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A global shift toward healthier diets could sharply reduce livestock farming, free up agricultural land, and cut emissions from land-use change by 85% by 2050. At the same time, fruit, vegetable, nut, and legume production could soar, creating a sweeping transformation of what the world grows and eats.

A 25-year study found that frequent consumption of soda, sports drinks, and fruit juice beginning in childhood was linked to a higher risk of high blood pressure in adulthood. Swapping one daily drink for whole fruit, milk, or water could significantly reduce that risk.

CONCLUSIONS: AGE-PAIRS demonstrates the feasibility of engaging physician alumni as mentors in early geriatrics education and suggests that structured intergenerational mentorship can support empathy and professional identity formation. Future work will integrate AGE-PAIRS more deeply into graded coursework, add structured mentor reflections, expand participation across all class years, and evaluate higher-level outcomes such as geriatrics knowledge, clinical performance, and interest in...

INTRODUCTION: Fidelity of detailed information retrieved from long-term memory (LTM) declines in aging due to changes affecting learning and remembering processes. Such behavioral deficits correspond with functional alterations in the hippocampal formation. However, it is unclear whether age-related decline in high-fidelity retrieval alters functional connections between hippocampal and cortical regions.

Researchers have developed a fluoride-free gel that could help rebuild damaged tooth enamel, something the body cannot naturally replace once it is lost. Inspired by the proteins that guide enamel formation in infancy, the gel fills microscopic cracks and draws calcium and phosphate from saliva to grow a new mineral layer that closely matches healthy enamel.

A plant-derived compound reduced swelling, inflammation, and joint damage in rats with rheumatoid arthritis. It also helped rebalance immune activity and improve the way certain fats were processed in the body. Researchers say the findings could lead to a new approach for treating the disease.

Researchers found that specific brain circuits help decide which jobs bees perform as they age. When those circuits were switched off, older worker bees began caring for the queen again instead of carrying out their normal later-life duties. The findings reveal that a bee colony’s complex division of labor may be guided by neural switches hidden inside each bee’s brain.

Colorectal cancer is now the leading cause of cancer death among people under 50, and cases in younger adults continue to rise. Warning signs can include persistent bowel changes, recurring rectal bleeding, dark or narrow stools, unexplained weight loss, and fatigue. These symptoms often have harmless causes, but they should not be dismissed, especially when they are new or ongoing. Early detection can greatly improve treatment outcomes.

Miniature brain models grown from patients’ cells revealed striking differences in how Alzheimer’s-related tissue responds to an antidepressant. The organoids and the particles they release could eventually guide more personalized treatments and provide new clues for diagnosing the disease.

Catfish melanomas are the first example of a transmissible cancer in fish, genetic studies reveal

CONCLUSIONS AND IMPLICATIONS: Among community-dwelling older adults, MRI-derived muscle quality deteriorated substantially faster than muscle quantity over 4 years and more closely paralleled declines in physical performance. These findings suggest that age-related muscle deterioration is driven primarily by qualitative degeneration rather than simple loss of muscle mass and support the use of imaging-based muscle quality measures as sensitive biomarkers of biological muscle aging.

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CONCLUSION: HBDL-based free-weight resistance training is a safe, feasible, and effective strategy to improve body composition, trunk extensor function, and mobility in older women.

Homotypic targeting is the inherent ability of cells to preferentially interact with cells of the same type, a phenomenon seen in cell adhesion, tissue formation and immune responses. However, its potential remains underexploited. Here we report a strategy to substantially enhance homotypic targeting through extracellular vesicles secreted by cells. By engineering the surface of small extracellular vesicles (sEVs) with lanthanides, we amplify specific cell-sEV interactions by more than 25-fold,...

Sickle cell disease (SCD) is a blood disorder affecting millions worldwide. Emerging evidence reveals that SCD pathophysiology increases the risk of myeloid malignancies and hematopoietic stem cell (HSC) dysfunction, likely because of chronic stress on bone marrow. To investigate this further, we interrogated bone marrow hematopoietic stem and progenitor cells (HSPCs) from mice and individuals with SCD and observed molecular signatures of chronic cellular stress including oxidative stress, DNA...