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Loneliness may steal nearly 6 years of good health
A large study suggests loneliness and social isolation can cost people years of healthy life, especially when it comes to mental health. Men experiencing both lost about 5.8 years free from depression and anxiety, while women lost roughly 3.7 years.
Bowel cancer “melted away” after immunotherapy, then stayed away
A short course of immunotherapy before surgery may offer remarkably durable protection for some patients with stage two or three bowel cancer. In the NEOPRISM-CRC trial, 32 patients with a specific genetic form of bowel cancer received pembrolizumab for up to nine weeks before surgery instead of the usual post-surgery chemotherapy. After nearly three years of follow-up, none of the patients had experienced a cancer recurrence, including those who still had small traces of disease after treatment.
ZNF865 (BLST) a Novel Regulator of DNA Damage and Cell Senescence in Back Pain
Senescence has been shown to contribute to the progression of aging-related diseases including degenerative disc disease (DDD). However, the mechanisms regulating senescence in the intervertebral disc (IVD) and other tissues/diseases remain poorly understood. Recently, ZNF865 (BLST) was identified as a previously uncharacterized zinc finger protein that regulates a wide array of genes related to protein processing, cell senescence, and DNA damage repair. Here, we show that ZNF865 expression...
Scientists may have found why diabetic wounds refuse to heal
Chronic diabetic wounds may fail to heal because immune cells remain locked in damaging inflammatory states instead of transitioning toward tissue repair. Researchers are exploring treatments that reprogram these immune responses, raising hopes for more targeted and effective therapies for diabetic ulcers.
Scientists discover 5 hidden brain patterns behind depression
Depression may not be one biological condition, but several distinct patterns of brain activity hiding under the same diagnosis. Researchers studying 263 people with depression identified five brain profiles, each showing different patterns of communication between brain regions and associations with symptoms such as anxiety, trauma, and substance abuse.
Problems in 22 scientific fields had solutions hiding in plain sight. An AI has found them
Teams led by physicist used “BootLoops” software to produce 36 papers in weeks on everything from linguistics to health policy
Only one workout helped older adults lose fat and keep muscle
A six-month study suggests that high-intensity interval training (HIIT) may offer older adults a powerful advantage: losing body fat while keeping their muscle. Unlike moderate-intensity workouts, which led to a small loss of lean muscle, HIIT preserved it while also improving body composition around the waist.
Magnetic Electroluminescent response as a predictive indicator of operational lifetime in phosphorescent blue OLEDs
Improving operational lifetime remains a major challenge for blue organic light-emitting diodes (OLEDs) harvesting triplet excitons. Achieving substantial lifetime enhancement requires analytical techniques that elucidate degradation mechanisms. Because conventional lifetime analysis involves destructive aging tests, developing non-invasive methods that correlate strongly with device longevity is highly desirable. Here, we show that the operational lifetime of blue phosphorescent OLEDs...
Menopause-associated proteomic changes link to brain ageing and dementia risk
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Author Correction: The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4(+) T cells by preventing ferroptosis
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Publisher Correction: Sleep chart of biological ageing clocks in middle and late life
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Goals and challenges for senescence research
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Lymph node contraction links sex-biased naive CD8<sup>+</sup> T cell decline to compromised antigen recognition during middle age
The abundance of diverse naive CD8^(+) T cell clones is essential for broad protection against infection and cancer, but how sex and aging jointly shape this compartment remains poorly understood. Here, using mouse models with supporting human data, we uncover a sex-biased mechanism of immune aging in which early male-biased depletion of naive CD8^(+) T cells driven by accelerated, antigen-agnostic differentiation into virtual memory cells combines with thymic involution, limiting naive CD8^(+)...
Mitochondrial dysfunction and inflammaging: a mechanistic bridge between bioenergetic failure and senescence
Ageing is characterized by a progressive decline in mitochondrial integrity that extends beyond impaired energy production to include redox imbalance, defective quality control, altered organelle dynamics, and persistent inflammatory signalling. This review examines mitochondrial dysfunction as a mechanistic bridge linking bioenergetic failure to cellular senescence and inflammaging, two central features of biological ageing. We discuss how impaired oxidative phosphorylation, loss of...
Identification of cognitive subtypes and risk networks in Chinese older adults: based on latent profile analysis and explainable machine learning
CONCLUSION: This study defines a cognitive impairment subtype primarily driven by education poverty and digital exclusion, which is prone to be missed in routine memory-centric screenings. The findings suggest that biomedical interventions alone may be insufficient to prevent such decline; promoting digital inclusion among older adults should be regarded as a critical public health strategy to compensate for early-life educational deficits and prevent the decline of calculation and executive...
Microbiota-regulated TCDCA associates with Parkinson's disease severity and promotes BBB dysfunction through VSMC TGR5 signaling in mice
Parkinson's disease (PD) is a systemic disorder linked to gut dysbiosis, yet key microbiota-regulated metabolites remain unclear. Here, we observe elevated taurochenodeoxycholic acid (TCDCA) in patients with PD that correlates with disease severity. Reduced bile salt hydrolase (BSH) gene abundance correlates inversely with circulating TCDCA, consistent with altered bile acid deconjugation. Exogenous TCDCA correlates with aggravated motor and gastrointestinal deficits, impaired blood-brain...
Tau phosphorylation from neuronal adaptation to Alzheimer's disease
Tau phosphorylation is classically associated with neurodegeneration, yet similar phosphorylation patterns emerge during physiological states and acute stress responses. How these overlapping patterns of phosphorylated Tau (pTau) relate to neuronal adaptation and Alzheimer's disease pathology remains unresolved. We synthesize findings from human to rodent and fly brains and from neuronal cell models, across neurodevelopment, sleep, hibernation, cellular stress, and disease. Across these...
Polysaccharide-based drug conjugates and related delivery systems for Alzheimer's disease: from molecular design to translational challenges
Alzheimer's disease (AD) presents distinct extracellular, intracellular and vascular delivery targets, yet brain exposure of candidate therapeutics remains difficult to establish. This narrative review compares hyaluronic acid, chitosan, cyclodextrin, dextran, alginate and pectin systems by construct architecture, route, blood-brain barrier (BBB) evidence, cargo release and biological response. The literature includes covalent drug conjugates, loaded or coated carriers, host-guest complexes and...
Single-cell analyses of global cohorts outline determinants of immune aging and link the ratio of GZMK(+) to GZMB(+) Tem cells to health trajectories
Human immune aging is heterogeneous, with immune responses becoming increasingly variable over the lifespan. Here, we integrated seven large-scale public single-cell peripheral blood mononuclear cell (PBMC) datasets and a newly generated cohort, encompassing 2,609 ostensibly healthy individuals across diverse ages, ancestries, and biological sexes. We identified both conserved and cohort-associated age-associated remodeling across 59 immune populations, together with sex- and ancestry-dependent...
Tau phosphorylation from neuronal adaptation to Alzheimer's disease
Tau phosphorylation is classically associated with neurodegeneration, yet similar phosphorylation patterns emerge during physiological states and acute stress responses. How these overlapping patterns of phosphorylated Tau (pTau) relate to neuronal adaptation and Alzheimer's disease pathology remains unresolved. We synthesize findings from human to rodent and fly brains and from neuronal cell models, across neurodevelopment, sleep, hibernation, cellular stress, and disease. Across these...