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Loss of age-accumulated <em>crh-1</em> circRNAs ameliorate amyloid β-induced toxicity in a <em>C. elegans</em> model for Alzheimer's disease
Circular RNAs (circRNAs) are non-coding RNAs mostly derived from exons of protein-coding genes via a back-splicing process. The expression of hundreds of circRNAs accumulates during healthy aging and is associated with Alzheimer's disease (AD), which is characterized by the accumulation of amyloid-beta (Aβ) proteins. In C. elegans, many circRNAs were previously found to accumulate during aging, with loss of age-accumulated circRNAs derived from the CREB gene (circ-crh-1) to increase mean...
Cerebrovascular burden and neurodegeneration linked to 15-year odor identification decline in older adults
CONCLUSION: Olfactory decline is related to both increased cerebrovascular burden and accelerated brain atrophy over time.
Incidence of Frailty, Dementia, and Disability Among Community-Living Older Americans According to County-Level Disadvantage
CONCLUSIONS: Community-living older Americans who reside in disadvantaged counties have a higher incidence of frailty, probable dementia, and ADL disability over a 5-year follow-up period compared to their non-disadvantaged counterparts. Findings underscore the vital, underappreciated role that county-level social contextual disadvantage plays on clinically meaningful outcomes in older persons in the U.S.
How do mpox outbreaks start? Dead baby monkey provides important clue
“Landmark” study fingers fire-footed rope squirrel as a reservoir of fatal disease