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CONCLUSION: Our results suggest that atrophy in aging- and AD-related cortical regions is associated with cognitive frailty. Plasma amyloid β42/β40-ratios were significantly lower in patients with frailty and cognitive frailty, suggesting that (pre-)frailty in general, rather than cognitive frailty specifically, is associated with AD-like changes. Hence, AD-related pathology seems to be associated with cognitive frailty, but the available data is not sufficient to indicate shared pathomechanisms...

CONCLUSIONS: Using BPS-RS II over I is recommended for biopsychosocial risk assessment and stratifying older people to interventions for population health management. The updated tool is theory-based, culturally sensitive to multi-ethnic contexts in Singapore, and shows improved associations with health-related outcomes, and strong associations with QoL.

BACKGROUND: There appears to be a lack of empirical investigation on how the public currently understands Parkinson's Disease (PD)and the impact this has on people with PD and their carers, across Ireland. This research hopes to build a greater public understanding of PD, reduce stigma and improve the quality of life for people with PD. The aim of this study is to (1) explore public perceptions, awareness and understanding about PD across the island of Ireland and (2) discover how this impacts...

CONCLUSION: With comprehensive preoperative evaluation and careful postoperative care, pancreatic surgery is safe for elderly patients in experienced pancreatic cancer centers.

CONCLUSION: This result highlights that interventions should be planned in order to reduce death anxiety among community-dwelling older adults by taking the attitude to ageing and the symptoms of depression into account.

BACKGROUND: Physical activity is a cornerstone of health for older adults. Recent evidence underscores that even regular light activity, such as routine walking, offers substantial health benefits. Traditional approaches to promoting walking often overlook the importance of the local neighbourhood environment and the wide range of abilities and preferences of older adults. A personalised walking intervention - emphasizing personal preferences and local facilitators by employing Geographic...

CONCLUSIONS: Despite the small/not representative sample size, the results highlight how, a built environment that is perceived as inadequate, could hamper ageing in place and participating in communities for frail seniors. This could be managed with appropriate interventions to be implemented taking into account the diversity between rural and urban sites.

Science, Volume 389, Issue 6755, July 2025.

Science, Volume 389, Issue 6755, July 2025.

Science, Volume 389, Issue 6755, July 2025.

Science, Volume 389, Issue 6755, July 2025.

Science, Volume 389, Issue 6755, July 2025.

Science, Volume 389, Issue 6755, July 2025.

Science, Volume 389, Issue 6755, July 2025.