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Five reasons for the failure of frailty screening in primary care: lessons from the experience with ICOPE monitor step 1
CONCLUSIONS: The study highlighted the social and financial obstacles hindering the use of ICOPE Monitor and more broadly, the implementation of frailty screening by primary care practitioners.
Intracranial self-stimulation mitigates spatial task deficits, modifies miR-146a and miR-495 serum levels and restores hippocampal NRF2 levels in a rat model of sporadic Alzheimer's disease
CONCLUSION: Prolonged MFB-ICSS treatment mitigates cognitive deficits, modulates circulating levels of miRNA-495 and miR-146a, restores hippocampal NRF2 levels, and preserves corpus callosum integrity in the SAD rat model by STZ injection. These findings highlight the therapeutic potential of MFB-ICSS as a non-pharmacological intervention in AD. Furthermore, this study confirms NRF2 as a target of miR-495 in the context of AD.
Early-Life Climbing Stratifies the Metabolome and Mortality Risk in Genetically Identical Flies
Studies in laboratory organisms typically minimize all environmental and genetic variation other than the intervention of interest. In aging studies, these highly controlled conditions have yielded profound insights into aging. But even within isogenic cohorts of lab animals in controlled environments, we observe substantial variation in lifespan. Here we exploited the climbing behavior of Drosophila to study variation in mortality among isogenic populations in a controlled environment. We show...
Human Umbilical Cord Plasma Metabolomics Uncover Potential Metabolites for Combating Aging
Human umbilical cord blood (HUCB) exhibits distinct characteristics compared to adult blood, offering significant potential for medical applications, particularly in antiaging therapies. However, the metabolic profile of HUCB relative to adult blood remains poorly understood. Moreover, the specific metabolites within HUCB that confer antiaging properties have yet to be identified. Here, we conducted an untargeted metabolomic analysis comparing cord plasma and adult plasma. Our results reveal a...
Mathematics is hard for mathematicians to understand too
Science, Volume 390, Issue 6776, November 2025.
Erratum for the Policy Forum “How collaboration with China can revitalize US automotive innovation” by J. P. Helveston
Science, Volume 390, Issue 6776, November 2025.
Targeted protein degradation in the transmembrane and extracellular space
Science, Volume 390, Issue 6776, November 2025.
Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes
Science, Volume 390, Issue 6776, November 2025.
Liquid-state dipolarcaloric refrigeration cycle with nitrate-based salts
Science, Volume 390, Issue 6776, November 2025.
Spectral kernel machines with electrically tunable photodetectors
Science, Volume 390, Issue 6776, November 2025.
Full utilization of noble metals by atom abstraction for propane dehydrogenation
Science, Volume 390, Issue 6776, November 2025.
Reranking partisan animosity in algorithmic social media feeds alters affective polarization
Science, Volume 390, Issue 6776, November 2025.
The dispersal of domestic cats from North Africa to Europe around 2000 years ago
Science, Volume 390, Issue 6776, November 2025.
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Science, Volume 390, Issue 6776, November 2025.