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Intraneuronal accumulation of hyperphosphorylated tau is a pathological hallmark of Alzheimer's disease (AD) and related tauopathies. Although dysregulation of both histone deacetylases (HDACs) and glycogen synthase kinase 3β (GSK-3β) has been implicated in tau pathogenesis, whether and how they functionally interact to drive tau pathology remains unclear. Here, we identify HDAC7 as a critical scaffold that promotes GSK-3β-tau complex formation, leading to GSK-3β activation and tau...

We demonstrate that the capacity for acute exercise to induce mitophagy in skeletal muscle is impaired in old male mice and corresponds to a loss of mitoAMPKα. We present evidence of age-dependent, exercise-induced phosphorylation of AMPK at S491, which may predispose mitoAMPKα to degradation by the E3-ubiquitin ligase Trim72. Our findings highlight the need to understand how aging alters spatial responses to energetic stressors, like exercise.

CONCLUSION: Aging is associated with task-specific alterations in neural complexity, hemodynamic complexity, and the cross-modal temporal relationship between EEG and fNIRS signals. These findings suggest that age-related changes in NVC-related dynamics are better characterized as dynamic reorganization rather than a uniform enhancement or impairment, and support the potential of multimodal entropy analysis for characterizing age-related neurovascular coupling change.

INTRODUCTION: Astrocytic senescence is increasingly recognized as a critical contributor to the pathogenesis of Parkinson's disease (PD). Ramelteon, a clinically approved MT1/MT2 melatonin receptor agonist, has demonstrated neuroprotective effects in various neurological disorders. However, whether Ramelteon can inhibit astrocytic senescence and the underlying mechanisms remain unknown.

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The frequent coexistence of white matter hyperintensities (WMHs) and β-amyloid (Aβ) pathology in cognitively unimpaired older adults complicates interpretation of vascular and neurodegenerative imaging findings. This narrative review synthesizes topographical, microstructural, and network-level evidence in cognitively unimpaired aging, distinguishing biomarker-characterized samples from supportive mixed or symptomatic cohorts. WMHs have heterogeneous etiologies. Posterior and some...

Aging is an intrinsic biological process; specifically, brain aging leads to cognitive decline, memory loss, and numerous neurodegenerative diseases. Fibroblast growth factor 13 (FGF13) is expressed in the central nervous system (CNS) and plays a critical role in several neuropathological conditions; however, the specific role of FGF13 in brain aging remains unclear. In this study, screening of public gene expression databases revealed that FGF13 is significantly downregulated in the brain...

Several efforts aim to make torrent of AI testing results easier to understand and use