Aging & Longevity

Hippocampal theta oscillations coordinate computations underlying learning and memory. The frequency of theta varies with factors such as locomotion and anxiety, but the effect of an animal's sleep history on theta frequency remains unknown. Using long-duration CA1 recordings in rats, we found that awake theta frequency progressively decreases following sleep but remains elevated during sleep deprivation. These changes were not accounted for by movement but were predicted by the proportion of...

The dynamics of stem cell maintenance and proliferative patterns are key determinants of tissue aging in multicellular organisms. Leveraging our previously developed SMALT system with enhanced sequencing compatibility, we performed longitudinal lineage tracing of the adult Drosophila melanogaster midgut across different developmental stages. Using ubiquitous Tubulin-GAL4-driven labeling, we first profiled midgut-wide clonal dynamics during early adulthood (3-33 days post-eclosion). Phylogenetic...

Mitochondrial stress activates nuclear transcriptional programs to restore homeostasis and promote longevity; yet, the nuclear effector that directly reshapes chromatin during stress remains unclear. Through a forward genetic screen in Caenorhabditis elegans, we identify FUBL-3, the homolog of human far-upstream elements binding protein 1 (FUBP1), as a conserved regulator that couples mitochondrial stress to chromatin remodeling. FUBL-3 translocates to intestinal nuclei upon stress, where it...

Germline deletions of UDP-glycosyltransferase (UGT) UGT2B17 and UGT2B28 genes are common in human populations, yet their association with aging remains unclear. In this exploratory study, we analyzed data from 12,934 participants, mostly Caucasian, in the Canadian Longitudinal Study on Aging (CLSA) to assess cross-sectional and prospective associations between UGT deficiencies and aging-related health outcomes, including mortality, multimorbidity, allostatic load, disease burden and...

CONCLUSIONS: Our findings showed that age, gender, experience, attitudes toward aging, and wisdom were related to attitudes toward dementia. This evidence could serve as a guide of practical implications in stigma-reduction campaigns, dementia education, and policy reform.

CONCLUSION: The findings indicate a high burden of self-reported chronic health problems and functional dependency among older adults in a hilly municipality of Nepal. Marital status, smoking, and physical activity were significantly associated with chronic illness, while age and chronic illness were significantly associated with ADL dependency. These results highlight the need for community-based geriatric screening and targeted behavioural interventions to improve health status among older...

CONCLUSIONS: Elderly patients with multimorbidity who underwent elective surgeries have high aging self‑stereotype scores, which are independently associated with first‑time surgery, multimorbidity burden, and decision‑making preference. A management model that combines multidisciplinary collaboration with family support should be established to reduce negative stereotypes and improve quality of life among these patients.

CONCLUSIONS: The findings suggest that the psychological consequences of LTCI exposure may be more visible in the upper tail of the depression distribution among older adults with high care needs than in average mental-health indicators, with the signal appearing stronger in women in exploratory analyses. Policy evaluation should therefore move beyond mean-based indicators and strengthen needs-matched, psychologically supportive long-term care for vulnerable older adults.

CONCLUSIONS: In this cross-sectional study in China, exposure to depressive symptoms was associated with IADL disability. This association was modified by age, sex, and outdoor activity engagement. These findings indicate a need to prevent depressive symptoms and a need for an intervention strategy for mental health to reduce the potential risk of IADL disability. Moreover, emphasizing personalized interventions that target individuals with depressive symptoms exposure may minimize the burden of...

Aging is a multifactorial process driven by interconnected hallmarks, including chronic inflammation, mitochondrial dysfunction, genomic and epigenetic alterations, and dysregulated intercellular communication. Extracellular vesicles (EVs), naturally derived nanoscale membrane vesicles capable of transporting diverse bioactive cargoes across tissues and biological barriers, have emerged as a highly promising platform for regenerative and anti-aging therapeutics. In this review, we systematically...

Southern European countries have some of the highest life expectancies in the world, yet they display relatively high frailty. We examined different diets to identify compositions that promote both healthspan and strength in mice. The western and ketogenic diets increased fat mass and frailty and increased either cholesterol or insulin resistance, whereas a low-protein longevity diet, modeling the traditional Mediterranean and Okinawan diets but supplemented with methionine (LDMM), reduced fat...

AMP-activated protein kinase (AMPK) is a crucial energy sensor that regulates a wide range of important processes in skeletal muscle. AMPK is present in several subcellular compartments (including the cytosol, nucleus, and mitochondria). However, the influence of physiologically relevant interventions on AMPK's localization in skeletal muscle is not well understood, especially during older age. Accordingly, this study examined AMPK signaling in skeletal muscle from aged male rats...

The mechanistic target of rapamycin complex 1 (mTORC1) serves as a central metabolic hub that integrates nutrient signals and orchestrates cellular metabolism to regulate many fundamental cell processes. While mTORC1 activation is known to occur both on lysosomal membranes and at the Golgi apparatus in response to environmental cues, the molecular mechanisms governing its Golgi-associated activation remain poorly understood. In this study, we identified YIF1A as a novel Golgi-localized regulator...

Exploiting cost-effective trifunctional electrocatalysts toward oxygen evolution reaction, hydrogen evolution reaction and oxygen reduction reaction is important for sustainable energy conversion and storage devices yet challenging. Here, we report a single-phase trifunctional electrocatalyst Sr(2)CoRuO(6-δ) with well-defined super-exchange double perovskite structure, which can efficiently catalyze oxygen evolution, hydrogen evolution and oxygen reduction under alkaline conditions. As an air...

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The long-term impact of atrial fibrillation (AF) and systemic inflammation on muscle health and, hence, functional decline remains unclear. This study investigates the link between AF and longitudinal trajectories of muscle mass and strength, considering the role played by systemic inflammation. Data were obtained from 2048 participants (≥ 60 years) in the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K), followed for 12 years. Muscle mass and strength were assessed using calf...

Future deep-space missions will expose astronauts to microgravity and ionizing radiation, which induce molecular changes that mirror biological aging, including inflammation, cellular senescence, and fibrotic remodeling. However, the regulatory mechanisms linking spaceflight stressors to aging-associated molecular responses in metabolically important organs such as the liver remain incompletely understood. In this study, we investigated the effects of simulated microgravity and deep-space...

Aging is accompanied by metabolic alterations that may precede or parallel functional decline. While chronological age correlates with numerous circulating metabolites, the extent to which these associations reflect age-independent functional deterioration remains unclear. To identify plasma metabolites associated with muscle quality (assessed by bioelectrical impedance phase angle at 50 kHz) and pulmonary function (forced vital capacity, FVC) independently of chronological age, and to...

With the aging of the population, frailty has become a common syndrome that severely affects the quality of life of older adults. This study aims to analyze the correlation between cognition and frailty, physical activity and frailty, and elucidate the potential pharmacological targets of cognitive frailty and physical frailty.We conducted logistic regression analyses using data from the China Health and Retirement Longitudinal Study (CHARLS) to examine the associations between total cognition...