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Mitonuclear discordance modulates mitochondrial ageing dynamics in natural Drosophila populations
Mitochondrial decline is a hallmark of ageing, yet the role of intergenomic compatibility in shaping ageing trajectories remains poorly understood, particularly in an ecologically relevant framework. Hormetic interventions have been proposed as strategies to modulate metabolism and lifespan, but it is unknown how this operates in the context of mitonuclear discordance. Here, we demonstrate that mitonuclear mismatch accelerates age-related mitochondrial decline, elevates reactive oxygen species...
Sex- and experience-dependent regulation of synaptic protein turnover
Synaptic transmission can be tuned through plasticity mechanisms that regulate synaptic strength, structure, and number. In vivo measurements demonstrate remarkable spine dynamics, with subsets of synapses persisting for months. This correlates with the longevity of certain memories, which can persist for an organism's lifetime. The molecular basis supporting the long-term stability of specific synapses and the long-term durability of memories remains unknown. At the protein level, most proteins...
Self-Reported Life Satisfaction and Life-Space Mobility in Older Adults With Mild Cognitive Impairment: A Cross-Sectional Study
CONCLUSIONS AND IMPLICATIONS: Greater life-space mobility was associated with higher life satisfaction regardless of MCI status. These findings suggest that maintaining and expanding life-space mobility may support well-being among community-dwelling older adults, including those with cognitive decline. Interventions aimed at preserving life-space mobility may have practical implications for promoting healthy aging and quality of life in older populations.
Enhancing the performance and interpretability of epigenetic clocks
Epigenetic clocks based on DNA methylation (DNAm) accurately predict age, but their biological underpinnings remain unclear. One primary mechanism by which DNAm might influence gene regulation is by modulating transcription factor binding activity. This study investigates the regulatory potential of predictive CpGs in established epigenetic clocks. Our analysis reveals that generally most CpGs used by epigenetic clocks do not overlap known transcription factor binding sites (TFBS), indicating...
Endosymbiotic theory of aging revisited: Age-related leakage of mitochondrial dsDNA/RNA stimulates cytosolic nucleic acid sensors which remodel the immune network and promote the aging process
About 1.5-2 billion years ago, an endosymbiosis between aerobic α-proteobacteria and anaerobic archaeal cells generated mitochondria, i.e., organelles capable of producing oxidative energy. The bacterial genome was fundamentally reduced and a circular mitochondrial genome evolved containing mainly the genes coding for the subunits of the electron transport chain. Before the symbiotic event, there existed a virus-host co-evolution which involved the development of sensors for detecting dangerous...
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
No abstract
Comparison of hip abduction range of motion and strength and ankle dorsiflexion in older adults with and without a history of falls
CONCLUSION: Concurrent weakness in the hip abductors and ankle dorsiflexors may be associated with an increased risk of falls in older adults. Combined assessment of muscle strength and range of motion in these regions may assist in identifying older adults with characteristics associated with fall history.
British ‘First Fleet’ brought smallpox to Australia—and may have killed millions
Two papers pin the deadly disease’s introduction on British colonists and suggest the continent held far more people than previously believed
Body-plan organizer in comb jellies hints at animal ancestry
‘Humanizer’ tool can erase signs of AI-written text — alarming scientists
Say hello to hard helium
How to avoid dementia — what the science really says
Keep the Hubble and James Webb Space Telescopes alive — the science is worth the price tag
Save Hubble: the race to preserve the space telescope kicks off
How to widen access to the critical minerals that the world needs
How long can humans live? All evidence points to a maximum of 125 years
AI can cause harm: safeguards must catch up
Listen to Gen Z when it comes to AI in education
Publisher Correction: A 98-qubit trapped-ion quantum computer with all-to-all connectivity
As flu virus threatens its unique bird species, New Zealand pins hopes on a vaccine
Arrival of H5N1 in Australia triggers ambitious vaccination program