Aging & Longevity

Chronic low-grade inflammation ("inflammaging") drives age-related decline, but whether anti-inflammatory medications preserve functional performance in older age remains unknown. This study evaluated the 5-year effect of aspirin on a modified Intrinsic Capacity (IC) index in older males and females. A post-hoc analysis of a randomised controlled trial comparing daily 100 mg aspirin to placebo in prolonging dementia- and disability-free survival (DFS) in community-dwelling individuals aged ≥ 65...

The locus coeruleus (LC) brainstem cell group is evolutionarily conserved across vertebrates and influences both mind (cognition) and body (cardiorespiratory, metabolic, and immune functions) via two-putatively distinct-spontaneous activity patterns. Yet, the degree to which spontaneous LC firing rates and patterns are homogeneous across species has never been assessed due to inherently limited sample sizes. To remedy this, we pooled cross-species data from 20 laboratories to show that firing...

Mitochondrial DNA (mtDNA) depletion and multiple deletions frequently coexist in mitochondrial disease, neurodegeneration, and aging, yet how the two relate and why deletions accumulate focally remain unresolved. Here, longitudinal bulk and in situ analyses of Mpv17^(-/-) murine muscle reveal that a compensatory rise in mitochondrial transcripts per mtDNA initially offsets severe, uniform mtDNA depletion, preserving the respiratory chain. However, this response carries a delayed cost: by six...

Genome stability depends on the accurate repair of DNA double-strand breaks (DSBs). While chromatin-based mechanisms have been well studied, emerging evidence reveals that nuclear mechanics actively shape repair outcomes, although the mechanisms remain unclear. Here we identify microtubule acetylation as a regulator of nuclear mechanics that promotes DSB repair via homologous recombination (HR). DNA damage induces progressive tubulin acetylation, leading to displacement of the perinuclear...

Aging is accompanied by a progressive decline in tissue regenerative capacity, driven by intrinsic stem cell dysfunction and age-associated deterioration of the surrounding stem cell niche. Mesenchymal stromal cells (MSCs) are ubiquitous components of stem cell niches, where they integrate structural, metabolic, inflammatory, and paracrine cues to regulate stem cell quiescence, activation, and differentiation. With age, MSCs undergo functional decline and senescence, altering their secretory and...

Aging is associated with progressive oxidative stress, chronic inflammation and functional deterioration across multiple organs. Increasing evidence suggests that the gut microbiota plays a pivotal role in regulating aging through the gut-brain axis and systemic immune interactions. The present study investigated the therapeutic potential of fecal microbiota transplantation (FMT) in a D-galactose-induced rat model of accelerated aging. Male rats were allocated into four experimental groups:...

Oxidative stress is a hallmark of aging and a key driver of neurodegenerative diseases. While much attention has been given to oxidative damage of macromolecules, the functional consequences of oxidizing the abundant nucleotide triphosphate (NTP) pool remain largely unknown. Here, we identify oxidized GTP (8-oxoGTP)-a major product of NTP oxidation-not as a mere marker of damage, but as an endogenous signaling molecule that drives microglial activation and neuroinflammation. 8-oxoGTP accumulated...

Chemotherapy-induced cognitive impairment (CICI), often referred to as "chemobrain," is a frequently persistent complication that significantly affects memory, attention, executive function, and overall quality of life among cancer survivors. Although mitochondrial dysfunction, oxidative stress, neuroinflammation, and gut microbiota dysbiosis have each been implicated in its pathogenesis, the way these processes interact to drive cognitive decline remains incompletely understood. In this...

The condition of having a healthy, functional proteome is known as protein homeostasis, or proteostasis. Establishing and maintaining proteostasis is the province of the proteostasis network, a highly interconnected system of over 3000 components that regulate protein synthesis, folding, localization, and degradation. The proteostasis network is a fundamental functional unit in biology that is essential for cellular health and has direct relevance to many diseases of protein conformation....

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CONCLUSION: This study demonstrates that digital engagement is significantly and positively associated with SPA among older adults, with Internet use skills serving as an important moderating factor. Three interventions are needed: age-friendly interfaces, targeted engagement strategies, and digital literacy programs. Bridging the digital divide is essential for positive aging.

CONCLUSIONS: Combining dual-task gait variability with clinical functional assessments via machine learning algorithms provides a robust and interpretable framework for faller identification. The integration of optical gait analysis and machine learning facilitates early risk screening and personalized retrospective evaluation, offering a promising tool to assist in detecting older adults at risk for fall-related injuries in the aging population.

CONCLUSIONS: Findings suggest that hs-CRP and CRP biomarkers are associated with physical performance decline in older adults. Future research including a broader range of inflammation biomarkers should provide insights and understanding of mechanisms linking inflammation and physical decline.

This commentary highlights the age illusion and advocates integrating biological age and artificial intelligence (AI) to enhance clinical precision in health care. By synthesizing geroscience and machine learning, practitioners and scientists can effectively bridge the gap between experimental biomarkers and personalized medicine and longevity care. This contribution is timely as the importance of biological age and predictive analytics offer transformative potential for diagnostics while...

The condition of having a healthy, functional proteome is known as protein homeostasis, or proteostasis. Maintaining proteostasis is the province of the proteostasis network, which consists of the cellular components that regulate protein synthesis, folding, localization, and degradation. The proteostasis network is a fundamental functional unit in biology with relevance to many diseases. Despite its importance, the human proteostasis network has until now lacked a precise definition, limiting...

ObjectiveThis study examined the longitudinal effects of social isolation on chronic diseases and depressive symptoms among middle-aged and older adults in South Korea, with attention to gender and age differences.MethodUsing data from three waves of the Korean Longitudinal Study of Aging, longitudinal path analysis was conducted on 5,585 participants.ResultsWomen and older adults showed higher levels of social isolation, chronic diseases, and depressive symptoms, indicating greater...

Speech-in-noise (SIN) perception is a difficult everyday listening task that becomes more difficult with age. Neural tracking of target speech is associated with successful speech perception in clean and noise-degraded listening environments. How aging impacts neural tracking of speech and behavioral decrements in SIN perception remains unclear. To address these questions, we measured neural speech tracking during a continuous SIN perception task in younger and older adults via multichannel...

How cell identity is maintained is a fundamental question, and loss of cell identity is a hallmark of aging associated with multiple age-related diseases. In the adult Drosophila midgut, we identified a posttranscriptional regulatory layer that supervises enterocyte (EC) identity and fails upon aging. Combining single-cell RNA-seq with lineage tracing in aging ECs and classical genetics, we found that aging ECs express genes that unlock the differentiated state. Upon aging, the protein Rogue...

Companion dogs are a valuable geroscience model because they share human environments, develop similar age-related diseases, and have compressed lifespans. The Dog Aging Project (DAP) is a large, prospective cohort designed to investigate intrinsic and extrinsic factors associated with canine aging and longevity. We analyzed 41,047 dogs from the 2024 DAP Curated Data Release with baseline Health and Life Experience Survey (HLES) data and mortality follow-up through 2024. All-cause mortality was...

Neurovascular ageing is a major contributor to cerebrovascular vulnerability and poor stroke outcomes in older adults. Progressive deterioration of the neurovascular unit (NVU), driven by oxidative stress, neurovascular coupling dysfunction, blood-brain barrier (BBB) disruption, inflammageing, cellular senescence, mitochondrial dysfunction, and impaired autophagy compromises neurovascular resilience and increases susceptibility to ischemic injury. Among the molecular pathways implicated in these...