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Specialized appendage responds to female sex hormones, allowing males to find sex organs in the dark

Government pledges to more than triple research spending by 2030

The abnormal protein degradation implicated in the pathogenesis of Parkinson's disease was previously attributed to defective H+ leakage from lysosomes via TMEM175 (https://doi.org/10.1016/j.cell.2022.05.021). In this issue, Riederer et al. (https://doi.org/10.1083/jcb.202501145) demonstrate that TMEM175 is instead a K+ channel, minimally permeable to H+.

DNA recovered from people buried at the site reveals surprises

Identity of the toe bones and other fossils could shake up the human family tree

CONCLUSION: Osteosarcopenia and its components (osteoporosis and sarcopenia) are inversely associated with BMI and fat mass, particularly in the trunk and android regions.

BackgroundWhile life expectancy has increased globally, chronic disease burdens remain high. Cancer, despite improved survival, remains a major cause of disability and the second leading cause of death. Though behavioral risks such as smoking, poor diet, and physical inactivity are linked to cancer, few studies examine their impact on cancer-free life expectancy and gender disparities.MethodsUsing U.S. Health and Retirement Study data (2004-2020) and a multistate model approach, we estimated...

CONCLUSIONS: To effectively assess autonomy in older adults, the focus must be on life goals and insights from caregivers. Our future tool may address this gap in clinical practice by capturing these essential aspects, ultimately enhancing quality of life in older adults.

CONCLUSION: Frailty, malnutrition, cognitive impairment, and depressive symptoms were frequent among community-dwelling very old adults, particularly women. These cross-sectional findings emphasize the need for multidisciplinary and gender-sensitive strategies within HACs to support functional independence and mental well-being. Longitudinal and multivariate studies are warranted to confirm these associations.

BACKGROUND: The Department of Veterans Affairs (VA) is the largest integrated healthcare system in the United States and serves a rapidly aging patient population. The VA's Home-Based Primary Care (HBPC) program is a home care model for older, complex, high-risk Veterans that provides comprehensive, longitudinal primary care delivered by an interdisciplinary team of VA staff, with plans for expansion by 2027. HBPC program implementation varies considerably across local sites and contexts....

CONCLUSION: This study shows a significant association between spousal health and cognitive function among older adults, with frailty serving as a fully mediator in this association. Crucially, activity engagement is associated with a weaker impact of frailty on cognitive abilities, with greater involvement linked to less pronounced cognitive decline. These findings emphasize the dual protective roles of a spouse's health and activity engagement in sustaining cognitive health.

CONCLUSIONS: The literature on vision screening in this population was sparse and there was heterogeneity in current practices, highlighting the need for standardised screening protocols. More research is needed to evaluate vision screening services in this population and to explore implementation barriers.

CONCLUSIONS: This study presents a decade-spanning model that reflects the multifactorial nature of fall risk and the diversity of aging trajectories in the U.S., providing a foundation for more inclusive and personalized fall prevention strategies.

CONCLUSIONS: The Turkish adaptation of GLFS-25 is a valid, reliable, and culturally appropriate tool for assessing locomotive dysfunction in Turkish older adults. Its strong psychometric properties and high correlation with functional mobility indicators suggest that it can be effectively integrated into geriatric healthcare and rehabilitation programs. Given the rapid aging of Turkey's population, this tool can support early detection, prevention strategies, and policy development to mitigate...

CONCLUSION: Lower educational attainment, musculoskeletal conditions, and abdominal obesity may contribute to a higher likelihood of disability in women. Additionally, abdominal obesity, arthritis and cardiometabolic diseases showed stronger associations with functional disability in women than in men.

CONCLUSIONS: Perceived fatigability is prevalent among older adults and exhibits strong associations with age, educational level, alcohol drinking, PA, depressive and anxiety symptoms, and sleep quality in regional China. These findings suggested that fatigability is a public health problem among older adults in China and particular attention should be paid to burden caused by fatigability and its associated factors.

CONCLUSION: Overall, the data suggest that the health status of Swedish centenarians has worsened over time. Although some of these changes may reflect improved diagnostics and increased drug prescriptions, it is likely that morbidity has also risen as a result of greater survival from disease at older ages.

CONCLUSION: The free health check-up program for the elderly was associated with a reduction in their medical use and an increase in their health, positioning it as a potential model for other countries grappling with an ageing populace. Despite free nature of the program, the increment in the health check-up utilization remains low among the elderly. Enhanced efforts to promote effective use and follow-up consultation are necessary.