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Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression
It has been established that N-acetyltransferase (murine NAT1 (mNAT1) and human NAT2 (hNAT2)) mediates insulin sensitivity in type 2 diabetes. Here we show that mNAT1 deficiency leads to a decrease in cellular spermidine-a natural polyamine exhibiting health-protective and anti-ageing effects-but understanding of its mechanism is limited. We identify that mNAT1 and hNAT2 modulate a type of post-translational modification involving acetylated spermidine, which we name acetylhypusination, on...
Association of low socioeconomic status with cognitive decline among older persons in underdeveloped areas in China - a data analysis of the Gansu aging study
CONCLUSION: This study suggested that, approximately one-quarter of older persons suffered from CI in Gansu, China. Low SES was substantially associated with risk of CI. Although interventions to modify traditional risk factors may decrease the risk of CI, disparities by SES may remain without addressing SES itself.
Sequential multiple mediating effect of loneliness and family health on physical frailty and willingness to age at home in older adults: a national survey in China
CONCLUSIONS: Reducing physical frailty in older adults, reducing their sense of loneliness, and enhancing their family health is essential, as it can increase their levels of confidence with regard to ageing at home.
Older patients affected by COVID-19: investigating the existence of biological phenotypes
CONCLUSION: Biological phenotypes might be used to identify different clinical and functional phenotypes in individuals affected by COVID-19.
Exploring the barriers to the development of organizational health literacy in health institutions to meet the needs of older patients from multiple perspectives: a mixed-methods study
CONCLUSION: The two most vulnerable aspects of OHL in medical institutions regarding the needs of older patients are health information and communication. The factors influencing the construction of OHL in medical institutions are multifaceted, encompassing micro, meso, and macro levels. At the macro level, it is essential for medical institutions to enhance leadership awareness of OHL and to incorporate its development into institutional strategic plans. At the meso-level, medical institutions...
Surprising identities of Pompeii victims rewrite stories from the cataclysm
Ancient DNA reveals victims may not have spent their last moments with close family, as long suspected
Cat brains age like ours - and could help scientists to understand cognitive decline
No abstract
Factors associated with the occupational balance in caregivers of people with dementia: A cross-sectional study from the ATENEA project
CONCLUSIONS: This study identified several associated factors with the OB of CGs of persons with dementia. Specifically, we remarked that the CGs' education, employment status, household chores assistance, overload presence, psychological distress symptoms and the functional level of the person with dementia who cared for were important variables that should be considered when evaluating OB or creating OB-related interventions in CGs.
Daily briefing: World’s first wooden satellite heads for space
Will South Africa become first country to accept controversial form of human genome editing?
Why do wet dogs shake themselves dry? Neuroscience has an answer
First DNA from Pompeii body casts illuminates who victims were
New CERN chief pledges to forge ahead with $17-billion supercollider
Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1
Author Correction: Three-dimensional wave breaking
Modifiable risk factors of dementia in Latin America
A case for altruistic cities
Science, Volume 386, Issue 6722, November 2024.
Activation of a helper NLR by plant and bacterial TIR immune signaling
Science, Volume 386, Issue 6728, Page 1413-1420, December 2024.
Ultrafast all-optical coherence of molecular electron spins in room-temperature water solution
Science, Volume 386, Issue 6724, Page 888-892, November 2024.
A canonical protein complex controls immune homeostasis and multipathogen resistance
Science, Volume 386, Issue 6728, Page 1405-1412, December 2024.