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The role of serum α-Klotho levels in preventing hearing impairment among middle-aged and older adults: insights from a nationally representative sample
CONCLUSION: This study provided novel evidence of a negative association between serum α-Klotho and hearing impairment in adults aged 40-69. Our results suggested a protective role of serum α-Klotho on adults with hearing loss.
Trajectories of cognitive function and frailty in older adults in China: a longitudinal study
CONCLUSION: Our findings suggest a co-development pattern between cognitive function and frailty in Chinese older adults aged 55 years and above. While cognitive impairment may be irreversible, frailty is a condition that can be potentially reversed. Early detecting is crucial in preventing cognitive decline, considering the shared trajectory of these conditions.
Daily briefing: How to get to 100 — centenarian cells teach us about ageing
Do you drink coffee? Ask your gut
Author Correction: Intravenous and intracranial GD2-CAR T cells for H3K27M<sup>+</sup> diffuse midline gliomas
Keeping endogenous retroviruses at bay
What’s the secret to living to 100? Centenarian stem cells could offer clues
Where in the world is there potential for tropical-forest regeneration?
Long orbit
This giant coral is the biggest ever found — November’s best science images
Audio long read: AI has dreamt up a blizzard of new proteins. Do any of them actually work?
Author Correction: Dynamic transition and Galilean relativity of current-driven skyrmions
Optoelectronic metadevices
Science, Volume 386, Issue 6725, November 2024.
Tlr7 drives sex differences in age- and Alzheimer’s disease–related demyelination
Science, Volume 386, Issue 6725, November 2024.
Molecular basis of mRNA delivery to the bacterial ribosome
Science, Volume 386, Issue 6725, November 2024.
Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance
Science, Volume 386, Issue 6725, November 2024.
PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance
Science, Volume 386, Issue 6725, November 2024.
Emerging biophysical techniques for probing synaptic transmission in neurodegenerative disorders
Plethora of research has shed light on the critical role of synaptic dysfunction in various neurodegenerative disorders (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD). Synapses, the fundamental units for neural communication in the brain, are highly vulnerable to pathological conditions and are central to the progression of neurological diseases. The presynaptic terminal, a key component of synapses...
TREM2 bridges microglia and extracellular microenvironment: Mechanistic landscape and therapeutical prospects on Alzheimer's disease
Neuroinflammation is closely related to the pathogenesis of Alzheimer's disease (AD). One of its prominent cellular components, microglia, is a potent coordinator of neuroinflammation in interplay with the characteristic AD pathological alterations including Aβ, tau, and neuronal defects, which constitute the AD-unique extracellular microenvironment. Mounting evidence implicates Triggering Receptors Expressed on Myeloid Cells 2 (TREM2) in the center of microglial activation, a vital event in the...
SPLICER: a highly efficient base editing toolbox that enables in vivo therapeutic exon skipping
Exon skipping technologies enable exclusion of targeted exons from mature mRNA transcripts, which have broad applications in medicine and biotechnology. Existing techniques including antisense oligonucleotides, targetable nucleases, and base editors, while effective for specific applications, remain hindered by transient effects, genotoxicity, and inconsistent exon skipping. To overcome these limitations, here we develop SPLICER, a toolbox of next-generation base editors containing near-PAMless...