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NMR metabolomic modeling of age and lifespan: A multicohort analysis
Metabolomic age models have been proposed for the study of biological aging, however, they have not been widely validated. We aimed to assess the performance of newly developed and existing nuclear magnetic resonance spectroscopy (NMR) metabolomic age models for prediction of chronological age (CA), mortality, and age-related disease. Ninety-eight metabolic variables were measured in blood from nine UK and Finnish cohort studies (N ≈31,000 individuals, age range 24-86 years). We used nonlinear...
Epigenetic age oscillates during the day
Since their introduction, epigenetic clocks have been extensively used in aging, human disease, and rejuvenation studies. In this article, we report an intriguing pattern: epigenetic age predictions display a 24-h periodicity. We tested a circadian blood sample collection using 17 epigenetic clocks addressing different aspects of aging. Thirteen clocks exhibited significant oscillations with the youngest and oldest age estimates around midnight and noon, respectively. In addition, daily...
The advent of Alzheimer treatments will change the trajectory of human aging
Do insects have an inner life? Animal consciousness needs a rethink
Detectors deep in South Pole ice pin down elusive tau neutrino
Living on Mars would probably suck — here's why
Australia’s Great Barrier Reef is ‘transforming’ from repeated coral bleaching
Dogwhistles, drilling and the roots of Western civilization: Books in brief
Interferon-γ and infectious diseases: Lessons and prospects
Science, Volume 384, Issue 6693, April 2024.
A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes
Science, Volume 384, Issue 6693, April 2024.
Generalized biomolecular modeling and design with RoseTTAFold All-Atom
Science, Volume 384, Issue 6693, April 2024.
Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need
Science, Volume 384, Issue 6693, April 2024.
Phage predation, disease severity, and pathogen genetic diversity in cholera patients
Science, Volume 384, Issue 6693, April 2024.
Africa intensifies battle against mpox as ‘alarming’ outbreaks continue
New variant identified in Congolese mining town renews worries about global spread
Where did Earth’s oddball ‘quasi-moon’ come from? Scientists pinpoint famed lunar crater
Impact that created the asteroid also blasted out the famous Giordano Bruno crater
Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila
Cdk8 in Drosophila is the orthologue of vertebrate CDK8 and CDK19. These proteins have been shown to modulate transcriptional control by RNA polymerase II. We found that neuronal loss of Cdk8 severely reduces fly lifespan and causes bang sensitivity. Remarkably, these defects can be rescued by expression of human CDK19, found in the cytoplasm of neurons, suggesting a non-nuclear function of CDK19/Cdk8. Here we show that Cdk8 plays a critical role in the cytoplasm, with its loss causing elongated...
Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain
Alzheimer's disease (AD) and dementia in general are age-related diseases with multiple contributing factors, including brain inflammation. Microglia, and specifically those expressing the AD risk gene TREM2, are considered important players in AD, but their exact contribution to pathology remains unclear. In this study, using high-throughput mass cytometry in the 5×FAD mouse model of amyloidosis, we identified senescent microglia that express high levels of TREM2 but also exhibit a distinct...
LKRSDH-dependent histone modifications of insulin-like peptide sites contribute to age-related circadian rhythm changes
To understand aging impact on the circadian rhythm, we screened for factors influencing circadian changes during aging. Our findings reveal that LKRSDH mutation significantly reduces rhythmicity in aged flies. RNA-seq identifies a significant increase in insulin-like peptides (dilps) in LKRSDH mutants due to the combined effects of H3R17me2 and H3K27me3 on transcription. Genetic evidence suggests that LKRSDH regulates age-related circadian rhythm changes through art4 and dilps. ChIP-seq analyzes...
Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila
Cdk8 in Drosophila is the orthologue of vertebrate CDK8 and CDK19. These proteins have been shown to modulate transcriptional control by RNA polymerase II. We found that neuronal loss of Cdk8 severely reduces fly lifespan and causes bang sensitivity. Remarkably, these defects can be rescued by expression of human CDK19, found in the cytoplasm of neurons, suggesting a non-nuclear function of CDK19/Cdk8. Here we show that Cdk8 plays a critical role in the cytoplasm, with its loss causing elongated...
Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain
Alzheimer's disease (AD) and dementia in general are age-related diseases with multiple contributing factors, including brain inflammation. Microglia, and specifically those expressing the AD risk gene TREM2, are considered important players in AD, but their exact contribution to pathology remains unclear. In this study, using high-throughput mass cytometry in the 5×FAD mouse model of amyloidosis, we identified senescent microglia that express high levels of TREM2 but also exhibit a distinct...