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Experimental validation and identification of ferroptosis-associated biomarkers for diagnostic and therapeutic targeting in hearing loss
CONCLUSION: Ferroptosis is a potential pathological mechanism in hearing loss research, and the nine ferroptosis-related genes identified provide promising targets for exploring new diagnostics and treatments for hearing loss. Notably, MEF2C and NEDD4 are associated with ARHL.
Reducing HuD Levels Alleviates Alzheimer's Disease Pathology in 5xFAD Mice
Alzheimer's disease (AD) is the most common neurodegenerative pathology in older persons. The accumulation of amyloid β (Aβ) plaques is a major contributor to AD development. The RNA-binding protein HuD/ELAVL4 has been implicated in the formation of Aβ plaques, but its role in AD is unclear. Here, we report that ablation of HuD from CAMK2A^(+) neurons (HuDcKO) in the 5xFAD mouse model of AD results in a significant reduction of Aβ plaques and the alleviation of some AD-associated behaviors....
Daily briefing: Chimp societies drum to a distinct beat
Migraine drug is first to tackle debilitating early symptoms
NSF terminates huge number of grants and stops awarding new ones
Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging
Author Correction: Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer
Why bad philosophy is stopping progress in physics
The scars of war last for centuries: how we understand collective trauma needs to change
Hunting extreme microbes that redefine the limits of life
‘AI models are capable of novel research’: OpenAI’s chief scientist on what to expect
North America’s birds are declining where they should be thriving
What language do bats speak? I’m trying to find out
Scientists turn lead into gold
Trump’s ‘fear factor’: Scientists go silent as funding cuts escalate
Many worry about retribution. But for others, speaking out is worth the risk
Aztec Empire sought obsidian from far and wide to make ritual jewelry and basic tools
Largest ever study of Tenochtitlan obsidian reveals complex trade networks and ritual preferences
Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging
Mesenchymal stem cells (MSCs), a vital component of the adult stem cell repertoire, are distinguished by their dual capacity for self-renewal and multilineage differentiation. The therapeutic effects of MSCs are primarily mediated through mechanisms such as homing, paracrine signaling, and cellular differentiation. Exosomes (Exos), a type of extracellular vesicles (EVs) secreted by MSCs via the paracrine pathway, play a pivotal role in conveying the biological functions of MSCs. Accumulating...
NIH’s key vaccine center slammed by contract cuts
Antibody and vaccine work is slowed after the National Institutes of Health loses as many as 2200 contract workers
Elevated serum leucine levels are associated with cognitive impairment and reduced gray matter and cerebral volume across the Alzheimer's disease continuum
Leucine, a branched-chain amino acid (BCAA), exhibits paradoxical effects in Alzheimer's disease (AD), demonstrating both neuroprotective and neurotoxic roles. While prior studies have investigated leucine's systemic and metabolic impacts, its influence on brain structure remains unexplored. This study aimed to fill this critical gap by examining the relationship between serum leucine levels, brain volume metrics, and cognitive performance in individuals across the AD continuum. Serum leucine...
Cellular senescence promotes macrophage-to-myofibroblast transition in chronic ischemic renal disease
Cellular senescence participates in the pathophysiology of post-stenotic kidney damage, but how it regulates tissue remodeling is incompletely understood. Macrophage-myofibroblast transition (MMT) contributes to the development of tissue fibrosis. We hypothesized that cellular senescence contributes to MMT and renal fibrosis in mice with renal artery stenosis (RAS). INK-ATTAC mice expressing p16^(INK-4a) and green fluorescent protein in senescent cells were assigned to control or unilateral RAS,...