Aging & Longevity

Impact of exercise on cognitive efficiency in older adults with subjective memory complaints: a randomized clinical trial

8 hours 13 minutes ago
CONCLUSION: Improvements in neuropsychological status and subjective memory were associated with reduced resting MCAv following exercise training. These exploratory associations suggest that variability in cerebrovascular responses may relate to cognitive responses; however, without consistent group-level effects, findings should be interpreted cautiously and do not imply causality.
Gustavo O Silva

Alzheimer's disease polygenic risk score associates with hippocampal subfield atrophy and immune-related genetic mechanism

8 hours 13 minutes ago
INTRODUCTION: Hippocampal atrophy is frequently observed in neurodegenerative diseases such as Alzheimer's disease (AD) or hippocampal sclerosis of aging (HS-aging). Volume loss in the hippocampus is described as prodromal stage of dementia and has been associated with AD polygenic risk score (PRS). CA1 and subiculum atrophy have been suggested to be a promising in vivo biomarker for HS-aging. Recent studies suggest that some loci associated with AD may be more related to other brain diseases...
Clàudia Olivé

Artificial intelligence and machine learning for precision prevention of cognitive decline: integrating multimodal biomarkers, lifestyle interventions, and natural medicines from prediction to clinical practice

8 hours 13 minutes ago
Cognitive decline and neurodegenerative diseases are progressive, multifactorial conditions that may begin years before overt clinical diagnosis and reflect interactions among biological vulnerability, modifiable exposures, environmental determinants, and reduced brain resilience. This structured narrative review examines how artificial intelligence (AI) and machine learning (ML) can integrate clinical, biological, behavioral, and digital data to support earlier, personalized, and clinically...
Erika Smeriglio

Noncircadian BMAL1-YAP activity amplifies persistent inflammation in aged epidermis

8 hours 13 minutes ago
Aging is characterized by persistent low-grade inflammation linked to impaired tissue homeostasis, yet the underlying molecular mechanisms remain poorly understood. The mammalian skin is a clinically relevant site of aging-driven inflammation associated with compromised barrier function, inefficient wound healing, elevated oxidative stress and DNA damage accumulation. Here we show that, in the murine epidermis, aging engages a previously uncharacterized BMAL1-YAP functional cooperation with...
Júlia Bonjoch

Human brain organoids record the passage of time over multiple years

8 hours 13 minutes ago
The human brain develops and matures over an exceptionally prolonged period of time that spans nearly two decades of life. Processes that govern species-specific aspects of human postnatal brain development are difficult to study in animal models¹. While human brain organoids offer a promising in vitro model, they have thus far been shown to largely mimic early stages of brain development. Here we develop human brain organoids for 5 years in culture, optimizing growth conditions to extend...
Irene Faravelli

The impact of cumulative obesity and genetic susceptibility on biological aging in Chinese older adults

8 hours 13 minutes ago
The detrimental impacts of cumulative obesity exposures and their interactions with genetics on biological aging remain poorly understood. We included 687 older adults (median age: 79.6 years) from the Rugao Longitudinal Ageing Study (RLAS), a community-based cohort study conducted in Rugao, Jiangsu, China. The cumulative exposures of body mass index (cBMI) and waist circumference (cWC) were calculated as the excessive exposure of BMI and WC relative to their reference values (BMI ≥ 24 kg/m²; WC...
Jiening Yu

Stakeholder perspectives informing the design and development of a digital self-help intervention for healthy aging and mental well-being among older adults in urban India: a qualitative study

8 hours 13 minutes ago
CONCLUSIONS: The findings suggest that digital interventions tailored to the sociocultural needs of older adults may play an important role in promoting healthy aging and supporting mental well-being in India. Stakeholder-informed digital modules addressing physical health, sleep, emotional well-being, social connectedness, and self-care practices may enhance engagement, accessibility, and preventive mental healthcare among older adults. Future research should evaluate the effectiveness,...
Indranil Saha

