Aggregator
Asteroid 2024 YR4 now unlikely to hit Earth — but scientists are ready for future threats
How to bring health and happiness to your lab
Putting early cancer detection to the test
How AI is revealing the language of the birds
Tropical forest’s last old growth is being toppled — illegally
Stories of people, past, present and future: Books in brief
A primary cilia–autophagy axis in hippocampal neurons is essential to maintain cognitive resilience
What sparked the COVID pandemic? Mounting evidence points to raccoon dogs
Experimental evolution of evolvability
Science, Volume 387, Issue 6736, February 2025.
Antiviral signaling of a type III CRISPR-associated deaminase
Science, Volume 387, Issue 6736, February 2025.
A neural basis for prosocial behavior toward unresponsive individuals
Science, Volume 387, Issue 6736, February 2025.
Reviving-like prosocial behavior in response to unconscious or dead conspecifics in rodents
Science, Volume 387, Issue 6736, February 2025.
Disease diagnostics using machine learning of B cell and T cell receptor sequences
Science, Volume 387, Issue 6736, February 2025.
More NIH job cuts coming? Agency’s scientists already reeling after week of firings
NIH is appealing loss of some lab leaders among in-house research program while bracing for the next actions from Trump administration
U.S. early-career researchers struggling amid chaos
Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard
Modest telescope with big plans, SPHEREx will probe cosmic ‘inflation’ after Big Bang
Spacecraft with gather and analyze infrared light in new ways to explain why our universe is “boring”
Judge says ban on NIH cut to overhead payments stands—for the moment
Temporary order blocking the change extended until a decision is handed down
Stressed microglia turn to the dark side in Alzheimer's disease
A microglia subpopulation termed "dark microglia" has been associated with aging and neurodegeneration, although its role has remained elusive. New research from Flury et al. in this issue of Neuron shows that dark microglia drive neurodegeneration via secretion of toxic lipids.¹.
Large-scale proteomic analyses of incident Parkinson's disease reveal new pathophysiological insights and potential biomarkers
The early pathophysiology of Parkinson's disease (PD) is poorly understood. We analyzed 2,920 Olink-measured plasma proteins in 51,804 UK Biobank participants, identifying 859 incident PD cases after 14.45 years. We found 38 PD-related proteins, with six of the top ten validated in the Parkinson's Progression Markers Initiative (PPMI) cohort. ITGAV, HNMT and ITGAM showed consistent significant association (hazard ratio: 0.11-0.57, P = 6.90 × 10^(-24) to 2.10 × 10^(-11)). Lipid metabolism...
Stressed microglia turn to the dark side in Alzheimer's disease
A microglia subpopulation termed "dark microglia" has been associated with aging and neurodegeneration, although its role has remained elusive. New research from Flury et al. in this issue of Neuron shows that dark microglia drive neurodegeneration via secretion of toxic lipids.¹.