Aging & Longevity

Recent studies have highlighted the crucial role of mechanical properties in the ovarian microenvironment for ovarian function. However, the mechanisms that cause ovarian matrix stiffening during aging remain incompletely understood. Here we utilized atomic force microscopy (AFM) to demonstrate that human ovarian matrix stiffness increases with aging and in pathophysiological conditions, such as chemotherapy-induced premature ovarian insufficiency (POI), polycystic ovary syndrome (PCOS) and...

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The d emographic shift toward an older population is accelerating the prevalence of age-related diseases. Precision geromedicine represents a paradigm shift in targeting the biological processes of ageing to optimise health and healthspan, which likely requires multimodal tailored interventions. PROMETHEUS, as part of the XPRIZE healthspan semi-finalist competition, is an 8-week feasibility and exploratory study including 20 middle-aged-to-older participants who received a multimodal...

[This corrects the article DOI: 10.1371/journal.pbio.3003306.].

Despite well-documented poor health outcomes among homebound older adults with diabetes, little is known about how homebound status affects glycemic outcomes. This study examined the association between homebound status and glycemic control among community-dwelling older adults with diabetes and identified key factors associated with glycemic outcomes. We conducted a cross-sectional analysis using data from the 2017 National Health and Aging Trends Survey (NHATS). Participants included...

Wound healing (WH) is a multi-component and highly orchestrated process, in which fibroblasts play a pivotal role. Wound healing is commonly attenuated during aging and the course of cellular senescence (CS). A growing body of evidence demonstrates that mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) can mitigate the aging and CS phenotype. In this study, we evaluated the effects of EVs derived from naïve MSCs (nMSCs) or anti-inflammatory polarized MSCs (pMSCs) on the rate of in...

CONCLUSIONS: No differences in late mortality, SMNs, and most CHCs were observed between patients who received VDC versus VDC/IE. Aging EWS survivors' elevated risk of morbidity and mortality underscores the need for lifelong survivorship care and therapies that reduce the risk for late effects.

CONCLUSIONS: Depressive symptoms appear to be the dominant negative correlate of spiritual well-being in geriatric outpatients, while religious coping shows an independent positive link. The attenuation of functional measures after accounting for depressive symptoms may align with gerotranscendence theory or simply reflect ceiling effects in this functionally well-preserved outpatient sample. Either way, these data underscore the relevance of addressing depressive symptoms and acknowledging...

CONCLUSION: Higher social participation is strongly associated with better subjective well-being in older adults, particularly through relational and health-oriented activities. Social participation scores may serve as a useful community-based indicator for detecting low well-being. Culturally sensitive interventions that promote meaningful, voluntary, and inclusive participation-alongside structural supports such as transportation and social prescribing-may help enhance psychological well-being...

CONCLUSIONS: CHAMPS, PASE, and LAPAQ showed the most acceptable psychometric properties. Most PROMs had limited responsiveness and inconsistencies. Implementation should focus on robust PROMs, while research should enhance measurement quality, validate tools in home care settings, and standardize measurement methods.

CONCLUSIONS: Medical students mostly demonstrated positive attitudes towards older people, particularly in terms of respect and willingness to provide support. Regular contact with older people and appropriately designed gerontological education may contribute to more positive attitudes towards older adults and help counteract ageism among future healthcare professionals.

Senescence of immune cells can drive senescence of solid organs, and reversing immune cell senescence ameliorates organismal senescence phenotypes. As the second largest subset of decidual immune cells, macrophages play a critical role in pregnancy. However, whether decidual macrophages (DM) exhibit senescence in advanced maternal age (AMA) pregnancies (≥ 35 years old) and their involvement in AMA-related adverse outcomes remain undefined. This study elucidates the phenotypic and functional...

Age-related breakdown of the blood-brain barrier (BBB) is associated with cerebrovascular and neurodegenerative diseases, yet its underlying mechanisms remain unclear. Here, we find that BBB leakage begins in midlife and is driven primarily by increased endothelial caveolar transcytosis rather than tight junction disruption. AAV-mediated knockdown of caveolin-1 or restoration of Mfsd2a expression reduces endothelial vesicle formation and BBB leakage in aged mice. Transforming growth factor...

Conventional BMI-based classifications, even when combined with traditional cardiometabolic risk factors, limit precision in aging-related risk assessment. Here, we perform metabolomic analysis in 13,202 older adults from the natural aging cohort (NCT04517513). Leveraging a panel of 39 core metabolites, we develop accurate and interpretable machine learning models to identify metabolic dysfunction across different BMI categories, achieving area under the receiver operating characteristic curve...

CONCLUSION: Higher TyG-related metabolic indices were associated with incident PE in this large prospective cohort. PhenoAgeAccel-related decomposition and genetic susceptibility analyses were exploratory and require external replication.

CONCLUSION: This study provides insights about the potential of simultaneous motor-cognitive training for improving motor capacities in older adults, even if its efficiency is not different to motor training. Furthermore, neither incorporated nor additional training seem to be the optimal modality. Future comparative studies are needed to draw firm conclusions.

Cellular senescence is a key driver of kidney aging, leading to functional decline and increased susceptibility to chronic kidney disease. While the senolytic combination of dasatinib and quercetin (D + Q) has shown promise in mitigating age-related pathologies, its long-term effects and underlying multi-level systemic mechanisms in the aging kidney remain poorly defined. Here, we systematically evaluated the long-term effects of D + Q in naturally aged mice using multi-omics approaches. We show...

Age-related decline in left ventricular (LV) diastolic function is a hallmark of cardiac aging and an early precursor to cardiovascular disease. While dyslipidemia is a known driver of coronary heart disease (CHD), the molecular pathways linking lipid metabolism to cardiac aging and subsequent CHD risk remain poorly understood. Furthermore, longitudinal lipidomic profiling of cardiac aging in large human populations has not been systematically conducted. Using an untargeted LC-MS, we repeatedly...

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