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Nicotinamide Mononucleotide Reduces Iron in BV-2 Cell by Up-Regulating Ferroportin 1 via Inhibiting the IL-6/STAT3/Hepcidin Pathway
Findings on the association of both nicotinamide mononucleotide (NMN) and iron metabolism with antiaging or aging led us to speculate that some pharmacological functions of NMN may be achieved partially by affecting iron metabolism. Here, we investigated the effects of NMN on cell viability, iron contents, oxidative stress, and the expression of ferritins, transferrin receptor 1 (TfR1), ferroportin1 (Fpn1), hepcidin, interleukin 6 (IL-6), interleukin-1β (IL-1β), and signal transducer and...
Epigenetic Age Prediction Using N6-Methyladenine in the Buff-Tailed Bumblebee (Bombus terrestris)
Epigenetic clocks are machine learning models that predict an organism's chronological age (the time elapsed since birth) or biological age (a proxy for physiological integrity) based on methylation levels from multiple genomic sites. To date, all epigenetic clocks rely exclusively on C5-methylcytosine (5 mC), the predominant DNA methylation mark in vertebrates. However, not all species possess detectable 5 mC levels. Here, we used N6-methyladenine (6 mA), a less-characterized DNA modification...
Ecological Perspectives on Aging
Controlled settings may offer limited insight into the complexities of aging in natural and variable ecosystems. Artwork by Zahida Sultanova.
Singing for memory: neural and cognitive effects of a choral intervention in older adults
INTRODUCTION: Lifestyle factors are important predictors of successful aging, and targeted interventions could be key to mitigating the negative effects of aging. Episodic memory is of particular interest as it is notably sensitive to aging. Given the social, intellectual, and physical stimulation that choral singing provides, along with the enjoyment it offers which is a strong motivator, it has been suggested as a particularly promising intervention to promote successful aging.
Decanoic acid, an MCT dietary component, alleviates cognitive impairment, cellular senescence, and promotes autophagy in accelerated aging and neurotoxic mouse models induced by chronic administration of D-galactose and D-galactose/AlCl(3)
INTRODUCTION: Cognitive decline advances with age, increasing the risk of dementia and Alzheimer's disease among older adults. Medium-chain triglyceride (MCT) ketogenic diets have shown potential in slowing down age-related cognitive decline; however, the exact neuroprotective roles of MCT components, specifically decanoic acid and octanoic acid, remain unclear.
Delineation of the cognitive and neuropsychiatric features of Pisa syndrome in dementia with Lewy bodies
CONCLUSION: Our study reveals that PS in DLB is associated with specific deficits in attention and visuospatial/executive function, alongside more severe neuropsychiatric symptoms. These findings highlight the need for comprehensive management targeting both postural control and neuropsychiatric issues to alleviate caregiver burden. Future longitudinal studies are warranted to clarify the causal nature of these relationships.
Neuroimmune dynamics and brain aging: mechanisms and consequences
Brain aging is accompanied by profound changes in neuroimmune interactions that shape the balance between resilience and vulnerability. Under healthy conditions, glial cells, neurons, vascular elements, and peripheral immune inputs cooperate to sustain homeostasis. With advancing age, however, immune remodeling and systemic inflammaging drive shifts in microglial surveillance, astrocytic reactivity, and neuronal susceptibility, creating conditions that compromise synaptic function and cognitive...
Microbiota safeguards ovarian reserve and extend reproductive lifespan
Fate of hepatitis B vaccine for US babies hangs in the balance
‘Incredible’ carved canoe dates back to first settlement of islands near New Zealand
Fibers found on waka in Chatham Islands roughly align in age with earliest known human arrival
Parallel supramammillary-hippocampal routes: Organization, dysregulation, and restoration
In this issue of Neuron, Luo et al.¹ report two supramammillary neuronal populations with segregated projections to the dorsal and ventral dentate gyrus that selectively modulate cognitive and emotional processes, respectively. Targeted activation of each pathway alleviates domain-specific behavioral deficits in an Alzheimer's disease mouse model.
