Aging & Longevity
The loss of a ClC anion channel increases life span, health span, and stress resistance by alkalinizing a pair of glial cells in <em>C. elegans</em>
Aging depends on genetic and environmental factors, but the specific cell types and mechanisms that coordinate aging of the entire organism are not yet fully understood. Glial cells regulate ionic homeostasis, which is essential for neuronal function and survival. Here, we investigated the role of glial ion channel CLH-1, which is a glial pH regulator, in aging. We found that loss of clh-1 extends life span, improves stress resistance, reduces neuronal damage, and extends health span. These...
Substantially improved efficiency and selectivity of carbon dioxide reduction by superior hydrated electron in microdroplet
The photochemical conversion of CO(2) into valuable fuels faces challenges of low efficiency and poor selectivity. Hydrated electrons (e(aq)^(-)), with their extremely negative reduction potential, are promising CO(2)-reducing agents, yet their short lifetime limits selectivity and high-energy-density product formation. Herein, we show that microdroplet interfaces with strong electric fields (10⁹ volts per meter) substantially extend the lifespan of e(aq)^(-) generated from industrial sulfite...
The Long Shadow of Incarceration: The Association of Incarceration History With Self-Reported Health Among Older Adults
CONCLUSION: Prior incarceration is a social determinant of health for older adults, even those with distant incarceration history, and is strongly associated with current poverty and meeting criteria for disability. Further research is needed to understand the mechanisms of these associations and means to mitigate health harms associated with prior incarceration.
Association of physical activity levels with frailty index in elderly Chinese: evidence from the China health and retirement longitudinal study (CHARLS)
As the global trend of population aging intensifies, frailty among the elderly has emerged as a significant public Health concern. This study examines the relationship between physical activity levels and the Frailty Index in older adults, utilizing data from the 2018 China Health and Retirement Longitudinal Study (CHARLS). The study sample included 10,240 Chinese adults aged ≥ 60 years.Frailty was assessed using the Frailty Index (FI), which was calculated based on the accumulation of...
The energy resistance principle
Living organisms are physical-energetic systems that must obey simple principles guiding energy transformation across physical and temporal scales. The energy resistance principle (ERP) describes behavior and transformation of energy in the carbon-based circuitry of biology. We show how energy resistance (éR) is the fundamental property that enables transformation, converting into useful work the unformed energy potential of food-derived electrons fluxing toward oxygen. Although éR is required...
Compromised autophagy in the aging epididymis: Evidence and relevance to male fertility
Impaired autophagy and increased cellular senescence in the aging epididymis may lead to cellular stress, inflammation, and epithelial dysfunction. This reduction in autophagy can be identified using light and electron microscopy, as well as molecular biology techniques. Autophagy, which may be selective or non-selective, is tightly regulated by genes such as LC3 and LAMP-2. Decreased autophagic activity in the epididymis results in reduced sperm quality and male fertility. These findings...
Chrysin, a glycolytic inhibitor, modulates redox homeostasis during aging via a potent calorie restriction mimetic effect in male wistar rats
Chrysin (5,7-dihydroxyflavone), a natural flavonoid present in honey, propolis, and various medicinal plants, has shown promise as a calorie restriction mimetic (CRM) through its glycolysis-inhibiting action. This inhibition promotes a metabolic shift toward oxidative phosphorylation and fatty acid oxidation, potentially activating beneficial pathways like AMPK and SIRT1. The mechanism likely involves the downregulation of Hexokinase-2, leading to suppressed glycolysis and promotion of...
Translational regulation in stress biology
Organisms must constantly respond to stress to maintain homeostasis, and the successful implementation of cellular stress responses is directly linked to lifespan regulation. In this Review we examine how three age-associated stressors-loss of proteostasis, oxidative damage and dysregulated nutrient sensing-alter protein synthesis. We describe how these stressors inflict cellular damage via their effects on translation and how translational changes can serve as both sensors and responses to the...
Senescence-coupled differentiation selectively eliminates cancer-prone stem cells
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A systematic review and meta-analysis of clinical trials on lavender for sleep disorders in the elderly
CONCLUSION: Based on preliminary evidence from this review, lavender may effectively treat sleep disorders, especially in the elderly. However, more research is required to fully understand its effectiveness and safety, especially with long-term use.
