Skip to main content

Aggregator

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox

11 months 2 weeks ago
Science, Volume 389, Issue 6756, Page 157-162, July 2025.
Laura F. DiGiovanni, Prabhsimran K. Khroud, Ruth E. Carmichael, Tina A. Schrader, Shivneet K. Gill, Kyla Germain, Robert Y. Jomphe, Christoph Wiesinger, Maxime Boutry, Maki Kamoshita, Daniel Snider, Garret Stubbings, Rong Hua, Noel Garber, Christian…

How short peptides disassemble tau fibrils in Alzheimer's disease

11 months 2 weeks ago
Reducing fibrous aggregates of the protein tau is a possible strategy for halting the progression of Alzheimer's disease (AD)¹. Previously, we found that in vitro, the D-enantiomeric peptide (D-peptide) D-TLKIVWC disassembles ultra-stable tau fibrils extracted from the autopsied brains of individuals with AD (hereafter, these tau fibrils are referred to as AD-tau) into benign segments, with no energy source other than ambient thermal agitation². To consider D-peptide-mediated disassembly as a...
Ke Hou

Plasma proteomics links brain and immune system aging with healthspan and longevity

11 months 2 weeks ago
Plasma proteins derived from specific organs can estimate organ age and mortality, but their sensitivity to environmental factors and their robustness in forecasting onset of organ diseases and mortality remain unclear. To address this gap, we estimate the biological age of 11 organs using plasma proteomics data (2,916 proteins) from 44,498 individuals in the UK Biobank. Organ age estimates were sensitive to lifestyle factors and medications and were associated with future onset (within 17...
Hamilton Se-Hwee Oh