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Trump imposes new NIH funding ban on human fetal tissue research
Agency may also be moving toward restricting use of embryonic stem cells
Bee-hunting beetles are the first animals known to fake the smell of flowers
Study of parasitic blister beetles reveals a new form of chemical deception
A monoclonal antibody targeting the C-terminal of alpha-synuclein fibrils mitigates pathology in a Parkinson's disease model
Parkinson's disease (PD) pathogenesis is driven by α-synuclein (α-syn) amyloid aggregation, with the flexible C-terminal region mediating pathological interactions with cellular receptors and facilitating disease propagation and neuroinflammation. Through immunization with human α-syn fibrils and iterative neuronal binding and propagation assays, we identify H21 as a high-affinity fibril-specific monoclonal antibody. H21 selectively binds to α-syn fibrils and specifically targets the C-terminal...
Cortical O<sub>2</sub> supply and metabolism are suppressed in the aged mice
Current evidence suggests that the rejuvenating effects of parabiosis on brain function arise from the exchange of blood factors that enhance synaptic plasticity, promote neurogenesis, and reduce neuroinflammation in aged animals. However, aging is also associated with diminished tissue oxygenation. Here, we report that erythrocytes (red blood cells, RBCs) from aged mice exhibit reduced responsiveness to low oxygen tension (PO(2)) and release O(2) slower than those from young mice. In vivo,...
MTFR1L is a cardiac antiaging factor for maintenance of mitochondrial homeostasis
Mitochondrial dysfunction is a hallmark of aging and a key contributor to age-related diseases including cardiovascular disease. However, molecular pathways that safeguard mitochondrial homeostasis in the aging heart remain poorly understood. Here, we identify MTFR1L as a regulator of mitophagy that binds p-S65-Ub, a key signal amplifying the PINK1/Parkin axis. We find that MTFR1L is enriched in metabolically active tissues, particularly in the heart, where it regulates Parkin signaling. Genetic...
Age-driven dysbiosis: gut microbiota in the pathogenesis and treatment of aging disorders
Aging, a complex physiological and molecular process, has undergone significant changes, of which gut microbiome composition has surfaced as an important key in the maintenance of neurological health. Recent studies have revealed the significant impact of age-related gut dysbiosis in the induction of neuroinflammation, metabolic syndrome, disruptions in gut-brain axis, and age-related neurological decline. Although significant studies have revealed the impact of the microbiome-gut-brain axis in...
Hierarchical disruption of lateral prefrontal cortex gradients in cognitive aging
The lateral prefrontal cortex (LPFC) plays a pivotal role in executive functions and exhibits a hierarchical rostro-caudal organization critical for higher-order cognition. Using connectome gradient mapping of resting-state fMRI data across young, middle-aged, and older adults (N = 478), we found preserved global gradient structure but significant compression of the principal gradient in older adults relative to middle-aged adults, particularly in dorsolateral (DLPFC) and frontopolar (FPC)...
Greenland is important for global research: what’s next for the island’s science?
Gladys Mae West obituary: mathematician who pioneered GPS technology
Briefing Chat: The canny cow that can use tools, and how babies share their microbiomes
What a $1-billion pledge means for CERN’s ambitious supercollider plans
Guinea-Bissau suspends US-funded vaccine trial as African scientists question its motives
Marvellous microbes, memory and the multiverse: Books in brief
Bird flu antibodies found in cow in the Netherlands, a first outside of U.S.
Dead cat led to discovery, but officials stress no further spread of H5N1 has been detected
ArXiv preprint server clamps down on AI slop
First-time posters to venerable platform now need an endorsement from an established author
Oil helped build Venezuela’s science. Can oil now revive it?
Decades ago, Venezuelan researchers helped the oil industry thrive. Now they hope to be part of its reconstruction
Watch this smiling robot walk on water
Inflatable structures inspired by human bone help the contraption grow, shrink, and float
Mysterious difference between Hawaiian volcanoes may reflect divide deep within Earth
Hot mantle plume could be split in two, might eventually produce separate island chains
The TREM2 T96K paradox: Stronger signaling in vitro, weaker microglia in vivo
Pilat, Le, and colleagues¹ reveal that the Alzheimer's-linked TREM2 T96K variant, previously labeled gain of function based on in vitro assays, unexpectedly weakens microglial activation and disease-associated microglial responses in female mice in vivo, prompting a reassessment of what "functional gain" means for TREM2 in neurodegeneration.
A multi-view DTI feature fusion framework for enhanced diagnosis of Alzheimer's disease
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder. Diffusion tensor imaging (DTI) is widely used to detect brain alterations for diagnosis, but most methods rely on single-scale information. Therefore, this study proposes the multi-view feature learning framework incorporating residual block-based 3D convolutional neural network (3D-CNN) for AD diagnosis. First, tract-based spatial statistics were applied to extract voxel-based features from fractional anisotropy (FA) and...