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The contribution of de novo coding mutations to meningomyelocele
Oxidation of retromer complex controls mitochondrial translation
Glutamate gating of AMPA-subtype iGluRs at physiological temperatures
BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments
Solidification of Earth’s mantle led inevitably to a basal magma ocean
Phosphate-enabled mechanochemical PFAS destruction for fluoride reuse
A superbug rose to the top after gaining a chemical weapon
New lasso-shaped antibiotic kills drug-resistant bacteria
Long-term impact and biological recovery in a deep-sea mining track
AI is transforming peer review — and many scientists are worried
Empower families to lead the design of their ageing loved ones’ health care
Mathematician who reshaped theory of symmetry wins Abel Prize
Exclusive: NIH to cut grants for COVID research, documents reveal
Trump officials will screen NIH funding opportunities
Staff at biomedical agency worry about political interference in setting priorities
This isn’t a spaceship. It’s a cuttlefish ‘cloaked’ while hunting
Motion camouflage makes creatures invisible while stalking prey
AI models miss disease in Black and female patients
Analysis of chest x-rays underscores need for monitoring artificial intelligence tools for bias, experts say
Evidence from a Mendelian randomization study: Delirium's noncausal role in dementia onset
CONCLUSION: The results of the MR analysis suggest a potential causal link between dementia and an increased risk of delirium. Nevertheless, it should be emphasized that the existing evidence does not provide support for a causal connection in the reverse direction, implying that delirium may not play a causative role in the onset of dementia.
Induction of epithelial cell senescence by SERPINE1 derived from fibroblasts in the amnion at parturition
Senescence of amnion epithelial cells not only disrupts the fetal membrane structure, but also becomes a source of proinflammatory signals contributing to membrane inflammation at parturition. However, the trigger initiating their senescence awaits identification. In this study, we found that SERPINE1 abundance was significantly increased in the amnion at parturition, where SERPINE1 was found predominantly expressed in amnion fibroblasts. SERPINE1 from amnion fibroblasts induced amnion...
Abeta-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer's disease
The emergence of Aβ pathology is one of the hallmarks of Alzheimer's disease (AD), but the mechanisms and impact of Aβ in progression of the disease is unclear. The nuclear pore complex (NPC) is a multi-protein assembly in mammalian cells that regulates movement of macromolecules across the nuclear envelope; its function is shown to undergo age-dependent decline during normal aging and is also impaired in multiple neurodegenerative disorders. Yet not much is known about the impact of Aβ on NPC...
Structural features of DNA and their potential contribution to blind mole rat (Nannospalax xanthodon) longevity
Recent research has shifted the focus from the genetic code of DNA to its structural variations, which significantly impact cancer, genetic diseases, and gene regulation. Structural changes, such as the transition from B-DNA to A-DNA, influence DNA stability and flexibility and are affected by factors like DNA methylation and sugar puckering. This study is the first to investigate the relationship between DNA conformational changes and lifespan in two rodent species. The analysis focused on...