Aging & Longevity

Corpus callosum microstructure in chimpanzees (pan troglodytes): associations with age, handedness and cognition

1 day ago
Studies on the human brain have emphasized the loss of gray matter volume and decreased thickness during normal aging, along with variations in the density of small axon fibers across different regions of the corpus callosum (CC). Here, we investigated age-related changes in white matter connectivity in the CC and their association with handedness and cognitive decline in chimpanzees. To this end, microstructural measures of CC morphology were obtained from a sample of 49 chimpanzees. Initial...
Maëlig Chauvel

Variation in the Content of Three Tandem Repeats of the Human Genome (Ribosomal, Satellite III, and Telomere) in Peripheral Blood Leukocyte DNA of People of Different Ages (5-101 Years)

1 day ago
The variation of ribosomal (parameter R), satellite III (1q12) (parameter S), and telomere (parameter T) tandem repeats content of the human genome was studied in DNA samples isolated from blood leukocytes of 535 people whose age varied from 5 to 101 years. For analysis we used the method of nonradioactive quantitative hybridization. The group of centenarians (90-101 years old, N = 106) differs from other age groups by a significantly narrower distribution of the ribosomal repeat content in DNA,...
E S Ershova

Dual-Lineage Chondrocyte-Like Cells in the Nucleus Pulposus of Aging Intervertebral Discs Are Accelerated by Hedgehog Signaling Inactivation

1 day ago
Intervertebral disc (IVD) degeneration, a major contributor to chronic low back pain, is characterized by the age-related replacement of notochord-derived nucleus pulposus cells (NPCs) with chondrocyte-like or fibrotic cells (CLCs). However, the cellular origins of CLCs and mechanisms driving their emergence remain contentious. Using genetic lineage tracing with Shh-Cre and Gli1-CreER^(T2) to track notochordal and non-notochordal cells, respectively, we demonstrate that CLCs arise from dual...
Lei Zhang

Telomeric DNA damage response mediates neurotoxicity of Aβ42 oligomers in Alzheimer's disease

2 days ago
Ageing is the major risk factor for Alzheimer's disease (AD), the most common neurodegenerative disorder. DNA damage is a hallmark of ageing, particularly when occurring at telomeres, genomic regions vulnerable to oxidative damage and often challenging for the cell to repair. Here, we show that brains of 3xTg-AD mice, an established AD model characterized by amyloid-β (Aβ)-induced pathology, exhibit increased activation of DNA damage response (DDR) pathways at telomeres. Exposure of mouse...
Sara Sepe

Association of an in vivo classifier for ARTerioloSclerosis (ARTS) with cortical thickness and cognition in older adults

3 days ago
Brain arteriolosclerosis, a prominent small vessel pathology in the aging brain, is associated with cognitive impairment. Understanding the link between arteriolosclerosis and neurodegeneration may be crucial towards unravelling pathways by which arteriosclerosis contributes to cognitive impairment. Using a novel magnetic resonance imaging (MRI) in-vivo classifier for ARTerioloSclerosis termed ARTS, we examined cross-sectional associations between ARTS, cortical thickness, and cognition. Data...
Alifiya Kapasi

Determination of the age-related changes in the rat cerebellar cortex by using histologic and histometric methods

3 days ago
Aging is characterized as a process resulting in the structural and functional deterioration of several essential organs and tissues. This study aimed to determine the effects of normal aging on the cerebellum by using histological and histometric techniques. A total of 24 male Wistar albino rats were divided into three groups: young (4-6 weeks), adult (20-22 weeks), and old (22-24 months). Cerebellar tissue samples were treated using histological and immunohistochemical techniques. The slides...
Tansu Kuşat

Psychometric Properties of the Everyday Ageism Scale: Results from the Experiences of Aging in Society Project

3 days ago
Objective: To comprehensively evaluate the psychometric properties of the relatively new Everyday Ageism Scale. Methods: Data were from the 2021-2023 Experiences of Aging in Society project (N = 237, ages 50+, multiracial/multiethnic, 72.6% female). We assessed the multidimensional structure, reliability, and validity of the Everyday Ageism Scale. Results: Confirmatory factor analysis generally substantiated the three-factor structure of the Everyday Ageism Scale: exposure to ageist messages,...
Julie Ober Allen

Telomerase modRNA Offers a Novel RNA-Based Approach to Treat Human Pulmonary Fibrosis

