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Neuroprotective role of Hippo signaling by microtubule stability control in <em>Caenorhabditis elegans</em>
The evolutionarily conserved Hippo (Hpo) pathway has been shown to impact early development and tumorigenesis by governing cell proliferation and apoptosis. However, its post-developmental roles are relatively unexplored. Here, we demonstrate its roles in post-mitotic cells by showing that defective Hpo signaling accelerates age-associated structural and functional decline of neurons in Caenorhabditis elegans. Loss of wts-1/LATS, the core kinase of the Hpo pathway, resulted in premature...
NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse populations
A core facet of the National Institute on Aging's mission is to identify pharmacological interventions that can promote human healthy aging and long life. As part of the comprehensive effort toward that goal, the NIA Division of Biology of Aging established the Caenorhabditis Intervention Testing Program (CITP) in 2013. The C. elegans model (with an ~ 21 day lifespan) has led the field in dissection of longevity genetics and offers features that allow for relatively rapid testing and for the...
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Beyond the binary: Navigating AI’s uncertain future in Africa
Science, Volume 388, Issue 6742, April 2025.
Erratum for the Research Article “Whale song shows language-like statistical structure” by I. Arnon et al.
Science, Volume 388, Issue 6742, April 2025.
Journal targeted by paper mill still grappling with the aftermath years later
Solar cells made of Moon dust could power up a lunar base
Hidden states and dynamics of fractional fillings in twisted MoTe<sub>2</sub> bilayers
Strategic atom replacement enables regiocontrol in pyrazole alkylation
Regeneration leads to global tissue rejuvenation in aging sexual planarians
After ‘coding error’ triggers firings, top NIH scientists called back to work
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In Science Journals
Science, Volume 388, Issue 6742, Page 42-44, April 2025.
Rubella and measles: The beginning of the endgame
Science, Volume 388, Issue 6742, Page 32-34, April 2025.
Dancing with the cells: How acoustically levitating a diamond enabled a redesign of biotech automation
Science, Volume 388, Issue 6742, Page 41-41, April 2025.
Empower the age of smart mRNA medicine: Programmable RNA sensor and molecular tools refine therapeutic payload production
Science, Volume 388, Issue 6742, Page 40-41, April 2025.
mRNA binding proteins join the longevity pipeline: Rebuilding muscle through the power of mRNA binding protein therapeutics
Science, Volume 388, Issue 6742, Page 41-41, April 2025.
New Products
Science, Volume 388, Issue 6742, Page 116-116, April 2025.