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Phenotypic upregulation of hexocylceramides and ether-linked phosphocholines as markers of human extreme longevity

1 year 3 months ago
Centenarians and their relatives possess a notable survival advantage, with higher longevity and reduced susceptibility to major age-related diseases. To date, characteristic omics profiles of centenarians have been described, demonstrating that these individuals with exceptional longevity regulate their metabolism to adapt and incorporate more resilient biomolecules into their cells. Among these adaptations, the lipidomic profile stands out. However, it has not yet been determined whether this...
Anna Fernàndez-Bernal

Estradiol deficiency as a consequence of aging contributes to the depletion of the satellite cell pool in female mice

1 year 3 months ago
The effects of aging on the satellite cell pool have primarily been studied in male mice, where the role of cell-intrinsic versus environmental changes on satellite cell function remains contentious. Estradiol is necessary for maintenance of satellite cell pool size in adult female mice-here we investigate the hypothesis that in females, estradiol is a major environmental driver of age-associated effects on satellite cells. In 24-26 month-old ovarian senescent mice, we find the satellite cell...
Brian P Sullivan

Similarities and differences in the gene expression signatures of physiological age versus future lifespan

1 year 3 months ago
Across all taxa of life, individuals within a species exhibit variable lifespans. Differences in genotype or environment are not sufficient to explain this variance, as even isogenic Caenorhabditis elegans nematodes reared under uniform conditions show significant variability in lifespan. To investigate this phenomenon, we used lifespan-predictive biomarkers to isolate, at mid-adulthood, prospectively long- and short-lived individuals from an otherwise identical population. We selected two...
Matthew C Mosley

Ecological erosion and expanding extinction risk of sharks and rays

1 year 3 months ago
Science, Volume 386, Issue 6726, December 2024.
Nicholas K. Dulvy, Nathan Pacoureau, Jay H. Matsushiba, Helen F. Yan, Wade J. VanderWright, Cassandra L. Rigby, Brittany Finucci, C. Samantha Sherman, Rima W. Jabado, John K. Carlson, Riley A. Pollom, Patricia Charvet, Caroline M. Pollock, Craig Hilton…

Programming tissue-sensing T cells that deliver therapies to the brain

1 year 3 months ago
Science, Volume 386, Issue 6726, December 2024.
Milos S. Simic, Payal B. Watchmaker, Sasha Gupta, Yuan Wang, Sharon A. Sagan, Jason Duecker, Chanelle Shepherd, David Diebold, Psalm Pineo-Cavanaugh, Jeffrey Haegelin, Robert Zhu, Ben Ng, Wei Yu, Yurie Tonai, Lia Cardarelli, Nishith R. Reddy, Sachdev S…