Aggregator
Tau protein can sneak into brain cells’ energy factories—and wreak havoc
Study of mitochondria suggests new treatment strategy for Alzheimer’s and other diseases
Nearly half of dementia cases may be linked to risks you can change
A long-term brain study found that common risks such as smoking, high blood pressure, heart disease, and high blood lipids were strongly linked to damage associated with vascular dementia. The findings suggest that healthier lifestyle choices could help delay dementia by reducing several harmful brain changes at once.
HNRNPC Succinylation Influences the Neurodegeneration of Alzheimer's Disease Through YME1L1-Mediated Mitochondrial Metabolism
Mitochondrial dysfunction and abnormal energy metabolism are important pathological features of Alzheimer's disease (AD). This study investigates how mitochondrial protease YME1L1 affects mitochondrial function and its upstream regulation in the pathogenesis of AD. The AD model was established by using APP/PS1 transgenic mice, primary neurons treated with Aβ1-42, and HT22 cells. The silencing of YME1L1 was achieved to evaluate its effects on mitochondrial function and OPA1 protein hydrolysis....
LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics
Parkinson's disease (PD) is a multisystemic disorder that manifests through motor and non-motor symptoms. Motor dysfunction results from the degeneration of dopamine-producing neurons in the substantia nigra pars compacta. Increasing evidence suggests that synapse dysfunction precedes neuronal loss by years. Still, early synaptic alterations in PD remain poorly understood. Here, we integrate literature meta-analysis and multi-omics with biochemical, imaging, and electrophysiological measurements...
Molecular switches of SQSTM1: the impact of post-translational modifications on autophagy and neurodegeneration
SQSTM1/p62 (sequestosome 1) is an important receptor protein involved in many cellular signaling processes, including macroautophagy/autophagy. It is a molecular hub for cellular homeostasis and cellular responses. Within autophagy, SQSTM1 targets ubiquitinated cargo for degradation, maintaining cellular proteostasis. Structurally, SQSTM1 consists of several domains that facilitate its binding to ubiquitinated cargo, the formation of SQSTM1 aggregate inclusions, interactions with MAP1LC3/LC3,...
Newly emerging IADL impairment predicts subsequent cognitive decline across four population-based aging cohorts
Scalable clinical markers of neurocognitive vulnerability in aging are needed, particularly in settings where biomarker access remains limited. Instrumental activities of daily living (IADLs) capture cognitively demanding everyday behavior and may provide a low-cost, repeatable functional marker of elevated risk. We harmonized longitudinal data from four population-based aging cohorts-CHARLS, ELSA, HRS, and SHARE-including adults aged ≥50 years with eligible baseline assessments. IADL impairment...
Advancements in non-pharmaceutical interventions for Alzheimer's disease management: an update review
Alzheimer's disease (AD) is a chronic, progressive neurodegenerative condition that is characterized by an increasing incidence rate due to global population aging, resulting in a significant social and economic burden. Current pharmacological interventions offer only limited relief and are unable to halt neuronal loss and cognitive decline. Therefore, safe and effective non-pharmacological interventions (NPIs) are needed for the management of AD. This review systematically synthesizes...
DEPACE-seq enables high-fidelity, single-nucleotide-resolution mapping of abasic sites and characterization of dynamic and long-lived AP landscapes in mammalian genomes
High-fidelity single-nucleotide-resolution mapping of abasic (AP) sites in mammalian genomes remains technically challenging due to low abundance and high background. Here we present DEPACE-seq (Dual-End PAB-Conjugated Endo IV-Cleaved Sequencing), a robust and easy-to-implement method for precise genome-wide profiling of AP sites. DEPACE-seq employs an N-pyrrolyl-alanine-2,2'-(ethylenedioxy)bis(ethylamine)-biotin (PAB) probe that selectively conjugates AP sites via a mild Pictet-Spengler...
A drug already used for osteoporosis blocked spinal damage in a new study
Genetic changes may set off a chain reaction that causes the spine’s natural shock absorbers to harden and deteriorate. Zebrafish with a faulty collagen-related gene developed mineral buildup and spinal fusion similar to human disc disease. Researchers were able to reduce the damage using an existing osteoporosis drug and by targeting fat metabolism. The discovery points to several exciting possibilities for future back pain treatments.
FAD is an immune checkpoint metabolite for cGAS and RIG-I
Social inequalities linked to accelerated biological aging
Scientists up in arms about cuts to UK physics and astronomy
Levitating sensor for magnetic fields could detect ultrafaint brain activity
How a steady drip-drip can erode the hardest stone
Operational Tropical Cyclone Forecasting with AI
AI agents are checking the scientific literature — and spotting decades-old errors
Pumas are drivers’ guardian angels
Dirty air may trigger painful rheumatoid arthritis flares
Tiny pollution particles from smoke, soot, and dust may worsen rheumatoid arthritis and raise the risk of painful flares, particularly after prolonged exposure. The findings suggest that avoiding poor air quality could become an important part of managing the disease.
THC medication made PTSD nightmares disappear for more than a third of patients
A prescription form of THC helped many people with PTSD escape recurring trauma-related nightmares, with more than one-third reporting that the nightmares disappeared completely after ten weeks. The results could point toward a long-awaited treatment for one of PTSD’s most distressing and stubborn symptoms.
DNA reveals the hidden past of North America’s bison—and keys to their future
Scientists are racing to conserve what remains of these majestic animals’ genetic diversity