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Ageing is linked to inflammation — but only in the industrialized world
Trump team says it’s axing some contracts with publishing giant Springer Nature
Stare into a whale’s colossal eye — June’s best science images
Natural nappers: monitoring the sleeping patterns of wild orangutans
Nonuniversality of inflammaging across human populations
Obesity drugs made in China could power next wave of treatments
’We couldn’t live without it’: the UCSC Genome Browser turns 25
I pioneered my country’s newborn health-screening programme
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis
A TFEB–TGFβ axis systemically regulates diapause, stem cell resilience and protects against a senescence-like state
Clusterin drives myeloid bias in aged hematopoietic stem cells by regulating mitochondrial function
What do dolphins talk about? One biologist is trying to listen in
If you’re a US researcher, now is the time to establish a plan B
EPA employees accuse Trump officials of undermining the agency’s mission
“Declaration of Dissent” denounces partisan messaging, rollback of environmental regulations, and dismantling of science office, among other concerns
Scientists identify culprit behind biggest-ever U.S. honey bee die-off
USDA research points to viruses spread by pesticide-resistant mites, indicating a worrying trend
Cathodal high-definition transcranial direct current stimulation improves sleep and motor symptoms in Parkinson's disease with possible rapid eye movement sleep behaviors disorder: A pilot open-label study
CONCLUSION: HD-tDCS could be a useful complementary treatment for improving sleep and movement in PD-pRBD patients.
Advancing Age and Risk From the Elevated Atherogenic Index: Triglyceride (TG) to High-Density Cholesterol (HDL-C) Ratio
CONCLUSION: The association between the TG/HDL-C ratio (atherogenic index) and incident ASCVD steadily attenuates with age. In adults over 65, an elevated ratio may be associated with a lower risk of incident ASCVD. These findings may reflect changes in metabolic atherosclerotic risk or a survival effect associated with aging and require further investigation.
Explaining tip-of-the-tongue experiences in older adults: The role of brain-based and cardiorespiratory fitness factors
Cognitive decline associated with healthy ageing is multifactorial: brain-based and lifestyle factors uniquely and jointly contribute to distinct neurocognitive trajectories of ageing. To evaluate existing models of neurocognitive ageing such as compensation, maintenance, or reserve, we explore how various known brain-based and cardiorespiratory fitness factors intersect to better understand cognitive decline. In a pre-registered study (https://osf.io/6fqg7), we tested 73 healthy older adults...
Age-related differences in cerebral morphology and microstructure in rhesus macaques
The rhesus macaque presents a promising model for translational research into human brain aging due to this species' long lifespan and close phylogenic relationship. We conducted a cross-sectional study identifying microstructural and morphological biomarkers of aging in a cohort of 37 healthy animals (18F/19M, aged 5-28 years), using high-resolution T2-weighted (T2w) and diffusion-weighted (DW) images. Using Tensor Based Morphometry, significant age-associated regional brain atrophy was...
Emerging uncertainty on the anti-aging potential of metformin
Metformin is the most commonly prescribed glucose-lowering agent worldwide for the treatment of type II diabetes. Due to evidence of improvements in healthspan and lifespan in model organisms, and mechanistic data relevant to the hallmarks of aging, it has been considered a promising candidate in the search for pharmacological interventions that may attenuate the ageing process in humans. Various epidemiological studies have been influential in generating support for this hypothesis. These...