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Genetic Reduction of the Translational Repressors FMRP and 4E-BP2 Preserves Memory in Mouse Models of Alzheimer's Disease

15 hours 18 minutes ago
Alzheimer's disease (AD) is characterized by progressive memory decline. Converging evidence indicates that hippocampal mRNA translation (protein synthesis) is defective in AD. Here, we show that genetic reduction of the translational repressors, Fragile X messenger ribonucleoprotein (FMRP) or eukaryotic initiation factor 4E (eIF4E)-binding protein 2 (4E-BP2), prevented the attenuation of hippocampal protein synthesis and memory impairment induced by AD-linked amyloid-β oligomers (AβOs) in mice....
Felipe C Ribeiro

Health literacy as a buffer: mitigating the impact of Multimorbidity on functional health in older adults

15 hours 18 minutes ago
CONCLUSION: Future research should focus on longitudinal designs and objective measures to further elucidate the pathways linking multimorbidity, health literacy, and functional health. Fostering the ability to independently obtain, understand and implement health information should be a key goal of clinical practice and policy interventions.
Aline Schönenberg

From Vulnerability to Resilience: Roles of Community Support for Well-Being of Older Rohingya Refugees in Bangladesh

15 hours 18 minutes ago
The Rohingya people have been subjected to egregious human rights abuses, culminating in a mass exodus to the Cox's Bazar district of Bangladesh in 2017. This study investigated the knowledge, attitudes, and practices surrounding older persons within the Rohingya refugee community while also elucidating the present community support mechanisms crucial for their well-being, through a sequential mixed-methods approach. The study specifically focuses on older Rohingya persons aged 60 years and...
Mohammed Mamun Rashid