Aging & Longevity

No abstract

The aging brain depends on coordinated fluid transport, immune surveillance, and clearance of metabolic byproducts to preserve cognitive and physiological homeostasis. While peripheral lymphatic decline is well established, growing evidence implicates brain-draining lymphatic pathways, particularly meningeal lymphatic vessels and their downstream drainage to deep cervical lymph nodes, as an aging-sensitive axis that intersects with neuroinflammation and neurodegenerative vulnerability. Here, we...

CONCLUSIONS AND IMPLICATIONS: Dynapenia in older men and sarcopenia in older women were independently associated with mortality, highlighting sex-sensitive prognostic differences and underscoring the need of phenotype-specific strategies for healthy ageing.

Multiplexed protein imaging enables spatial analysis of complex tissues, but detecting proteins expressed at low levels remains challenging, particularly in widely available formalin-fixed, paraffin-embedded (FFPE) specimens. Many biologically important regulators-including senescence markers, transcription factors, and secreted proteins-are therefore difficult to study in situ using existing high-plex methods. Here we show that integrable Co-detection of Low-Abundant Proteins (iCLAP) enables...

Biological aging and immunosenescence are central to longevity, yet their interplay in centenarians remains unclear. We conducted a cross-sectional study in 160 Colombian centenarians to examine associations between biological age (PhenoAge), immunosenescence and age-related clinical variables. Cytokine profiling (n = 114) and lymphocyte immunophenotyping (n = 42) were assessed. It was observed that better QoL and well-being were significantly associated with lower biological age, while...

Postural control depends on the integration of visual and proprioceptive inputs, yet how aging modifies this sensorimotor integration in upright standing remains unclear. We examined age-related differences in postural responses to visual and proprioceptive disturbances during upright standing by applying (i) bilateral Achilles or tibialis anterior tendon vibration and (ii) and simulated forward or backward self-motion in a virtual environment. Eighteen young [22.8 (1.6)yr] and eighteen old...

Visible light influences a range of physiological processes, yet how animals respond to it independently of the visual system remains largely unknown. Here, we uncover a previously undescribed light-induced transcriptional pathway that modulates behavioral plasticity in Caenorhabditis elegans, a roundworm without eyes. We demonstrate that ambient visible light or controlled-intensity visible-spectrum LED activates an effector gene cyp-14A5 in non-neuronal tissues through the bZIP transcription...

The brain continuously integrates rapidly changing visual input across eye movements to maintain stable perception, yet the precise mechanisms underpinning dynamic working memory and how these break down in brain diseases remain unclear. We developed a novel eye-tracking paradigm and computational models to investigate how spatial and colour information are updated across saccades in the human brain. Our findings reveal that saccades selectively impair spatial but not colour memory....

Frailty is a clinically recognizable condition of vulnerability with aging, leading to adverse health outcomes. Previous GWASs on frailty have identified 59 susceptibility loci, although the underlying mechanisms remain unclear. We investigated the genetic determinants of frailty and biological relationship between frailty and aging genes in 14,664 middle-aged and elderly Korean participants. We performed cohort-based (KoGES and KNHANES) meta-analysis of GWAS and candidate gene approach focusing...

An aging global population requires preventive and curative interventions to address cognitive decline. Touchscreen computerized cognitive training provides an engaging, portable, cost-effective, and accessible solution for seniors. We conducted a systematic review of randomized controlled trials (RCTs) to determine, using meta-analysis, the effects of computerized cognitive training on older adults using touchscreens. We conducted a literature review to identify RCTs involving older adults in...

CONCLUSIONS: This confirms triadic interdependencies where biological aging partially mediates periodontitis/depression effects on cognition. Prioritizing periodontal care and mental health may mitigate cognitive decline, especially in low-resource settings.

No abstract

Age-related obesity is a growing public health concern linked to various metabolic disorders, yet its underlying mechanisms remain incompletely understood. Here we report that S-nitrosoglutathione reductase (GSNOR), a pivotal denitrosation enzyme, increases in adipose tissue of both male mice and humans from middle-age. GSNOR knockout protects against age-related weight gain and enhances metabolism, whereas adipose-specific GSNOR knock-in mice promotes obesity and metabolic decline. Further...

No abstract

Aging impairs immune function and reduces vaccine efficacy, but whether dendritic cells (DCs), which play a central role in initiating immune responses via antigen presentation, contribute to this decline remains unclear. Through single-cell RNA sequencing analysis of lymph node changes upon vaccination in young versus aged mice, here we identify defects in DC migration during aging, alongside a dysfunction-associated gene signature in migratory DCs, and implicate these defects in the diminished...

No abstract

CONCLUSIONS: We classified the motion patterns of older adults during diaper wearing. Our results provide fundamental insights into appropriate care and rehabilitation interventions. Furthermore, these findings inform further hypothesis-driven research on diaper-wearing kinematics and support the development of effective strategies to enhance independence diaper use in older adults.

The aging process is predominantly influenced by genetic and environmental factors. Environmental factors that accelerate biological aging, known as gerontogens, increase organismal vulnerability and susceptibility to disease, thereby elevating the risks of multiple aging-related disease onset and mortality. However, there is a notable deficiency in effective biomarkers for predicting aging-related phenotypes accelerated by gerontogens. Melatonin and cortisol serve as markers of the circadian...

The growing ageing population presents significant challenges for healthcare systems, particularly in monitoring age-related physiological decline. Ageing is a complex, multifactorial process that manifests without specific symptoms and is shaped by lifestyle, environmental exposures, diet, and underlying health conditions. Identifying reliable biomarkers of ageing could enable early interventions, improve prognostic accuracy, and reduce healthcare burdens. One promising avenue is exhaled breath...

No abstract