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Publisher Correction: A metagenomic ‘dark matter’ enzyme catalyses oxidative cellulose conversion
NIH has cut one mRNA-vaccine grant. Will more follow?
‘Boggles the mind’: US defence department slashes research on emerging threats
Author Correction: AI models collapse when trained on recursively generated data
Author Correction: Heritable polygenic editing: the next frontier in genomic medicine?
A systematic review with a Burden of Proof meta-analysis of health effects of long-term ambient fine particulate matter (PM<sub>2.5</sub>) exposure on dementia
Alarmingly large care deficits globally for people living with dementia and disability
‘All this is in crisis’: US universities curtail staff and spending as Trump cuts take hold
Ship-pollution cuts have an electrifying effect: less lightning at sea
The Sikkim flood of October 2023: Drivers, causes, and impacts of a multihazard cascade
Science, Volume 387, Issue 6740, March 2025.
Unifying spatial scaling laws of biodiversity and ecosystem stability
Science, Volume 387, Issue 6740, March 2025.
Epithelial polarization by the planar cell polarity complex is exclusively non–cell autonomous
Science, Volume 387, Issue 6740, March 2025.
Synaptic architecture of a memory engram in the mouse hippocampus
Science, Volume 387, Issue 6740, March 2025.
Regulatory T cells constrain T cells of shared specificity to enforce tolerance during infection
Science, Volume 387, Issue 6740, March 2025.
One red square can change your entire perception of the world
New film explores how scientists see nature differently from each other—and from everyone else
Watch these ‘liquid marbles’ pull off a daring heist
Water-resistant armor gives delicate water droplets the nimbleness of white blood cells
Biomedical research takes hits in U.S. budget deal
Programs at NIH and Defense Department are pared back by bill that keeps funding at 2024 levels
Debate erupts around Microsoft’s blockbuster quantum computing claims
Physicists cast doubt on measurements validating Microsoft’s first quantum chip, Majorana 1
Sexual dimorphism in cerebrovascular dysfunction: The pivotal role of endothelial CD2AP in Alzheimer's disease
Why there is sex-biased susceptibility to cerebrovascular dysfunction remains enigmatic. Vandal et al.¹ reveal a sex-specific vulnerability to endothelial deficiency in CD2AP, an Alzheimer's disease risk gene, with impaired cerebrovascular reactivity, compromised cerebrovascular function, and cognitive decline, highlighting sex as an important biological variable in Alzheimer's disease.
APOE genotype determines cell-type-specific pathological landscape of Alzheimer's disease
The apolipoprotein E (APOE) gene is the strongest genetic risk modifier for Alzheimer's disease (AD), with the APOE4 allele increasing risk and APOE2 decreasing it compared with the common APOE3 allele. Using single-nucleus RNA sequencing of the temporal cortex from APOE2 carriers, APOE3 homozygotes, and APOE4 carriers, we found that AD-associated transcriptomic changes were highly APOE genotype dependent. Comparing AD with controls, APOE2 carriers showed upregulated synaptic and...