Aging & Longevity

Analysis of GRK2 aggregation in the pathology of Alzheimer disease in animal models

1 day 3 hours ago
The G-protein-coupled receptor kinase 2 (GRK2) exerts essential functions in cell growth and survival. Searching for a connection between GRK2 and the neurodegenerative Alzheimer disease (AD), we find increased aggregated serine-670-phosphorylated GRK2 (phospho-S670-GRK2) in brains of AD mice and patients with dementia likely due to AD. Harmful phospho-S670-GRK2 aggregation is induced by two hallmark proteins of AD: beta-amyloid and the neurofibrillary-tangle-inducing, TAU-P301L. Aggregated...
Joshua Abd Alla

Survival implications of BMI in nonagenarians and centenarians of the CEPH aging cohort

1 day 3 hours ago
As global life expectancy rises, understanding predictors of survival in extreme old age is crucial. Body mass index (BMI) is a widely used proxy for adiposity and nutritional status. In adults, a BMI between 18.5 and 24.9 kg/m² is considered healthy and associated with better life expectancy; yet in nonagenarians and centenarians it remains unclear whether this BMI range is ideal due to age-related physiological changes. We examined BMI and mortality associations in 780 adults aged ≥90 years...
Nasreddine Rajoua

MicroRNA-128-3p Deficiency Alleviates Bone Loss in Age-Related Osteoporosis via Activation of Canonical Wnt Signaling

1 day 3 hours ago
MicroRNA-128-3p (miR-128-3p) has emerged as a crucial regulator of the aging process and age-associated disorders. Recent research highlights the vital role of miR-128-3p in osteoclast (OC) differentiation and the progression of osteoporosis following ovariectomy. Nonetheless, the mechanism by which miR-128-3p influences osteoblast (OB)-mediated bone formation and contributes to bone loss associated with aging is poorly understood. The present investigation began with an analysis of human bone...
Gengyang Shen

Correspondence of large-scale functional brain network decline across aging mice and humans

1 day 3 hours ago
Human aging is marked by progressive reorganization of large-scale functional brain networks; these brain network changes have been linked to cognitive decline and disease vulnerability. Conversely, while mice have served as powerful models for understanding the molecular and cellular changes that occur over the lifespan, an absence of precise characterization of age-related changes in large-scale functional brain network organization has limited cross-species translational insights. Here, using...
Ezra Winter-Nelson

Reversible aggregation-redispersion of Cu sites in Cu/CeO<sub>2</sub> catalysts with unlocked hydrogenation activity

1 day 3 hours ago
For oxide-supported metal catalysts, metal-support interaction (MSI) facilitates metal dispersion at the expense of the metallic character, resulting in a trade-off between active site utilization and intrinsic activity. Here, we used a thermal aging strategy to modulate the MSI in Cu/CeO(2) catalysts, facilitating the formation of metallic Cu sites upon H(2) reduction while maintaining metal dispersion. Systematic experiments confirmed that thermal aging at 800°C lowered the reduction...
Yu Zhang

Generation of proliferative hESC-derived grape-clustered hepatocyte organoids with multipolar architecture as regenerative counterpart via synergy of YAP and IGF2 pathways

1 day 3 hours ago
Primary human hepatocyte (PHH)-derived organoids form grape-like clusters with proliferative capacity, hepatocyte functionality, and multipolar polarity, serving as valuable models for liver biology and therapeutics. However, deriving comparable organoids from human embryonic stem cells (hESCs) remains difficult. Here, we established a defined system to differentiate hESC-derived hepatoblast organoids into hepatocyte organoids (heporgs) with two morphologies: spheroid-like (S-heporgs) and...
Haibin Wu

Acquisitive plants exhibit stronger phenological shifts in response to warming: insights from meta-analysis and long-term monitoring

1 day 3 hours ago
As climate warming accelerates, shifts in plant phenology are reshaping the functioning and stability of terrestrial ecosystems. While the roles of climatic drivers in shaping phenological responses to warming are well established, the influence of intrinsic plant functional traits remains poorly understood. Here, we combine two complementary approaches through a meta-analysis of 124 field warming experiments and an analysis of long-term phenological monitoring networks (CPON and USA‑NPN) to...
Kexin Xiong

