Aggregator
Daily briefing: There are two kinds of beer drinkers — these are the flavours that divide them
Trump called for ‘gold-standard science’: how the NIH, NSF and others are answering
Hundreds of suspicious journals flagged by AI screening tool
Spouses tend to share psychiatric disorders, massive study finds
The vibrant colours of a house-hunting crab — August’s best science image
Audio long read: How to detect consciousness in people, animals and maybe even AI
When will life expectancy reach 100? No time soon
Why scientists are flocking to Substack
How LinkedIn helped me to carve out a career path after my PhD
Research posts on Bluesky are more original — and get better engagement
Author Correction: Dual neuromodulatory dynamics underlie birdsong learning
Legal adviser warns NIH not to kill 900 grants a second time
Advice follows Supreme Court ruling that threatened previously restored grants, but reprieve may be brief
Stalagmites reveal devastating droughts that helped spur Maya breakdown
Series of droughts chronicled in cave rocks likely pushed civilization to breaking point
Trust in elections rises after ‘inoculations’ meant to preempt false fraud claims
New U.S.-Brazil study points to ways of countering election misinformation, political scientists say
Has a huge blob of dark matter been found in our galactic neighborhood?
If confirmed, vast cloud could test predictions about the Milky Way’s hidden architecture
AI enters the grant game, picking winners
Funders test algorithms to spot promising science, raising hopes of faster reviews—and fears of bias
<em>Erin Brockovich</em> toxic metal detected in air after LA fires
The unusually tiny particles of hexavalent chromium could pose a health hazard despite low levels, researchers say
Amyloid β-dependent neuronal silencing through synaptic decoupling
Amyloid β (Aβ)-dependent circuit dysfunction in Alzheimer's disease (AD) is determined by a puzzling mix of hyperactive and inactive ("silent") brain neurons. Recent studies identified excessive glutamate accumulation as a key Aβ-dependent determinant of hyperactivity. The cellular mechanisms underlying neuronal silence depend on both Aβ and tau protein pathologies, with an unknown role of Aβ. Here, by using single-cell-initiated rabies virus (RV) tracing in mouse models of β-amyloidosis, we...
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease
Recent discoveries reveal that post-translational modifications (PTMs) do more than regulate protein activity - they encode conformational states that transform chaperones into epichaperomes: multimeric scaffolds that rewire protein-protein interaction networks. This emerging paradigm expands the framework of chaperone biology in disease and provides a structural basis for systems-level dysfunction in disorders such as cancer and Alzheimer's disease. This review explores how PTMs within...
Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes
Aging increases the risk of a myriad of chronic diseases, which are expensive and difficult to treat owing to their various risk factors. Repurposing existing medications has accelerated the development of therapies aimed at slowing aging. In this study, using IMR90 cells and aged mice, we revealed that enalapril, a drug widely prescribed for hypertension, can improve both cellular senescence and individual health. Mechanistically, phosphorylated Smad1/5/9 act as pivotal mediators of the...