Aging & Longevity

ObjectivesTo examine whether the association between vision and cognitive difficulties varies by age group.MethodsWe analyzed pooled data from the 2021-2023 National Health Interview Survey, including 52,582 U.S. adults aged 45 and older. Vision and cognitive difficulties were based on self-reports. Logistic regression with interaction terms assessed age-related differences.ResultsVision difficulty was reported by 22.7% of respondents. It was associated with over twice the odds of cognitive...

The gap between lifespan and healthspan is increasing globally, resulting in millions of individuals spending additional years burdened by frailty or disease. This disparity, paired with the increasingly aged populations of Western nations, poses a palpable predicament to public health and the economy. Deterioration of the skeletal muscle system is a key contributor to illness, loss of independence, and diminishing healthspan. Muscle quality correlates to longevity due to its significant role in...

Testosterone insufficiency disrupts spermatogenesis and expedites male aging. Autophagy facilitates testosterone synthesis. However, a molecular reduction mechanism of autophagy-related protein 4 homolog B (ATG4B) has not been established. Herein, we reveal that peroxiredoxin 1 (PRDX1) is clinically associated with male fertility disorders. Adult mutant mice with Leydig cell (LC)-specific deletion of the Prdx1 gene exhibit premature testicular aging and infertility. A series of in vivo and in...

For the last 140 years, the mechanisms of transport and dissipation of energy in a turbulent flow have not been completely understood. Previous research has focused on analyzing the so-called coherent structures, organized flow patterns characterized by their spatial coherence, lifespan and significant contribution to momentum and energy transfer. However, the connection between these structures and the flow development is still uncertain. Here, we show a data-driven methodology for objectively...

The lack of safe, durable therapeutics that act against both biological aging and Alzheimer's disease is an unmet clinical need. To bridge this gap, we devised an artificial intelligence (AI)-enabled approach that pairs rapid compound triage with mechanistic target deconvolution. Our AI-driven screening highlighted melatonin (MLT) as a promising candidate. Serum profiling of 161 human individuals confirmed an age-related fall in circulating MLT level, while subsequent in vivo and in vitro...

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CONCLUSIONS: This study revealed that depressive symptoms not only directly influenced cognitive impairment among older adults but also indirectly via proactive health. Exercise should be encouraged among the older people to promote their participation in social activities, thereby improving their proactive health and ultimately preventing cognitive impairment.

Macroautophagy/autophagy is a highly conserved pathway responsible for the bulk degradation of cytoplasmic material through the formation of a double-membrane structure known as the autophagosome. However, the precise mechanisms governing the transport of autophagosomes to the vacuole for degradation in plants remain largely elusive. There exists an ongoing debate about whether RAB7, a key regulatory protein, is involved in the plant autophagy pathway. In this study, we demonstrate that upon...

BACKGROUND: Population ageing increases frailty prevalence, a condition linked to higher disability risk. The Integrated Care for Older People (ICOPE) model promotes early frailty identification in primary care and integration of health, social, and community services. However, evidence of adaptations of ICOPE models in different contexts is scarce, as is knowledge of health literacy's (HL) role in frailty screening. This study protocol describes a project applying ICOPE indications to identify...

CONCLUSION: This study revealed that one-fourth of the study population had anaemia. The overall prevalence of anaemia was equal in males and females. The most common type of anaemia was the normocytic normochromic type and there was a significant association between anaemia and characteristics such as age, number of comorbidities and diabetes mellitus.

Temporal lobe epilepsy (TLE) is the most common pharmacoresistant epilepsy in adults, yet few patients receive curative surgery due to diagnostic and prognostic uncertainty. In a multicenter cohort, we analyzed multimodal MRI and clinical data from 282 TLE patients, 298 healthy controls, and 45 disease controls. Patient-specific deviations from typical lifespan trajectories of intrinsic brain function were mapped using normative modeling. Regional functional alterations were heterogeneous but...

Social isolation and poor nutrition are recognized risk factors for cognitive decline in older adults. However, the relationship between solitary eating, brain structure, and dietary patterns remains unclear. This study investigated the relationship between solitary eating, brain structure, and diet in healthy older Japanese adults. A total of 727 cognitively normal participants (mean age 70.32 years) underwent MRI and dietary assessments. Results showed that individuals who frequently eat alone...

A growing number of compounds are reported to extend lifespan, but it remains unclear whether they reduce mortality across the entire life course or only at specific ages. This uncertainty persists because the commonly used log-rank test cannot detect age-specific effects. Here, we introduce a new analytical method that addresses this limitation by revealing when, how long, and to what extent interventions alter mortality risk. Applied to survival data from 42 compounds tested in mice by the...

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Aging constitutes the largest risk factor for melanoma progression. While a contribution of factors secreted from senescent skin fibroblasts to the progression of melanoma has been proposed, the nature of such factors and subsequent underlying mechanisms remains elusive. Here we show that the chemokine GCP-2 is excessively released by senescent fibroblasts in vitro and the skin of old melanoma patients. GCP-2 regulates, via phosphorylation of the transcription factor CREB at serine 133,...

CONCLUSION: These results underscore the importance of assessing and addressing perceived risk levels in this population, to promote proactive and effective coping mechanisms. Such efforts may help prevent or delay diabetes-related complications and enhance the quality of life for older adults with type 2 diabetes. Moreover, the findings provide an evidence-based foundation for the development of targeted clinical interventions.

A recent study by Ding et al. harnesses cutting-edge proteomics to explore protein changes linked to human aging over 50 years across 12 tissues and plasma. It uncovered asynchronous aging clocks in different organs, redefining aging as a coordinated, targetable network.

COX7RP is a critical factor that assembles mitochondrial respiratory chain complexes into supercomplexes, which is considered to modulate energy production efficiency. Whether COX7RP contributes to metabolic homeostasis and lifespan remains elusive. We here observed that COX7RP-transgenic (COX7RP-Tg) mice exhibit a phenotype characterized by a significant extension of lifespan. In addition, metabolic alterations were observed in COX7RP-Tg mice, including lower blood glucose levels at 120 min...

Perovskite solar cells (PSCs) based on formamidinium lead iodide (FAPbI₃) demonstrate near-ideal bandgaps approaching the Shockley-Queisser efficiency limit, yet residual MA⁺ from methylammonium chloride (MACl) additives compromises their operational stability under thermal/light stress. Therefore, we developed an α-phase-assisted antisolvent method employing MACl-free precursors to fabricate α-FAPbI(3) films. These films exhibit enhanced thermal stability and structural integrity, which were...

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