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Shirley Meng explains why her passion for decarbonizing the global economy required her to relocate

Sensor array traces how rocks conduct electricity, exposing ancient continental fragments, mineral targets, and grid hazards

Gut microbiota dysbiosis is a driving factor in Alzheimer's disease (AD), yet the mechanisms behind remain elusive. Emerging evidence highlights that outer membrane vesicles (OMVs) are critical mediators of microbiota-host communication. Here, we observed a reduction in a gut probiotic Escherichia coli Nissle 1917 (EcN)-like strain in AD patients, and its levels are positively associated with cognitive ability. The EcN OMVs containing outer membrane protein A (OmpA) translocate to the brain,...

Synaptic function and plasticity depend on the precise control of protein abundance and turnover, governed by the balance of synthesis and degradation. This review examines the regulatory mechanisms that maintain synaptic protein stability, focusing on the Ubiquitin-Proteasome System (UPS), autophagy-lysosomal pathways, and related proteolytic systems. We detail how key enzymes, including E3 ligases such as Nedd4-1, Mdm2, and Parkin, and deubiquitinating enzymes like USP46 and USP8, dynamically...

Physical resilience is a term used to describe an individual's response to physical and physiological stressors across the fields of gerontology and rehabilitation sciences. However, the term has not yet undergone a rigorous examination of its underlying assumptions, which has hindered its theoretical development and empirical measurement. This paper reviews the existing definitions of physical resilience in the context of human physical and psychological systems to examine its underlying,...

Global population aging has sharply increased the prevalence of age-related degenerative diseases, posing severe challenges to global public health and socioeconomic stability. Growing evidence links these disorders to the bidirectional crosstalk between gut microbiota and cellular senescence, yet the integrated interaction network governing multi-organ degeneration remains poorly defined. Age-related gut microbial remodeling reshapes metabolite profiles: beneficial metabolites mitigate cellular...

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CONCLUSION: This protocol represents the first structured effort to embed the WHO ICOPE model within the Greek healthcare system. By integrating professional training, community-based assessment, and digital documentation, the initiative aims to strengthen person-centred care, prevent dependency, and align national ageing policies with international standards.

The lymphatic system plays critical roles in immune defense, fluid homeostasis, substance metabolism, and cellular communication. Traditionally, it was believed that the vertebrate brain lacked a classical lymphatic system. Studies have revealed the presence of the glymphatic system (GS) and meningeal lymphatic vessels (MLVs), which are thought to play important roles in regulating material transport and immune processes within the central nervous system (CNS), in ways that resemble aspects of...

TP53 is the most commonly mutated gene in cancer, but it remains recalcitrant to clinically meaningful therapeutic reactivation. We present here the discovery and characterization of a small molecule chemical inducer of proximity that activates mutant p53. We named this compound TRanscriptional Activator of p53 (TRAP-1) due to its ability to engage p53^(Y220C) and BRD4 in a ternary complex, which potently activates mutant p53 and triggers robust p53 target gene transcription. Treatment of...

CONCLUSION: This study provides community-based evidence on dementia severity among older adults in two districts of Hai Duong province, Vietnam, showing that more than half of participants had moderate-to-severe dementia. Functional independence and quality of life were associated with dementia severity and may represent important considerations when designing community-based dementia care strategies.

Advanced glycation end products (AGEs) accumulate with aging and metabolic stress and are increasingly implicated in osteoarthritis (OA) pathology. However, how AGEs regulate osteoclast-chondrocyte signaling remains poorly defined. Here, we integrated proteomic and transcriptomic analyses with machine learning to identify molecular networks altered by AGEs in osteoclasts. SIRT1 emerged as a central regulator suppressed following AGE exposure. Loss of SIRT1 deacetylase activity activated the...

Traditional deep-brain stimulation via implanted electrodes can effectively treat neurological disorders, but surgical injury limits its clinical application. Here, we developed ultrasound-responsive piezoelectric nanoparticles for minimal-invasive and wireless neuromodulation. In the 6-OHDA-induced Parkinson's disease (PD) mouse model, these nanoparticles are injected into the subthalamic nucleus (STN) of the mouse brain. After ultrasound stimulation for several days, the motor behavior,...

Pancreatic cancers, whose incidence increases with age, are often refractory to treatment. Here, we identified a core mechanism shared by physiological homeostasis, senescent cell accumulation during aging, and pancreatic cancers. Pancreatic acinar cells, when stressed, secrete CXCL13, which protects stressed cells while transiently activating paracrine Hippo/YAP signaling to induce proliferation and PD-L1-mediated immune protection to maintain organ homeostasis. In the aged pancreas,...

Aging is a major risk factor for chronic diseases. Unlike the general population, members of long-lived families maintain exceptional health as they age, with over 10 years delayed onset of their first chronic disease. We therefore hypothesize that one of the key features explaining healthy survival up to high ages (longevity) is the absence of chronic disease risk alleles. We investigated this hypothesis in the Leiden Longevity Study, a cohort with data from more than 420 long-lived families in...

Lysosomal dysfunction is a hallmark of cellular senescence, yet the mechanisms governing lysosomal protein trafficking remain incompletely understood. Here, we show that CD-M6PR, a principal receptor for lysosomal enzyme transport, is markedly reduced in senescent fibroblasts and in aged mice and humans, and that its loss correlates with the severity of autolysosomal impairment. Mechanistically, the reduction of CD-M6PR in senescent cells mainly stems from the accelerated proteasome-mediated...

CONCLUSION: The needs of older adults and community workers in utilizing technology for health exhibit a multi-layered interaction. Older adults require simplified technologies and social support, and community workers demand technical training and policy backing. The study's findings support a reframing of immediate recommendations towards age-friendly design, structured training for community workers, and policy support for resources. Developing artificial intelligence-assisted tools is a...

CONCLUSION: The findings reinforce the multidimensional nature of dementia and the importance of accessible factors for supporting screening/triage and prioritization in primary care. Strengthening public policies focused on promoting brain health can contribute significantly to the efficient allocation of resources in primary care and dementia prevention in Brazil.