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A simple change to your daily routine could make a surprising difference in how you feel, both physically and mentally. University of Missouri researchers found that older adults who followed consistent daily schedules reported less physical pain and fewer symptoms of depression, even when they struggled with insomnia. Keeping regular times for sleeping, eating, and other activities may help regulate the body's internal clock, which influences mood, sleep, and overall health.

Scientists have developed a promising new fiber supplement that improves gut health in people with irritable bowel syndrome (IBS) without worsening bloating, pain, or other digestive symptoms. The specially designed blend also improved gut-related anxiety and produced surprisingly rapid changes in gut bacteria, potentially offering a new way to manage IBS.

Stanford researchers have discovered that hidden patterns of brain activity can predict Alzheimer’s risk years before memory problems appear, potentially offering an earlier warning than traditional biomarkers. The same patterns also reveal which brains are unusually resistant to aging, raising hopes for future treatments that could help protect memory.

A new study suggests that the right kind of exercise could help protect young adults from early knee osteoarthritis following ACL surgery. Researchers found that a four-month supervised rehabilitation program improved pain, muscle strength, and quality of life without damaging knee cartilage. The findings challenge fears that exercise worsens injured knees and could transform how patients recover from ACL reconstruction.

Yale researchers have discovered that certain prescription drugs, healthy diets, and exercise can measurably slow biological aging, while popular anti-aging supplements appear largely ineffective. Their analysis of 51 studies could transform how scientists evaluate anti-aging treatments, although whether these biological changes actually extend life remains uncertain.

Smiling may not always make you happier, and new research suggests that forcing yourself to smile repeatedly could actually make you feel worse. In a University of Florida study involving more than 1,100 participants, researchers discovered that while a single artificial smile can provide a small mood boost, repeatedly faking smiles can erase that benefit or even reverse it.

A new study reveals that viral infections may leave behind hidden damage to the immune system long after symptoms disappear. Researchers found that mice recovering from an acute infection experienced lasting changes to their spleens and weakened immune responses, potentially leaving them more vulnerable to future threats. Surprisingly, prior vaccination completely prevented these harmful changes in the mouse model.

A study of more than 750,000 pregnancies found that early exposure to Ozempic, Wegovy, and similar drugs was not linked to increased pregnancy complications when used for weight loss, but was associated with a higher risk of premature birth when prescribed for diabetes. The surprising difference suggests that diabetes itself may be driving the risk, although researchers caution that the drugs' safety during pregnancy remains uncertain.

A major study of nearly 1,900 older adults suggests that stopping statins after age 70 may be relatively safe in the short term for people who have never experienced a heart attack or stroke. However, a higher rate of serious cardiovascular events or death during longer follow-up raises questions about the risks of discontinuing these widely prescribed medications.

Aging reduces the quality and quantity of sleep, and sleep disruption is predictive of neurodegeneration and cognitive decline. Sleep loss could affect brain health through disruption of cerebrospinal fluid (CSF) circulation, which is important for brain homeostasis. In young adults, large CSF flow waves appear during non-rapid eye movement sleep; however, whether sleep-dependent brain fluid physiology changes in aging is not known. Here we imaged large-scale CSF flow and hemodynamics in young...

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Asymmetry on the left-right axis is an organizing principle of the human brain that is important for diverse cognitive and behavioural functions. Advances in neuroimage analysis, genomics and large-scale data collection in the past decade have transformed our understanding of the biological foundations and multivariate nature of brain asymmetry. In this Review, we synthesize evidence across scales - from functional and macro-anatomical asymmetries and their inter-relations to microstructural,...

CONCLUSIONS: These findings demonstrate that reference genome choice impacts the identification and interpretation of specific Alzheimer's Disease-associated genes, despite overall reproducibility of genome-wide differential expression signatures, underscoring the critical importance of reference selection in Alzheimer's Disease transcriptomic studies.

CONCLUSION: This review consolidates evidence that GLP-1RAs exert broad neuroprotective effects through multiple mechanisms, but clinical translation is still evolving. The potential of GLP-1-based therapies as disease-modifying interventions for neurodegeneration warrants further investigation, with particular attention to bridging preclinical and clinical findings and optimizing drug delivery strategies.

Type 3 Diabetes (T3D) is a conceptual framework used to describe the association between cerebral insulin resistance, metabolic dysfunction and neurodegenerative processes, particularly those associated with Alzheimer's disease (AD). The advanced glycation end products (AGEs)-receptor for advanced glycation end products (RAGE) axis has been implicated in oxidative stress, inflammatory signaling and neuronal dysfunction. However, conventional biochemical approaches often provide endpoint...

Extraembryonic tissues and many cancers share unusual DNA methylation landscapes, but how these states arise remains unclear. Here, we use GATA6- and CDX2-driven reprogramming of mouse embryonic stem cells to track genome-wide epigenetic remodeling during acquisition of extraembryonic cell fates. Despite activating distinct transcriptional programs from non-overlapping genomic targets, both transcription factors trigger rapid and genomically synchronized convergence to cancer-like DNA...

Aging is a multifactorial process shaped by genetic, metabolic, and environmental factors. Yet one physical constant-gravity-has rarely been considered as a potential contributor to the aging process. This perspective explores the hypothesis that chronic exposure to Earth's gravity, through its lifelong hydrostatic effects on cerebral blood flow (CBF), may represent an unrecognized driver of systemic aging. The brain, particularly deep regulatory centers in the hypothalamus and brainstem,...

Cardiac aging is traditionally framed as a progressive loss of energetic capacity, yet accumulating evidence indicates that iron-dependent lipid peroxidation and ferroptotic susceptibility may contribute to age-related myocardial vulnerability. Here, we integrate evidence linking mitochondrial quality control, membrane lipid remodeling, antioxidant capacity, and iron handling to the emergence of a ferroptosis-permissive state in aging cardiomyocytes. We further propose that aerobic exercise may...

The ability to recover skeletal muscle after periods of disuse declines with age leading to persistent deficits in strength and function that extend beyond muscle mass loss. Here, we investigated whether age-related alterations in lipid remodeling contribute to impairment in skeletal muscle recovery following disuse. Lipidomic and oxylipin profiling revealed that aged mouse muscle is characterized by sustained phosphatidylcholine and omega-6-dependent COX-prostaglandin signaling during early...

Natural products derived from traditional medicines are valuable sources of potential geroprotective compounds; however, their translation into therapeutic candidates is limited by chemical complexity, polypharmacology, limited mechanistic resolution, and lengthy experimental validation. Artificial intelligence (AI) offers an emerging framework for integrating chemical, pharmacological, multi-omics, imaging, and literature derived data to accelerate natural product anti-aging research. This...