Aging & Longevity

The accumulation of senescent cells is a recognized hallmark of biological aging and is associated with the onset of multiple chronic medical conditions. Senescent cells exhibit a distinct secretory profile, known as the senescence-associated secretory phenotype (SASP), which can propagate cellular senescence to neighboring and distant tissues. Measuring SASP factors in blood serves as a practical proxy for cellular senescence burden and may help track disease states and intervention outcomes....

Aging drives physiological decline and predisposes individuals to multiple age-related pathologies, constituting a major global health challenge. Growth hormone receptor (GHR), a critical regulator of growth, development, and metabolism, has emerged as a potential therapeutic target. However, its precise role in aging and age-related diseases remains incompletely defined. Here, we demonstrate that hepatocyte-specific GHR knockout mice display accelerated aging-related phenotypes, characterized...

CONCLUSION: Healthcare professionals perceive that participation and learning among residents, relatives, and colleagues in long-term care facilities do occur, but to varying degrees and are associated with multiple challenges. Drawing on a learning model, such as Illeris, can help identify which components need to be developed, which together with a deeper understanding and implementation of person-centredness, could contribute to increased participation and learning, and thereby to the...

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Diet is an environmental factor influencing aging and life expectancy. Age-associated DNA methylation and epigenetic clocks are primary hallmarks of aging and may be modified by diet. However, observed associations between diet and epigenetic clocks may be confounded by familial factors. Using data from monozygotic twins in the Danish GEMINAKAR cohort, established in 1997-2000, when participants were aged 18-67 years, and with a 12-year follow-up, we examined whether adherence to Danish dietary...

CONCLUSIONS: Composite IC declined from early adulthood to midlife, and predicted key physical, mental, and functional outcomes. Formative-reflective approaches and earlier IC assessment may strengthen prevention-oriented healthy ageing strategies.

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Aging is a progressive decline in physiological functions and the capacity to maintain homeostasis, representing a major risk factor for numerous chronic diseases. Geroprotectors, defined as natural or synthetic compounds capable of improving healthspan and delaying age-associated functional decline, have attracted increasing attention in aging research. However, clinically validated interventions for promoting healthy aging remain unavailable. Plant-derived polysaccharides, owing to their...

Erigeron breviscapus Hand-Mazz. (EBHM) is a well-documented herbal medicine with recognized antioxidant, anti-apoptotic, and anti-inflammatory bioactivities. However, its anti-senescence effects and the underlying mechanisms remain poorly understood. Here, we investigated the anti-senescence potential of EBHM employing Caenorhabditis elegans and SAMP8 mice. In C. elegans, EBHM treatment prolonged the average lifespan of C. elegans to a maximum of 18.68%, while also significantly enhancing stress...

CONCLUSION: Gait mat and stopwatch measurements showed acceptable agreement, supporting clinical use. However, greater disagreement at faster speeds suggests gait mats may be more appropriate for faster walking speeds. These findings support future investigations of ST and DT gait performance within ARIC and other aging cohorts, including relationships with cognitive decline, mobility limitations, and adverse health outcomes.

INTRODUCTION: Since many hospitalized older adults have delirium, assessment of baseline cognitive function often requires proxy-based measures. While the 16-item Informant Questionnaire on Cognitive Decline in Elderly (IQCODE) specifies cutoff scores for mild cognitive impairment (MCI) and dementia, the 8-item Informant Interview to Differentiate Aging and Dementia (AD8) provides only a single cutoff for "cognitive impairment," limiting its usefulness and precision. Our aim was to develop a...

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Retinal fundus images offer a non-invasive window into systemic aging. Here, we fine-tune a foundation model (RETFound) to predict chronological age from color fundus images in 71,343 participants from the UK Biobank, achieving a mean absolute error of 2.85 years. The resulting retinal age gap, i.e. the difference between predicted and chronological age, is associated with cardiometabolic traits, inflammation, cognitive performance, all-cause mortality, dementia, cancer, and incident...

Epigenetic aging is a hallmark of chronic diseases. While such epigenetic changes can arise following tissue injury, the cell types most affected remain largely unknown. Here we built a cross-species single-cell multiomics atlas of DNA methylation, chromatin accessibility and transcription profiles from healthy, injured (human) and aged (mouse) kidneys. We found that tubular epithelial cells in diseased kidneys exhibit pronounced accelerated epigenetic aging and showed that this pathological...

Aging is accompanied by progressive physiological decline, yet the microbiome determinants that modulate aging remain unclear. Here, we identify Neisseria flavescens (Nf) as an oral commensal associated with decelerated aging in humans. Using AURORA, a generative multi-modality framework, we developed multi-modality aging clocks, performed in silico screening for age-gap-reducing interventions and predicted Nf as a top hit. In silico perturbations linked increased Nf abundance to favorable...

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The "healthy drinking" paradox refers to situations where alcohol consumption is misleadingly associated with better health outcomes, a pattern frequently observed in observational studies that are prone to a range of confounding factors. Some recent studies developing organ-specific proteomic aging clocks report that alcohol consumption is linked to slower aging in select organs, even as it accelerates aging in others, thus echoing this paradox, with substantial discrepancies across such...

Cardiovascular health, depressive symptoms, and cognitive performance are closely interconnected and jointly influence all-cause mortality. We investigated the independent associations of Life's Simple 7 (LS7), depressive symptom trajectories, and cognitive performance with all-cause mortality and conducted exploratory four-way decomposition analyses to evaluate complementary mechanistic hypotheses linking these factors. We analyzed data from the Healthy Aging in Neighborhoods of Diversity...

Perovskite photovoltaics are limited by structural instabilities initiated during crystallization and amplified under operation. We report that a lattice-matched Prussian blue scaffold directs heterogeneous nucleation to produce highly oriented, strain-relaxed films. Its redox-active Fe-C≡N-Fe network mediates the conversion of Pb⁰ and I⁰ defects, and its rigid open framework suppresses A-site cation redistribution and the resulting electronic inhomogeneity under bias. This strategy yielded...

Infant macaques showed immune changes and signs of faster aging years after inhaling smoke.