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Magnetically programmed diffractive robotics
Science, Volume 386, Issue 6725, Page 1031-1037, November 2024.
Aromatic-aliphatic hydrocarbon separation with oriented monolayer polyhedral membrane
Science, Volume 386, Issue 6725, Page 1037-1042, November 2024.
Suppression of neurons in circumventricular organs enables months-long survival without water in thirteen-lined ground squirrels
Science, Volume 386, Issue 6725, Page 1048-1055, November 2024.
A tetramer of BCL11A is required for stable protein production and fetal hemoglobin silencing
Science, Volume 386, Issue 6725, Page 1010-1018, November 2024.
Identification of a factor that accelerates substrate release from the signal recognition particle
Science, Volume 386, Issue 6725, Page 996-1003, November 2024.
Footprint evidence for locomotor diversity and shared habitats among early Pleistocene hominins
Science, Volume 386, Issue 6725, Page 1004-1010, November 2024.
DNA and deli sandwiches
Science, Volume 386, Issue 6725, Page 978-979, November 2024.
The philosopher’s intuition
Science, Volume 386, Issue 6725, Page 980-980, November 2024.
Natural selection could determine whether Acropora corals persist under expected climate change
Science, Volume 386, Issue 6727, Page 1289-1294, December 2024.
Ancient footprints capture coexistence of two kinds of human ancestor
About 1.5 million years ago, early members of our genus Homo walked along a lakeshore in Africa within hours of another kind of hominin, likely Paranthropus
News at a glance: Pterosaur clues, AI’s risks to biosecurity, and graduate students’ mental health
The latest in science and policy
War-torn Ukraine has become a breeding ground for lethal drug-resistant bacteria
Urgent action underway to prevent dangerous microbes from spreading beyond country's borders
Controversial health economist is Trump’s pick to head NIH
Researchers have mixed views on nomination of Jay Bhattacharya to head biomedical research agency
Gene behind orange fur in cats found at last
After 60 years, scientists know why gingers, calicos, and tortoiseshells look the way they do
Dino droppings reveal how the giant beasts came to dominate Earth
Most comprehensive study yet of dinos’ poop and vomit traces their rise in Poland
The immunomodulatory effects of psychedelics in Alzheimer's disease-related dementia
Dementia is an increasing disorder, and Alzheimer's disease (AD) is the cause of 60% of all dementia cases. Despite all efforts, there is no cure for stopping dementia progression. Recent studies reported potential effects of psychedelics on neuroinflammation during AD. Psychedelics by 5HT(2A)R activation can reduce proinflammatory cytokine levels (TNF-α, IL-6) and inhibit neuroinflammation. In addition to neuroinflammation suppression, psychedelics induce neuroplasticity by increasing...
Chronic Nf-kappaB Inhibition Prevents Experimental Aging Nephropathy
Introduction The pathogenesis of aging nephropathy is yet to be elucidated. Intrarenal Angiotensin-II (AngII) and activation of the NF-κB and NLRP3 inflammasome pathways exert a relevant pathogenic role in the progression of chronic kidney disease (CKD). We sought to investigate whether monotherapy with Losartan and combined treatment with Losartan and the NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC) would attenuate experimental aging nephropathy. Materials and Methods Forty adult Male...
Cerebral white matter hyperintensity volumes: Normative age- and sex-specific values from 15 population-based cohorts comprising 14,876 individuals
White matter hyperintensities (WMH) increase with age, with marked interindividual variation. There is a need for normative data by age and sex, to improve individualized WMH burden assessment. In this study, we pooled cross-sectional data from 15 population-based cohorts (14,876 nondemented individuals, age 18-97 years), through the Meta VCI Map consortium. Whole brain and tract-specific MRI-assessed WMH volumes were calculated in MNI-152 space. We used quantile regression to create centile...
Sex-specific poor physical performance in Korean community-dwelling older adults
CONCLUSIONS: Most main outcome measures in physical performance worsened over time across age groups while poor performance pattern was different between older males (strength) and females (functional mobility). We highlighted the importance of assessing strength, functional mobility, and postural control in older adults. Based on observed poor performance patterns across age groups by sex, sex-specific interventions should be implemented.
Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance
Mitochondrial calcium (mtCa^(2+)) uptake via the mitochondrial calcium uniporter (MCU) couples calcium homeostasis and energy metabolism. mtCa^(2+) uptake via MCU is rate-limiting for mitochondrial activation during muscle contraction, but its pathophysiological role and therapeutic application remain largely uncharacterized. By profiling human muscle biopsies, patient-derived myotubes, and preclinical models, we discovered a conserved downregulation of mitochondrial calcium uniporter regulator...