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Science, Volume 389, Issue 6755, Page 48-52, July 2025.

Science, Volume 389, Issue 6755, Page 84-91, July 2025.

Science, Volume 389, Issue 6755, Page 35-35, July 2025.

Science, Volume 389, Issue 6755, Page 36-36, July 2025.

Science, Volume 389, Issue 6764, Page 1003-1011, September 2025.

Science, Volume 389, Issue 6761, Page 736-740, August 2025.

The halt will let Taylor &Francis focus on checking Bioengineered’s papers for fraudulent works and paid authorships

A policy tweak to the ban on foreign “subawards” should allow clinical trials worldwide to continue

Cells from human brain tissue have genetic hallmarks of neural progenitors, AI-aided study finds

Found in China, 300,000-year-old digging sticks reveal a lost technology

Cognitive scientists question new Centaur model’s ability to predict human behavior

In recent years, acquired brain injuries (ABIs) have been implicated in the development and pathogenesis of dementia; however, existing data is conflicting and often lacks precise classifications or comprehensive analyses. This review sought to synthesize available evidence to assess the association between four major ABI types-traumatic brain injury (TBI), cerebral atherosclerosis (AS), intracranial hemorrhage, and ischemic stroke-and risk of subsequent all-cause dementia (ACD) and dementia...

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mRNA-based in vivo chimeric antigen receptor (CAR)-T cell engineering offers advantages over ex vivo therapies, including streamlined manufacturing and transient expression. However, current delivery methods require antibody-modified vehicles with manufacturing challenges. In this study, inspired by cardiolipin, we identify cardiolipin-like di-phosphoramide lipids that improve T cell transfection without targeting ligands, both in vitro and in vivo. The T cell-favored tropism is likely due to...

Perturbing mitochondrial translation represents a conserved longevity intervention, with proteostasis processes proposed to mediate the resulting lifespan extension. Here, we explore whether other mechanisms may contribute to lifespan extension upon mitochondrial translation inhibition. Using multi-omics and functional in vivo screening, we identify the ethylmalonyl-CoA decarboxylase orthologue C32E8.9 in C. elegans as an essential factor for longevity induced by mitochondrial translation...

Aging is a dominant risk factor for atherosclerotic cardiovascular disease and is associated with compositional and functional changes in our immune system, called immunosenescence. To gain insights into the impact of immunosenescence on atherosclerosis, we investigated plaque development and the immune landscape in an AAV-PCSK9 mouse model. Young (3 months) and aged (18 months) male C57Bl/6 mice received a single i.v. injection of a recombinant adeno-associated virus encoding murine PCSK9...

Brain metastasis occurs in up to 40% of patients with non-small cell lung cancer (NSCLC). Considerable genomic heterogeneity exists between the primary lung tumor and respective brain metastasis; however, the identity of the genes capable of driving brain metastasis is incompletely understood. Here, we carried out an in vivo genome-wide CRISPR activation screen to identify molecular drivers of brain metastasis from an orthotopic xenograft model derived from a patient with NSCLC. We found that...

SARS-CoV-2-neutralizing antibody titers serve as immune correlates of protection against COVID-19; however, the durability varies among vaccinees. Here, we demonstrate that the durability of vaccine-boosted antibody responses is closely correlated with the pre-booster capacity of spike-reactive CD4^(+) T cells to produce interleukin (IL)-2 and T helper type 2 (Th2) cytokines. IL-2 production by CD4^(+) T cells was also associated with extensive B cell clonal expansion, which preceded the durable...

The taurine transporter (TAUT) mediates cellular taurine uptake, playing a critical role in human health and longevity. In this study, we present cryogenic electron microscopy structures of both mouse and human TAUT in various conformational states. The taurine-bound, occluded forms of mouse and human TAUT reveal the substrate binding pocket and the ion binding sites. The amino group of taurine interacts with Glu406 at the binding site, constituting a key structural feature determining substrate...

The morphological features of particles, notably shape anisotropy, critically influence the rheological properties of dense suspensions, spanning both natural and engineered systems. This work explores the potential of using shape memory particles to dynamically regulate suspension fluid flow through controllable shape transformations. First, we synthesize shape-memory particles with programmable anisotropy from liquid crystal elastomers, such that the stiffness and shapes of the particles can...