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Scientists create a needle-thin brain implant that can do three jobs at once
A new needle-thin brain implant can record neural activity, deliver drugs, and stimulate multiple brain regions using a single flexible fiber. Successful tests in mice suggest it could give scientists a more precise, less invasive way to study the brain and may eventually help treat neurological disorders such as epilepsy.
Chronic stress may be quietly reshaping your heart
Chronic inflammation tied to stress, lifestyle, mental health, and socioeconomic conditions may silently change the heart for years before any symptoms appear. People with the highest inflammation levels faced a 43% greater risk of heart attack and stroke, raising hopes that earlier testing and anti-inflammatory treatments could help prevent serious heart disease.
This dolphin chased a fish until it puked—then ate the vomit
The behavior, known as kleptoparasitism, marks one of the few well-documented examples of a cetacean stealing food
Stanford scientists discover the human brain may actually be two separate organs
Scientists have found that the human brain develops from two distinct cellular systems, suggesting that evolution fused together two ancient nervous systems with very different jobs. The discovery also allowed researchers to grow human hindbrain neurons in the lab, opening new possibilities for studying ALS, spinal muscular atrophy, and other brainstem diseases.
Life-Course Adversity, Adult Socioeconomic Position, and Possible Sarcopenia Among Older Adults in Postwar Vietnam
ObjectivesThis study examines how early-life hardship, wartime exposure, military service, and adult socioeconomic position are associated with grip strength-based possible sarcopenia among older adults in postwar Vietnam.MethodsWe analyzed data from the Wave 1 Vietnam Health and Aging Study among 2,166 adults aged 59 and older. Possible sarcopenia was defined using Asian Working Group for Sarcopenia 2019 grip-strength thresholds; survey-adjusted logistic regression models were...
Association of B-Type Natriuretic Peptide With Intrinsic Capacity Trajectories Among Chinese Older Adults
CONCLUSIONS: Elevated and persistent BNP abnormalities are consistently associated with IC decline, supporting BNP as a practical biomarker for early identification of older adults at risk of functional deterioration.
'Epigenetic' editing is here: gene-tagging technique banishes hepatitis B virus
AI co-scientists are revolutionizing how research is done
China punishes prominent academics exposed by research sleuth
Edible batteries inspired by rice paper power medical devices in the body
Chemist-aligned retrosynthesis by ensembling diverse inductive bias models
How do I change labs gracefully during my PhD?
Losing your way of life to climate change matters — and we need a way to measure it
Six principles for supporting academic freedom in universities
Millions take calcium and vitamin D for bone health. A major review finds little benefit
A sweeping review of more than 153,000 adults found that calcium and vitamin D supplements, alone or together, do little to prevent fractures or falls in most older people. Researchers say the findings challenge routine supplementation for prevention and point instead toward strategies such as balance and resistance exercise.
8 common food additives linked to high blood pressure and heart disease
Common preservatives hiding in processed foods may carry unexpected heart risks, with heavy consumption linked to substantially higher rates of high blood pressure and cardiovascular disease. Researchers identified eight widely used preservatives associated with hypertension, although the observational study cannot prove they were directly responsible.
Complex, but not simple, motor tasks assessment improves detection of motor-cognitive interaction in midlife
Executive and motor function are bidirectionally linked and decline as we age, yet motor-cognitive links are predominantly studied in older adults, while studies focused on midlife report mixed results. We aimed to evaluate whether motor tasks of varying complexity reflect executive function in midlife, a sensitive window for identifying early cognitive-functional risks that are otherwise undetected, thus informing timely intervention strategies. Using a cross-sectional study design, we assessed...
Sex-specific trajectories of nonlinear immune aging at single-cell level
Despite the female predominance in age- and immune-associated diseases, the pathways underlying sex differences in healthy immune aging remain incompletely understood. Here, we analyze a multi-ethnic single-cell transcriptome of healthy human immune aging (35% Asian), comprising 3.8 million peripheral blood mononuclear cells (PBMCs) from 1,828 individuals aged 19-97 years. Prominent peaks of differential gene expression around 40 (mainly CD4 T cells) and after 60 (mainly CD8 T cells) years of...
Unlocking the Blood-Brain Barrier: Can Low-Intensity Focused Ultrasound Enable Effective Delivery of Anti-Amyloid and Anti-Tau Antibodies in Alzheimer's Disease?
Alzheimer's disease (AD) remains a major unmet medical challenge despite decades of progress in medicines that target tau and amyloid-β (Aβ) pathology. The clinical benefit of monoclonal antibodies (mAbs) against Aβ is limited, with current data showing only slight slowing of cognitive decline despite encouraging biomarker responses and recent regulatory approval of these drugs. Moreover, their wider clinical use is restricted by dose-dependent toxicities such as amyloid-related imaging...
Multimorbidity and long-term condition burden as markers of incident sarcopenia risk: A prospective cohort study
CONCLUSIONS: Multimorbidity and greater cumulative LTC burden were prospectively associated with incident sarcopenia in both females and males. The graded association across LTC burden and the estimated population-level burden suggest that multimorbidity is an important marker of subsequent sarcopenia risk. Further research should determine whether incorporating muscle health assessment into the care of people with multimorbidity improves prediction or clinical outcomes.