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ObjectivesPhysical health often declines with age, yet subjective well-being (SWB) tends to remain stable. Stereotype Embodiment Theory proposes that internalized self-perceptions of aging (SPAs) shape how physical changes are interpreted. This study tested whether SPA buffered the affective impact of health decline. The role of SPA was tested in midlife and late adulthood.MethodsData came from the ILSE, a population-based study of 1,002 adults initially aged 40 or 60 and followed for 20 years....

This study examined hypothesized differences across males and females in the relationship between cognitive trajectories and mortality in older adults. Data were drawn from the ZARADEMP study on dementia and depression in adults aged 55 and older in Zaragoza, Spain. A total of 2403 cognitively healthy individuals who completed at least three of four waves over a 12-year follow-up were included. Cognitive trajectories were derived from Mini-Mental State Examination (MMSE) scores. Using growth...

Aging-associated sarcopenia is driven in part by the progressive loss of type II glycolytic fibers and the functional decline of their resident stem cells, the satellite cells (SCs). We show here that these defects result from attenuation of the hypoxia-inducible factor-1α (HIF-1α) signaling pathway and can be reversed by pharmacological HIF-1α reactivation. In the tibialis anterior muscle of 18-month-old C57BL/6J mice, HIF-1α protein abundance decreased by ≈46% and canonical targets (Vegfa,...

Glutamate accumulation linked to Parkinson's disease (PD) pathogenesis. While glutamate chemical exchange saturation transfer (GluCEST) imaging has been applied in various CNS disorders, its utility in PD remains underexplored. This study investigated the clinical relevance of dentate nucleus and cerebellar hemisphere glutamate levels across PD motor subtypes. We enrolled 36 resting-tremor predominant PD (PDRT), 33 akinetic-rigid predominant PD (PDAR), and 40 healthy controls (HCs). GluCEST data...

The current clinical diagnostic criteria for Parkinson disease (PD) have limitations and are inherently insensitive to the earliest stages of disease, when classical motor signs can be absent. Imaging and genetic tests are currently used to support or establish a diagnosis of PD, but no validated biomarker-based diagnostic framework currently exists. Substantial progress has been made in the field of molecular disease markers, most notably with the development and validation of seed...

Dementia diagnosis increasingly relies on blood-based biomarkers, yet their performance in diverse populations remains insufficiently characterized. Latin America, with substantial genetic and environmental heterogeneity, is particularly underrepresented in biomarker research. Here we show that plasma AT(N) biomarkers can distinguish Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD) in a multinational Latin American cohort (N = 605). Aβ(42)/Aβ(40) amyloid-β ratios were...

Ageing entails a variety of cellular and physiological changes that increase susceptibility to disease and death. A significant contributor to ageing is cellular senescence, a state of irreversible cell cycle arrest triggered by stressors such as DNA damage, telomere shortening, and the senescence-associated secretory phenotype. It is challenging to understand the nonlinear interactions between these complex mechanisms using conventional laboratory approaches. Mathematical modelling is capable...

Ischemic stroke (IS) is a cerebrovascular disorder that, if left untreated, can lead to secondary neurodegeneration and Post Stroke Cognitive Impairment (PSCI). Current therapies offer a narrow time window, highlighting the need for alternative approaches. Flavonoids, known for their neuroprotective properties, are promising candidates. Chrysin, a flavone with multiple pharmacological activities, was investigated for its therapeutic role in IS and PSCI. Pharmacokinetic and toxicological profiles...

Copper (Cu)-based single-atom catalysts (SACs) enable electrocatalytic CO(2) reduction into methane (CH(4)) fuel for thermal power plant decarbonization, yet conventional Cu SACs face industrial deployment barriers like instability and sluggish kinetics caused by d - p orbital coupling. Herein, we develop a Cu-Ti(1)O(3) catalyst with localized Cu single-atom sites by oxygen vacancy (O(v))-involved orbital engineering, achieving industrial-level CH(4) production. Theoretical and in-situ studies...