Fate mapping of peripherally-derived macrophages after traumatic brain injury in mice reveals a long-lasting population with a distinct transcriptomic signature
Traumatic brain injury (TBI) is an environmental risk factor for dementia and long-term neurological deficits, posing a significant public health challenge. TBI-induced neuroinflammation involves both brain-resident microglia and peripheral monocyte-derived macrophages (MDMs). Previous research has shown that MDMs contribute to the development of long-term memory deficits, yet their long-term behavior following brain infiltration remains unclear. To address this, our study uses two complementary...
CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway
Sarcopenia, a degenerative condition marked by progressive skeletal muscle atrophy and impaired regeneration, is closely associated with aging, chronic inflammation, and disrupted proteostasis. While macroautophagy has been extensively studied in this context, little of the role of chaperone-mediated autophagy (CMA) has been known. In this study, we identified C1q/TNF-related protein 9 (CTRP9) as a novel autocrine myokine secreted by skeletal muscle that exerts dual protective...
CD4 T cells acquire Eomesodermin to modulate cellular senescence and aging
Aging is characterized by the progressive deterioration of tissue structure and function, leading to increased vulnerability to diseases. Senescent cells (SCs) accumulate with age, but how the immune system regulates their burden is unclear. Here we show that CD4 T cells differentiate into Eomesodermin (Eomes)^(+)CCL5^(+) T lymphocytes (CD4-Eomes) in a SC-rich environment and that a reduction in the SC load, achieved using senolytic drugs, was sufficient to halt this differentiation. We further...
Age differences in what-if thinking from midlife onwards: Prefrontal contribution and implications for emotional health in late life
Reduced counterfactual ("What-If") thinking (CFT) in late life is believed to reflect successful adaptation to limited resources for overcoming missed opportunities, thereby preventing feelings of regret. We propose that this adaptation becomes critical from midlife onwards, affects emotional regulation, and is mediated by the preserved functionality of the ventromedial prefrontal cortex (vmPFC). To test this, an epidemiological sample from the Hamburg City Health Study (N = 494), aged 48 to 75,...
A ternary-code DNA methylome atlas of mouse tissues
CONCLUSIONS: Our work reveals how tissue, sex, and age jointly govern the dynamics of the two cytosine modifications, augments the scope of DNA modification biomarker discovery, and provides a reference atlas to explore epigenetic dynamics in development and disease.
Potential associated factors of postoperative neurocognitive dysfunction in elderly patients: precursor of BDNF and mature BDNF in serum
CONCLUSIONS: The PND was significantly associated with postoperative proBDNF and mBDNF.
Synergistic effects of diabetes and sarcopenic obesity on cardiovascular disease risk in middle-aged and elderly Chinese adults: a large-scale prospective cohort study
CONCLUSIONS: The coexistence of diabetes and sarcopenic obesity synergistically increases cardiovascular disease risk beyond the effects of either condition alone in Chinese adults. These findings highlight the importance of comprehensive screening and integrated management strategies for individuals with both conditions to prevent cardiovascular complications.
Inflammaging and the sex-frailty paradox
CONCLUSIONS: Trying to delineate the unique molecular profile of older women and men becomes essential for understanding the mechanisms underlying the sex-frailty paradox. Further research on sex-specific determinants is required to enhance our understanding of aging and develop effective strategies to promote health and longevity in both sexes.
When Melodies Cue Memories: Electrophysiological Correlates of Autobiographically Salient Music Listening in Older Adults
Autobiographical memory is essential for older adults, providing a foundation for self-identity. Although healthy aging is accompanied by changes in memory retrieval, musical memory remains relatively unaffected, suggesting music may serve as a cue for autobiographical memory recall. Autobiographically salient (ABS) music (i.e., deeply encoded songs associated with significant people, places, and events) is posited to engage distinct memory processes from familiar (FAM) music (i.e., songs that...
Cisformer: a scalable cross-modality generation framework for decoding transcriptional regulation at single-cell resolution
Single-cell multiomic technologies enable the joint analysis of different modalities, but face challenges due to experimental complexity. Current computational methods for single-cell cross-modality translation lack biological interpretability. Here, we present Cisformer, a cross-attention-based generative model tailored for cross-modality generation between gene expression and chromatin accessibility at single-cell resolution. Systematic benchmarking demonstrates the superior accuracy and...
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