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This common vitamin deficiency can mimic normal aging

20 hours 6 minutes ago
Vitamin B12 is needed in microscopic amounts, but a shortage can have major effects on health and energy. The vitamin was first linked to a lifesaving liver treatment for pernicious anemia nearly 100 years ago. Today, researchers are finding that B12 may also help keep cellular powerhouses called mitochondria functioning properly. This could explain why some people experience fatigue and brain fog even before traditional signs of deficiency show up.

Disrupted brain functional network topology and potential network reorganization in early-stage Parkinson's disease with probable REM sleep behavior disorder

1 day 1 hour ago
CONCLUSION: Early PD + pRBD exhibit specific and more severe neurofunctional network impairment pattern. Characterized by more significantly disrupted neurofunctional network topology and widespread functional connectivity abnormalities across multiple brain networks, with potential functional network reorganization. These functioning abnormalities may serve as imaging biomarkers for this clinically malignant subtype and provide potential neurobiological mechanism for understanding its poorer...
Congli Huang

From Plastics to Pathology: The Neurodegenerative Impact of Bisphenol-A on Alzheimer's Disease

1 day 1 hour ago
Bisphenol-A (BPA), a ubiquitous component of polycarbonate plastics and epoxy resins, has emerged as a significant environmental risk factor for neurodegenerative diseases, particularly Alzheimer's disease (AD). It is widely detected in the environment and humans due to its extensive use in plastics and epoxy resins for consumer products such as bottles, containers, and tableware. This review synthesizes current evidence on the molecular and cellular mechanisms by which BPA exposure may...
Sneha Kumari

Toll-like Receptor Signaling in Parkinson's Disease: Focusing on TLR2 and TLR4 as Therapeutic Targets for Natural Compounds

1 day 1 hour ago
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuronal loss and the accumulation of α-synuclein-containing Lewy bodies. Growing evidence indicates that neuroinflammation, particularly through the activation of Toll-like receptors (TLRs), contributes significantly to PD pathogenesis. TLRs, particularly TLR2 and TLR4, detect endogenous damage-associated molecular patterns such as misfolded α-synuclein. This recognition initiates signaling...
Dong Han

Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress

1 day 1 hour ago
Neurodegenerative diseases are frequently associated with proteotoxic stress linked to disease specific proteins. The autophagy-lysosome system provides essential control of proteotoxic stress and its failure can lead to initiation of apoptosis. However, in aging and neurodegenerative diseases apoptosis is insufficient to account for all neuronal death, and several different cell death types have been reported in these contexts. Here we show that karyoptosis, a distinct form of cell death, can...
Rebecca Casterton

Divergent effects of pathological α-synuclein truncations and mutations on phase separation

1 day 1 hour ago
Phase separated condensates of α-synuclein (α-Syn) accelerate amyloid fibril formation, a process implicated in Parkinson's disease pathogenesis. Yet, the precise effects of pathologically relevant α-Syn sequence modifications on this process remain unclear. Here, we show that sequence truncations exert the strongest influence on condensate thermodynamics, material properties, and amyloid aggregation, whereas familial point mutations impart minimal effects. Among the tested familial variants...
Soumik Ray

Paf1 Counteracts transcriptional arrest to maintain rDNA stability during pol I elongation

1 day 1 hour ago
Genomic instability drivers of senescence and carcinogenesis. The ribosomal RNA gene (rDNA) locus in budding yeast provides an excellent model to study these processes. Because of its highly repetitive structure and the gene amplification system that maintains its copy number, rDNA represents one of the most unstable regions in the genome. Here, we demonstrate that the integrity of rDNA transcription is essential for maintaining genomic stability and lifespan. Loss of Paf1, an elongation factor...
Zijun Zhong

Title: Same Day Discharge in Primary Total Joint Arthroplasty in Octogenarians: A Case Series and Narrative Review of Optimization Strategies and Perioperative Outcomes

