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Age- and cell-type-specific effects of histone variant H2BE in the brain

1 day ago
Transcription is regulated in part through histone proteins. Histones can be replaced with variant forms that are particularly critical in the brain and accumulate throughout the lifespan. Recent findings demonstrated that the histone variant H2BE regulates chromatin structure, neuronal transcription, and mouse behavior. However, the role of H2BE in other cell types and throughout the lifespan remains unknown. Here, we discovered that H2BE is enriched in astrocytes and accumulates with age in...
Sean Louzon

A geological carbon cycle sink hosted by ocean crust talus breccias

1 day ago
Calcium carbonate precipitation in ageing ocean crust sequesters carbon dioxide dissolved in seawater through seafloor weathering reactions, influencing atmospheric CO(2) concentrations on million-year timescales. However, this crustal carbon sink, and the extent it balances CO(2) degassing during crustal formation at mid-ocean ridges, remain poorly quantified due to limited sampling of the vast ridge flanks where CO(2) uptake continues for millions of years. Here we quantify the carbon sink...
Rosalind M Coggon

Muscle strength and the risk of Multimorbidity in Middle-aged and older Chinese adults: A prospective cohort study

1 day ago
CONCLUSIONS: A low level of muscle strength is significantly associated with an increased risk of comorbidities among middle-aged and older adults. Therefore, incorporating strength training into comorbidity prevention and control strategies is of great importance and should be considered a key intervention. Particular emphasis should be placed on lower limb strength exercises, which do not exhibit a plateau effect in reducing comorbidity risk and can thus yield more substantial health benefits.
Zhuofan Zhang

Cognitive training effects are shaped more by individual brain dynamics than age-evidence from younger and older women

1 day ago
Given the well-established structural and functional changes in the aging brain, it is widely assumed that cognitive aging is primarily driven by robust group-level differences between young and older adults. However, our individual-level EEG functional connectivity analysis challenges this notion. We investigated the impact of cognitive training on functional brain connectivity using task-switching paradigms in 39 younger (18-25 years) and 40 older (60-75 years) women. Participants were...
Zsófia Anna Gaál

Healthy diet and slower biological aging as protective factors against microvascular complications in type 2 diabetes

1 day ago
This study aimed to evaluate the independent and joint effects of adherence to healthy dietary patterns and slower biological aging on the incidence of diabetic microvascular complications in individuals with type 2 diabetes mellitus (T2DM), and to assess the mediating role of biological aging. In a prospective cohort of 13,294 T2DM participants without baseline DMCs, dietary quality was assessed using a validated 10-point score, while biological aging was calculated from nine biomarkers and...
Han Zhou

Comparative analysis of human and mouse ovaries across age

1 day 3 hours ago
Science, Volume 390, Issue 6778, December 2025.
Eliza A. Gaylord, Mariko H. Foecke, Ryan M. Samuel, Bikem Soygur, Angela M. Detweiler, Tara I. McIntyre, Leah C. Dorman, Michael Borja, Amy E. Laird, Ritwicq Arjyal, Juan Du, James M. Gardner, Norma Neff, Faranak Fattahi, Diana J. Laird

Locating the missing chlorophylls f in far-red photosystem I

1 day 3 hours ago
Science, Volume 390, Issue 6778, December 2025.
Giovanni Consoli, Fiazall Tufail, Ho Fong Leong, Stefania Viola, Geoffry A. Davis, Nicholas Rew, Daniel Medranda, Michael Hofer, Paul Simpson, Marco Sandrin, Benoit Chachuat, Jenny Nelson, Thomas Renger, James W. Murray, Andrea Fantuzzi, A. William…