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11 months 2 weeks ago
Science, Volume 386, Issue 6724, Page 863-864, November 2024.

Corinne Simonti, and
Jesse Smith,
Jesse Smith,
Di Jiang,
Madeleine Seale,
Mattia Maroso,
Sacha Vignieri,
Brad Wible, and
Jake S. Yeston

Ship collision risk threatens whales across the world’s oceans

11 months 2 weeks ago
Science, Volume 386, Issue 6724, Page 870-875, November 2024.
Anna C. Nisi, Heather Welch, Stephanie Brodie, Callie Leiphardt, Rachel Rhodes, Elliott L. Hazen, Jessica V. Redfern, Trevor A. Branch, Andre S. Barreto, John Calambokidis, Tyler Clavelle, Lauren Dares, Asha de Vos, Shane Gero, Jennifer A. Jackson,…

Whole-brain spatial transcriptional analysis at cellular resolution

11 months 2 weeks ago
Science, Volume 386, Issue 6724, Page 907-915, November 2024.
Shigeaki Kanatani, Judith C. Kreutzmann, Yue Li, Zoe West, Lea Lydolph Larsen, Danai Vougesi Nikou, Ilse Eidhof, Abigail Walton, Songbai Zhang, Leslie Rubio Rodríguez-Kirby, Jacob Lercke Skytte, Casper Gravesen Salinas, Kimiharu Takamatsu, Xiaofei Li,…

Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency

11 months 3 weeks ago
Progranulin (PGRN) deficiency is linked to neurodegenerative diseases, including frontotemporal dementia (FTD), Alzheimer's disease, and Parkinson's disease. Proper PGRN levels are critical for brain health; however, the function of PGRN is unclear. PGRN is composed of 7.5 repeat domains, called granulins, and processed into granulins inside the lysosome. PGRN is beneficial for neuronal health, but the role of individual granulins is controversial and unclear. We find that the expression of...
Jessica Root