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Impact of sarcopenia and obesity on skeletal muscle size, gene expression, and mitochondrial function
Skeletal muscle is a primary tissue of dysfunction during both aging and obesity. Recently, the coincidence of obesity and aging has gained attention due to the intersection of the obesity epidemic with an aging demographic. Both aging and obesity are associated with marked defects in skeletal muscle metabolic health. Despite these findings, we have a poor understanding of how obesity and aging may interact to impact skeletal muscle mass and metabolic health. Therefore, we investigated the...
Impact of lifestyle factors on quantitative motor and cognitive performance: insights from a longitudinal study on healthy ageing
The process of ageing is extremely variable in progression and phenotypic features including significant variations in disease milestones, such as cognitive impairment, frailty, or recurrent falls. Our aim was to analyze the influence of lifestyle factors on motor and cognitive performance in a longitudinal ageing study in older people on healthy ageing. We conducted a longitudinal analysis in a cohort of 744 older participants (mean 70 years) over an 8-year period. Cognitive performance was...
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Clonal hematopoiesis driven by microbial metabolite
Bridging the divide: Why the science-policy interface matters for global food systems
Science, Volume 388, Issue 6752, June 2025.
Erratum for the Research Article “La- and Mn-doped cobalt spinel oxygen evolution catalyst for proton exchange membrane electrolysis” by L. Chong et al.
Science, Volume 388, Issue 6752, June 2025.
Cat1 forms filament networks to degrade NAD+ during the type III CRISPR-Cas antiviral response
Science, Volume 388, Issue 6752, June 2025.
Evolutionary-scale enzymology enables exploration of a rugged catalytic landscape
Science, Volume 388, Issue 6752, June 2025.
Aberrant basal cell clonal dynamics shape early lung carcinogenesis
Science, Volume 388, Issue 6752, June 2025.
Introgression dynamics of sex-linked chromosomal inversions shape the Malawi cichlid radiation
Science, Volume 388, Issue 6752, June 2025.
Acid-humidified CO2 gas input for stable electrochemical CO2 reduction reaction
Science, Volume 388, Issue 6752, June 2025.
A metabolite-based resistance mechanism against malaria
Science, Volume 388, Issue 6752, June 2025.
How to address gender equity in science in Africa
An instantaneous voice-synthesis neuroprosthesis
BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction
Science, Volume 389, Issue 6758, Page 409-415, July 2025.
Carbonyl-to-sulfur swap enabled by sequential double carbon-carbon bond activation
Science, Volume 388, Issue 6754, Page 1436-1440, June 2025.
In Science Journals
Science, Volume 388, Issue 6752, Page 1174-1176, June 2025.