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Journal retracts weed killer study backed by Monsanto, citing ‘serious ethical concerns’
Highly cited paper was used as evidence that the widely used herbicide Roundup is safe
The Proinflammatory Secretome of Senescent Cells Can Be Controlled by a HIF2A-Dependent Upregulation and a FURIN-Dependent Cleavage of the ANGPTL4 Secreted Factor
Senescent cells are characterized by a stable proliferation arrest and a senescence-associated secretory phenotype or SASP. Although these cells can have some beneficial effects, including protecting from tumor formation, their accumulation is deleterious during aging as it promotes age-related diseases, including cancer initiation and progression. Although the SASP has a critical role, its composition, regulation and dual role in cancer remain largely misunderstood. Here, we show that ANGPTL4...
The immuno-neurological axis: association between autoimmune diseases and dementia risk
Dementia is a growing global public health concern, with an increasing number of individuals affected due to the aging population. Although chronic inflammation is implicated in cognitive impairment, studies on its association with autoimmune diseases, which are representative chronic inflammatory diseases, are lacking. This study aimed to investigate whether the onset of autoimmune diseases is associated with an increased risk of dementia or cognitive impairment. This study used data from the...
A Longitudinal Investigation of Prediabetes, Diabetes, HbA1c and Cognitive Trajectories Among Cognitively Unimpaired Individuals
CONCLUSIONS: The results suggest that prediabetes and diabetes significantly shorten the timeframe before a potentially clinically noticeable change in global and domain-specific cognition is reached. Thus, lifestyle modification to reverse prediabetes and prevent diabetes could potentially reduce the rate of cognitive decline in aging populations. The findings differed by sex (i.e., the effect of diabetes on decline in global cognition, attention and visuospatial domains was more pronounced in...
Development and Implementation of a Medical Cannabis Clinic Within a Geriatrics Primary Care Clinic: Preliminary Data
CONCLUSIONS: This model demonstrates a feasible approach to integrating MC care into primary care for medically complex older adults. This integration prevents MC care fragmentation, provides thorough drug interaction screening, and supports informed MC risk-benefit assessment.
Nicotinamide Mononucleotide Reduces Iron in BV-2 Cell by Up-Regulating Ferroportin 1 via Inhibiting the IL-6/STAT3/Hepcidin Pathway
Findings on the association of both nicotinamide mononucleotide (NMN) and iron metabolism with antiaging or aging led us to speculate that some pharmacological functions of NMN may be achieved partially by affecting iron metabolism. Here, we investigated the effects of NMN on cell viability, iron contents, oxidative stress, and the expression of ferritins, transferrin receptor 1 (TfR1), ferroportin1 (Fpn1), hepcidin, interleukin 6 (IL-6), interleukin-1β (IL-1β), and signal transducer and...
Epigenetic Age Prediction Using N6-Methyladenine in the Buff-Tailed Bumblebee (Bombus terrestris)
Epigenetic clocks are machine learning models that predict an organism's chronological age (the time elapsed since birth) or biological age (a proxy for physiological integrity) based on methylation levels from multiple genomic sites. To date, all epigenetic clocks rely exclusively on C5-methylcytosine (5 mC), the predominant DNA methylation mark in vertebrates. However, not all species possess detectable 5 mC levels. Here, we used N6-methyladenine (6 mA), a less-characterized DNA modification...
Ecological Perspectives on Aging
Controlled settings may offer limited insight into the complexities of aging in natural and variable ecosystems. Artwork by Zahida Sultanova.
Singing for memory: neural and cognitive effects of a choral intervention in older adults
INTRODUCTION: Lifestyle factors are important predictors of successful aging, and targeted interventions could be key to mitigating the negative effects of aging. Episodic memory is of particular interest as it is notably sensitive to aging. Given the social, intellectual, and physical stimulation that choral singing provides, along with the enjoyment it offers which is a strong motivator, it has been suggested as a particularly promising intervention to promote successful aging.
Decanoic acid, an MCT dietary component, alleviates cognitive impairment, cellular senescence, and promotes autophagy in accelerated aging and neurotoxic mouse models induced by chronic administration of D-galactose and D-galactose/AlCl(3)
INTRODUCTION: Cognitive decline advances with age, increasing the risk of dementia and Alzheimer's disease among older adults. Medium-chain triglyceride (MCT) ketogenic diets have shown potential in slowing down age-related cognitive decline; however, the exact neuroprotective roles of MCT components, specifically decanoic acid and octanoic acid, remain unclear.
Delineation of the cognitive and neuropsychiatric features of Pisa syndrome in dementia with Lewy bodies
CONCLUSION: Our study reveals that PS in DLB is associated with specific deficits in attention and visuospatial/executive function, alongside more severe neuropsychiatric symptoms. These findings highlight the need for comprehensive management targeting both postural control and neuropsychiatric issues to alleviate caregiver burden. Future longitudinal studies are warranted to clarify the causal nature of these relationships.
Neuroimmune dynamics and brain aging: mechanisms and consequences
Brain aging is accompanied by profound changes in neuroimmune interactions that shape the balance between resilience and vulnerability. Under healthy conditions, glial cells, neurons, vascular elements, and peripheral immune inputs cooperate to sustain homeostasis. With advancing age, however, immune remodeling and systemic inflammaging drive shifts in microglial surveillance, astrocytic reactivity, and neuronal susceptibility, creating conditions that compromise synaptic function and cognitive...
AI is saving time and money in research — but at what cost?
These are a few of my favourite sounds: Books in brief
Microbiota safeguards ovarian reserve and extend reproductive lifespan
Fate of hepatitis B vaccine for US babies hangs in the balance
‘Incredible’ carved canoe dates back to first settlement of islands near New Zealand
Fibers found on waka in Chatham Islands roughly align in age with earliest known human arrival
Parallel supramammillary-hippocampal routes: Organization, dysregulation, and restoration
In this issue of Neuron, Luo et al.¹ report two supramammillary neuronal populations with segregated projections to the dorsal and ventral dentate gyrus that selectively modulate cognitive and emotional processes, respectively. Targeted activation of each pathway alleviates domain-specific behavioral deficits in an Alzheimer's disease mouse model.
Decoding Senescent Drivers in Alzheimer's Disease: From Bench to Bedside
Alzheimer's disease (AD) is the most common neurodegenerative disorder associated with dementia. Cellular senescence, widely acknowledged as a key hallmark of aging, has increasingly been recognized as a significant factor in the pathogenesis of AD, although the precise mechanisms underlying this relationship have yet to be fully understood. In the brains of individuals with AD, neurons, glial cells, and cerebrovascular endothelial cells exhibit premature senescence, characterized by...
Progress in Anti-ageing Drug Research for Age-related Diseases: A Review
This review explores the anti-ageing potential of nine repurposed drugs: aspirin, atorvastatin, enalapril, metformin, canagliflozin, liraglutide, acarbose, N-acetylcysteine and dasatinib (commonly combined with quercetin). Specifically, it focuses on their mechanisms through the mechanistic target of rapamycin, adenosine monophosphate-activated protein kinase, nuclear factor kappa B and senescence-associated secretory phenotype pathways. The repurposed drugs show promise in extending healthspan...