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A neuroimmune circuit mediates cancer cachexia-associated apathy
Science, Volume 388, Issue 6743, April 2025.
Rules of engagement for condensins and cohesins guide mitotic chromosome formation
Science, Volume 388, Issue 6743, April 2025.
The genetic architecture of and evolutionary constraints on the human pelvic form
Science, Volume 388, Issue 6743, April 2025.
A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals
Science, Volume 388, Issue 6743, April 2025.
Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues
Science, Volume 388, Issue 6743, April 2025.
Chief of NIH’s international center is latest director to lose job under Trump
Kathleen Neuzil had led the Fogarty International Center for less than 1 year
Sexual orientation, gender options cut from U.S. Ph.D. graduate survey
After adding questions to a key survey last year, the U.S. National Science Foundation is reversing course
After Trump grant cuts, some universities give researchers a lifeline
“Bridge” programs are temporary help, officials say, but no substitute for sustained federal funding
Astronomers spot a planetary ‘suicide’
World seen plunging into its star for the first time
CDC firings gut research on traumatic brain injuries
Last week’s mass layoffs removed small team studying concussions
Did cult sacrifices in ancient Egypt give rise to the cat?
“Murder pathway” may have tamed wildcats over several generations
A cloaked human stem-cell-derived neural graft capable of functional integration and immune evasion in rodent models
Human pluripotent stem cell (hPSC)-derived therapies are a realistic possibility for numerous disorders, including Parkinson's disease. While generating replacement neurons is achievable, immunosuppressive drug challenges, to prevent rejection, remain. Here we adopted a hPSC line (termed H1-FS-8IM), engineered to overexpress 8 immunomodulatory transgenes, to enable transplant immune evasion. In co-cultures, H1-FS-8IM PSC-derived midbrain neurons evaded rejection by T lymphocytes, natural killer...
Subthalamic nucleus dynamics during executive functioning: Insights from local field potentials in Parkinson's disease
This study explores the involvement of the subthalamic nucleus (STN) in executive functions, particularly cognitive flexibility, in Parkinson's disease (PD) patients. Utilizing a computerized Wisconsin Card Sorting Task (WCST) and local field potential (LFP) recordings from implanted deep brain stimulation (DBS) electrodes, we investigated task-specific neural dynamics. Behavioural results demonstrated increased error rates and prolonged response times in trials requiring set-shifting and rule...
New biomarkers for early-stage tau pathology in Alzheimer's disease
No abstract
Microglia underlie amyloid-beta clearance in immunized people with Alzheimer disease
No abstract
The bridge-like lipid transport protein VPS13C/PARK23 mediates ER-lysosome contacts following lysosome damage
Based on genetic studies, lysosome dysfunction is thought to play a pathogenetic role in Parkinson's disease. Here we show that VPS13C, a bridge-like lipid-transport protein and a Parkinson's disease gene, is a sensor of lysosome stress or damage. Following lysosome membrane perturbation, VPS13C rapidly relocates from the cytosol to the surface of lysosomes where it tethers their membranes to the ER. This recruitment depends on Rab7 and requires a signal at the damaged lysosome surface that...
Brain cells given an 'invisibility cloak' fix Parkinson's symptoms in rats
No abstract
Expression of anti-amyloid CARs in microglia promotes efficient and selective phagocytosis of Aβ1‒42
Genetic engineering of microglial cells is a promising therapeutic avenue emerging with advancements in gene delivery techniques. Using a recently developed AAV capsid for efficient in vitro transduction we report the engineering of microglia with CARs (CAR-Mic) targeting phagocytosis of amyloid beta 1‒42 (Aβ42). Functional screening of seven CAR constructs in human iPSC-derived microglia revealed up to 6-fold increases in internalized Aβ relative to viral control. CAR-driven phagocytic...
Multi-ancestry GWAS identifies 16 novel Alzheimer disease risk loci
No abstract
Lower aperiodic EEG activity is associated with reduced verbal fluency performance across adulthood
Age-related cognitive decline associations with human electroencephalography (EEG) have previously focused on periodic activity. However, EEG primarily consists of non-oscillatory aperiodic activity, characterised with an exponent and offset value. In a secondary analysis of a cohort of 111 healthy participants aged 17 - 71 years, we examined the associations of the aperiodic exponent and offset in resting EEG with a battery of cognitive tests consisting of the Colour-Word Interference Test,...