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A small device that gently stimulates nerves through the ear could offer a new way to tackle stubborn high blood pressure. In a clinical trial of 63 patients already taking medication, the treatment proved safe, easy to use at home, and well tolerated. Although it did not significantly outperform a placebo overall, patients with more severe hypertension showed promising reductions in blood pressure.

A major study has uncovered hidden warning signs of inflammatory bowel disease in the blood up to 10 years before diagnosis. Researchers discovered distinct antibody patterns that could help predict who would later develop Crohn’s disease or ulcerative colitis, even distinguishing people at risk of more complicated disease.

Scientists have discovered that switching off a protein called Mitch makes human cells burn more fat and prevents new fat cells from developing. The breakthrough builds on experiments in mice that showed remarkable resistance to obesity and improved muscular endurance, raising hopes for a new approach to weight-loss treatment.

Scientists discovered that the thick, sticky fluid surrounding glioblastoma tumors can make brain cancer cells smaller, more flexible, and better at invading surrounding tissue. Even more troubling, some of these changes persist after the cells leave the thick fluid, revealing a previously overlooked mechanism that could help this deadly cancer spread.

Researchers have uncovered a surprising reason dental implant infections often resist antibiotics: the implants themselves can contribute to the problem. Bacteria corrode titanium implants, releasing microscopic particles that hijack immune cells, trigger destructive inflammation, and accelerate jawbone loss.

A newly FDA-cleared PTSD treatment uses personalized brain mapping and magnetic stimulation to target abnormal brain activity, with a clinical trial reporting a 52% reduction in symptoms and 68% remission. Researchers believe the technology could transform PTSD care and pave the way for more precise treatments for other mental health conditions.

A seven-year study found that people with Parkinson’s disease who were more physically active experienced slower declines in memory, thinking, and movement abilities. Those exercising more than eight hours per week showed almost no average cognitive decline, suggesting that staying active may offer important benefits as the disease progresses.

Mitochondrial dysfunction is increasingly recognized as a shared downstream pathogenic mechanism across a wide spectrum of neurological disorders, ranging from primary mitochondrial diseases to conditions including amyotrophic lateral sclerosis, Alzheimer disease, Parkinson disease, multiple sclerosis, hereditary ataxias and idiopathic inflammatory myopathies. This Review examines the role of mitochondrial biomarkers in improving diagnostic accuracy, patient stratification and monitoring of...

Lipodystrophies are a group of disorders featuring reduced adipose tissue mass or function, which often leads to significant metabolic disease, reduced lifespan and impaired quality of life. Individuals with congenital generalised lipodystrophy (CGL) have severely reduced adipose tissue mass. The loss of healthy systemic lipid storage typically causes hepatic steatosis and lipoatrophic diabetes. In addition, adipocyte-secreted hormones including leptin and adiponectin are dramatically reduced....

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Endothelial cells (ECs) are critical regulators of vascular function and exhibit tissue-specialized roles. During aging, these cells become dysfunctional, resulting in increased susceptibility to cardiovascular disease. Although single-cell transcriptomics has revealed extensive endothelial heterogeneity, a comprehensive atlas of human EC transcriptomes over the course of the adult human lifespan has been lacking. Here, we present the Human Aging Endothelial Cell Atlas (HAECA), a harmonized...

Neurodegenerative diseases are emerging as an important consequence of population ageing in sub-Saharan Africa (SSA), but their scientific relevance extends beyond a projected rise in case numbers. SSA combines exceptional human genomic diversity with marked heterogeneity in vascular and metabolic risk, infection, nutrition, occupational exposures, air pollution, and access to health care. This combination creates an underused setting in which to study why biological ageing produces...

Blood phosphorylated tau 217 (p-tau217) accurately detects Alzheimer's disease (AD) pathology but is also elevated in amyotrophic lateral sclerosis (ALS), likely reflecting peripheral (big) tau released from muscle. Assays selectively measuring brain-derived (BD-) tau and BD-p-tau217 are therefore needed. We analysed serum BD-tau and p-tau217 in ALS (n = 139), AD (n = 101) and controls (n = 75) using direct immunoassays and after BD-Tau immunoprecipitation (BD-Tau-IP), and tau species in brain...

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CONCLUSION: Bibliometric and semantic analyses indicate growing research interest in cell-type-specific senescence, inflammatory-fibrotic remodelling, HF phenotype heterogeneity, biomarkers, and senotherapeutics. These findings highlight opportunities for integrating mechanistic research with clinical investigation. Future studies should prioritize cell-specific senescence atlases, multidimensional biomarkers, comorbidity-aware HF stratification, and cautious evaluation of senotherapeutics in HF...

Global health policies and the World Health Organization consistently promote aging in place, reflecting the strong preference of older adults to remain in their home environments. Yet frailty, cognitive decline, caregiver exhaustion, and social vulnerability frequently make nursing home admission necessary and position institutional care as the default response to severe dependency. The COVID-19 pandemic exposed vulnerabilities of nursing home care and renewed debate about the sustainability of...

Corpus callosum microstructure is a proposed risk biomarker for vascular contributions to cognitive impairment. This study compared corpus callosum microstructure measures from the "Standard Model" biophysical diffusion model with diffusion tensor and kurtosis imaging (DTI, DKI) measures for differences related to age and cerebral small vessel disease (cSVD) in a population-based sample of cognitively unimpaired older adults (n = 112, mean age 69.9). Standard Model measures included axonal water...

Whether a decline in taurine drives aging is debated, and despite high millimolar intracellular concentrations, its function as a potential guardian of cytosolic homeostasis is unclear. Here, we show that aging increases circulating taurine concentrations in humans and mice. Further elevating taurine in aged mice enhances health span, engaging anti-inflammatory pathways previously linked to youthfulness, and reduces mortality from sepsis and inflammasome-mediated inflammation, suggesting an...

Physical activity promotes health primarily by decelerating the aging process. Bone is one of the tissues capable of sensing mechanical force and can adapt to different physical demands. However, its role in whole-body aging is unknown. We found that reduced mechano-sensing in osteocytes, caused by deletion of the mechanosensory channel, Piezo1, accelerated whole-body aging in mice. Dynamic tibial axial loading (DTAL) in mice at 20-24 months of age extended both healthspan and lifespan...

Neurodegenerative diseases are emerging as an important consequence of population ageing in sub-Saharan Africa (SSA), but their scientific relevance extends beyond a projected rise in case numbers. SSA combines exceptional human genomic diversity with marked heterogeneity in vascular and metabolic risk, infection, nutrition, occupational exposures, air pollution, and access to health care. This combination creates an underused setting in which to study why biological ageing produces...