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A global shift toward healthier diets could sharply reduce livestock farming, free up agricultural land, and cut emissions from land-use change by 85% by 2050. At the same time, fruit, vegetable, nut, and legume production could soar, creating a sweeping transformation of what the world grows and eats.

A 25-year study found that frequent consumption of soda, sports drinks, and fruit juice beginning in childhood was linked to a higher risk of high blood pressure in adulthood. Swapping one daily drink for whole fruit, milk, or water could significantly reduce that risk.

Cellular senescence is a context-dependent cellular state characterised by persistent cell-cycle arrest, epigenetic remodelling, metabolic reprogramming and acquisition of a senescence-associated secretory phenotype. Transient senescence contributes to embryogenesis, tissue repair and tumour suppression, whereas persistent senescent cell populations accumulate with advancing age across multiple tissues, in part owing to declining immune-mediated clearance and intrinsic resistance to apoptosis,...

Global population ageing is increasing the burden of chronic disease, functional decline, and loss of independence. For most organs, decline in function starts during the 5th decade of life. Micronutrient (MN) insufficiencies/deficiencies are common and may accelerate biological ageing. MNs are required to support multiple physiologic processes, including mitochondrial homeostasis. Age-related declines in organ function are tightly linked to mitochondrial dysfunction, oxidative stress,...

Heterochronic parabiosis improves physiological and cognitive function in aging rodents; these benefits appear to be derived from the removal of aged blood plasma components and the addition of younger ones. In humans, removing plasma from older individuals with Alzheimer's disease (AD) and replacing it with saline and albumin delayed cognitive deterioration in a large clinical trial. However, mimicking heterochronic parabiosis in humans by removing large volumes of a patient's blood plasma and...

CONCLUSIONS: AGE-PAIRS demonstrates the feasibility of engaging physician alumni as mentors in early geriatrics education and suggests that structured intergenerational mentorship can support empathy and professional identity formation. Future work will integrate AGE-PAIRS more deeply into graded coursework, add structured mentor reflections, expand participation across all class years, and evaluate higher-level outcomes such as geriatrics knowledge, clinical performance, and interest in...

INTRODUCTION: Fidelity of detailed information retrieved from long-term memory (LTM) declines in aging due to changes affecting learning and remembering processes. Such behavioral deficits correspond with functional alterations in the hippocampal formation. However, it is unclear whether age-related decline in high-fidelity retrieval alters functional connections between hippocampal and cortical regions.

Science, Ahead of Print.

Science, Ahead of Print.

Girl’s death in China raises questions about the safety and cost of gene therapy, China’s biotech push, and scientific publishing practices

The 278 winners now face 9-month race to prove they deserve additional funding

Researchers have developed a fluoride-free gel that could help rebuild damaged tooth enamel, something the body cannot naturally replace once it is lost. Inspired by the proteins that guide enamel formation in infancy, the gel fills microscopic cracks and draws calcium and phosphate from saliva to grow a new mineral layer that closely matches healthy enamel.