Aging & Longevity

Skeletal muscle is a fundamental tissue as it is found throughout the body, sustains posture, and produces movement. Yet, skeletal muscle disorders, such as myopathies, affect a large percentage of the population, degrading an individual's quality of life. A recent study links myopathy progression to the decline in chaperone-mediated autophagy that occurs during aging. Underscoring the importance of a balanced CMA pathway in maintaining skeletal muscle function and integrity, the study also...

In an ever-changing environment, the ability to adapt behavior based on feedback is a crucial skill. Although this process is assumed to decline with age, initial evidence suggests that emotional information processing may help buffer against these age-related impairments. We therefore conducted a probabilistic learning task with emotional faces in two varying emotional intensities (weak vs. strong) to investigate whether healthy younger and older adults would benefit from strong emotional...

Autism spectrum disorder (ASD) is a neurodevelopmental disorder. While previous studies have reported a high prevalence of dementia diagnoses in the ASD population, the risk of dementia-related neurodegeneration remains poorly understood. This study aimed to assess dementia-sensitive composite measures of brain structure and brain age across the lifespan in an ASD cohort (ages 7-73) to investigate neuroanatomical features linked to neurodegenerative vulnerability. The composite score and brain...

CONCLUSION: We propose a comprehensive framework comprising three components: cohort setting, measuring contributing factors, and full assessment. This framework sets the stage for a unified, supranational protocol that harmonizes survey methods across countries, integrates multidisciplinary perspectives, and adopts a longitudinal approach. It would enable larger sample sizes and more robust statistical analyses, allowing researchers to explore complex relationships and derive more accurate...

The aim of this study is to investigate perceptions of aging among Hispanic adults. Fifty participants in Texas and Arkansas were asked to take a short questionnaire including multiple-choice and Likert scale format questions. Individuals 18 and older who identified as Hispanic were included in the study. Counts and frequencies for each response were obtained. Furthermore, an exploratory comparison of responses between younger and middle-aged/older respondents was conducted. According to the...

Aging is associated with a decline in the regenerative capacity of many tissues. Central to this decline is a complex interplay between inflammation and stem cell function. How these two processes are linked and influence regenerative capacity remains unclear. Here, we undertake a comprehensive assessment of age-related changes in the mouse colon at single-cell resolution. A survey of immune and epithelial compartments revealed a hyperactivated inflammatory state in the colon of old mice...

DNA-protein crosslinks (DPCs) are toxic DNA lesions that block all DNA transactions including replication and transcription, and the consequences of impaired DNA-protein crosslink repair (DPCR) are severe. At the cellular level, impaired DPCR leads to the formation of double strand breaks, genomic instability, and cell death, while at the organismal level, it is associated with cancer, aging, and neurodegeneration. Despite its importance, the mechanisms of DPCR at the organismal level are...

Chronic systemic inflammation and DNA methylation changes are two major hallmarks of aging, yet their interaction is poorly known. We investigated the relation between circulating inflammatory proteome and epigenetic age acceleration as assessed by DNA methylation in four independent cohorts of different ages and health conditions. Epigenetic age scores known to predict human health span (GrimAge and PhenoAge) were more strongly associated with age-associated inflammatory proteins, frailty, and...

Inundations of pelagic Sargassum plague the tropical Atlantic, with size and impacts steadily increasing to surpass 30 million tons in 2025. Understanding the drivers of Sargassum growth in the so-called Great Atlantic Sargassum Belt is fundamental to developing effective mitigation strategies for affected nations. We present a nonlinear regression model that both explains the seasonal and interannual variability observed between 2011 and 2022 and predicts Sargassum concentrations in 2023 and...

Adipose tissues are highly dynamic in response to environmental temperature changes. During aging, subcutaneous white adipose tissues (WAT) decreases, yet whether this atrophy exacerbates cold stress and triggers systemic aging remains unclear. Here we show that adipocyte-specific expression of the Lmna^(G609G) mutation in male mice leads to progressive WAT atrophy, accelerates aging, and shortens lifespan, whereas female mice remain unaffected. This lipoatrophy exacerbates cold stress,...