3 days ago
Pulmonary Fibrosis (PF) is a life-threatening illness that is characterized by progressive scarring in the lung interstitium. There is an urgent need for new PF therapies because current treatments only slow down the progression of fibrosis, and the median life expectancy post-diagnosis is only 4-6 years. Since PF patients frequently exhibit telomere attrition, overexpressing telomerase, the enzyme responsible for synthesizing telomeres, represents a compelling therapeutic option. In this study,...
Jia Li Ye

Melatonin's role in ameliorating perturbed circadian immune molecular links with aging and sleep deprivation in central and peripheral clocks in male Wistar rats

3 days ago
Sleep deprivation (SD) and aging are linked to chronic inflammation, a contributor to age-associated diseases. Circadian rhythms, governed by suprachiasmatic nucleus (SCN), regulate immune and inflammatory responses. While aging and SD elevate pro-inflammatory cytokines such as IL-1β, TNF-α, and IL-6, their impact on temporal dynamics of inflammation across tissues and age groups remains unclear. This study examines age-dependent effects of chronic total SD on daily expression rhythms of...
Zeeshan Akhtar Khan

Substrate stiffness dictates unique paths towards proliferative arrest in WI-38 cells

3 days ago
Finite replicative potential is a defining feature of non-transformed somatic cells, first established by Leonard Hayflick in vitro using WI-38 human lung fibroblasts. Once proliferative capacity is exhausted due to telomere shortening, cells enter into a state called replicative senescence, which can be avoided through ectopic expression of telomerase reverse transcriptase (hTERT). As WI-38 cells approach replicative arrest, molecular pathways linked to mechanotransduction are induced,...
Alyssa M Kaiser

Exploring the impact of metformin on testicular aging in Syrian hamsters

3 days ago
Biochemical and molecular mechanisms associated with testicular aging are still poorly understood. Here, using the Syrian hamster as a natural model of aging, we observed a disturbed spermatogenesis with reduction of the testicular weight and the gonadosomatic index, altered histology including tubular wall fibrosis, increased collagen deposition, and diminished steroidogenesis in testes of aged animals. These changes took place in parallel with an increase in the levels of inflammatory and...
Alina Cavallotti Gomez

Hyperoside extends lifespan in Caenorhabditis elegans through SEK-1/PMK-1/SKN-1 pathway

3 days ago
The progressive functional decline associated with aging is a primary risk factor for numerous chronic diseases. The discovery of natural compounds that can modulate conserved longevity pathways offers a promising strategy for promoting healthy aging. Hyperoside, a flavonoid abundant in edible plants such as hawthorn, possesses various pharmacological activities, but its specific role and molecular mechanisms in geroprotection remain poorly understood. This study aimed to elucidate the...
Xin-Tian Yu

Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice

3 days ago
Mice bred in 2021 were tested by the Interventions Testing Program (ITP) for possible lifespan benefits of 2BAct (2BA), dichloroacetate (DCA), Epicatechin (EPI), Forskolin (FSK), Halofuginone (HAL) and Mitoglitazone (MIT). All agents were administered in the diet ad libitum beginning at 7 months of age. In male mice, EPI increased median lifespan by ~ 5%, and HAL and MIT each increased median lifespan by ~ 9%. EPI and HAL, but not MIT, increased 90% survival. In addition to adding 3 new agents...
Randy Strong

DP1 Receptor Blockade Attenuates Microglial Senescence and Cognitive Decline Caused by PTGDS in Exosomes From Aged Brains

3 days ago
Aging leads to neurodegenerative diseases, such as cognitive decline, which are induced by persistent chronic low-grade inflammation in the brain driven by microglial activation. However, whether and how brain-derived exosomes from aged mice (A-exo) induce a pro-inflammatory state and cellular senescence in microglia within the aging brain is poorly understood. Here, we report that brain-derived exosomes from aged mice (A-exo) cause cognitive decline in normal young mice, inducing microglial...
Yaru Liu

Enhanced C/EBPalpha Function Extends Healthspan and Lifespan in the African Turquoise Killifish

4 days ago
The transcription factor CCAAT/enhancer binding protein alpha (C/EBPα) regulates cell differentiation, proliferation, and function in various tissues, including the liver, adipose tissue, skin, lung, and hematopoietic system. Studies in rats, mice, humans, and chickens have shown that CEBPA mRNA undergoes alternative translation initiation, producing three C/EBPα isoforms. Two of these isoforms act as full-length transcription factors with N-terminal transactivation domains and a C-terminal...
Christine Müller
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