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Brain Aging Mediating Heart Imaging-Derived Phenotypes and Mental and Nervous System Disorders
Mental and nervous system disorders often co-occur with cardiovascular diseases in aging populations, yet the biological relationships underlying these associations remain incompletely understood. Using heart and brain imaging data from 33,573 UK Biobank (UKB) participants, we developed a brain age prediction model to estimate the brain age gap (BAG), an imaging-based marker of brain aging. We then examined BAG as a mediator between 82 cardiac imaging-derived phenotypes (IDPs) and 11 disorders....
Beyond lifespan and healthspan: a biological framework for experienced longevity
Aging research has traditionally focused on lifespan and healthspan as primary outcome domains, implicitly treating chronological time as a uniform container of value. The memory-structured reconstruction of extended chronological intervals has not been systematically examined as an aging-related variable. I introduce experienced longevity, defined as the amount of lived time subjectively contained within a fixed chronological interval. Drawing on established distinctions between retrospective...
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Science, Volume 392, Issue 6796, April 2026.
Molecular solar thermal energy storage in Dewar pyrimidone beyond 1.6 megajoules per kilogram
Science, Volume 392, Issue 6796, April 2026.
Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex
Science, Volume 392, Issue 6796, April 2026.
A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex
Science, Volume 392, Issue 6796, April 2026.
An unrecognized mode of small particles in the lower stratosphere
Science, Volume 392, Issue 6796, April 2026.
Mapping transcription factor functions in astrocytes using in vivo gain-of-function Perturb-seq
Science, Volume 392, Issue 6796, April 2026.
Mechanical load inhibits cancer growth in mouse and human hearts
Science, Volume 392, Issue 6796, April 2026.