ScienceDaily Health

Some people live past 100 with remarkable health, and researchers may have uncovered one reason why. A new study found that centenarians have a unique chemical "fingerprint" in their blood that sets them apart from normal aging, including unusual patterns of bile acids and steroids linked to longer survival.

A UCLA study has identified a hidden Achilles' heel in aggressive small cell cancers that have resisted new treatments for decades. Scientists found that tumors lacking the RB gene become critically dependent on the protein E2F3 for survival. Blocking E2F3 shut down tumor growth in laboratory models, and existing FDA-approved drugs may be able to exploit this vulnerability. The discovery could pave the way for faster development of more effective therapies.

A new intranasal DNA vaccine may give the immune system an extra weapon against tuberculosis by targeting bacteria that can hide from antibiotics. In animal studies, it helped clear infections faster, reduced lung inflammation, and prevented relapse after treatment. The vaccine also enhanced the performance of drugs used against drug-resistant TB.

Using alcohol to cope with stress when young may permanently alter the brain, making it harder to adapt to challenges and increasing the risk of returning to drinking later in life. Researchers also found signs of brain damage associated with early dementia, suggesting the effects can linger long after alcohol use has stopped.

Some brains appear to fight back against Alzheimer's by helping immature brain cells survive damage instead of succumbing to it. Understanding this natural resilience could point researchers toward entirely new ways to protect memory and slow dementia.

Scientists at UCLA discovered a surprising reason aging muscles heal more slowly. In older muscle stem cells, a protein called NDRG1 builds up and acts like a brake, slowing the cells’ ability to jump into repair mode after injury. But there’s a twist: that same protein helps the cells survive the stresses of aging, allowing them to stick around longer.

Scientists have discovered that a common type of stroke may have a very different cause than doctors once thought. Instead of fatty plaque clogging arteries, the strongest link was found with enlarged and damaged blood vessels deep within the brain. The finding helps explain why standard treatments like aspirin are often less effective and is driving the search for new therapies that target the brain’s tiny blood vessels directly.

Bumble bees astonished researchers by inventing a new way to reach a hidden reward, despite never being taught the trick. The discovery adds to growing evidence that these tiny insects are far smarter and more adaptable than once believed.

A protein called “Mitch” may hold the key to a new generation of obesity treatments. Researchers found that disabling it in human cells boosts fat burning, increases energy use, and makes it harder for new fat cells to develop. The findings help explain why mice lacking Mitch were leaner, more athletic, and resistant to obesity.

A new spray-on powder developed by KAIST can stop life-threatening bleeding in about one second by instantly forming a strong gel over a wound. It works on deep and irregular injuries where conventional hemostatic products often struggle and remains effective even after years of storage in harsh conditions. Originally created for the battlefield, the technology could also transform emergency care in disasters, ambulances, and hospitals.

A massive national study found that nearly half of Americans with kidney failure who are referred for a transplant never even begin the evaluation process, and only 19% make it onto the transplant waitlist. Researchers discovered that factors such as where a person lives, whether they are married, their income level, language, age, and even which transplant center they use can dramatically affect their chances of moving forward.

A surprising discovery is overturning a long-held assumption about how the brain’s movement center works. Researchers found that two key cerebellar cell types—thought to be tightly linked—often don’t behave in predictable ways, even though one directly influences the other. The finding suggests scientists may have been relying on the wrong signals when studying disorders such as dystonia, ataxia, and tremor.

What if Sigmund Freud was onto something that modern neuroscience is only now beginning to explain? A new paper argues that today's leading theory of the brain—as a prediction machine constantly anticipating the world—closely mirrors ideas psychoanalysis has explored for more than a century.

Could something as simple as vitamin C help support a healthier aging brain? In a study of more than 2,000 older adults in Japan, researchers found that people with lower vitamin C levels in their blood also tended to have less gray matter and weaker connections in a key brain network involved in memory, attention, and other cognitive functions.

Scientists have solved a long-standing mystery by discovering the missing genetic ingredient that helps melanoma cells become effectively immortal. The breakthrough could open the door to new treatments aimed at disrupting one of cancer's most important survival strategies.

Researchers have uncovered an unexpected antiviral defense system in sea anemones that works very differently from the one humans use. The discovery suggests evolution developed multiple ways to combat viruses, challenging long-held ideas about how animal immune systems evolved.

A Colorado research team has created experimental osteoarthritis treatments that appear to regenerate damaged joints rather than just relieve pain. In animal studies, a single injection restored arthritic joints to a healthy state within weeks, while a second therapy repaired cartilage and bone defects by harnessing the body’s own healing cells.

A common brain protein may be giving Alzheimer’s disease an unexpected way to spread, carrying toxic Tau proteins from damaged neurons into healthy ones. By blocking these harmful protein packages before they reach new cells, researchers believe it may one day be possible to slow the disease's relentless progression.

Scientists at the University of Oxford have created a calculator that predicts a person's individual risk of serious muscle disorders from statin medications. Their analysis found that more than 98% of people who qualify for statins are at low risk for these rare complications, despite widespread concerns about side effects. The study also revealed that most eligible patients are not taking statins, potentially missing important protection against heart attacks and strokes.

Creatine is best known as a muscle-building supplement, but scientists are now investigating whether it could also help treat depression by boosting the brain's energy supply. A new review examined five randomized clinical trials involving 238 participants and found mixed results. Two studies, both involving women with major depressive disorder, reported that adding creatine to standard treatment improved symptoms, while three others found no meaningful benefit.