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Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
Understanding the pathophysiology of neurological symptoms observed after severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection is essential to optimizing outcomes and therapeutics. To date, small sample sizes and narrow molecular profiling have limited the generalizability of findings. In this study, we profiled multiple cortical and subcortical regions in postmortem brains of patients with coronavirus disease 2019 (COVID-19) and controls with matched pulmonary pathology (total...
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
Understanding the pathophysiology of neurological symptoms observed after severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection is essential to optimizing outcomes and therapeutics. To date, small sample sizes and narrow molecular profiling have limited the generalizability of findings. In this study, we profiled multiple cortical and subcortical regions in postmortem brains of patients with coronavirus disease 2019 (COVID-19) and controls with matched pulmonary pathology (total...
A sample of the Moon’s far side retrieved by Chang’e-6 contains 2.83-billion-year-old basalt
Science, Volume 386, Issue 6728, Page 1395-1399, December 2024.
Daily briefing: Tech giants invest in next-generation geothermal energy
How human brains got so big: our cells learned to handle the stress that comes with size
Major biomedical funder NIH poised for massive reform under Trump 2.0
Radiation for dummies: the female mannequins testing space-travel safety
Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial
Fragments of eternal youth
Stress can disrupt memory and lead to needless anxiety — here’s how
Lunar farside volcanism 2.8 billion years ago from Chang’e-6 basalts
Chemical genetic approaches to dissect microbiota mechanisms in health and disease
Science, Volume 386, Issue 6723, November 2024.
Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1
Science, Volume 386, Issue 6723, November 2024.
Sequence modeling and design from molecular to genome scale with Evo
Science, Volume 386, Issue 6723, November 2024.
SPL13 controls a root apical meristem phase change by triggering oriented cell divisions
Science, Volume 386, Issue 6723, November 2024.
A glutamine metabolic switch supports erythropoiesis
Science, Volume 386, Issue 6723, November 2024.
Saber-toothed kitten frozen in Siberian ice reveals new details about species
Ice mummy preserves extinct cat from claws to paws
Prospect of RFK Jr. as head of HHS panics many in medical science community
Robert F. Kennedy Jr. has vowed radical change including scrutinizing long-standing vaccines and slashing staff at research and regulatory agencies
The first people on Tasmania brought fire and forever changed the land
Study of charcoal and pollen could give Aboriginal advocates of traditional burns “more voice at the table”
Progress in the mechanisms of pain associated with neurodegenerative diseases
Neurodegenerative diseases (NDDs) represent a class of neurological disorders characterized by the progressive degeneration or loss of neurons, impacting millions of individuals globally. In addition to the typical manifestations, pain is a prevalent symptom associated with NDDs, seriously impacting the quality of life for patients. The pathogenesis of pain associated with NDDs is intricate and multifaceted. Currently, the clinical management of NDDs-related pain symptoms predominantly relies on...