Aggregator
China now tops the U.S. in R&D spending by one key measure
China reached long expected milestone in 2024
Urogenital dysfunction in neurological diseases
Neural damage at any level of the neuraxis can lead to urogenital dysfunction, involving the lower urinary tract (LUT) and/or the sexual organs. The LUT consists of the bladder and the urethra (plus the prostate in males); LUT dysfunction can manifest as an underactive bladder, leading to urinary retention, or as an overactive bladder, leading to urinary incontinence. Manifestations of sexual dysfunction include loss of libido and dysfunction of erection, ejaculation and orgasm. In this Review,...
Dialling up the circadian clock to target ageing
No abstract
ss-adrenergic-like signalling engages CrebB in Drosophila gut to promote female longevity
Adrenergic signalling is heavily implicated in human age-related disease and yet the potential for this neuroendocrine signalling pathway to modulate ageing has received little attention. Here, we use Drosophila melanogaster to test if adrenergic-like signalling can promote longevity by manipulating tyramine (TA) or octopamine (OA), the invertebrate equivalents of adrenergic hormones. Increased neuronal synthesis of TA boosts health and longevity in both sexes, whereas OA is marginally...
Scientists brace for expansion of Alzheimer's blood tests
Growing use of p-tau217 raises concerns about testing in healthy people.
Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response
The integrated stress response (ISR) is essential for cellular homeostasis and cognitive function. We investigated how persistent ISR activation affects cognitive performance by studying the PPP1R15B^(R658C) genetic variant associated with intellectual disability. To model this condition, we generated a mouse line with the pathogenic allele inserted. This variant destabilized the PPP1R15B•PP1 phosphatase complex, causing persistent ISR activation, impaired protein synthesis, and long-term memory...
Siah-1 is Critical for Hypoxia-Induced Lifespan Extension in Caenorhabditis elegans by Regulating the Expression of SKN-1
CONCLUSION: The present study identifies Siah-1 as a novel mediator linking hypoxic signaling to SKN-1-dependent transcriptional programs, providing insights into conserved mechanisms of stress adaptation and aging. This work underscores the importance of ubiquitin-mediated regulatory nodes in coordinating longevity pathways under environmental stressors.
Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response
The integrated stress response (ISR) is essential for cellular homeostasis and cognitive function. We investigated how persistent ISR activation affects cognitive performance by studying the PPP1R15B^(R658C) genetic variant associated with intellectual disability. To model this condition, we generated a mouse line with the pathogenic allele inserted. This variant destabilized the PPP1R15B•PP1 phosphatase complex, causing persistent ISR activation, impaired protein synthesis, and long-term memory...
Blood-catalyzed n-doped polymers for reversible optical neural control
Biocompatible integration of synthetic materials with living tissue remains a major challenge for bioelectronics. In this case, substrate-free conducting polymer (CP) interfaces could help bridge this gap. We report in vivo assembly of n-doped poly(benzodifurandione) (n-PBDF) using whole blood-catalyzed polymerization in awake zebrafish and mice. This approach leverages endogenous catalysts, specifically hemoproteins, to form stable, thermally and ionically sensitive CP networks, ensuring...
Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and glucocerebrosidase activity
The endolysosomal phospholipid bis(monoacylglycerol)phosphate (BMP) is aberrantly elevated in urine from Parkinson's patients carrying mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GCase). Because BMP resides on, and regulates biogenesis of, endolysosomal intralumenal membranes that become extracellular vesicles (EVs) upon release, we hypothesized that increased urinary BMP reflects enhanced exocytosis of BMP-enriched EVs. We analyzed BMP metabolism and EV-associated...
Adenosine signals an imbalance between activity and supply in privileged cells
Extracellular adenosine (e-Ado) is a critical signaling molecule, yet its origin beyond energy stress and inflammation is underexplored. Herein, we propose that Ado is ubiquitously generated in the S-adenosylmethionine transmethylation pathway and integrate this source with the concept of cellular privilege in nutrient acquisition. In this model, less privileged cells convert Ado to adenosine monophosphate (AMP) under nutrient scarcity, activating AMP-activated protein kinase, while privileged...
Memory T cell aging and rejuvenation
Aging reshapes T cell immunity, as evidenced by eroding naive diversity and remodeled memory hierarchies. This generates an experienced yet constrained repertoire, with weakened protection against novel infections and malignancies and blunted vaccine responsiveness. However, the pace and extent of decline vary widely between individuals. Such heterogeneity signals a recalibration of immune priorities that favors persistence over plasticity of memory T cells. Here, we discuss how aging shapes...
Why some cancer-fighting immune cells lose their strength inside tumours
Breakthrough computer chip tech could help meet ‘monumental demand’ driven by AI
‘Treasure trove’ of antiviral proteins could inspire powerful molecular tools
Artemis II is go: humans head to the Moon after half-century absence
The great education contradiction
Science, Volume 392, Issue 6793, April 2026.
Targeting modulated vascular smooth muscle cells in atherosclerosis via FAP-directed immunotherapy
Science, Volume 392, Issue 6793, April 2026.
A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform
Science, Volume 392, Issue 6793, April 2026.
Blood-catalyzed n-doped polymers for reversible optical neural control
Science, Volume 392, Issue 6793, April 2026.