Aggregator

A kimchi-derived bacterium can bind to nanoplastics under gut-like conditions and may help carry them out of the body. In mice, the probiotic more than doubled the amount of nanoplastics detected in feces, pointing to a surprising potential use for microbes from fermented foods.

A natural compound produced by gut bacteria after digesting foods such as pomegranates, walnuts, and berries may help repair and protect the intestinal lining. The discovery reveals a surprising beneficial side of an inflammatory pathway and could inspire more targeted treatments for Crohn’s disease and ulcerative colitis.

Scientists discovered that brain-cell axons may not be smooth tubes as textbooks have shown for more than a century, but instead naturally resemble strings of tiny pearls. Those pearl-like structures can change with neural activity and may help control how quickly electrical signals travel through the brain.

Toward development of an autologous, induced pluripotent stem cell (iPSC)-based cell therapy for Parkinson's disease (PD), we demonstrate successful, reproducible genomic and transcriptomic qualification of patient-derived dopaminergic neuron precursor cells (DANPCs) across multiple donors. Our analysis includes whole-genome sequencing data from fibroblasts, iPSCs, and DANPCs and the development of NeuriTest, an RNAseq-based bioinformatic analysis of DANPCs designed to predict cell quality based...

Interest in fasting-based diets to improve metabolic health is growing. Caloric restriction (CR) with one meal per day includes an extended fasting component that contributes to its metabolic and longevity benefits, yet the role of fasting within CR remains unclear. Here, we compare CR with a fasting-refeeding-fasting (FRF) regimen while controlling food intake and fasting duration. Changes in plasma insulin and free fatty acids, hepatic mTOR signaling and ketogenesis, metabolic rhythms, and...

Individuals of the same chronological age differ in biological aging, and scalable, noninvasive markers are needed. The deep learning-derived retinal age gap (RAG) is a promising measure of retinal aging, but its associations with real-world health determinants remain unclear. We developed a multi-task model to predict retinal age using 29,530 fundus images from 7535 participants in a health screening cohort and evaluated RAG in cohort A for lifestyle, socioeconomic, and systemic factors (n =...

Aging in mammals is characterized by widespread yet coordinated epigenetic alterations. However, integrative analyses of DNA methylation and gene expression in dogs remain largely unexplored, particularly within genetically homogeneous single-breed populations. To elucidate the molecular signatures of canine aging, we profiled the genome-wide methylome and transcriptome of clinically healthy beagle dogs representing three distinct age groups. Global methylation levels were highly conserved...

Pigeons (Columba livia) rely heavily on spatial cognition for navigation. As such, this species is commonly used to investigate the neural correlates of spatial behaviours in birds, particularly the hippocampus and septum. As this species can live for decades when housed in the laboratory, several studies have recently used pigeons to examine long-term effects of aging on the brain, a concept that is less well-understood in birds compared to mammals. Studies assessing age-related structural...

Over the past two decades, human aging has been characterized across DNA methylation, transcriptomic, proteomic, and clinical modalities, yet no benchmark evaluates whether AI systems can interpret these heterogeneous data types in the context of aging biology. We introduce LongevityBench, an open suite of 17 tasks spanning five biodata domains, and use it to assess 18 frontier AI systems from six developer teams. Despite recent advances in AI, no single model dominates all tasks, with...

CONCLUSIONS: Hearing loss was associated with adverse cognitive trajectory membership and modified the association between baseline cognitive function and moderate decline. The association with rapid decline was particularly consistent across sensitivity analyses. These findings support considering hearing status when assessing cognitive aging risk, while further studies should determine whether hearing interventions alter cognitive trajectories.

Skin ageing is a multidimensional process driven by the convergence of intrinsic biological changes and cumulative environmental stressors. These alterations progressively disrupt epidermal barrier integrity, compromise extracellular matrix (ECM) homeostasis, and establish a chronic low-grade inflammatory state that significantly impairs tissue repair. Consequently, aged skin represents a particularly vulnerable substrate for delayed or chronic wound healing, a condition that disproportionately...

CONCLUSIONS: The majority of the 5Ms are covered in the curriculum, though notable gaps remain in several subcategories. Recommendations include strengthening preclinical exposure to concepts students will encounter in clinicals, such as pharmacology and delirium. This is the first known published study to explicitly identify how the 5Ms are covered in a U.S. undergraduate medical school curriculum.

ObjectiveThis study examines associations between neighborhood socioeconomic disadvantage during adolescence and early adulthood and chronic disease accumulation in mid- to late life.MethodsUsing Panel Study of Income Dynamics data linked to U.S. Census and American Community Survey data, we identify four trajectories of neighborhood disadvantage, namely persistent disadvantage, increasing disadvantage, decreasing disadvantage, and persistent advantage, and estimate their associations with...