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A new nature-inspired membrane uses perfectly uniform one-nanometer pores to filter molecules with remarkable precision. The technology could transform industries such as pharmaceuticals and textiles by reducing energy consumption, improving water reuse, and delivering separation performance far beyond current filters.

A low-calorie fasting-style diet significantly reduced inflammation linked to gum disease in a small clinical study. The findings suggest that what people eat may influence gum health almost as much as what they do with a toothbrush.

Researchers discovered that mutations linked to blood cancers may help trigger Alzheimer’s disease by creating overly inflammatory immune cells in the brain. The unexpected finding could lead to new blood-based screening methods and potential treatments borrowed from cancer medicine.

A new treatment that blocks an aging-related protein restored lost cartilage in old mice and helped prevent arthritis after knee injuries. Human cartilage samples showed similar signs of regeneration, raising hopes for a future drug that could repair joints instead of replacing them.

Advanced age is a major determinant of adverse outcomes during acute infections, yet the immunological mechanisms by which aging alters immune regulation and shapes disease trajectories remain poorly understood. Using SARS-CoV-2 infection as a model of acute viral challenge, we investigated how aging alters myeloid responses in the lungs. Across infected mouse models and human cohorts, disease severity was associated with a pronounced shift in myeloid balance, characterized by an increased...

Frailty is a dynamic and potentially reversible condition, yet limited evidence has examined whether oral functional limitation is associated not only with frailty onset but also with long-term frailty transitions. We analyzed 6-year prospective data (2016-2023) from 2731 community-dwelling adults aged 70-84 years in the Korean Frailty and Aging Cohort Study. Oral functional limitation was defined as self-reported difficulty in chewing or pronunciation. Frailty was assessed using Fried's...

CONCLUSIONS: Abnormal health indicators among rural older adults exhibit a metabolism-centered and systemically interconnected co-occurrence pattern. Fatty liver, diabetes, and hypertension are structurally central nodes in the network, highlighting their prominence rather than implying causality. Females show stronger indicator interconnections, and advanced age is associated with more complex co-occurrence patterns. These findings provide network-based, hypothesis-generating evidence to...

CONCLUSIONS: Social frailty was independently associated with all-cause mortality among older adults in this Colombian regional cohort. These findings suggest that incorporating social vulnerability measures into geriatric assessment may improve risk stratification and help identify individuals who could benefit from supportive interventions.

CONCLUSION: Digital technologies provide a limited but meaningful contribution to sustaining social cohesion among older adults in rural, conflict-affected Myanmar by supporting communication, emotional connection, and access to information. However, their contribution remains uneven, as structural inequalities, political constraints, and infrastructural limitations continue to restrict equitable access. Addressing these challenges requires context-sensitive, age-appropriate digital inclusion...

Autophagy constitutes a major adaptive response that preserves cellular and organismal homeostasis during stress. However, stress responses also engage systemic communication pathways that may either maintain resilience or propagate pathology. We previously identified acyl-CoA-binding protein, also known as diazepam-binding inhibitor (DBI/ACBP), as a phylogenetically conserved extracellular factor secreted by stressed cells through an unconventional autophagy-dependent pathway. Once released,...

The Endless Frontier traces the lives of three scientists as they train students and deal with funding pressures

Just 90–120 minutes of strength training a week may deliver some of the biggest long-term health rewards, according to a study tracking more than 147,000 people for 30 years. That amount was linked to lower risks of death overall, particularly from cardiovascular and neurological diseases. Combining strength workouts with aerobic exercise produced even stronger benefits.