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Peppermint oil may have an unexpected benefit for people with mildly high blood pressure. Adults who took a small dose twice daily for 20 days saw their systolic blood pressure fall by an average of 8.5 mmHg, while a placebo group showed little change. Researchers say the inexpensive oil could eventually provide a simple additional option for managing elevated blood pressure.

Exercise may not be a powerful weight-loss tool on its own, but it appears to play a much bigger role in preventing lost weight from returning. By preserving muscle, supporting metabolism, improving fat burning, and regulating appetite and blood sugar, regular activity can make long-term weight maintenance easier.

People who speak several languages may have brains that age more slowly, with four-language speakers showing brains that appeared about 13 years younger than those of monolinguals. Starting earlier and becoming highly fluent were also linked to a stronger effect.

A simple yeast-based food supplement may help restore the immune system’s ability to fight cancer, according to new research in mice. Scientists found that yeast beta-glucan reprogrammed early immune cells in the bone marrow, leading to stronger, longer-lasting cancer-fighting responses against colorectal, skin, and breast cancer cells.

Pancreatic cancer patients with at least 21 natural teeth survived nearly two years longer after surgery than those with fewer teeth in a study of 339 people. Researchers suspect tooth loss may reflect decades of inflammation, frailty, nutrition, and other factors tied to the body’s overall resilience.

Scientists have linked a specific gut bacterium, Roseburia inulinivorans, to stronger muscles in both humans and mice. Older adults who carried it had 29% greater handgrip strength, while treated mice gained about 30% more grip strength and developed larger, more fast-twitch muscle fibers. The bacterium was also less common in older people. Researchers say it could eventually become a probiotic candidate for helping combat age-related muscle loss.

A few minutes of sprinting may reshape the bloodstream far more dramatically than a much longer moderate workout. Six 30-second sprints altered nearly a quarter of the blood proteins measured and more than 200 metabolites, while 90 minutes of moderate cycling produced far smaller immediate changes. Many of the proteins affected by sprinting were also associated with lower risks of obesity, type 2 diabetes, and other metabolic diseases.

A hormone already known for curbing appetite and supporting weight loss may have a surprising second job: protecting the liver from inflammation and scarring. Researchers at McMaster University found that GDF15 activates a previously unknown brain-to-liver pathway that triggers the release of glucocorticoids, helping calm immune activity in the liver.

AI may be able to predict how strongly someone will respond to a vaccine before they receive it. By analyzing antibody patterns in more than 4,000 people, researchers found signs of “immune readiness” that helped distinguish strong responders from weak ones. Surprisingly, even some healthy people responded poorly, while some immunosuppressed people mounted strong responses.

Immunosenescence is not a uniform decline but a trajectory shaped jointly by age and sex. Using continuous high-dimensional immunophenotyping, we show that aging T cells accumulate a senescent signature of CD28 loss and CD57 gain, and that males reach an inverted CD4:CD8 ratio earlier and more severely than females. We argue that age-by-sex stratification should guide vaccination and geroprotective strategies in an aging population.

Aging biomarkers can potentially allow researchers to rapidly monitor the impact of an aging intervention without the need for decade-spanning trials. However, before the use of aging biomarkers, such as epigenetic clocks, as surrogate endpoints, their responsiveness to interventions that target aging must be tested. Here we curate TranslAGE, a harmonized database of 51 public and private longitudinal interventional studies, and calculate a consistent set of 16 prominent epigenetic clocks for...

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Frailty and cognitive impairments frequently co-occur in older adults. It remains unclear whether this overlap reflects shared underlying biological mechanisms or parallel but distinct disease pathways. We hypothesize that physical weakness and cognitive impairment share circulating markers already in an early disease stage. We therefore recruited and analyzed a relatively healthy population with partially overlapping pre-frailty and mild cognitive impairment (MCI), and applied a multi-omics...

Family dogs' human-analogue attachment to the owner has long been recognised; however, how this dog-owner attachment develops and changes with age remains an open question. We examined age-related variation and the effect of training experience on the attachment behaviour in family dogs (N = 222) using the Strange Situation Test (SST). Across three age groups (puppy-juvenile, adult, and senior dogs), dogs were assessed by scores for three behavioural factors: attachment to the owner, anxiety...

The increase in life expectancy over the past century has been accompanied by the recognition of age as the primary risk factor for a wide range of pathologies, including cardiovascular and neurodegenerative diseases, as well as cancer. Thus, the development of interventions that slow the underlying biological processes of aging could have beneficial effects on the prevention or progression of these diseases. To evaluate such geroprotective interventions, quantifying biological damage via aging...

Parkinson's disease (PD) motor symptoms are linked to excessive beta band (13-35 Hz) oscillations and basal ganglia-cortical (BGC) synchrony, yet their dynamic inter-relation remains unclear. Based on computational modeling, we hypothesize that transient high-beta (20-35 Hz) BGC coupling induces subcortical low-beta (13-20 Hz) amplification. We recorded intraoperative neural signals from the globus pallidus internus and externus (GPi and GPe, respectively) and motor cortex (M1) in 23 PD patients...

Population aging is accompanied by a parallel increase in cardiovascular disease (CVD), vascular cognitive impairment (VCI), and dementia, highlighting the urgent need to better understand the complex interactions linking cardiovascular, cognitive, and emotional health. Growing evidence suggests that cardiovascular dysfunction, emotional dysregulation, and cognitive decline are not isolated conditions but interconnected manifestations of shared vascular, inflammatory, neurohumoral, metabolic,...

Chronic diseases can continue to progress after the initiating insult has subsided, indicating that injured tissues may retain a persistent imprint of failed repair. Here, senescent repair memory refers to a tissue state in which transient repair-associated senescence fails to resolve and is maintained by persistent senescent cells, altered secretory and metabolic programmes, defective immune clearance, epigenetic stabilization and spatial niche interactions. Once established beyond the adaptive...

Ageing is a process of continuous decline of cellular health. This decline could be attributed to loss of functions to various crucial protein players regulating the triage of cellular physiology. Systematic decline of cellular proteostasis is one major change that orchestrates alterations in functioning of other biological indicators, including cellular energetics, signal transduction, and metabolic adaptation. Among many molecular players governing physiological changes, E3 ubiquitin ligases...