Role of dysregulated calcium homeostasis in astrocytes in neurodegenerative disorders

1 day 3 hours ago
Calcium signalling in astrocytes is a fundamental mechanism for maintaining brain homeostasis, shaping neuronal activity, and coordinating vascular and immune responses. Once considered secondary to neuronal signalling, astrocytic Ca^(2+) dynamics are now recognized as highly versatile, spatially compartmentalized and essential for regulating neurotransmitter uptake, ion buffering, metabolic support and mitochondrial function. Accumulating evidence shows that these Ca^(2+) signalling pathways...
Maria V Sanchez-Mico

Metabolomic signatures of extreme old age: findings from the New England Centenarian Study

1 day 3 hours ago
The New England Centenarian Study (NECS) provides a unique resource for the study of extreme human longevity (EL). To gain insight into biological pathways related to EL, chronological age and survival, we used an untargeted serum metabolomic approach (> 1400 metabolites) in 213 NECS participants, followed by integration of our findings with metabolomic data from four additional studies. Compared to their offspring and matched controls, EL individuals exhibited a distinct metabolic profile...
Stefano Monti

Cognitive improvement by non-pharmacological electrical stimulation modalities in mild cognitive impairment: a protocol for systematic review and network meta-analysis

1 day 3 hours ago
CONCLUSION: This study will synthesize evidence from multiple studies on various electrical stimulation therapies for improving cognitive function in patients with mild cognitive impairment, thereby providing a diverse body of evidence to support clinical decision-making by physicians and optimization of treatment strategies for patients.
Tao Zhu

Senescence-Driven Remodeling Defines an Aggressive and Immunomodulatory Subtype of Endometriosis

1 day 3 hours ago
Endometriosis is a benign yet invasive disease characterized by ectopic endometrial growth and immune remodeling. While emerging evidence implicates cellular senescence in disease progression, the underlying mechanisms remain largely undefined. In this study, we identified marked heterogeneity in senescence across ectopic lesions and observed that P21-activated kinase 4 (PAK4) was consistently upregulated in senescent cells. Mechanistically, senescence induced PAK4 expression, which in turn...
Jingchun Liu

Myeloid cell nuclear differentiation antigen (MNDA) is an interferon-inducible regulator of myelopoiesis. Potential role in the myeloid-biased aging process

2 days 3 hours ago
Aging is a myeloid-biased process, i.e., the differentiation of myeloid cells increases, while the lymphoid lineage declines. Cellular senescence increases the secretion of inflammatory mediators which skew hematopoiesis toward myeloid cell generation. Myeloid cell nuclear differentiation antigen (MNDA) is a type-1 interferon (IFN)-inducible factor which is mainly expressed in the cells of the granulocyte-monocyte lineage, especially it is enriched in M2 macrophages and myeloid-derived...
Antero Salminen

Testicular aging revisited: Current understanding of mechanisms and emerging interventions

2 days 3 hours ago
Male reproductive aging is a complex physiological process characterized by progressive deterioration in spermatogenesis, hormonal imbalance, and increased susceptibility to infertility and genetic disorders. This review comprehensively summarizes the pivotal molecular mechanisms underlying testicular aging, with emphasis on mitochondrial dysfunction, oxidative stress, DNA damage, autophagy impairment, chronic inflammation, cellular senescence, and dysregulated apoptosis. Accumulating evidence...
Feng Jiang

Gut Luminal Exosomes in Young and Old Mice: Multi-Omic Characteristics and Regulation of Gut Permeability

2 days 3 hours ago
Aging is a multifaceted process impacting physiological, genomic, metabolic, and immune functions. This study investigates the role of luminal fecal exosomes (LFEs) in age-associated metabolic dysfunction. We analyzed LFEs from young (3-month) and old (24-month) male and female C57BL/6 mice to characterize age-related differences in exosomal proteomic and miRNA cargos. To explore interactions between LFEs and the gut microbiome, naïve young mice were gavage fed with LFEs from old donors,...
Abdelnaby Khalyfa
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