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When what you see doesn’t make sense, your brain does something remarkable
The brain may have a built-in way to quickly settle disagreements between regions processing the same scene. Researchers found that matching signals between two visual areas lasted longer, while conflicting signals rapidly faded away. This “consensus building” mechanism could help explain how the brain turns many specialized inputs into one unified view of the world.
Scientists thought they knew how this 70-year-old leukemia drug worked
A 70-year-old leukemia drug is still revealing new secrets. Researchers found that removing a protein called NUDT5 protected cells from the drug, even though simply blocking the protein had little effect. The unexpected result points to a hidden cellular role that could help explain why people respond differently to certain leukemia treatments.
Aging muscles may be losing strength for a reason scientists missed
A newly identified breakdown in communication between nerves and muscles could help explain why people lose strength as they age. Researchers were able to improve muscle strength in an animal model by targeting a key protein, raising hopes that some age-related weakness could eventually be treated.
Functional brain network connectivity patterns associated with midlife metabolic syndrome and cognitive vulnerabilities
CONCLUSION: Midlife MetS was associated with modest reductions in within-network DMN connectivity, with abdominal obesity and low HDL cholesterol as the primary contributing MetS components. Reduced DMN connectivity was associated with poorer verbal fluency performance. These findings suggest that subtle differences in higher-order functional brain network organization associated with metabolic syndrome can be detected during midlife and are related to cognitive functioning, highlighting the...
beta-Nicotinamide Mononucleotide Inhibits Cellular Senescence in Mouse C2C12 Skeletal Muscle Cells
β-Nicotinamide mononucleotide (NMN), as the precursor of nicotinamide adenine dinucleotide (NAD^(+)), has remarkable therapeutic potential in aging-associated diseases. Skeletal muscle exhibits not only reduced mass but also impaired strength and function during aging. However, the protective effects of NMN against skeletal muscle cell senescence remain to be fully elucidated. In this study, we used D-galactose (D-gal) to establish a senescence model in C2C12 cells. Our results demonstrate that...
The Role of EVs in the Aging Hematopoietic System
Extracellular vesicles (EVs) are membrane-enclosed nanoparticles that mediate intercellular communication by transferring proteins, nucleic acids, and lipids. Within the hematopoietic system, EVs orchestrate critical signaling between bone marrow (BM) niche cells and hematopoietic stem and progenitor cells (HSPCs) to regulate quiescence, proliferation, and lineage commitment. During aging, senescence and telomere attrition drive a profound remodeling of EV biogenesis and cargo. Aged EVs,...
Mapping the Landscape of AgeTech Standards and Guidelines: A Gray Literature Review
CONCLUSIONS: Although AgeTech standardization is advancing, critical gaps remain. Limited attention to safety, security, privacy, and digital economy and community inclusion raises concerns for trust, equity, and sustainable adoption. Addressing these gaps through targeted and coordinated standardization efforts is essential to support inclusive, trustworthy, and scalable AgeTech solutions in the context of rapid global population aging.
A cross-species single-cell kidney epigenome atlas reveals epithelial-dominant aging-like states in disease
Multi-modality profiling identifies <i>Neisseria flavescens</i> as a central geroprotective oral commensal in humans
Publisher Correction: Physical activity delays ovarian aging in part through adiponectin-related signaling pathways
GLP-1 drugs fail to help some people lose weight — scientists are on a quest for answers
AlphaFold 'goes viral': database adds protein complexes of common viruses
AI agent hacks government website for first time: why this breach matters
AI system helps lab devices ‘talk’ with each other — streamlining research
Youthful fans of YouTube sports videos stick to the sofa
Bumblebees don’t mind a little plastic in their honeypots
Verification makes discovery matter
Science, Ahead of Print.
In-cell structures visualize human pre-ribosome assembly in the nucleolus
Science, Ahead of Print.
Stereodivergent telomerization of linear functionalized dienes with amines
Science, Ahead of Print.
Antiferroelectric hafnia down to the 2D limit
Science, Ahead of Print.