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Correction for Meireles et al., Aging populations threaten conservation goals of zoos
No abstract
Structural vibration monitoring with diffractive optical processors
Structural health monitoring (SHM) is vital for maintaining the safety and longevity of civil infrastructure, yet current solutions remain constrained by cost, power consumption, scalability, and the complexity of data processing. Here, we present a diffractive vibration monitoring system, integrating a jointly optimized diffractive layer with a shallow neural network-based backend to remotely extract three-dimensional (3D) structural vibration spectra, offering a low-power, cost-effective, and...
Effects of Radiotherapy in Normal Tissue
Radiotherapy is a key foundation of oncologic treatment that is used across the spectrum of cancer indications. Advances in imaging, treatment planning, and dose delivery have led to increasingly conformal and even ablative treatments, which have resulted in improved tumor control with no increase in the risk of side effects (or with a decrease in risk) as compared with previous treatments. These advances have facilitated the combined use of radiotherapy with efficacious systemic therapies,...
Many heat-stressed tropical insects are reaching their limits
Vast study in Peru and Kenya confirms limited defenses against rising temperatures, redoubling climate concerns
Chaperone-mediated autophagy: the Achilles heel of the retinal pigment epithelium during age-related macular degeneration
Chaperone-mediated autophagy (CMA) is a selective autophagy pathway that targets specific proteins containing a KFERQ-like motif for lysosomal degradation. It has been shown by us and others that CMA decreases during physiological aging in most tissues, and its impairment is associated with increased incidence of age-related pathologies, such as cardiovascular disease, neurodegenerative disorders or sarcopenia. However, its involvement in age-related macular degeneration (AMD), a prevalent...
Correction: Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish
No abstract
Dual roles of basal NLRP3 expression in cognitive and neurogenic aging
Aging is accompanied by increasing inter-individual variability in cognitive and functional outcomes, reflecting differences in biological resilience and vulnerability. Chronic low-grade inflammation (inflammaging) is a central driver of this process, yet the contribution of individual inflammatory pathways to adaptive versus maladaptive brain aging remains incompletely understood. The NLRP3 inflammasome has been widely implicated in age-related neurodegeneration, but its physiological roles...
Women's reproductive factors predict local brain aging profiles mapped using deep neural networks
Deep neural networks (DNNs) trained on magnetic resonance images can estimate global brain age (GBA), which reflects women's neurological disease risk. GBA gap (GBAG), the difference between GBA and chronological age (CA), quantifies excessive global aging; local BAG (LBAG) has not been examined despite allowing voxelwise resolution. Using a novel DNN architecture, we estimate LBAG for 12,284 UK Biobank females with chronological ages (CAs) ranging between 46 and 82 years (y) and quantify how it...
Behavioral deficits and exacerbated neural and hemodynamic odor responses during lifespan of a mouse model of late onset Alzheimer's disease expressing humanized APOEepsilon4 and Trem2*R47H
Alzheimer's disease (AD) poses a significant global health challenge, being the most prominent cause of dementia with prevalence increasing as the population ages. While the majority of AD cases are late-onset (LOAD), current animal models predominantly represent the more aggressive, faster progressing early-onset AD (EOAD), limiting their ability in assessing early biomarkers and gaining deeper understanding of LOAD progression. This study explores a promising translatable model, the...