Aging & Longevity

The human gut harbors thousands of microbial species, each exhibiting significant inter-individual genetic variability. Although many studies have associated microbial relative abundances with human-health-related phenotypes, the substantial intraspecies genetic variability of gut microbes has not yet been comprehensively considered, limiting the potential of linking such genetic traits with host conditions. Here, we analyzed 32,152 metagenomes from 94 microbiome studies across the globe to...

Nicotinamide adenine dinucleotide (NAD) is a ubiquitous electron carrier essential for energy metabolism and post-translational modification of numerous regulatory proteins. Dysregulations of NAD metabolism are widely regarded as detrimental to health, with NAD depletion commonly implicated in aging. However, the extent to which cellular NAD concentration can decline without adverse consequences remains unclear. To investigate this, we generated a mouse model in which nicotinamide...

CONCLUSIONS: This study confirms and adds nuance to international findings that overnight hospitalization is associated with accelerated cognitive decline. This association was dose-dependent, had a recency effect and was independent of illness severity in the case of cLOS. These findings suggest that all-cause acute hospitalization may be a reversible risk factor for cognitive decline. This needs further clarification and the development of interventions to minimise the impact of acute illness...

BACKGROUND: Even when older people are discharged directly home after an emergency department (ED) visit, the risk of deterioration of health status and loss of independence persists. We hypothesize that among older adults discharged from the ED, hospital-community transition care provided by geriatric mobile teams (GMTs) may reduce the early readmission rate and level of disability. Such approaches have rarely been evaluated and cannot be generalized yet. Providing evidence of the positive...

Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein's function and dysfunction in Parkinson's disease and other synucleinopathies is thought to be tightly linked to synaptic vesicle binding. Age is the biggest risk factor for synucleinopathy, and ~15% of synaptic vesicle proteins have been linked to central nervous system diseases. Yet, age- and disease-induced changes in synaptic vesicles remain unexplored. Via systematic analysis of synaptic vesicles at the...

The female reproductive organs present with the earliest aging characteristics, such as a decline in fertility and estrous cyclicity. While age-related changes in the ovary are well documented, it is unclear if any age-associated changes occur in the other female reproductive organs, such as the oviduct/Fallopian tube. At the distal end of aged oviducts in mice, we found vacuolated multi-ciliated cells (MCCs) with a severely apically displaced and deformed nucleus. This phenotype was unique to...

Cardiac aging is associated with metabolic changes, including an increased reliance on glycolysis, and an increased susceptibility to cardiovascular diseases. This study explores the relationship between enhanced cardiac glycolysis and aging using the Glyco^(Hi) mouse model, characterized by constitutively elevated glycolysis. We compared cardiac function, metabolism, mitochondrial performance, and hallmarks of aging between aged (21 and 24 months) Glyco^(Hi) and wild-type (WT) mice across...

Contrasting almost all other mammalian wintering strategies, Eurasian common shrews, Sorex araneus, endure winter by shrinking their brain, skull, and most organs, only to then regrow to breeding size the following spring. How such tiny mammals achieve this unique brain size plasticity while maintaining activity through the winter remains unknown. To discover potential adaptations underlying this trait, we analyzed seasonal differential gene expression in the shrew hypothalamus, a brain region...

The differentiation of human pluripotent stem cells (hPSCs) provides access to a wide range of cell types and tissues. However, hPSC-derived lineages typically represent a fetal stage of development, and methods to expedite the transition to an aged identity to improve modeling of late-onset disease are limited. In this study, we introduce RNAge, a transcriptome-based computational platform designed to enable the evaluation of an induced aging or a rejuvenated state. We validated this approach...

[This corrects the article DOI: 10.3389/fnagi.2025.1539508.].

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CONCLUSION: Ethnic disparities in frailty prevalence persist across community-based settings in different countries and are not fully explained by known inequalities. Addressing these disparities will likely require careful frailty measurement and assessment; confronting structural inequalities; and tailoring interventions to the needs of minoritised populations.

Conversion electrodes offer higher reversible capacity and lower cost than conventional intercalation chemistry electrodes, but suffer from kinetic limitation and large volume expansion. Despite significant efforts, developing conversion electrodes with fast charging capability and extended lifespan remains challenging. Here, by leveraging the advantages of high-entropy doping and morphology tailoring, we develop a high-entropy hierarchical micro/nanostructured sulfoselenide...

Recent studies using single-cell RNA sequencing technology have uncovered several subpopulations of CD4^(+) T cells that accumulate with aging. These age-associated T cells are emerging as relevant players in the onset of inflammaging and tissue senescence. Here, based on information provided by single-cell RNA sequencing data, we present a flow cytometry panel that allows the identification of age-associated T cell subsets in systematic larger analysis in mice. We use this panel to evaluate at...

Marine plastic pollution is a global issue, with microplastics (1 µm-5 mm) dominating the measured plastic count^(1,2). Although microplastics can be found throughout the oceanic water column^(3,4), most studies collect microplastics from surface waters (less than about 50-cm depth) using net tows⁵. Consequently, our understanding of the microplastics distribution across ocean depths is more limited. Here we synthesize depth-profile data from 1,885 stations collected between 2014 and 2024 to...

During the twentieth century, inflammatory bowel disease (IBD) was considered a disease of early industrialized regions in North America, Europe and Oceania¹. At the turn of the twenty-first century, IBD incidence increased in newly industrialized and emerging regions in Africa, Asia and Latin America, while the prevalence in early industrialized regions continued to grow steadily^(2-4). Changes in the incidence and prevalence denote the evolution of IBD across four epidemiologic stages: stage 1...

Oncogenic mutations are widespread in normal human tissues¹. Similarly, in murine chimeras, cells carrying an oncogenic lesion contribute normal cells to adult tissues without causing cancer^(2-4). How lineages that escape cancer via normal development differ from the minority that succumb is unclear. Tumours exhibit characteristic cancer hallmarks; we therefore searched for hallmarks that differentiate cancer-prone lineages from resistant lineages. Here we show that total cell cycle duration...

To examine the association between body mass index (BMI) trajectories, early and recent BMI changes, and phenotypic age acceleration (PhenoAgeAccel), addressing inconsistent findings in previous studies on weight change and aging. Data from the National Health and Nutrition Examination Survey from 2005 to 2018 were used, selecting participants aged 50 years and older. A growth mixture model was employed to identify BMI trajectories. The association between different BMI trajectories and...

CONCLUSIONS: Three distinct LSM trajectory patterns, each with unique demographic and clinical characteristics, were identified. Because older cancer survivors have distinct LSM patterns, interventions should be tailored to address specific characteristics and clinical needs. LSM measurement can contribute to assessment of older adults generally and should become part of standard assessment in older cancer survivors.

CONCLUSIONS: The location of caregiving, and caregiver's age and gender play an important role for changes in grip strength. The findings suggest that caregiving outside the household might be helpful for grip strength, in particular for older and male adults. Older caregivers inside the household, however, seem to need more support to prevent further decline in grip strength.