Aggregator
Dysfunction of lipid metabolism and lysosomal capacity: at the core of microglial aging?
As primary immune cells of the central nervous system (CNS), microglia maintain immune surveillance, inflammation regulation, cell interactions and debris clearance. These dynamic and adaptive effector functions are reciprocally sustained by microglial metabolism. Lipids are emerging as a key programmer of microglial metabolic and functional flexibility in conditions of homeostasis, cellular stress, and pathology. The delicate equilibrium in microglial lipid homeostasis is dependent on the...
Olfactory context and memory across the adult lifespan: effects on mnemonic discrimination and olfactory function
Odor is a powerful contextual cue that can influence memory and is closely linked to brain regions involved in episodic memory, including the hippocampus. Age-related olfactory dysfunction is among the earliest behavioral changes associated with cognitive decline and may contribute to memory impairments in older adults. Hippocampal pattern separation, or the process of reducing interference among similar experiences, provides a sensitive measure of age-related memory decline, yet little is known...
Plasma p-tau181 moderates the association between ten-year atherosclerotic cardiovascular disease risk and mild cognitive impairment - HABS-HD
CONCLUSION: Greater ten-year ASCVD risk was consistently associated with cognitive impairment independent of plasma AD biomarkers, with evidence that p-tau181 modifies these associations and that their magnitude varies across racial and ethnic groups.
Consumer preferences for hearing health care information and services as described by older adults surveyed in Australia, Canada, England, and the United States
CONCLUSIONS: Our survey results indicate that older adults preferred to seek and receive HHC through traditional medical settings. These data were collected prior to the pandemic and before some of the recent OTC policy changes; nonetheless, they align with more recent findings and capture the attitudes of individuals who are likely still making HHC decisions today. These findings, therefore, provide contextual evidence about older adults' reported preferences against which future studies of...
DNMT1 Regulates Testosterone Synthesis in Aged Rat Leydig Cells via FTO-Mediated HSP90AA1 m<sup>6</sup>A Levels
Testosterone levels decline progressively with age from the third decade of life, impairing spermatogenesis and contributing to age-related disorders, underscoring the importance of enhancing endogenous testosterone production. DNA methyltransferase 1 (DNMT1) promotes testosterone synthesis in Leydig cells (LCs), yet the underlying mechanism remains unclear. Here, we found that DNMT1 expression is downregulated in aging rat testes and senescent LCs in vitro, correlating with reduced testosterone...
For women academics, feeling devalued can be a fatal career blow
Thousands shared their stories for a new study of faculty attrition