an edible medicinal plant recognized for its potential health benefits. We previously demonstrated the protective effects of PJ against muscle atrophy in young mice. In the present study, we investigated whether PJ also inhibits age-related muscle loss in aged mice. PJ treatment of primary myoblasts derived from aged mice attenuated myotube diameter reduction, suppressed the expression of atrogenes, and prevented the...
Pro-longevity compounds extend Caenorhabditis elegans male lifespan and reproductive healthspan
Sex differences in aging are robust and ubiquitous. Demographic differences in aging generated by sex have long been recognized, but the underlying biological basis for these differences and the potential for sex-specific interventions remain understudied. To explore sex differences in the response to pro-longevity interventions, we utilized the C. elegans aging model and asked whether male lifespan and reproductive healthspan can be extended via compounds known to have pro-longevity effects in...
Genetic regulation of fasting-induced longevity effects
Dietary interventions such as caloric restriction and periodic fasting improve metabolic health and extend lifespan in preclinical models, yet individuals differ widely in their physiological responses-variation that remains poorly understood but is critical for safe and effective translation to humans. We applied a two days per week intermittent fasting (IF) regimen to 10 inbred strains from the Collaborative Cross (CC), a genetically diverse, reproducible panel ideal for dissecting genetic...
The role of comorbidities in the associations between air pollution and Alzheimer's disease: A national cohort study in the American Medicare population
CONCLUSIONS: Our findings suggest that PM2.5 exposure was associated with increased AD risk, primarily through direct rather than comorbidity-mediated pathways. Stroke may modestly increase susceptibility. These findings highlight the need for air quality interventions as part of dementia prevention strategies in aging populations, especially those facing overlapping environmental and clinical vulnerabilities.
Giant viruses hijack their hosts’ protein factories
Researchers identify a complex that hands mimivirus control of protein synthesis in infected amoebae
If AI discovers a drug, who gets the money?
Two intellectual property lawyers on why questions of AI inventorship and profit remain wide open
The relationship between metacognitive beliefs and healthy aging among older adults
No abstract
Excessive sleep duration increases the risk of dementia among older Chinese adults: evidence from the CLHLS
CONCLUSIONS: Overall, the present study findings demonstrate that excessive sleep duration (over 10 h) is an independent predictor of increased risk of dementia among older Chinese adults. Conversely, maintaining a moderate sleep duration of 6 to 8 h appears to be a protective factor, correlating with a lower incidence of the condition.
Dynamin-Related Protein 1-Dependent Disruption of Mitochondrial Homeostasis Drives Blue Light-Induced Epithelial-Mesenchymal Transition in Retinal Aging
Age-related macular degeneration (AMD) stands as a leading cause of blindness in the elderly, yet the fundamental aging processes that underpin its pathogenesis remain incompletely defined. The dysfunction of retinal pigment epithelial (RPE) cells is a central event in AMD, a process that shares key hallmarks with broader cellular aging, particularly the progressive decline in mitochondrial function. In this study, we investigated how a common environmental stressor-blue light-triggers a key...
Post-Stroke Depression and Activities of Daily Living: Sex-Differentiated Analysis of the Moderating Role of Physical Activity in Older European Adults
ObjectivesTo examine the mediating role of activities of daily living (ADL) in the association between stroke and depressive symptoms, and to investigate whether moderate physical activity (MPA) moderates this mediation in older adults, using sex-stratified analyses.MethodsCross-sectional data from 31,137 participants (≥65 years) were analysed using wave eight of the Survey of Health, Ageing and Retirement in Europe. Depression, ADL limitations, stroke history and weekly frequency of MPA were...