The aging population experiences concurrent brain aging and deterioration of bone health. Imaging-derived brain age gap (BAG) demonstrates enhanced predictive capacity for age-related pathologies compared to chronological age. This study included 28,705 participants who underwent brain MRI at a mean age of 63.2 years, with brain age predicted from 1705 imaging-derived phenotypes using LASSO regression (mean predicted brain age: 63.2 years). We then assessed the associations of BAG with BMD at 4...

Arms races between parasites and hosts are key drivers of evolution. Selfishly replicating transposable elements (TEs) are thought to follow similar dynamics, but strong evidence is missing. We test this in termites, social insects in which TEs have been linked to ageing. Sequencing genomes and profiling DNA methylation across the termite phylogeny reveal corresponding phylogenetic signals in TEs and TE methylation, indicative of co-evolution. TE methylation reduces TE success, as both TE...

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Older individuals exhibit distinct biochemical and functional changes in their immune cells that can lead to chronic inflammation, reduced immunity to pathogens and organ dysfunction. Immune cells from older individuals acquire dysfunctional immunosenescent phenotypes that are classified as inflammatory, exhausted or senescent. Key molecular mechanisms, commonly described as hallmarks of ageing, drive the development of these phenotypes through both cell-autonomous and non-autonomous mechanisms....

CONCLUSIONS: Improving food access for older adults requires a multilevel approach. The government should ensure inclusive food welfare, while communities should develop local systems to support older adults, especially those facing food shortages.

CONCLUSION: This study provides an integrated and stage-specific understanding of life satisfaction among older Chinese adults. The findings deepen the theoretical understanding of life course influences, social support, and psychological resilience in later life. The study also suggests the need for tailored policy interventions that prioritize mental health care, social engagement, and basic living conditions at lower satisfaction levels, and incorporate early-life experiences and emotional...

Decoding human movement from invasive neural signals has traditionally relied on complex machine learning algorithms using data collected from short-term laboratory tasks, limiting understanding of brain function during natural behavior and hindering development of clinically viable closed-loop neuromodulation. Here, we demonstrate the first in-human, at-home classification of a specific movement state-walking-using a fully implantable, bidirectional neurostimulator. In four individuals with...

Associations between healthy dietary patterns and life expectancy remain unclear. Here, we reported the prospective associations of five dietary patterns with mortality and life expectancy in 103,649 UK Biobank participants. Over a median follow-up period of 10.6 years, 4314 total deaths were documented. Alternate Healthy Eating Index-2010, Alternate Mediterranean Diet (AMED), healthful Plant-based Diet Index (hPDI), Dietary Approaches to Stop Hypertension, and Diabetes Risk Reduction Diet...

The gradual decline in thymic function with age, known as age-related thymic involution, leads to reduced T cell production, thereby increasing the risk of infections and cancer susceptibility and leading to poor vaccine responses. Moreover, T cell defects were recently involved in the age-related loss of tissue integrity and function. Mechanistically, thymic involution is driven by several factors, including hormonal modifications and chronic inflammation, leading to functional changes in the...

Telomere shortening is a hallmark of aging and has been implicated in cardiovascular disease, but its mechanistic link to atrial fibrillation (AF) remains elusive. Using a high-throughput, single-gene-calibrated dot blot assay, we developed to quantify leukocyte telomere length (LTL). In age-stratified analyses, shorter LTL was associated with AF predominantly in individuals younger than 70 years. In telomerase-deficient (TERT^(-/-)) mice with telomere dysfunction, higher AF inducibility, atrial...

Senescent cells accumulate with age and after exposure to various stresses, contributing to chronic diseases and cancer, effects largely driven by the senescence-associated secretory phenotype (SASP). Recent evidence indicates that a subset of senescent cells exhibits immunogenic properties. However, the extent to which immunogenicity depends on the cell type and the senescence inducer remains unclear. In this study, we evaluated the immunogenic properties of various human cell types induced to...