1 day 1 hour ago
CONCLUSION: Primary same-day TJA can be safely and effectively performed in selected octogenarian patients when guided by comprehensive preoperative assessment and multidisciplinary perioperative care. This case series reinforces growing evidence that age alone should not preclude surgical intervention. Our findings contribute to an evolving understanding of evidence-based, age-inclusive arthroplasty practices.
Jonathan Liu

Ubiquitination in cardiovascular diseases: from molecular mechanisms to therapeutic targeting

1 day 1 hour ago
Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide, with ageing constituting a major underlying risk factor. Ubiquitination, a highly conserved and reversible posttranslational modification, has emerged as a pivotal regulator of CVDs through the modulation of target proteins through various mechanisms, including protein stability, activity, subcellular localization, and molecular interactions. This process is orchestrated by ubiquitin-activating (E1),...
Jia-Yin Wang

Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress

1 day 1 hour ago
Neurodegenerative diseases are frequently associated with proteotoxic stress linked to disease specific proteins. The autophagy-lysosome system provides essential control of proteotoxic stress and its failure can lead to initiation of apoptosis. However, in aging and neurodegenerative diseases apoptosis is insufficient to account for all neuronal death, and several different cell death types have been reported in these contexts. Here we show that karyoptosis, a distinct form of cell death, can...
Rebecca Casterton

Somatic mutations impose an entropic upper bound on human lifespan

1 day 1 hour ago
Somatic mutations accumulate with age and can cause cell death, but their quantitative contribution to limiting human lifespan remains unclear. We developed an incremental modeling framework that progressively incorporates factors contributing to aging into a model of population survival dynamics, which we used to estimate lifespan limits if all aging hallmarks were eliminated except somatic mutations. Our analysis reveals fundamental asymmetry across organs: post-mitotic cells such as neurons...
Evgeniy Efimov

Age-adjusted leukocyte telomere length predicts long-term mortality in older patients discharged from acute care hospitals

1 day 1 hour ago
Leukocyte telomere length (LTL) is a widely studied biomarker of biological aging, reflecting cumulative cellular damage beyond chronological age. However, its prognostic relevance in clinically complex populations such as hospitalized older adults remains uncertain. In this prospective observational study, 872 patients aged ≥ 65 years admitted to acute care wards of IRCCS INRCA within the Report-AGE cohort were included. LTL was measured by quantitative real-time PCR and expressed as...
Rosanna Maniscalco

Effects of Baduanjin combined with cognitive training in older adults with mild cognitive impairment of mixed etiologies: a study protocol for a randomized controlled trial

1 day 1 hour ago
BACKGROUND: Amid the accelerating aging trend, addressing mild cognitive impairment (MCI) is critical for dementia prevention. Current evidence suggests that standalone interventions have limited efficacy, whereas combined physical‑cognitive training may yield greater benefits. However, the neurophysiological mechanisms of sequential combinations, particularly their effects on regional brain activation and functional connectivity, remain unclear. Functional near‑infrared spectroscopy (fNIRS)...
Li-Bing Liang

Challenging the assumption that medical conditions are the prime drivers of older people's needs: a qualitative baseline study about the experienced needs of older people who age in place with COPD

1 day 1 hour ago
CONCLUSIONS: The article contributes to the methodological literature on involving older people in the development of technology for ageing in place by challenging the assumption that medical conditions are prime drivers of older people's needs. It illustrates how this assumption may point technology developers in the wrong direction unless it is supplemented by a strong focus on the everyday experience of ageing.
J M Bergschöld

Association between body composition and bone mineral density in community-dwelling older adults from Chile: a sex-stratified DXA-based cross-sectional study

1 day 1 hour ago
CONCLUSIONS: Lean mass showed the strongest independent association with whole-body BMD in community-dwelling older Chilean adults, with modest differences between women and men. These findings support the relevance of lean mass as an important correlate of bone health during aging and provide evidence from a Latin American population.
Nicole Fritz-Silva