Aggregator
Voxel-wise insights into early Alzheimer's disease pathology progression: the association with APOE and memory decline
Longitudinal investigation of the Apolipoprotein E (APOE) genotype's impact on Alzheimer's disease (AD) biomarker progression, focusing on amyloid beta (Aβ) accumulation and gray matter (GM) atrophy, integrating cognitive decline and baseline levels. Longitudinal florbetapir-PET and T1-weighted MRI data from 100 cognitively normal (CN) and mild cognitive impaired (MCI) participants both with considerable global Aβ accumulation ("high Aβ accumulators") were analyzed using a voxel-wise approach....
Neuronal antenna senses signals from the bone to sustain cognition by boosting autophagy
The common occurrence of cognitive decline is one of the most significant manifestations of aging in the brain, with the hippocampus - critical for learning and memory - being one of the first regions to exhibit functional deterioration. BGLAP/OCN/osteocalcin (bone gamma-carboxyglutamate protein), a pro-youth systemic factor produced by the bone, improves age-related cognitive decline by boosting hippocampal neuronal autophagy. However, the mechanism by which hippocampal neurons detect BGLAP/OCN...
Linking cognitive reserve to neuropsychological outcomes and resting-state frequency bands in healthy aging
INTRODUCTION: As the proportion of older people has surged in the past 100 years, healthy aging has emerged as a crucial topic in neuroscience research. This study aimed to investigate the spectral power of EEG frequency bands during resting-state in older people with high and low cognitive reserve (CR).