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Rock hunters, tree huggers and taxi drivers: Books in brief
Author Correction: Warming and cooling catalyse widespread temporal turnover in biodiversity
Ice-hunting Moon lander runs into trouble ― leaving scientists in suspense
A subcellular map of translational machinery composition and regulation at the single-molecule level
Science, Volume 387, Issue 6738, March 2025.
Historic manioc genomes illuminate maintenance of diversity under long-lived clonal cultivation
Science, Volume 387, Issue 6738, March 2025.
G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation
Science, Volume 387, Issue 6738, March 2025.
Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae
Science, Volume 387, Issue 6738, March 2025.
Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development
Science, Volume 387, Issue 6738, March 2025.
Tropical forests in the Americas are changing too slowly to track climate change
Science, Volume 387, Issue 6738, March 2025.
NIH will eliminate many peer-review panels and lay off some scientists overseeing them
Friday Trump Tracker: science rallies, last-minute job extensions, food safety panels killed
Follow President Donald Trump’s impact on U.S. research and science globally
RFK Jr. says federal vaccine advisers are beholden to industry. The evidence does not support him
A Science investigation finds no sign that members of a key CDC vaccine committee are compromised
Thousands gather across U.S. and world in Stand Up for Science events
Scientists and their supporters rallied across the country in response to layoffs and funding cuts ordered by the Trump administration
Panels giving scientific advice to Census Bureau disbanded by Trump administration
New commerce secretary tells advisers to federal statistical agencies that their mission has been “fulfilled”
USDA ordered to reinstate nearly 6000 fired workers
Temporary ruling brings relief, but could be followed by a new wave of firings
Hippocampal neural stem cell exosomes promote brain resilience against the impact of tau oligomers
A promising therapeutic intervention for preventing the onset and progression of Alzheimer's Disease (AD) is to protect and improve synaptic resilience, a well-established early vulnerability associated with the toxic effects of oligomers of Aβ (AβO) and Tau (TauO). We have previously reported that exosomes from hippocampal neural stem cells (NSCs) protect synapses against AβO. Here, we demonstrate how exosomes can also shield against TauO toxicity in adult mice synapses, potentially benefiting...
Retraction: Larson et al., "Soluble alpha-Synuclein is a Novel Modulator of Alzheimer's Disease Pathophysiology"
No abstract
Retraction: Larson et al., "The Complex PrP(c)-Fyn Couples Human Oligomeric Abeta with Pathological Tau Changes in Alzheimer's Disease"
No abstract
New mechanisms highlight the complex relationship of Apolipoprotein E and tau pathogenesis
A rare variant of Apolipoprotein E3 with neuroprotective properties has been identified in autosomal-dominant Alzheimer's disease. In this issue of Neuron, Chen et al.¹ show that direct interaction between this variant and tau blocks tau pathogenesis in rodent models.
Microglial mechanisms drive amyloid-beta clearance in immunized patients with Alzheimer's disease
Alzheimer's disease (AD) therapies utilizing amyloid-β (Aβ) immunization have shown potential in clinical trials. Yet, the mechanisms driving Aβ clearance in the immunized AD brain remain unclear. Here, we use spatial transcriptomics to explore the effects of both active and passive Aβ immunization in the AD brain. We compare actively immunized patients with AD with nonimmunized patients with AD and neurologically healthy controls, identifying distinct microglial states associated with Aβ...