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Cancer cell death: Cell-autonomous and immunogenic dimensions

1 day 4 hours ago
Regulated cell death (RCD) shapes neoplastic transformation, tumor progression, and response to treatment. While apoptosis was long viewed as the only RCD variant, additional modalities, including necroptosis, pyroptosis, and ferroptosis, have been characterized. These interconnected pathways operate in a context-dependent manner to influence the dynamic interplay between malignant and non-malignant cells that governs disease progression or regression, both naturally and during therapy. Major...
Lorenzo Galluzzi

The skeletal muscle function deficit: From an operational definition to clinic results from the InCHIANTI longitudinal study

1 day 4 hours ago
Age-related muscle dysfunction is a major contributor to disability, frailty, and poor clinical outcomes in older adults. Skeletal Muscle Function Deficit (SMFD) framework integrates multiple domains as: muscle mass, muscle density, strength, and power to capture a broader spectrum of age-related muscle dysfunction. The primary aims of these analyses are to develop and validate a composite SMFD score and evaluate its association with key geriatric outcome. This study used data from the InCHIANTI...
Angelo Di Iorio

Longevity of cardiac and skeletal muscle proteins is dependent on tissue and subcellular compartmentation patterns

1 day 4 hours ago
Myocytes are exceptionally long-lived cells that must maintain proteome integrity over decades while adjusting for changes in functional output and metabolic demand. We used in vivo stable isotope labeling combined with mass spectrometry proteomics and correlated multi-isotope imaging mass spectrometry to quantify and visualize protein turnover across cardiac, fast-twitch, and slow-twitch skeletal muscles, creating a resource of hundreds of individual protein turnover rates from each tissue. We...
Jack Gugel

Immunosuppressive macrophages determine the effect of cellular senescence on tumor progression

1 day 4 hours ago
Cells terminally arrested in the cell cycle that exhibit a distinct secretory phenotype are referred to as senescent. These cells play a complex role during tumor progression; they can inhibit or promote tumor growth depending on disease stage. We developed a mouse model that allows monitoring and selective elimination of cells expressing high levels of the cyclin-dependent kinase inhibitor p16 and interleukin-6. These mice, termed SuSe (suicidal senescence), were crossed with the mouse mammary...
Marta Lalinde-Gutiérrez

In Science Journals

1 day 8 hours ago
Science, Volume 391, Issue 6780, Page 42-44, January 2026.
Michael Funk, and Henk A. Dijkstra, Yury Suleymanov, Jelena Stajic, Jake S. Yeston, Madeleine Seale, Mark Aldenderfer, Wei Wong, Phil Szuromi, Mattia Maroso, Caroline Ash, Michael A Funk, Sacha Vignieri, Corinne Simonti, Yevgeniya Nusinovich, Keith T…