Injury-driven stromal exhaustion disrupts intrinsic regenerative capability

1 day 8 hours ago
Bone marrow stromal cells, marked by leptin receptor (Lepr) and C-X-C motif chemokine ligand 12 (Cxcl12), orchestrate osteogenesis and maintain bone homeostasis. Following injury, these stromal cells directly generate reparative bone and subsequently restore the marrow microenvironment, a process widely regarded as a reliable regenerative response. However, it remains unclear whether stromal cells retain full regenerative capacity after prior injury. Here, we show that Lepr^(+)Cxcl12^(+) stromal...
Sixun Wu

CD4 CTLs in supercentenarians: Signs of adaptive expansion in healthy aging

1 day 8 hours ago
Our previous study identified CD4 cytotoxic T lymphocytes (CD4 CTLs) as a hallmark of supercentenarians. CD4 CTLs have primarily been studied in disease contexts; however, their role in healthy aging remains unclear. Using single-cell immune profiling, we analyzed T cells from supercentenarians and found that CD4 CTLs begin to expand around the age of 100, characterized by sequential CD27/CD28 loss without exhaustion. CD4 CTLs were dominated by large clones, with top clones averaging 33.3%,...
Kosuke Hashimoto

Aging in the air we breathe: mechanisms and consequences of air pollution exposure for biological aging

1 day 8 hours ago
Air pollution is the leading environmental cause of disease burden worldwide and is increasingly recognized as a potent driver of accelerated biological aging. Rather than acting through organ-specific toxicity alone, air pollutants appear to affect the fundamental hallmarks of aging itself, including oxidative stress, chronic inflammation, epigenetic dysregulation, telomere attrition, mitochondrial dysfunction, and cellular senescence. The pollutants of greatest concern are fine and ultrafine...
Parinaz Poursafa

Tryptophan Metabolism Regulates Immunosenescence and Inflammaging: The Macrophage Immunometabolic Axis and Therapeutic Targets

1 day 8 hours ago
Aging features two linked immune traits: immunosenescence and chronic low-grade inflammaging. Other than senescent lymphocytes, pathologically remodelled macrophages are key drivers of age-related immune dysfunction, mainly via tryptophan (Trp) metabolism through the kynurenine pathway (KP) and microbiota-related indole pathway. This review suggests a bidirectional amplification loop model, in which dysbiosis of the microbiota in the aged gut causes decreased production of microbial indoles and...
Dengchuan Wang

A lactate-alpha-ketoglutarate metabolic circuit in tumor-infiltrating regulatory T cells accelerates tumor progression by inducing NK cell senescence

1 day 8 hours ago
Regulatory T (T(reg)) cells prevent autoimmune diseases but limit antitumor immunity. Tumor‑infiltrating Treg (Ti‑T(reg)) cells exhibit metabolic traits as potential antitumor targets. Here, we find that Ti-T(reg) cells upregulate glutamate dehydrogenase 1 (GDH1), increasing α-ketoglutarate (α-KG) levels. Elevated GDH1 in Ti-T(reg) cells accelerates tumor progression. Mechanistically, in a lactate rich microenvironment, GDH1 lactylation boosts α-KG production to fuel ALKBH5-mediated Wnt2...
Tiezhu Shi

Palliative Care Interventions for Patients With Kidney Disease: A Scoping Review by the Kidney Disease Aging Research Collaborative

1 day 8 hours ago
CONCLUSIONS: In our sample of studies evaluating CKD palliative care interventions, limited quality domains were addressed, a variety of measurement tools were used, and less than a quarter of studies were conducted only in older adults. Future research should address the holistic nature of palliative care, apply standardized instruments, and increase inclusion of older adults.
Eleanor Rivera

Microglia-astrocyte crosstalk as a key organizing principle of Alzheimer's disease: from homeostatic cooperation to maladaptive signaling loops

1 day 8 hours ago
Alzheimer's disease (AD) has long been framed around amyloid-beta (Aβ) and tau pathology, yet mounting evidence indicates that dysfunctional microglia-astrocyte crosstalk is an important, and often underappreciated, contributor to disease progression that operates alongside-rather than in place of-neuronal, vascular, and proteinopathic mechanisms. Here we propose a three-stage framework in which glial communication transitions from silent vulnerability through organized defense to maladaptive...
Mingqiang Gong
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1 hour 33 minutes ago
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