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Regular exercise does more than strengthen the heart. New research reveals that it actually reshapes the nerves controlling how the heart functions, and the changes are surprisingly different on the left and right sides of the body.

CONCLUSIONS: Among older adults in Shenzhen, the burden of stroke with comorbid hypertension and diabetes showed a long-term upward trajectory over the study period. Model-based projections suggested that the burden may increase from 2024 to 2033, particularly among males and older age groups. These findings provide population-level descriptive and projection evidence that may inform risk stratification and health service planning for ageing urban populations.

CONCLUSION: Life satisfaction in later life is associated with a multidimensional interplay of structural resources, health status, and existential orientation. Socioeconomic security and religious belief emerged as significant predictors of well-being, after controlling for health status. These findings highlight the importance of integrated policies addressing both material and psychosocial predictors of aging well.

CONCLUSIONS: Uptake and sustained engagement with SP via AAC referral appeared to be shaped less by individual capability than by physical opportunity, social opportunity and motivation. Primary care providers are well placed to facilitate engagement by leveraging trusted patient relationships, while centre managers and policymakers should address structural barriers such as zoning restrictions, language mismatch and age-identity mismatch. These findings offer actionable insights to optimise the...

Age-friendly cities and communities (AFCC), together with initiatives to combat ageism, are recognised as two of the four action areas of the United Nations (UN) Decade of Healthy Ageing, have received global attention. However, there is a lack of understanding regarding the distinct experiences of older adults in their cities and communities, as well as the extent to which these experiences are linked to their perceptions of ageism. Using a sample of 398 older adults from four cities in...

Centenarians - individuals aged ≥100 years - provide a unique human model for understanding resilience to cardiovascular ageing. Although cardiovascular and metabolic diseases, including hypertension, heart failure, atrial fibrillation and chronic kidney disease, are common in centenarians, their onset is typically delayed relative to that in individuals aged 80-100 years. Centenarians characteristically have structural changes in the heart and vessels, including concentric left ventricular...

A powerful new AI system could help doctors detect pancreatic cancer years before it becomes visible on conventional scans. The technology, called REDMOD, identified hidden warning signs an average of 475 days before diagnosis and was nearly twice as sensitive as experienced radiologists. By spotting cancer-related changes at their earliest stages, it could dramatically improve the chances of successful treatment for one of the deadliest forms of cancer.

A simple liquid painted onto teeth in seconds can stop cavities without drilling, injections, or anesthesia, according to a major clinical trial involving young children. The inexpensive treatment could spare thousands of children painful dental procedures and surgery while paving the way for broader FDA-approved use.

Missing blood pressure medication could mean losing much of its protection against heart attacks and strokes, according to an analysis of more than 91,000 people. Patients who consistently took their medication experienced an 11% reduction in major cardiovascular events, while those who missed too many doses saw little or no measurable benefit.

A major new study reveals that drinking just two alcoholic beverages a day is associated with a 1 in 25 lifetime risk of death from alcohol-related causes, challenging the idea that moderate drinking is harmless. Researchers also found no significant overall health benefits from alcohol, with risks rising as consumption increases.

Scientists have discovered how pancreatic cancer cells continually reshape their genetic makeup to become more aggressive, spread, and evade treatment. In laboratory experiments, blocking a key gene reversed some of these dangerous changes, revealing a potential new way to fight the deadly disease.

A common, inexpensive medication could hold an unexpected clue to preventing dementia. Researchers found that older adults with a specific genetic profile had a 70% lower relative risk of dementia when taking low-dose aspirin, even though previous studies found no overall protective effect. The discovery suggests that genetics could help explain why some people benefit while others do not.

Aging is accompanied by a progressive decline in immune function, increasing susceptibility to infections, cancer, and poorer treatment outcomes. The diversity of the T cell receptor (TCR) repertoire, reflecting the capacity to recognize diverse antigens, is known to decline with age. However, how intrinsic and extrinsic factors jointly shape TCR diversity and its rate of decline, as well as the extent to which this diversity influences clinical outcomes in cancer, remain poorly characterized....

Mitochondria are central regulators of cellular metabolism, integrating energy production, redox balance, and signaling pathways that shape aging trajectories. If mitochondrial organization contributes to lifespan divergence, exceptionally long-lived species should exhibit distinctive metabolic signatures reflecting adaptations promoting long-term cellular maintenance. Comparative approaches across species with extreme lifespan variation provide a powerful framework for identifying potential...

Ginsenoside Rg1, the main active component of Panax ginseng, has been shown to improve mitochondrial function and delay cell aging by regulating chaperone-mediated mitophagy. However, how Rg1 works in Caenorhabditis elegans is still unclear. In this study, C. elegans was used as a model to study how Rg1 regulates autophagy and mitochondrial function, and to understand its anti-aging mechanism. The results showed that Rg1 treatment significantly kept cells alive and maintained muscle shape in...

For nearly a century, people in distant parts of the world have reported a bizarre experience after eating certain wild mushrooms: seeing dozens or even hundreds of tiny, colorful humans moving through the real world. Now, scientists have identified a mushroom species, Lanmaoa asiatica, responsible for these extraordinary hallucinations in China and the Philippines.

A cannabis-derived ingredient commonly found in sleep gummies may be more habit-forming than previously thought, with new research showing that repeated exposure caused tolerance and withdrawal symptoms in mice. Scientists warn that CBN may carry risks similar to THC, although its long-term effects in humans remain largely unknown.

Scientists have uncovered a surprising new clue to why the Mediterranean diet is so good for the heart, brain, and healthy aging. Researchers at USC found that older adults who closely followed the diet had higher levels of two tiny proteins, humanin and SHMOOSE, produced by the mitochondria, the energy-producing structures inside cells. These proteins have been linked to protection against heart disease, Alzheimer's disease, and age-related damage.

A small device that gently stimulates nerves through the ear could offer a new way to tackle stubborn high blood pressure. In a clinical trial of 63 patients already taking medication, the treatment proved safe, easy to use at home, and well tolerated. Although it did not significantly outperform a placebo overall, patients with more severe hypertension showed promising reductions in blood pressure.