CONCLUSIONS: The NCDs exacerbate healthcare inequities with socio-economically vulnerable older adult households at greater risk of CHE, impoverishment and worsened economic condition. Public funded health insurance programmes offered limited protection compared to private schemes.

CONCLUSION: Engaging in physical activity among the elderly South Asian population is affected by a complex mixture of individual, social, and cultural factors. For South Asians, it is important that interventions be implemented in a manner that meets the needs regarding capabilitymotivation, and support.

Spatial disorientation represents a clinically meaningful vulnerability during aging and is an early manifestation along the Alzheimer's disease continuum. Understanding how aging-related central nervous system (CNS) changes affect the neural computations required for spatial perspective taking (SPT) is essential for characterizing early neurodegenerative processes. In this study, older adults with mild cognitive impairment (MCI) and subjective cognitive decline (SCD) completed a simplified...

Mitochondrial dysfunction is a prominent hallmark of aging contributing to the decline of metabolic plasticity in late life. While genetic distortions of mitochondrial integrity elicit premature aging, the mechanisms leading to "natural" aging of mitochondria are less clear. Here we use proteomics, lipidomics, genetics and functional tests in wild type Caenorhabditis elegans and long-lived clk-1(qm30) and isp-1(qm150) mitochondrial mutants to identify molecular pathways that support longevity...

The spatiotemporal dynamics of hydrogen peroxide (H(2)O(2)) signaling and its effects on gene expression and cell fitness remain unclear. Using fission yeast, we applied genetic tools to control and monitor intracellular H(2)O(2) levels. We expressed the H(2)O(2) biosensor HyPer7 in four subcellular compartments, overexpressed D-amino acid oxidase (Dao1) in specific locations to induce localized H(2)O(2) production, and modulated H(2)O(2) detoxification or sensing. H(2)O(2) concentrations showed...

Cerebral ischemic small vessel disease (SVD) is a leading cause of vascular dementia and stroke. Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common monogenic SVD, is caused by dominant missense mutations in Notch3 expressed in smooth muscle cells (SMCs) and pericytes. However, cell-type-specific contributions driving CADASIL remain unknown. Here, we generate two conditional knockin mouse models carrying the CADASIL-causing...

The pro-inflammatory, senescence-associated secretory phenotype (SASP) is a hallmark of senescent cells (SnCs) that exacerbates age-related pathophysiology and chronic diseases. Although unique gene regulation is essential for fulfilling the pro-inflammatory SASP, the epigenomic basis in SnCs remains largely unknown. Here, we show that FOXF1/2 define the senescence-specific enhancer landscape by shaping chromatin accessibility. FOXF1/2 interact with p300/CREB-binding protein (CBP) and stimulate...

The global aging population presents a pressing challenge, highlighting the urgent need for interventions that target the fundamental mechanisms of aging. Gene therapy, leveraging its success in treating monogenic and aging-related diseases such as progeria and neurodegenerative disorders, has emerged as a promising strategy. It holds the potential not only to mitigate specific age-related pathologies but also to robustly extend healthspan. Although preclinical studies have shown encouraging...

The liver performs a wide range of physiological functions, including lipid/glucose metabolism, energy storage, immune regulation, molecular biosynthesis, and the clearance of xenobiotics, all of which are essential for maintaining systemic homeostasis. Liver ageing increases its susceptibility to acute stress and injury, which in turn enhances the body's sensitivity to ageing-related responses. These processes interact with other organs, accelerating systemic ageing and the pathogenesis of...

Aging is a complex biological process characterized by the loss of metabolic homeostasis, epigenetic drift, and systemic functional decline. Although exercise is widely recognized as a potent non-pharmacological intervention for aging, the mechanisms by which it translates transient metabolic fluctuations into long-term systemic adaptations remain incompletely understood. During physical activity, skeletal muscle exhibits significantly enhanced glycolytic flux, leading to the accumulation of...