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A blueprint for tumor-infiltrating B cells across human cancers
Science, Volume 384, Issue 6695, May 2024.
A single cell atlas of sexual development in Plasmodium falciparum
Science, Volume 384, Issue 6695, May 2024.
Induction of social contagion for diverse outcomes in structured experiments in isolated villages
Science, Volume 384, Issue 6695, May 2024.
CDK4/6 activity is required during G2 arrest to prevent stress-induced endoreplication
Science, Volume 384, Issue 6695, May 2024.
A scientist is likely to win Mexico’s presidency. Not all researchers are rejoicing
Claudia Sheinbaum Pardo would be first researcher to lead the country, but critics worry she’ll be as hostile to science as her predecessor
Increased intestinal bile acid absorption contributes to age-related cognitive impairment
Cognitive impairment in the elderly is associated with alterations in bile acid (BA) metabolism. In this study, we observe elevated levels of serum conjugated primary bile acids (CPBAs) and ammonia in elderly individuals, mild cognitive impairment, Alzheimer's disease, and aging rodents, with a more pronounced change in females. These changes are correlated with increased expression of the ileal apical sodium-bile acid transporter (ASBT), hippocampal synapse loss, and elevated brain CPBA and...
The broken Alzheimer's disease genome
The complex pathobiology of late-onset Alzheimer's disease (AD) poses significant challenges to therapeutic and preventative interventions. Despite these difficulties, genomics and related disciplines are allowing fundamental mechanistic insights to emerge with clarity, particularly with the introduction of high-resolution sequencing technologies. After all, the disrupted processes at the interface between DNA and gene expression, which we call the broken AD genome, offer detailed quantitative...
Brain-muscle communication prevents muscle aging by maintaining daily physiology
A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, we created a basic clock module involving a central and a peripheral (muscle) clock. Reconstituting the brain-muscle clock network is sufficient to preserve fundamental daily homeostatic functions and prevent premature muscle aging. However, achieving whole...
Increased intestinal bile acid absorption contributes to age-related cognitive impairment
Cognitive impairment in the elderly is associated with alterations in bile acid (BA) metabolism. In this study, we observe elevated levels of serum conjugated primary bile acids (CPBAs) and ammonia in elderly individuals, mild cognitive impairment, Alzheimer's disease, and aging rodents, with a more pronounced change in females. These changes are correlated with increased expression of the ileal apical sodium-bile acid transporter (ASBT), hippocampal synapse loss, and elevated brain CPBA and...
Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function
Here, we investigated the mechanisms by which aging-related reductions of the levels of Numb in skeletal muscle fibers contribute to loss of muscle strength and power, two critical features of sarcopenia. Numb is an adaptor protein best known for its critical roles in development, including asymmetric cell division, cell-type specification, and termination of intracellular signaling. Numb expression is reduced in old humans and mice. We previously showed that, in mouse skeletal muscle fibers,...
Alterations of human CSF and serum-based mitophagy biomarkers in the continuum of Alzheimer disease
Defective mitophagy is consistently found in postmortem brain and iPSC-derived neurons from Alzheimer disease (AD) patients. However, there is a lack of extensive examination of mitophagy status in serum or cerebrospinal fluid (CSF), and the clinical potential of mitophagy biomarkers has not been tested. We quantified biomarkers of mitophagy/autophagy and lysosomal degradation (PINK1, BNIP3L and TFEB) in CSF and serum from 246 individuals, covering mild cognitive impairment due to AD (MCI-AD, n...
Alterations of human CSF and serum-based mitophagy biomarkers in the continuum of Alzheimer disease
Defective mitophagy is consistently found in postmortem brain and iPSC-derived neurons from Alzheimer disease (AD) patients. However, there is a lack of extensive examination of mitophagy status in serum or cerebrospinal fluid (CSF), and the clinical potential of mitophagy biomarkers has not been tested. We quantified biomarkers of mitophagy/autophagy and lysosomal degradation (PINK1, BNIP3L and TFEB) in CSF and serum from 246 individuals, covering mild cognitive impairment due to AD (MCI-AD, n...
US National Academies report outlines barriers and solutions for scientist carers
My PI yelled at me and I’m devastated. What do I do?
UTIs make life miserable — scientists are finding new ways to tackle them
'Orangutan, heal thyself': First wild animal seen using medicinal plant
A deconstruction-reconstruction strategy for pyrimidine diversification
Never mind little green men: life on other planets might be purple
In Science Journals
Science, Volume 384, Issue 6695, Page 521-523, May 2024.
Unsettled science on longer-run effects of early education
Science, Volume 384, Issue 6695, Page 506-508, May 2024.