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State shifts in the deep Critical Zone drive landscape evolution in volcanic terrains
Volcanic provinces are among the most active but least well understood landscapes on Earth. Here, we show that the central Cascade arc, USA, exhibits systematic spatial covariation of topography and hydrology that are linked to aging volcanic bedrock, suggesting systematic controls on landscape evolution. At the Cascade crest, a locus of Quaternary volcanism, water circulates deeply through the upper [Formula: see text]1 km of crust but transitions to shallow and dominantly horizontal flow as...
The androgen clock is an epigenetic predictor of long-term male hormone exposure
Aging is a complex process characterized by biological decline and a wide range of molecular alterations to cells, including changes to DNA methylation. In this study, we used a male-specific epigenetic marker of aging to build an epigenetic predictor that measures long-term androgen exposure in sheep and mice (median absolute error of 4.3 and 1.4 mo, respectively). We term this predictor the androgen clock and show its "tick" is mediated by the androgen receptor and can be accelerated beyond...
Loss of HNRNPK During Cell Senescence Linked to Reduced Production of CDC20
Cellular senescence is a complex biological response to sublethal damage. The RNA-binding protein HNRNPK was previously found to decrease prominently during senescence in human diploid fibroblasts. Here, analysis of the mechanisms leading to reduced HNRNPK abundance revealed that in cells undergoing senescence, HNRNPK mRNA levels declined transcriptionally and full-length HNRNPK protein was progressively lost, while the abundance of a truncated HNRNPK increased. The ensuing loss of full-length...
Restoring bone healing potential
A combination of intermittent fasting and administering Wnt3a proteins to a bone injury can rejuvenate bone repair in aged mice.
Daily briefing: The science behind the deadly Los Angeles firestorm
Publisher Correction: Cohort trends in intrinsic capacity in England and China
‘Nicotine Nazis’: the brickbats hurled at scientists researching tobacco’s harms
‘Expansion microscopy’ turns ten: how a tissue-swelling method brought super-resolution imaging to the masses
A new vision for how evolution works is long overdue
PhD parents: the pros and cons of having a child during your doctorate
Did Pluto ‘kiss and capture’ its largest moon?
My work on quantum computing aims to solve the world’s most complex problems
Somatic mutation as an explanation for epigenetic aging
Why a silly-sounding name suits the serious mission of our biotech spin-off
Pictograms, comics and other illustrations: Books in brief
Why the ‘Ferrari of viruses’ is surging through the Northern Hemisphere
Norovirus, which causes explosive diarrhea and vomiting, may be on the rise because of an antibody-dodging variant and post–COVID-19 socializing
In sign of rising tensions, University of Michigan ends partnership with Chinese campus
Republicans in Congress had raised concerns about work with Shanghai Jiao Tong University
‘Absolutely insane.’ Dragonfly’s extreme loop-the-loops are unparalleled in nature
Insects use “crazy turning” to dry off after a cooling dip in water
Scientists reveal 1200-year-old mummies’ tattoos in stunning detail
Inked skin from the Chancay culture shows tattooing rivaled other forms of art in complexity
The investigation of peripheral inflammatory and oxidative stress biomarkers in dementia with Lewy Bodies, compared with Alzheimer's Disease, and mild cognitive impairment
Although inflammation and oxidative stress have been increasingly recognised as components of Alzheimer's disease (AD) and Parkinson's disease (PD) pathologies. Few studies have investigated peripheral inflammation, and none have examined oxidative stress in Dementia with Lewy bodies (DLB). The purpose of our study was to characterize and compare those biomarkers in DLB with those in AD and amnestic mild cognitive impairment (aMCI). Plasma samples were obtained from Chinese patients with DLB (n...