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Spending panel wants his policies reversed—but it may not have sufficient clout to succeed

Ethics experts raise concerns over consent, study design

After just 100 days, agency scientists say U.S. health institutes are demoralized and have lost essential staff and funding

The scientific workforce, biomedical research, and global health initiatives all face widespread, perhaps permanent damage

Trump’s chaotic push to remake federal research will have lasting consequences

Agency plans to promote alternative methods and address “bias” toward animal studies in grant review

Records could reveal how much humanity has altered Sahel rains

Hundreds of grants axed in a field where the United States was a global leader

Tau accumulation is closely related to cognitive symptoms in Alzheimer's disease (AD). However, the cellular drivers of tau-dependent decline of memory-based cognition remain elusive. Here, we employed in vivo Neuropixels and patch-clamp recordings in mouse models and demonstrate that tau, independent of β-amyloid, selectively debilitates complex-spike burst firing of CA1 hippocampal neurons, a fundamental cellular mechanism underpinning learning and memory. Impaired bursting was associated with...