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Association of metabolomic aging acceleration and body mass index phenotypes with mortality and obesity-related morbidities
This study aims to investigate the association between metabolomic aging acceleration and body mass index (BMI) phenotypes with mortality and obesity-related morbidities (ORMs). 85,458 participants were included from the UK Biobank. Metabolomic age was determined using 168 metabolites. The Chronological Age-Adjusted Gap was used to define metabolomically younger (MY) or older (MO) status. BMI categories were defined as normal weight, overweight, and obese. Participants were categorized into MY...
Urolithin A and nicotinamide riboside differentially regulate innate immune defenses and metabolism in human microglial cells
INTRODUCTION: During aging, many cellular processes, such as autophagic clearance, DNA repair, mitochondrial health, metabolism, nicotinamide adenine dinucleotide (NAD+) levels, and immunological responses, become compromised. Urolithin A (UA) and Nicotinamide Riboside (NR) are two naturally occurring compounds known for their anti-inflammatory and mitochondrial protective properties, yet the effects of these natural substances on microglia cells have not been thoroughly investigated. As both UA...
A study of the correlation between sarcopenia and cognitive impairment in older individuals over 60 years: cross-sectional and longitudinal validation
CONCLUSION: There is a correlation between sarcopenia and cognitive function, individuals with sarcopenia performing poorly in overall cognition as well as refined dimensions. The degree of cognition like fluency degenerates over time with increasing severity of sarcopenia.
Daily briefing: How AI is decoding the calls of the wild
<b>Neanderthals and humans interbred more recently than scientists thought</b>
How a biochemistry department used redacted job applications to achieve gender parity
Mars rover makes epic climb to explore some of the oldest rocks in the Solar System
Earliest modern human genomes constrain timing of Neanderthal admixture
Author Correction: Early-childhood linear growth faltering in low- and middle-income countries
In good hands: A case for improving robotic dexterity
Science, Volume 386, Issue 6727, December 2024.
Making kidney tests work for everyone
Io’s tidal response precludes a shallow magma ocean
Author Correction: HRG-9 homologues regulate haem trafficking from haem-enriched compartments
In Science Journals
Science, Volume 386, Issue 6727, Page 1235-1237, December 2024.
Indigenizing conservation science for a sustainable Amazon
Science, Volume 386, Issue 6727, Page 1229-1232, December 2024.
The great work continues
Science, Volume 386, Issue 6727, Page 1193-1193, December 2024.
The long shot
Science, Volume 386, Issue 6727, Page 1208-1209, December 2024.
Breakdowns of the year
Science, Volume 386, Issue 6727, Page 1216-1217, December 2024.
Runners-up
Science, Volume 386, Issue 6727, Page 1210-1215, December 2024.
Study reveals kinship among first modern humans in Europe
Science, Volume 386, Issue 6727, Page 1207-1207, December 2024.