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Biological Aging Acceleration in Major Depressive Disorder: A Multi-Omics Analysis

12 hours 44 minutes ago
Major depressive disorder (MDD) is linked to a higher risk of premature aging, but the mechanisms underlying this association remain unclear. Using data from two population cohorts (UK Biobank and Finnish Twin Cohort), we evaluate the relationship between systemic and organ-specific proteomic and epigenetic aging acceleration and MDD. A lifetime history of MDD was associated with accelerated proteomic aging at both systemic and organ-specific levels-including the brain-in both cohorts, with...
Breno Satler Diniz

PBX1 Improves Cognition and Reduces Amyloid-β Pathology in APP/PS1 Mice by Transcriptionally Activating the CRTC2-CREB Pathway

12 hours 44 minutes ago
Alzheimer's disease (AD) is characterized by progressive cognitive decline, amyloid β (Aβ) deposition, and synaptic dysfunction. However, the mechanisms underlying neurodegeneration remain poorly understood. In this study, we investigated the therapeutic potential of PBX1, a transcriptional regulator implicated in neurodevelopment and neuroprotection, against AD. PBX1 expression was significantly downregulated in postmortem hippocampal tissues from patients with AD and in the APP/PS1 mouse...
Zinan Liu

Association of healthy lifestyle patterns with changes in physical frailty and subjective cognitive function among community-dwelling older adults: a 3-year longitudinal study

12 hours 44 minutes ago
CONCLUSIONS: Different lifestyles were associated with different health risks in older adults. These lifestyle patterns, such as low physical activity and social participation, were associated with increased physical frailty and subjective cognitive decline. These findings suggest that latent class analysis may be useful for identifying lifestyle patterns that could inform the development of targeted interventions to promote healthy aging.
Mengjiao Yang

Biological Aging Acceleration in Major Depressive Disorder: A Multi-Omics Analysis

12 hours 44 minutes ago
Major depressive disorder (MDD) is linked to a higher risk of premature aging, but the mechanisms underlying this association remain unclear. Using data from two population cohorts (UK Biobank and Finnish Twin Cohort), we evaluate the relationship between systemic and organ-specific proteomic and epigenetic aging acceleration and MDD. A lifetime history of MDD was associated with accelerated proteomic aging at both systemic and organ-specific levels-including the brain-in both cohorts, with...
Breno Satler Diniz

In Science Journals

16 hours 44 minutes ago
Science, Volume 390, Issue 6777, Page 1012-1014, December 2025.
Michael Funk, and Jelena Stajic, Di Jiang, Phil Szuromi, Michael A. Funk, Madeleine Seale, Annalisa VanHook, Marc S. Lavine, Christiane P. Koch, Caroline Ash, Ekeoma Uzogara, Christiana N. Fogg, and Molly Ogle