Aggregator
Accurate detection of somatic single-nucleotide variants from bulk RNA-seq data using RNA-MosaicHunter
Somatic variants are increasingly recognized as contributors to diverse non-cancer, developmental, and aging-related disorders. However, most tools for detecting somatic single-nucleotide variants (sSNVs) were designed for DNA sequencing and primarily tailored to cancer datasets, leaving a critical gap in harnessing the rich potential of RNA-seq for sSNV identification, particularly in non-cancer tissues with low mutation rates. Here, we introduce RNA-MosaicHunter, a novel bioinformatic tool for...
Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in <em>Caenorhabditis elegans,</em> challenges a proposed role in heme trafficking
Mutations in the TANGO2 gene are associated with a severe neurometabolic disorder in humans, often presenting with life-threatening metabolic crisis. However, the function of TANGO2 protein remains unknown. It has recently been proposed that TANGO2 transports heme within and between cells, from areas with high heme concentrations to those with lower concentrations. Here, we demonstrate that prior heme-related observations in Caenorhabditis elegans lacking TANGO2 homologs HRG-9 and HRG-10 may be...
A mechanism for telomere-specific telomere length regulation
Telomere length is a critical determinant of telomere function and hence chromosome stability. Critically short telomeres induce cellular senescence and division arrest, which eventually may lead to devastating age-related degenerative diseases. Conversely, maintenance of telomere length is a hallmark of cancer. How telomere set-length is established and molecular mechanisms for telomere-specific length regulation remained unknown. Here, we detail a mechanism of a telomere-specific set-length...
Accurate detection of somatic single-nucleotide variants from bulk RNA-seq data using RNA-MosaicHunter
Somatic variants are increasingly recognized as contributors to diverse non-cancer, developmental, and aging-related disorders. However, most tools for detecting somatic single-nucleotide variants (sSNVs) were designed for DNA sequencing and primarily tailored to cancer datasets, leaving a critical gap in harnessing the rich potential of RNA-seq for sSNV identification, particularly in non-cancer tissues with low mutation rates. Here, we introduce RNA-MosaicHunter, a novel bioinformatic tool for...
Natural grasslands used for grazing livestock can mitigate climate change
Science, Volume 391, Issue 6781, January 2026.
Erratum for the Research Article “Invasion impacts in terrestrial ecosystems: Global patterns and predictors” by M. P. Thakur et al.
Science, Volume 391, Issue 6781, January 2026.
Facial gestures are enacted through a cortical hierarchy of dynamic and stable codes
Science, Volume 391, Issue 6781, January 2026.
Chinese Immune Multi-Omics Atlas
Science, Volume 391, Issue 6781, January 2026.
Ontogeny of the spinal cord dorsal horn
Science, Volume 391, Issue 6781, January 2026.
Bark microbiota modulate climate-active gas fluxes in Australian forests
Science, Volume 391, Issue 6781, January 2026.
IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation
Science, Volume 391, Issue 6781, January 2026.
Deep contrastive learning enables genome-wide virtual screening
Science, Volume 391, Issue 6781, January 2026.
Mapping somatosensory afferent circuitry to bone identifies neurotrophic signals required for fracture healing
Science, Volume 391, Issue 6781, January 2026.
Putting immune cells into ‘night mode’ reduces heart-attack damage
Will mpox go global again? Research shows it's evolving in curious ways
Author Correction: Structural insights into BCDX2 complex function in homologous recombination
In Science Journals
Science, Volume 391, Issue 6781, Page 143-145, January 2026.
Did the illicit fentanyl trade experience a supply shock?
Science, Volume 391, Issue 6781, Page 134-136, January 2026.
Weathering budget cuts: Lessons from NASA
Science, Volume 391, Issue 6781, Page 109-109, January 2026.
New conflicts erupt over key virus database
Science, Volume 391, Issue 6781, Page 116-117, January 2026.