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Exergames (EG) are interactive video games that require physical activity and use gamification to make exercise more engaging. EG interventions demonstrated various benefits for older adults including improved mental health, quality of life, and a reduced risk of falls. Enhanced cognition is considered one of the principal targets driving these benefits. This systematic review aimed to identify the neurobiological effects of EG interventions in healthy older adults and those with neurocognitive...

Osteoimmunology is an interdisciplinary study of the interaction between the immune system and the skeletal system, aiming to reveal the immune regulation mechanisms that affect bone health and disease. Aging is a macro concept, which is not limited to the senescence of cells, but also includes the aging of the body as a whole. Studies have shown that aging can affect osteoimmune function through various mechanisms such as affecting the bone marrow microenvironment, causing immune cell...

Aging is a multifactorial process characterized by cellular dysfunction and increased susceptibility to age-related diseases. The interplay between autophagy and inflammasome has emerged as a critical factor influencing the aging process. Autophagy, which is responsible for degrading damaged cellular components, declines with age, leading to the accumulation of dysfunctional organelles and misfolded proteins. At the same time, the inflammasome, a key mediator of inflammatory responses, becomes...

OBJECTIVES: Investigate whether engaging in cognitive and physical activity is associated with cognitive performance and gray matter volume. Specifically, this study investigated the role of both activity types performed in close temporal proximity to each other.

Low back pain (LBP), primarily driven by intervertebral disc degeneration (IVDD), has become a core challenge in public health. DDX1, an RNA-binding protein, plays key roles in RNA metabolism but its function in IVDD remains unclear. We identify DDX1 as a substrate of methyltransferase EZH2, which methylates DDX1 at lysine 234 (K234), promoting IVDD in vitro and in vivo. EZH2 inhibition restores matrix homeostasis in nucleus pulposus (NP) cells and slows IVDD progression. Methylation at DDX1...

The autonomic nervous system (ANS) plays a pivotal role in regulating organ functions through descending brain-to-body signalling. The pathways involved are broadly categorized into two major branches: the sympathetic nervous system, which mediates 'fight or flight' responses, and the parasympathetic nervous system, which governs 'rest and digest' functions. Historically, the ANS was considered to mediate simple motor functions with limited neurochemical diversity. However, recent advances in...

CONCLUSION: The results indicate that clean energy use among older adults in China is regionally unbalanced and affected by various internal and external factors. Strategies to improve clean energy utilization among elderly adults in China should focus on rural areas with low socioeconomic levels and poorer health and living conditions.

CONCLUSIONS: Prolonged sitting time is significantly associated with accelerated aging, systemic immune-inflammation index and creatinine levels play important mediating roles in this process.

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B-1a cells, a self-renewing B cell subset essential for innate immunity, produce natural IgM antibodies that defend against pathogens, yet mechanisms sustaining their maintenance during aging remain unclear. We report that aging B-1a cells exhibit hallmarks of decline, including DNA damage, apoptosis, and reduced proliferation, with striking sex-specific disparities: aged females retain higher B-1a cell numbers than males, correlating with enhanced glycolysis and chromatin accessibility. Motif...

CONCLUSION: Cognitive status influences physical function in older adults. Identifying physical indicators linked to cognitive decline may improve screening efforts in clinical trials.

Aging is a prominent risk factor for heart disease, driving pathological cardiac changes such as hypertrophy, fibrosis, and cellular senescence. While BubR1 has been linked to systemic aging in mammalian models, its specific role in regulating cardiac aging remains unclear. Here, we investigated how BubR1 regulates heart aging and its potential contribution to the pathogenesis of cardiac disease, including heart failure. BubR1 insufficiency in mice resulted in marked cardiac hypertrophy,...

We examined the socioeconomic and health characteristics of centenarians (100 years or above) and near-centenarians (90-99 years) in India. Utilizing data from the Wave-1 of the Longitudinal Ageing Study of India (LASI), we compared the distribution of centenarians and near-centenarians with those aged 60-89 years across socioeconomic, health, and subjective well-being indicators. Our findings revealed that most of the sample centenarians and near-centenarians were female, educated, and widowed....

Dopaminergic neurons in the ventral midbrain are critical for regulating movement, cognition, and emotion. Ventral midbrain organoids can be used to model both development and diseases of the dopaminergic system, especially Parkinson's disease. Here, we summarize recent advances and remaining challenges in developing such three-dimensional organoids from human pluripotent stem cells. We outline how ventral midbrain organoid systems have progressed from early three-dimensional culture models to...

From fertilization onwards, the cells of the human body acquire variations in their DNA sequence, known as somatic mutations. These postzygotic mutations arise from intrinsic errors in DNA replication and repair, as well as from exposure to mutagens. Somatic mutations have been implicated in some diseases, but a fundamental understanding of the frequency, type and patterns of mutations across healthy human tissues has been limited. This is primarily due to the small proportion of cells...

Acute inflammation is an essential response that our bodies use to combat infections¹. However, in the absence of infections, chronic inflammation can have a pivotal role in the onset and progression of chronic diseases, such as arthritis, cancer, autoimmune disorders, metabolic-dysfunction-associated steatohepatitis (MASH), and most ageing-associated pathologies^(2,3). The underlying mechanisms that distinguish chronic inflammation from its acute counterpart remain unclear, posing challenges to...

CONCLUSIONS: This study combines the Kano Model with the self-designed needs questionnaire to systematically classify and rank the health information needs of older patients with chronic diseases by priority. The results provide a novel analytical framework for related research. By clarifying the satisfaction paths of different types of needs, the study can serve as a valuable guide for optimising service supply and promoting the efficient allocation of health information resources. In...

CONCLUSION: This study confirmed the role of public health services in shaping the health lifestyles of older adults, so as to promote healthy aging. The study also has limitations in the comprehensive assessment of health lifestyles, causal inference, and the acquisition of recent data.

CONCLUSIONS: This research provides critical insights for global policymakers facing similar demographic challenges, advocating for a resilient, holistic, and inclusive aged care system.

CONCLUSIONS: This study offers a practical and interpretable predictive model for sarcopenia, highlighting key modifiable risk factors such as BMI and sleep duration. The findings underscore the critical need for evidence-based, individualized prevention strategies and a multidisciplinary approach to mitigate sarcopenia in aging populations.