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Intracranial self-stimulation mitigates spatial task deficits, modifies miR-146a and miR-495 serum levels and restores hippocampal NRF2 levels in a rat model of sporadic Alzheimer's disease

10 hours 35 minutes ago
CONCLUSION: Prolonged MFB-ICSS treatment mitigates cognitive deficits, modulates circulating levels of miRNA-495 and miR-146a, restores hippocampal NRF2 levels, and preserves corpus callosum integrity in the SAD rat model by STZ injection. These findings highlight the therapeutic potential of MFB-ICSS as a non-pharmacological intervention in AD. Furthermore, this study confirms NRF2 as a target of miR-495 in the context of AD.
Andrea Riberas-Sánchez

Early-Life Climbing Stratifies the Metabolome and Mortality Risk in Genetically Identical Flies

10 hours 35 minutes ago
Studies in laboratory organisms typically minimize all environmental and genetic variation other than the intervention of interest. In aging studies, these highly controlled conditions have yielded profound insights into aging. But even within isogenic cohorts of lab animals in controlled environments, we observe substantial variation in lifespan. Here we exploited the climbing behavior of Drosophila to study variation in mortality among isogenic populations in a controlled environment. We show...
Benjamin R Harrison

Human Umbilical Cord Plasma Metabolomics Uncover Potential Metabolites for Combating Aging

10 hours 35 minutes ago
Human umbilical cord blood (HUCB) exhibits distinct characteristics compared to adult blood, offering significant potential for medical applications, particularly in antiaging therapies. However, the metabolic profile of HUCB relative to adult blood remains poorly understood. Moreover, the specific metabolites within HUCB that confer antiaging properties have yet to be identified. Here, we conducted an untargeted metabolomic analysis comparing cord plasma and adult plasma. Our results reveal a...
JiaYu Liu

Spectral kernel machines with electrically tunable photodetectors

13 hours 35 minutes ago
Science, Volume 390, Issue 6776, November 2025.
Dehui Zhang, Yuhang Li, Jamie Geng, Hyong Min Kim, Marco Ma, Shifan Wang, Inha Kim, Theodorus Jonathan Wijaya, Naoki Higashitarumizu, I. K. M. Reaz Rahman, Dorottya Urmossy, James Bullock, Aydogan Ozcan, Ali Javey