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Plants Facing the Heat
Science, Volume 388, Issue 6752, Page 1146-1147, June 2025.
Global importance of nitrogen fixation across inland and coastal waters
Science, Volume 388, Issue 6752, Page 1205-1209, June 2025.
Observed trend in Earth energy imbalance may provide a constraint for low climate sensitivity models
Science, Volume 388, Issue 6752, Page 1210-1213, June 2025.
Antagonism as a foraging strategy in microbial communities
Science, Volume 388, Issue 6752, Page 1214-1217, June 2025.
Differential absorption of circularly polarized light by a centrosymmetric crystal
Science, Volume 388, Issue 6752, Page 1194-1197, June 2025.
RNA transcripts regulate G-quadruplex landscapes through G-loop formation
Science, Volume 388, Issue 6752, Page 1225-1231, June 2025.
Gate-driven band modulation hyperdoping for high-performance p-type 2D semiconductor transistors
Science, Volume 388, Issue 6752, Page 1183-1188, June 2025.
Pan-viral ORFs discovery using massively parallel ribosome profiling
Science, Volume 388, Issue 6752, Page 1218-1224, June 2025.
Rapid model-guided design of organ-scale synthetic vasculature for biomanufacturing
Science, Volume 388, Issue 6752, Page 1198-1204, June 2025.
Dark matters
Science, Volume 388, Issue 6752, Page 1141-1141, June 2025.
North America’s last prairies
Science, Volume 388, Issue 6752, Page 1142-1142, June 2025.
Physicists’ hopes for an exotic muon collider get a boost
U.S. should plan to build machine to hunt for new subatomic particles, National Academies report says
Trump’s cuts to more than 1700 NIH grants get court hearing
District judge could declare terminations unlawful—or toss suit based on technicalities
Tropical forests are heating up. Can they cope?
Scientists are pushing plants beyond their comfort zone to test their resilience to warming
Climate change threatens India-Pakistan pact over major river system
Warming world could further heighten tensions over access to Indus River waters
Historical records expose role of Black inmates in unethical malaria studies decades ago
Science chats with James Tabery about the overlooked role of Black prisoners in understanding the genetics of drug reactions
Newly discovered plant genes could slash cost of making key cancer drug
Shifting production from yew trees to yeast could lead to cheaper synthesis of Taxol precursor
This brain implant lets a man who lost his speech to ALS produce natural-sounding sentences instantaneously
New brain-computer interface allows control of intonation, and generates a person’s voice at the speed of typical speech
‘Dragon prince’ dinosaur may be missing link in <em>T. rex</em> evolution
Newly described fossils point to ancient movement between Asia and North America
Massively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition state
Amyloid aggregates are pathological hallmarks of many human diseases, but how soluble proteins nucleate to form amyloids is poorly understood. Here, we use combinatorial mutagenesis, a kinetic selection assay, and machine learning to massively perturb the energetics of the nucleation reaction of amyloid-β (Aβ42), the protein that aggregates in Alzheimer's disease. In total, we measure the nucleation rates of >140,000 variants of Aβ42 to accurately quantify the changes in free energy of...