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Late-Life Aerobic Exercise Attenuates DNA Damage and Telomere Dysfunction in Non-Atheroprone but Not in Atheroprone Aortic Regions

1 year 2 months ago
Cellular senescence is a state of persistent cell cycle arrest and is a critical contributor to arterial aging. The primary drivers of cellular senescence are the DNA damage response (DDR) and telomere dysfunction, which is induced by increasing exposure to DNA-damaging stimuli such as atheroprone shear stress. While late-life aerobic exercise is an effective intervention to mitigate arterial aging, its specific impact on the DDR and telomere dysfunction is unknown and may not show uniform...
Jisok Lim

Septal LYVE1+ macrophages control adipocyte stem cell adipogenic potential

1 year 2 months ago
Science, Volume 389, Issue 6763, August 2025.
Xiaotong Yu, Yanan Hu, Hwee Ying Lim, Ziyi Li, Diego Adhemar Jaitin, Katharine Yang, Wan Ting Kong, Jiaqian Xu, David Alejandro Bejarano, Mathilde Bied, Lucie Orliaguet, Gowshika Rengasamy, Zachary Chow, Christopher Zhe Wei Lee, Josephine Lum, Jing Tian,…

In Science Journals

1 year 2 months ago
Science, Volume 389, Issue 6763, Page 890-892, August 2025.
Michael Funk, and Angela Hessler, Bianca Lopez, Michael A. Funk, Marc S. Lavine, Ian S. Osborne, Vadim Cherezov, Jack Huang, Annalisa VanHook, Jesse Smith, Mattia Maroso, Yevgeniya Nusinovich, Stella M. Hurtley, Sarah H. Ross, Sacha Vignieri, Christiana…