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The role of inhibitory and excitatory neurometabolites in age-related differences in action selection
Aging is accompanied by changes in the level of neurometabolites. However, their role in vital behavioral functions is still unclear. We aimed to explore the impact of aging on the neurochemical mechanisms underlying action selection. Young (YA) (n = 25) and older adults (OA) (n = 26) performed a simple (SRT) and a choice (CRT) reaction time tasks. Magnetic resonance spectroscopy was utilized to track task-induced modulations in GABA and glutamate in the sensorimotor cortex (SM1) and...
Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage
The Human BioMolecular Atlas Program (HuBMAP) aims to construct a 3D Human Reference Atlas (HRA) of the healthy adult body. Experts from 20+ consortia collaborate to develop a Common Coordinate Framework (CCF), knowledge graphs and tools that describe the multiscale structure of the human body (from organs and tissues down to cells, genes and biomarkers) and to use the HRA to characterize changes that occur with aging, disease and other perturbations. HRA v.2.0 covers 4,499 unique anatomical...
Exercise-Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart
The lymphatic vasculature plays essential roles in fluid balance, immunity, and lipid transport. Chronic, low-grade inflammation in peripheral tissues develops when lymphatic structure or function is impaired, as observed during aging. While aging has been associated with a broad range of heart pathophysiology, its effect on cardiac lymphatic vasculature has not been characterized. Here, we analyzed cardiac lymphatics in aged 20-month-old mice versus young 2-month-old mice. Aged hearts showed...
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Identification of antigen-presenting cell–T cell interactions driving immune responses to food
Science, Volume 387, Issue 6739, March 2025.
Evolutionary adaptations of doublet microtubules in trypanosomatid parasites
Science, Volume 387, Issue 6739, March 2025.
Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms
Science, Volume 387, Issue 6739, March 2025.
Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling
Science, Volume 387, Issue 6739, March 2025.
Tunneling nanotube–like structures regulate distant cellular interactions during heart formation
Science, Volume 387, Issue 6739, March 2025.
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Structure of human PINK1 at a mitochondrial TOM-VDAC array
Mutations in the ubiquitin kinase PINK1 cause early onset Parkinson's Disease, but how PINK1 is stabilized at depolarized mitochondrial translocase complexes has remained poorly understood. We determined a 3.1-Å resolution cryo-electron microscopy structure of dimeric human PINK1 stabilized at an endogenous array of mitochondrial TOM and VDAC complexes. Symmetric arrangement of two TOM core complexes around a central VDAC2 dimer is facilitated by TOM5 and TOM20, both of which also bind PINK1...
Polypharmacy and its association with dementia, Parkinson's disease, and mortality risk in UK adults: a multistate modeling approach
Polypharmacy is common among older adults and has been linked to adverse outcomes such as dementia, Parkinson's disease (PD), and mortality. However, its influence on transitions between these health states remains understudied in large, population-based cohorts. Using data from 361,970 UK Biobank participants aged 50 and older with up to 15 years of follow-up, we examined the association between polypharmacy, defined as the use of five or more medications, and transitions between health states:...