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CONCLUSIONS: Controlling body weight and encouraging older adults to engage in physical activities that enhance handgrip strength can reduce the risk of dynapenia. Therefore, promoting self-care behaviors to reduce the adverse outcomes of dynapenia is crucial for enhancing healthy life in older populations.

INTRODUCTION: Mechanisms underlying age-related weakness are not fully understood, with neuronal mechanisms recently gaining attention. Despite studies on excitatory and inhibitory inputs, conflicting findings on α-motoneuron intrinsic excitability and PIC changes highlight a major gap in explaining age-related strength decline.

Changes in brain [NADPH]/[NADP^(+)] and [NAD^(+)]/[NADH] may contribute to aging. Anti-aging dietary restriction (DR) and intermittent fasting (IF) alter redox states that may contribute to their longevity effects. Pyruvate/lactate and acetoacetate/beta-hydroxybutyrate are indicators of the cytoplasmic and mitochondrial [NAD^(+)]/[NADH], respectively, while the malate/pyruvate and isocitrate/alpha-ketoglutarate are indicators of the cytoplasmic [NADPH]/[NADP^(+)]. Using these metabolite-pair...

High-speed video reveals how fast-moving cracks in tape’s adhesive layer produce shock waves that make the stuff sing as it unrolls

First-of-its-kind product raises questions about costs, access, and equity

CONCLUSIONS: The strength and significance of our study are that it is the first to indicate, on the basis of the α-syn mechanism, that the mean RNFL thickness partly reflects striatal dopamine uptake in the brain, suggesting that the mean RNFL thickness may have a certain value for the early diagnosis of PD.

Blood factors transfer the benefits of exercise to the aged brain independent of physical activity. Here, we show that the liver-derived exercise factor (exerkine) glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (GPLD1), a GPI-degrading enzyme, reverses aging- and Alzheimer's-related memory loss by targeting the brain vasculature. GPLD1 has the potential to cleave over 100 putative GPI-anchored proteins, necessitating the identification of downstream targets that mediate cognitive...

Insulating sheaths of myelin accelerate neuronal communication in the mammalian brain. Oligodendrocytes that produce myelin are generated throughout life to gradually increase myelin coverage, but these dynamics have not been defined brain-wide across the lifespan. We developed a cellular mapping pipeline involving tissue clearing, lightsheet microscopy, and AI-assisted analysis to identify the precise location of millions of oligodendrocytes and assess regional myelin density in the mouse...

Interference from distracting stimuli renders short-term memory vulnerable. While behavioral evidence suggests short-term memory deficits in Alzheimer's disease (AD), the underlying neural mechanisms remain poorly understood. Using a mouse model of AD (APP-KI), we identified increased susceptibility of short-term memory to sensory perturbations. Simultaneous two-photon calcium imaging across eight cortical regions during a delayed-response task showed that distractors disrupted neural...

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder whose progression is closely associated with time. However, most diagnostic models are based on single time-point data, overlooking longitudinal disease characteristics. Structural magnetic resonance imaging (sMRI) has been widely utilized in the study of AD. To address the need for multi-time series analysis in longitudinal AD research and the integration of features from different brain tissues, we propose a Multi-Branch...

Predicting not just if, but also when, cognitively unimpaired individuals are likely to develop onset of Alzheimer's disease (AD) symptoms would be useful to clinical trials and, eventually, clinical practice. Although clock models based on amyloid and tau positron emission tomography have shown promise in predicting the onset of AD symptoms, a model based on plasma biomarkers would be more accessible. Using longitudinal plasma %p-tau217 (the ratio of phosphorylated to non-phosphorylated tau at...

No abstract

Most diseases are not caused by large-effect single factors but by the cumulative impact of small, context-dependent perturbations arising from genetic variants, personal behavior, or environmental exposures, a phenomenon we term the "long tail" of biology. Early disease signals often differ from late-stage biomarkers and evolve across demographic, lifestyle, and environmental contexts. Shifting medicine from reactive treatment to proactive health requires detecting and interpreting these...

Blood factors transfer the benefits of exercise to the aged brain independent of physical activity. Here, we show that the liver-derived exercise factor (exerkine) glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (GPLD1), a GPI-degrading enzyme, reverses aging- and Alzheimer's-related memory loss by targeting the brain vasculature. GPLD1 has the potential to cleave over 100 putative GPI-anchored proteins, necessitating the identification of downstream targets that mediate cognitive...

Insulating sheaths of myelin accelerate neuronal communication in the mammalian brain. Oligodendrocytes that produce myelin are generated throughout life to gradually increase myelin coverage, but these dynamics have not been defined brain-wide across the lifespan. We developed a cellular mapping pipeline involving tissue clearing, lightsheet microscopy, and AI-assisted analysis to identify the precise location of millions of oligodendrocytes and assess regional myelin density in the mouse...

No abstract

CONCLUSIONS: The LTC Data Cooperative offers novel EHR data capturing clinical measures not available in the Minimum Data Set or claims data on a SNF resident population that is comparable to the national population. Studies using these data can generate evidence to inform and improve clinical care and outcomes for older adults in the SNF setting.

Mixed-matrix membranes (MMMs) with high chain packing density by incorporating soluble macrocycle compounds represent a promising class of materials for gas separation. However, achieving the ultra-high selectivity (He/CH(4) > 1000) for helium extraction from natural gas with ultra-low helium content remains a formidable challenge, especially for Matrimid membranes, which are commercially available but exhibit relatively low permeability and moderate selectivity. Herein, the cyclic Cyclen with...