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Design of customized coronavirus receptors
Scalable ultrastrong MXene films with superior osteogenesis
Polyclonality overcomes fitness barriers in <i>Apc</i>-driven tumorigenesis
Smooth trends in fermium charge radii and the impact of shell effects
Polyclonal-to-monoclonal transition in colorectal precancerous evolution
The midlife crisis is not universal
How to recover from the trauma of a climate disaster
Endogenous self-peptides guard immune privilege of the central nervous system
Pharmacologic restoration of GTP hydrolysis by mutant RAS
Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture
Nine reasons we love our spooky, kooky model organisms
How to demonstrate the real-world impact of your research
What’s so special about the human brain? A graphical guide
How to recover when a climate disaster destroys your city
For sale: baby shoes, worn way too often
Chinese scientists say funding shake-up has made it harder to win grants
Researchers ‘in a state of panic’ after Robert F. Kennedy Jr. says Trump will hand him health agencies
Former presidential candidate holds extreme views on vaccines, disease research, drug regulation
Isotschimgine promotes lifespan, healthspan and neuroprotection of Caenorhabditis elegans via the activation of nuclear hormone receptors
Isotschimgine (ITG) is a bornane-type monoterpenoid derivative naturally occurring in genus Ferula plants and propolis. Its effects on aging and the underlying mechanisms are not yet well understood. This study employed Caenorhabditis elegans (C. elegans) as a model organism to evaluate the potential of ITG in extending lifespan, enhancing healthspan, and promoting neuroprotection, while exploring the underlying mechanisms involved. The results showed that ITG extended the lifespan and...
Decoding the impact of ageing and environment stressors on skin cell communication
The integumentary system serves as a crucial protective barrier and is subject to complex signaling pathways that regulate its physiological functions. As the body's first line of defense, the skin is continuously exposed to environmental stressors, necessitating a robust network of signaling molecules to maintain homeostasis. Considering the main cellular components to be keratinocytes, melanocytes, fibroblasts, and fibrous components, collagen of various types, this review explores the...
The evolution of ageing: classic theories and emerging ideas
Ageing is generally regarded as a non-adaptive by-product of evolution. Based on this premise three classic evolutionary theories of ageing have been proposed. These theories have dominated the literature for several decades. Despite their individual nuances, the common thread which unites them is that they posit that ageing results from a decline in the intensity of natural selection with chronological age. Empirical evidence has been identified which supports each theory. However, a consensus...