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1 month 2 weeks ago
Science, Volume 391, Issue 6783, Page 364-365, January 2026.
Corinne Simonti, and Jesse Smith, Bianca Lopez, Yevgeniya Nusinovich, Joana Osório, Corinne Simonti, Ian S. Osborne, Jack Huang, and Jelena Stajic

Evaluating senescence-targeted approaches in Alzheimer's Disease: What we know and what lies ahead

1 month 2 weeks ago
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease, which represents the most prevalent dementia worldwide. Although amyloid-β (Aβ) and tau pathology have been the classic focus of treatment, accumulating evidence indicates that ageing-associated cellular senescence plays a central role in AD pathogenesis. Senescent neurons, astrocytes, microglia and endothelial cells accumulate in the ageing and Alzheimer's brain and adopt a senescence-associated secretory...
Pratik Prashant Doshi

Cell type-specific gene regulatory atlas prioritizes drug targets and repurposable medicines in Alzheimer's disease

1 month 2 weeks ago
Alzheimer's disease (AD) is a complex and poorly understood neurodegenerative disorder that lacks sufficiently effective treatments. Computational and integrative analyses that leverage multiomic data provide a promising strategy to uncover disease mechanisms and identify therapeutic opportunities. Here, we develop a cell type-specific regulatory atlas of the human middle temporal gyrus via leveraging single-nucleus RNA-seq (1,197,032 nuclei) and ATAC-seq (740,875 nuclei) data sets from 84...
Yunxiao Ren