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Science, Volume 389, Issue 6756, Page 200-206, July 2025.

Science, Volume 389, Issue 6756, Page 157-162, July 2025.

Science, Volume 389, Issue 6756, Page 169-175, July 2025.

Science, Volume 389, Issue 6756, Page 132-132, July 2025.

Science, Volume 389, Issue 6756, Page 133-133, July 2025.

Science, Volume 389, Issue 6759, Page 479-482, July 2025.

Science, Volume 389, Issue 6759, Page 508-511, July 2025.

Science, Volume 389, Issue 6758, Page 357-358, July 2025.

Now-canceled CMB-S4 project would have searched the afterglow of the Big Bang for signs of cosmic exponential growth spurt

Adults in the ICU often don’t know about the genetic diagnoses related to their symptoms, DNA sequencing study shows

Understanding the origins of mysterious seeps could help prospectors extract natural hydrogen fuel

Some worry new members of the long-running Advisory Committee to the Director will mirror agency chief Jay Bhattacharya’s views

Its support for a flat budget is a sign of congressional resistance to drastic cuts Trump has proposed

After decades in the doldrums, atom-based machines could overtake rival technologies

Reducing fibrous aggregates of the protein tau is a possible strategy for halting the progression of Alzheimer's disease (AD)¹. Previously, we found that in vitro, the D-enantiomeric peptide (D-peptide) D-TLKIVWC disassembles ultra-stable tau fibrils extracted from the autopsied brains of individuals with AD (hereafter, these tau fibrils are referred to as AD-tau) into benign segments, with no energy source other than ambient thermal agitation². To consider D-peptide-mediated disassembly as a...

Plasma proteins derived from specific organs can estimate organ age and mortality, but their sensitivity to environmental factors and their robustness in forecasting onset of organ diseases and mortality remain unclear. To address this gap, we estimate the biological age of 11 organs using plasma proteomics data (2,916 proteins) from 44,498 individuals in the UK Biobank. Organ age estimates were sensitive to lifestyle factors and medications and were associated with future onset (within 17...

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It is well-known that physical activity exerts health benefits, yet the potential impacts of early-life regular exercise on later-life health and lifespan remains poorly understood. Here, we demonstrate that 3 months of early-life exercise in mice results in lasting health benefits, extending healthspan, but not lifespan. C57BL/6J mice underwent swimming exercise from 1 to 4 months of age, followed by detraining for the remainder of their lives. While early-life exercise did not extend the...

Aging is the primary risk factor for many cancer types, including lung adenocarcinoma (LUAD). To understand how aging-related alterations in the regulation of key cellular processes might affect LUAD risk and survival, we built individual-specific gene regulatory networks integrating gene expression, transcription factor protein-protein interaction, and sequence motif data, using PANDA/LIONESS algorithms, for non-cancerous lung samples from GTEx project and LUAD samples from TCGA. In healthy...

Weight loss significantly improves metabolic and cardiovascular health in people with obesity^(1-3). The remodelling of adipose tissue (AT) is central to these varied and important clinical effects⁴. However, surprisingly little is known about the underlying mechanisms, presenting a barrier to treatment advances. Here we report a spatially resolved single-nucleus atlas (comprising 171,247 cells from 70 people) investigating the cell types, molecular events and regulatory factors that reshape...