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The hidden skeleton “gatekeeper” inside brain cells could help fight Alzheimer's
Researchers have discovered that a microscopic skeleton inside neurons does much more than hold cells together. It acts as a gatekeeper that controls what brain cells absorb and when they absorb it. When this protective structure weakens, neurons rapidly take in harmful proteins associated with Alzheimer's disease, suggesting that stabilizing it could become a promising new strategy for preventing brain cell damage.
This pet gecko could help scientists unlock the secrets of cancer
An unusual leopard gecko that naturally develops aggressive tumors may become an important new model for cancer research. Scientists found its tumors share key genetic changes with human cancers, offering a rare opportunity to study the disease as it develops naturally.
Tree-killing beetle is spreading to urban forests around the world
As researchers piece together the pest’s global trek, countries are working to contain the growing threat
Did U.S. scrutiny of foreign research drive prominent geneticist to decline authorship?
George Church moved to paper’s acknowledgements section, triggering exodus
A comparative evaluation of brain MRI modalities, modality-specific measures, brain regions, and cognitive tests for brain age prediction
Brain age estimation using machine learning has gained significant attention as a promising approach to assess cognitive health and aging. By analyzing structural and functional MRI data, these models can predict an individual's brain age, providing insights into neurological conditions and potential interventions. The purpose of this study is to compare the performance of different MRI modalities in predicting brain age and to determine the relative importance of specific brain regions. In this...
Age-associated microglial heterogeneity includes emergence of mobile microglial states
Microglia maintain neuronal homeostasis through dynamic surveillance strategies that depend on their functional state. In the healthy brain, highly ramified microglia monitor neuronal integrity via motile processes and transient soma contacts. Aging is associated with reduced process motility and diminished expression of homeostatic markers, raising the question of how microglial surveillance adapts to these changes. Here, we used ex vivo time-lapse imaging of acute cortical slices from young...