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Global influence of soil texture on ecosystem water limitation
Selection bias obfuscates the discovery of fast radio burst sources
Bureaucrat incentives reduce crop burning and child mortality in South Asia
Large-scale medieval urbanism traced by UAV–lidar in highland Central Asia
Anti-viral defence by an mRNA ADP-ribosyltransferase that blocks translation
This plankton balloons in size to soar upwards through the water
Why a fortunate few don’t get ill after HIV infection
Uncovering a lost mountain metropolis
Long-term lineage commitment in hematopoietic stem cell gene therapy
Publisher Correction: Using both faces of polar semiconductor wafers for functional devices
Molecular mechanism of IgE-mediated FcεRI activation
METTL3 governs thymocyte development and thymic involution by regulating ferroptosis
How to run a successful internship programme
Is it time to give up trying to save coral reefs? My research says no
DNA ‘printing press’ could quickly store mountains of data
Inspired by ancient invention of movable type, researchers use blocks of DNA to dramatically increase writing speed
Differentiating visceral sensory ganglion organoids from induced pluripotent stem cells
The ability to generate visceral sensory neurons (VSN) from induced pluripotent stem (iPS) cells may help to gain insights into how the gut-nerve-brain axis is involved in neurological disorders. We established a protocol to differentiate human iPS-cell-derived visceral sensory ganglion organoids (VSGOs). VSGOs exhibit canonical VSN markers, and single-cell RNA sequencing revealed heterogenous molecular signatures and developmental trajectories of VSGOs aligned with native VSN. We integrated...
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis
Senescent neural progenitor cells have been identified in brain lesions of people with progressive multiple sclerosis (PMS). However, their role in disease pathobiology and contribution to the lesion environment remains unclear. By establishing directly induced neural stem/progenitor cell (iNSC) lines from PMS patient fibroblasts, we studied their senescent phenotype in vitro. Senescence was strongly associated with inflammatory signaling, hypermetabolism, and the senescence-associated secretory...
Divergent regulation of long non-coding RNAs H19 and PURPL affects cell senescence in human dermal fibroblasts
Cellular senescence is a permanent cell growth arrest that occurs in response to various intrinsic and extrinsic stimuli and is associated with cellular and molecular changes. Long non-coding RNAs (lncRNAs) are key regulators of cellular senescence by affecting the expression of many important genes involved in senescence-associated pathways and processes. Here, we evaluated a panel of lncRNAs associated with senescence for their differential expression between young and senescent human dermal...
Aging and senescent fates of oligodendrocyte precursor cells in the mouse brain
Age-related changes in oligodendrocyte precursor cells (OPCs) contribute to white matter dysfunction. In aged mice, we hypothesized that myelin-dense fimbria OPCs possess niche-specific properties, compared to hippocampal OPCs. Aged fimbria OPCs were fewer, larger, and localized to neighboring microglia. We identified age-increased p16/Cdkn2a-expressing OPCs enriched for senescence-related pathways and distinct senescence signatures between hippocampus and fimbria. Aged brain OPC populations...
Metformin slows signs of primate aging
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