Decoding Senescent Drivers in Alzheimer's Disease: From Bench to Bedside
Alzheimer's disease (AD) is the most common neurodegenerative disorder associated with dementia. Cellular senescence, widely acknowledged as a key hallmark of aging, has increasingly been recognized as a significant factor in the pathogenesis of AD, although the precise mechanisms underlying this relationship have yet to be fully understood. In the brains of individuals with AD, neurons, glial cells, and cerebrovascular endothelial cells exhibit premature senescence, characterized by...
Progress in Anti-ageing Drug Research for Age-related Diseases: A Review
This review explores the anti-ageing potential of nine repurposed drugs: aspirin, atorvastatin, enalapril, metformin, canagliflozin, liraglutide, acarbose, N-acetylcysteine and dasatinib (commonly combined with quercetin). Specifically, it focuses on their mechanisms through the mechanistic target of rapamycin, adenosine monophosphate-activated protein kinase, nuclear factor kappa B and senescence-associated secretory phenotype pathways. The repurposed drugs show promise in extending healthspan...
Histone deacetylase SIRT6 regulates tryptophan catabolism and prevents metabolite imbalance associated with neurodegeneration
In the brain, tryptophan byproducts are involved in the biosynthesis of proteins, energy-rich molecules (e.g., NAD^(+)), and neurotransmitters (serotonin and melatonin). Impaired tryptophan catabolism, seen in aging, neurodegeneration and psychiatric diseases, affects mood, learning, and sleep; however, the reasons for those impairments in the elderly and in those suffering from these ailments remain unknown. Our results from cellular, Drosophila melanogaster, and mouse models indicate that...
Impaired glycolysis-derived serine metabolism as a key driver of podocyte injury with senescence
Chronic kidney disease (CKD) is a major health issue, with podocyte injury with senescence playing a central role in glomerulosclerosis. This study investigates the link between glycolysis-derived serine metabolism and podocyte injury with senescence, focusing on the role of phosphoglycerate kinase 1 (PGK1) in the regulation of L-serine synthesis and podocyte homeostasis. Using in vivo and in vitro models, we examined the effects of angiotensin II (Ang II)-induced metabolic dysregulation on...
Multiphase aqueous soggy sand electrolyte for zinc metal batteries applications at elevated temperatures
Aqueous zinc metal batteries often encounter uncontrollable failure or performance decay under thermal environments, primarily due to the severe side reactions caused by aqueous electrolytes. Here, an organic-inorganic-H(2)O multiphase aqueous soggy sand electrolyte is reported to enhance high-temperature performance of aqueous zinc metal batteries. Soggy sand components form strong interactions between the heterogeneous phases, reconstructing hydrogen-bond networks and forming water-deficient...
Diurnal dynamics of multilayer brain networks predict cognitive trajectories in aging
Resting-state functional connectivity (rsFC) is a highly dynamic process that varies across different times of the day within each individual. Although this variability was long considered to be noise, recent evidence suggests it may allow for an optimal adaptation to changes in the environment. However, the way rsFC is shaped on a circadian scale and its association with cognition are still unclear. We analyzed data from 90 late middle-aged participants from the Cognitive Fitness in Aging study...
Food insecurity and its association with the quality of life of older individuals: a cross-sectional study
CONCLUSIONS: Food insecurity affects 6 out of every 10 older adults in central Mexico, is associated with a lower QoL, and may contribute to nutritional deficits and reduced functional capacity. The association persists even after adjusting for socioeconomic and contextual vulnerabilities.
Physical activity and nutritional status as mediators in the relationship between mental health and quality of life in older women: a cross-sectional mediation study in northern Iran
CONCLUSIONS: PA and NS significantly mediate the relationship between MH and QoL in older women. Promoting regular physical activity and balanced nutrition may improve overall quality of life. These findings highlight the need for integrated, lifestyle-based interventions in ageing health programmes.
Latent space-based network analysis for brain-behavior linking in neuroimaging
We propose a latent space-based statistical network analysis (LatentSNA) method that implements network science in a generative Bayesian framework, preserves neurologically meaningful brain topology and improves statistical power for imaging biomarker detection. LatentSNA (1) addresses the lack of power and inflated type II errors in current analytic approaches when detecting imaging biomarkers, (2) allows unbiased estimation of the influence of biomarkers on behavioral variants, (3) quantifies...