Aggregator

CONCLUSIONS: In this nationally representative cohort, vision difficulty and motor impairments were independently associated with increased dementia risk over up to 11 years. The presence of multiple sensory difficulties and motor impairments substantially increased the risk of dementia, emphasizing the importance of their early detection and management to reduce dementia risk.

Painting roofs white and adding screens to doors and windows is a low-cost way to increase comfort and curb malaria risk

Disruption of the blood-brain barrier (BBB) increases vascular permeability and promotes neuroinflammation, contributing to Alzheimer's disease (AD) progression. However, the molecular drivers of BBB dysfunction and neuroinflammation in AD remain poorly defined. Here, we identify angiopoietin-2 (ANGPT2) as a central mediator of BBB breakdown and AD progression. Transcriptomic analyses of human AD brains revealed elevated ANGPT2 expression in endothelial cells correlating with disease severity....

Working memory (WM) processes decline with increasing age. According to recent concepts, it is necessary to differentiate between dynamically changing 'WM states' which are regulated via gating mechanisms. We investigated which neural oscillatory processes underlying WM gating and updating are affected by age with a focus on alpha and theta band activity. With an EEG beamforming approach, we examined the data of N = 132 healthy individuals aged 18-76 years who performed the reference-back...

CONCLUSION: Texture analysis combined with machine learning could provide non-invasive biomarkers to classify muscles of young and old individuals, and assist in function prediction.

CONCLUSIONS AND IMPLICATIONS: Compared with married veterans, widowers had greater rates of cognitive decline, greater difficulty completing IADLs, and increased medical comorbidities. These findings may inform access to mental health services addressing bereavement and other clinical outcomes after widowhood.

Tumor necrosis factor α (TNFα) regulates inflammation in metabolic diseases and probably aging-associated inflammation. Here, TNFα´s role in aging-related liver inflammation and fibrosis and underlying mechanisms was assessed in mice. In male C57BL/6J mice, aging increased hepatic inflammation, senescence markers p16 and p21 and Tnfa mRNA expression in liver tissue. In a second study, 4 and 24-month-old TNFα^(-/-) and wild-type (WT) mice were compared for senescence, liver damage, intestinal...

Age-related inflammation plays a pivotal role in osteoarthritis (OA) pathogenesis, but the mechanism is not fully understood. Here, we identify decreased IL-36 receptor antagonists (IL-36Ra) in epidermal keratinocytes from a premature-aged skin mice model, aged mice and patients. Decreased IL-36Ra leads to increased secretion of IL-36 agonists to serum and joints, which activates proinflammatory signaling and promotes senescence in chondrocytes and synovial fibroblasts, thereby aggravates OA...

CONCLUSION: These findings emphasize the significant geographic disparity in SO prevalence across China and reveal that SO is associated with a substantially elevated risk of dementia, underscoring the need for targeted interventions in aging populations.

Variability ensures that complex biological systems, including the brain, are capable of responding to changing environmental demands. While the importance of neural variability in electrophysiological and hemodynamic aspects of brain activity is beginning to be understood, little is known about how variability in molecular activity influences brain function. Here, we examine how temporal variability in glucodynamics, or time-varying glucose use, is related to cognition in 35 younger and 43...

Age-associated decline in mitochondrial membrane potential (MMP) is a ubiquitous aspect of eukaryotic organisms and is associated with many aging-related diseases. However, it is not clear whether this decline is a cause or consequence of aging, and therefore whether interventions to reduce MMP decline are a viable strategy to promote healthier aging and longer lifespans. We developed a screening platform in Saccharomyces cerevisiae to identify mutations that slowed or abrogated the...

Aging is a multifactorial process influenced by genetic, environmental, and metabolic factors. Dysregulated nutrient sensing and metabolic dysfunction are hallmarks of aging, and reduction of insulin/IGF-1 signaling or metabolic interventions such as caloric restriction extend lifespan across species. Endogenous metabolites reflect and mediate these metabolic cues, linking nutrient status to epigenetic and transcriptional programs by serving as cofactors for chromatin-modifying enzymes or as...