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Longitudinal association between oral health and dementia among older adults: evidence from the Korean longitudinal study of ageing
No abstract
Associations Between 40-Year Trajectories of BMI and Proteomic and Epigenetic Aging Clocks: Deciphering Nonlinearity and Interactions
The potential of proteomic aging clocks for obesity research, and the extent of nonlinearity in longitudinal associations between body weight and biological aging, remain underexplored. We investigated how BMI at ages 18 and ~60, as well as changes in BMI from age 18 to ~60, relate to downstream epigenetic and proteomic aging. We also examined nonlinearity and interactions in these associations. Analyses were conducted in 401 Finnish twins with up to nine self-reported or measured BMI values...
The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer's disease
CONCLUSION: These findings place mitochondrial proteome collapse at the center of aging and AD-seeded pathology, distinguish Aβ- and Tau-driven proteotoxic routes, and nominate a conserved panel of aggregation-prone proteins as mechanistic drivers and candidate biomarkers for early detection and intervention in AD.
Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance
Epidemiological approaches to refine biomarkers of aging
Five ways to make the academic workplace happier and healthier this year
This AI has chemical expertise — and helps synthesize 35 new compounds
ArXiv says submissions must be in English: are AI translators up for the job?
Developmental convergence and divergence in human stem cell models of autism
Critical social media posts linked to retractions of scientific papers
Earth-size planet spotted with yearlong orbit
Long-overlooked Kepler signal discovered by citizen scientists reveals promising world worth a closer look
Strategies for blood-brain barrier rejuvenation and repair
Blood-brain barrier (BBB) dysfunction is a hallmark of many diseases of the brain, including those that represent the largest healthcare burden (for example, Alzheimer disease and stroke). Despite this, rejuvenation and repair of the BBB is not a mainstream concept. During life, the BBB is subjected to perturbations and stresses from a wide range of endogenous or exogenous sources, which can promote brain health or can lead to brain pathologies. The BBB supports many functions that are critical...
Intestinal macrophages modulate synucleinopathy along the gut-brain axis
Emerging evidence suggests that Parkinson's disease (PD) may have its origin in the enteric nervous system (ENS), from where α-synuclein (αS) pathology spreads to the brain^(1-4). Decades before the onset of motor symptoms, patients with PD suffer from constipation and present with circulating T cells responsive to αS, suggesting that peripheral immune responses initiated in the ENS may be involved in the early stages of PD^(1,5-7). However, cellular mechanisms that trigger αS pathology in the...
Strategies for blood-brain barrier rejuvenation and repair
Blood-brain barrier (BBB) dysfunction is a hallmark of many diseases of the brain, including those that represent the largest healthcare burden (for example, Alzheimer disease and stroke). Despite this, rejuvenation and repair of the BBB is not a mainstream concept. During life, the BBB is subjected to perturbations and stresses from a wide range of endogenous or exogenous sources, which can promote brain health or can lead to brain pathologies. The BBB supports many functions that are critical...
Publisher Correction: Shear stress governs hematopoietic stem cell fate to promote inflammation-induced aging
No abstract
Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming
Spatiotemporal changes in the nuclear lamina and cell metabolism shape cell fate, yet their interplay is poorly understood. Here we identify lamin A/C as a key regulator of cysteine catabolic flux essential for proper cell fate and longevity. Its loss in naive mouse pluripotent stem cells leads to upregulation of the cysteine-generating and catabolizing enzymes, cystathionine γ-lyase (CTH) and cystathionine β-synthase (CBS), thereby promoting de novo cysteine synthesis. Increased cysteine flux...
Radiation-tolerant atomic-layer-scale RF system for spaceborne communication
Integrated circuits for communications play an enabling role when it comes to outer-space exploration thanks to their small footprint and low weight^(1-3). However, owing to the severe irradiation effects of space energetic particles, the implementation of radiation-tolerant electronic circuits remains a challenge^(4-6). Here we report the observation of the space radiation effect on a satellite-based device and find that atomically thin materials are expected to accumulate minimal...
Development and validation of a machine learning model for frailty screening using claims data in Japan: the Longevity Improvement & Fair Evidence Study
CONCLUSION: This claims-based frailty prediction model showed reasonable performance and prognostic value. It may support efficient, population-level frailty screenings where questionnaire-based assessments are impractical.
A versatile platform for sequential glyco-, phospho-, and proteomics with multi-PTMs integration
Serial multi-omic analysis of proteome, phosphoproteome, and glycoproteome is pivotal for elucidating drug mechanisms, discovering biomarkers, and identifying therapeutic targets. However, simultaneous multi-level post-translational modifications (PTMs) analysis via parallel processing is hampered by laborious, time-consuming procedures and inconsistent reproducibility. We present an integrated Multi-level PTMs-Proteomic Enrichment platform (MuPPE), enabling sequential glycoproteome,...
A cross-population compendium of gene-environment interactions
Environmental differences in genetic effect sizes, namely, gene-environment interactions, may uncover the genetic encoding of phenotypic plasticity^(1-3). We provide a cross-population atlas of gene-environment interactions comprising 440,210 individuals from European and Japanese populations, with replication in 539,794 individuals from diverse populations. By decomposing the contributions from age, sex and lifestyles, we delineate the aetiology of these gene-environment interactions, including...